{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T13:49:37Z","timestamp":1758808177458,"version":"3.44.0"},"reference-count":32,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2006,1,1]],"date-time":"2006-01-01T00:00:00Z","timestamp":1136073600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2006,1,1]],"date-time":"2006-01-01T00:00:00Z","timestamp":1136073600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100017391","name":"Japan Private School Promotion Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100017391","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","journalofsurgicalresearch.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Surgical Research"],"published-print":{"date-parts":[[2006,1]]},"DOI":"10.1016\/j.jss.2005.08.002","type":"journal-article","created":{"date-parts":[[2005,9,13]],"date-time":"2005-09-13T07:14:21Z","timestamp":1126595661000},"page":"38-44","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"title":["Administration of rhHGF-Activator Via Portal Vein Stimulates the Regeneration of Cirrhotic Liver After Partial Hepatectomy in Rats1"],"prefix":"10.1016","volume":"130","author":[{"given":"Hidesuke","family":"Yanagida","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masaki","family":"Kaibori","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takeshi","family":"Hijikawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A-Hon","family":"Kwon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuo","family":"Kamiyama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tadayoshi","family":"Okumura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jss.2005.08.002_bib1","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1038\/342440a0","article-title":"Molecular cloning and expression of human hepatocyte growth factor","volume":"342","author":"Nakamura","year":"1989","journal-title":"Nature"},{"key":"10.1016\/j.jss.2005.08.002_bib2","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1016\/0006-291X(89)92316-4","article-title":"Molecular cloning and sequence analysis of cDNA for human hepatocyte growth factor","volume":"163","author":"Miyazawa","year":"1989","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.jss.2005.08.002_bib3","doi-asserted-by":"crossref","first-page":"20114","DOI":"10.1016\/S0021-9258(19)88673-8","article-title":"Activation of hepatocyte growth factor by proteolytic conversion of a single chain form to a heterodimer","volume":"267","author":"Naka","year":"1992","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jss.2005.08.002_bib4","doi-asserted-by":"crossref","first-page":"8966","DOI":"10.1016\/S0021-9258(17)37062-X","article-title":"Proteolytic activation of hepatocyte growth factor in response to tissue injury","volume":"269","author":"Miyazawa","year":"1994","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jss.2005.08.002_bib5","series-title":"Hepatocyte Growth Factor-Scatter (HGF-SF) and the c-met Receptor","first-page":"131","article-title":"Structure, biosynthesis and biochemical properties of the HGF receptor in normal and malignant cells","author":"Comoglio","year":"1993"},{"key":"10.1016\/j.jss.2005.08.002_bib6","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1093\/oxfordjournals.jbchem.a021283","article-title":"Emerging multipotent aspects of hepatocyte growth factor","volume":"119","author":"Matsumoto","year":"1996","journal-title":"J. Biochem."},{"key":"10.1016\/j.jss.2005.08.002_bib7","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1111\/j.1432-1033.1995.tb20463.x","article-title":"Activation of hepatocyte growth factor by two homologous proteases, blood-coagulation factor XIIa and hepatocyte growth factor activator","volume":"229","author":"Shimomura","year":"1995","journal-title":"Eur. J. Biochem."},{"key":"10.1016\/j.jss.2005.08.002_bib8","doi-asserted-by":"crossref","first-page":"3615","DOI":"10.1074\/jbc.271.7.3615","article-title":"Activation of hepatocyte growth factor in the injured tissues is mediated by hepatocyte growth factor activator","volume":"271","author":"Miyazawa","year":"1996","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jss.2005.08.002_bib9","doi-asserted-by":"crossref","first-page":"10024","DOI":"10.1016\/S0021-9258(18)82167-6","article-title":"Molecular cloning and sequence analysis of the cDNA for a human serine protease reponsible for activation of hepatocyte growth factor. Structural similarity of the protease precursor to blood coagulation factor XII","volume":"268","author":"Miyazawa","year":"1993","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jss.2005.08.002_bib10","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/S0167-4781(00)00029-4","article-title":"Mouse hepatocyte growth factor activator gene","volume":"1491","author":"Itoh","year":"2000","journal-title":"Biochim. Biophys. Acta."},{"key":"10.1016\/j.jss.2005.08.002_bib11","doi-asserted-by":"crossref","first-page":"22927","DOI":"10.1016\/S0021-9258(18)41615-8","article-title":"Activation of the zymogen of hepatocyte growth factor activator by thrombin","volume":"268","author":"Shimomura","year":"1993","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jss.2005.08.002_bib12","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1006\/mthe.2000.0210","article-title":"Liver cirrhosis is reverted by urokinase-type plasminogen activator gene therapy","volume":"2","author":"Salgado","year":"2000","journal-title":"Mol. Ther."},{"key":"10.1016\/j.jss.2005.08.002_bib13","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1136\/gut.52.5.694","article-title":"Hepatocyte growth factor gene therapy accelerates regeneration in cirrhotic mouse livers after hepatectomy","volume":"52","author":"Xue","year":"2003","journal-title":"Gut"},{"key":"10.1016\/j.jss.2005.08.002_bib14","doi-asserted-by":"crossref","first-page":"399","DOI":"10.3727\/000000002783985729","article-title":"Role of intrasplenic hepatocyte transplantation in improving survival and liver regeneration after hepatic resection in cirrhotic rats","volume":"11","author":"Ahmad","year":"2002","journal-title":"Cell Transplant."},{"key":"10.1016\/j.jss.2005.08.002_bib15","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/S1386-6346(02)00031-1","article-title":"Anti-transforming growth factor-beta1 antibody improves survival rate following partial hepatectomy in cirrhotic rats","volume":"24","author":"Ohara","year":"2002","journal-title":"Hepatol. Res."},{"key":"10.1016\/j.jss.2005.08.002_bib16","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/S0168-3659(02)00463-7","article-title":"A trial on regeneration therapy of rat liver cirrhosis by controlled release of hepatocyte growth factor","volume":"88","author":"Oe","year":"2003","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jss.2005.08.002_bib17","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1006\/bbrc.2001.6170","article-title":"Exogenously administered HGF-activator augments liver regeneration through the production of biologically active HGF","volume":"290","author":"Kaibori","year":"2002","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.jss.2005.08.002_bib18","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1006\/jsre.2002.6438","article-title":"Impairment of activation of hepatocyte growth factor precursor into mature form in rats with liver cirrhosis","volume":"106","author":"Kaibori","year":"2002","journal-title":"J. Surg. Res."},{"key":"10.1016\/j.jss.2005.08.002_bib19","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1016\/S0168-8278(85)80747-9","article-title":"A Dimethylnitrosamine-induced model of cirrhosis and portal hypertension in rat","volume":"1","author":"Jenkins","year":"1985","journal-title":"J. Hepatol."},{"key":"10.1016\/j.jss.2005.08.002_bib20","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/S0168-8278(87)80570-6","article-title":"A morphological study of the early stage of hepatic fibrosis induced by low doses of dimethylnitrosamine in the rat","volume":"5","author":"Jezequel","year":"1987","journal-title":"J. Hepatol."},{"key":"10.1016\/j.jss.2005.08.002_bib21","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/S0168-8278(97)80185-7","article-title":"Stimulation of liver regeneration and function after partial hepatectomy in cirrhotic rats by continuous infusion of recombinant human hepatocyte growth factor","volume":"27","author":"Kaibori","year":"1997","journal-title":"J. Hepatol."},{"key":"10.1016\/j.jss.2005.08.002_bib22","doi-asserted-by":"crossref","first-page":"984","DOI":"10.3109\/00365528608996409","article-title":"Effects of H2-receptor antagonists on the rat liver after partial hepatectomy or carbon tetrachloride-induced hepatic injury","volume":"21","author":"Lee","year":"1986","journal-title":"Scand. J. Gastroenterol."},{"key":"10.1016\/j.jss.2005.08.002_bib23","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1111\/j.1432-1033.1991.tb15876.x","article-title":"An alternatively processed mRNA generated from human hepatocyte growth factor gene","volume":"197","author":"Miyazawa","year":"1991","journal-title":"Eur. J. Biochem."},{"key":"10.1016\/j.jss.2005.08.002_bib24","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/S0168-8278(02)00455-5","article-title":"Hepatocyte growth factor inhibits insulin-stimulated glycogen synthesis in primary cultured hepatocytes","volume":"38","author":"Kaibori","year":"2003","journal-title":"J. Hepatol."},{"key":"10.1016\/j.jss.2005.08.002_bib25","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1677\/jme.0.0280099","article-title":"Hepatocyte growth factor stimulates proliferation of pancreatic beta-cells particularly in the presence of subphysiological glucose concentrations","volume":"28","author":"Gahr","year":"2002","journal-title":"J. Mol. Endocrinol."},{"key":"10.1016\/j.jss.2005.08.002_bib26","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1002\/hep.1840160520","article-title":"Direct evidence that hepatocyte growth factor is a hepatotrophic factor for liver regeneration and has a potent antihepatitis effect in vivo","volume":"16","author":"Ishiki","year":"1992","journal-title":"Hepatology"},{"key":"10.1016\/j.jss.2005.08.002_bib27","doi-asserted-by":"crossref","first-page":"1443","DOI":"10.1016\/0270-9139(93)90237-H","article-title":"Stimulation of liver growth by exogenous human hepatocyte growth factor in normal and partially hepatectomized rats","volume":"18","author":"Fujiwara","year":"1993","journal-title":"Hepatology"},{"key":"10.1016\/j.jss.2005.08.002_bib28","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1002\/hep.1840150125","article-title":"Hepatocyte growth factor","volume":"15","author":"Michalopoulos","year":"1992","journal-title":"Hepatology"},{"key":"10.1016\/j.jss.2005.08.002_bib29","doi-asserted-by":"crossref","first-page":"16871","DOI":"10.1074\/jbc.270.28.16871","article-title":"Sulfated oligosaccharides promote hepatocyte growth factor association and govern its mitogenic activity","volume":"270","author":"Zioncheck","year":"1995","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jss.2005.08.002_bib30","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1073\/pnas.94.2.701","article-title":"Diverse tumorigenesis associated with aberrant development in mice overexpressing hepatocyte growth factor\/scatter factor","volume":"94","author":"Takayama","year":"1997","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.jss.2005.08.002_bib31","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1023\/A:1006685218766","article-title":"Hepatocyte growth factor promotes migration of human hepatocellular carcinoma via phosphatidylinositol 3-kinase","volume":"17","author":"Nakanishi","year":"1999","journal-title":"Clin. Exp. Metastasis"},{"key":"10.1016\/j.jss.2005.08.002_bib32","first-page":"1728","article-title":"Evidence for the presence of an inactive precursor of human hepatocyte growth factor in plasma and sera of patients with liver diseases","volume":"22","author":"Arakaki","year":"1995","journal-title":"Hepatology"}],"container-title":["Journal of Surgical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S002248040500449X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S002248040500449X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T14:37:21Z","timestamp":1758379041000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S002248040500449X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,1]]},"references-count":32,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2006,1]]}},"alternative-id":["S002248040500449X"],"URL":"https:\/\/doi.org\/10.1016\/j.jss.2005.08.002","relation":{},"ISSN":["0022-4804"],"issn-type":[{"type":"print","value":"0022-4804"}],"subject":[],"published":{"date-parts":[[2006,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Administration of rhHGF-Activator Via Portal Vein Stimulates the Regeneration of Cirrhotic Liver After Partial Hepatectomy in Rats1","name":"articletitle","label":"Article Title"},{"value":"Journal of Surgical Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jss.2005.08.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2006 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}