{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T19:03:47Z","timestamp":1786993427730,"version":"build-2736575974"},"reference-count":58,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2006,6,1]],"date-time":"2006-06-01T00:00:00Z","timestamp":1149120000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Surgical Research"],"published-print":{"date-parts":[[2006,6]]},"DOI":"10.1016\/j.jss.2005.10.008","type":"journal-article","created":{"date-parts":[[2005,12,22]],"date-time":"2005-12-22T18:18:40Z","timestamp":1135275520000},"page":"143-149","source":"Crossref","is-referenced-by-count":91,"title":["Nitrotyrosine and Chlorotyrosine: Clinical Significance and Biological Functions in the Vascular System"],"prefix":"10.1016","volume":"133","author":[{"given":"Imran","family":"Mohiuddin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Chai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter H.","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan B.","family":"Lumsden","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qizhi","family":"Yao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changyi","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jss.2005.10.008_bib1","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1111\/paa.1999.111.5.383","article-title":"Myeloperoxidase","volume":"111","author":"Klebanoff","year":"1999","journal-title":"Proc Assoc Am Physicians"},{"key":"10.1016\/j.jss.2005.10.008_bib2","doi-asserted-by":"crossref","first-page":"3007","DOI":"10.1182\/blood.V92.9.3007","article-title":"Inside the neutrophil phagosome","volume":"92","author":"Hampton","year":"1998","journal-title":"Blood"},{"key":"10.1016\/j.jss.2005.10.008_bib3","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1080\/13510002.1997.11747085","article-title":"Myeloperoxidase","volume":"3","author":"Kettle","year":"1997","journal-title":"Redox Rep"},{"key":"10.1016\/j.jss.2005.10.008_bib4","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1159\/000041062","article-title":"Consequences of total and subtotal myeloperoxidase deficiency","volume":"104","author":"Kutter","year":"2000","journal-title":"Acta Haematol"},{"key":"10.1016\/j.jss.2005.10.008_bib5","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1067\/mhj.2001.116769","article-title":"A functional myeloperoxidase polymorphic variant is associated with coronary artery disease in French-Canadians","volume":"142","author":"Nikpoor","year":"2001","journal-title":"Am Heart J"},{"key":"10.1016\/j.jss.2005.10.008_bib6","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1046\/j.1523-1755.63.s84.32.x","article-title":"A functional variant of the myeloperoxidase gene is associated with cardiovascular disease in end-stage renal disease patients","volume":"84","author":"Pecoits-Filho","year":"2003","journal-title":"Kidney Int Suppl"},{"key":"10.1016\/j.jss.2005.10.008_bib7","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/S0891-5849(00)00204-5","article-title":"Biomarkers of myeloperoxidase-derived hypochlorous acid","volume":"29","author":"Winterbourn","year":"2000","journal-title":"Free Radic Biol Med"},{"key":"10.1016\/j.jss.2005.10.008_bib8","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1016\/S0891-5849(97)00084-1","article-title":"Mass spectrometric quantification of 3-chlorotyrosine in human tissues with attomole sensitivity","volume":"23","author":"Hazen","year":"1997","journal-title":"Free Radic Biol Med"},{"key":"10.1016\/j.jss.2005.10.008_bib9","doi-asserted-by":"crossref","first-page":"1716","DOI":"10.1161\/01.ATV.20.7.1716","article-title":"Oxidation of LDL by myeloperoxidase and reactive nitrogen species","volume":"20","author":"Carr","year":"2000","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.jss.2005.10.008_bib10","doi-asserted-by":"crossref","first-page":"1717","DOI":"10.1016\/S0891-5849(00)00229-X","article-title":"Myeloperoxidase-generated oxidants and atherosclerosis","volume":"28","author":"Podrez","year":"2000","journal-title":"Free Radic Biol Med"},{"key":"10.1016\/j.jss.2005.10.008_bib11","doi-asserted-by":"crossref","first-page":"1433","DOI":"10.1074\/jbc.272.3.1433","article-title":"Reactive nitrogen intermediates promote low density lipoprotein oxidation in human atherosclerotic intima","volume":"272","author":"Leeuwenburgh","year":"1997","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jss.2005.10.008_bib12","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/S0076-6879(94)33026-3","article-title":"Oxidative chemistry of peroxynitrite","volume":"233","author":"Beckman","year":"1994","journal-title":"Methods Enzymol"},{"key":"10.1016\/j.jss.2005.10.008_bib13","first-page":"77","article-title":"Inducible nitric oxide synthase is present within human atherosclerotic lesions and promotes the formation and activity of peroxynitrite","volume":"75","author":"Buttery","year":"1996","journal-title":"Lab Invest"},{"key":"10.1016\/j.jss.2005.10.008_bib14","doi-asserted-by":"crossref","first-page":"13032","DOI":"10.1073\/pnas.0405292101","article-title":"The myeloperoxidase product hypochlorous acid oxidizes HDL in the human artery wall and impairs ABCA1-dependent cholesterol transport","volume":"101","author":"Bergt","year":"2004","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.jss.2005.10.008_bib15","doi-asserted-by":"crossref","first-page":"2075","DOI":"10.1172\/JCI119379","article-title":"3-Chlorotyrosine, a specific marker of myeloperoxidase-catalyzed oxidation, is markedly elevated in low density lipoprotein isolated from human atherosclerotic intima","volume":"99","author":"Hazen","year":"1997","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jss.2005.10.008_bib16","doi-asserted-by":"crossref","first-page":"42977","DOI":"10.1074\/jbc.M406762200","article-title":"Human atherosclerotic intima and blood of patients with established coronary artery disease contain high density lipoprotein damaged by reactive nitrogen species","volume":"279","author":"Pennathur","year":"2004","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jss.2005.10.008_bib17","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/0014-5793(93)80269-Z","article-title":"Peroxynitrite modification of low-density lipoprotein leads to recognition by the macrophage scavenger receptor","volume":"330","author":"Graham","year":"1993","journal-title":"FEBS Lett"},{"key":"10.1016\/j.jss.2005.10.008_bib18","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/S0014-5793(02)02263-9","article-title":"Participation of peroxynitrite in oxidative modification of LDL by aqueous extracts of cigarette smoke","volume":"512","author":"Yamaguchi","year":"2002","journal-title":"FEBS Lett"},{"key":"10.1016\/j.jss.2005.10.008_bib19","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1038\/34923","article-title":"Formation of nitric oxide-derived inflammatory oxidants by myeloperoxidase in neutrophils","volume":"391","author":"Eiserich","year":"1998","journal-title":"Nature"},{"key":"10.1016\/j.jss.2005.10.008_bib20","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1161\/01.RES.85.10.950","article-title":"Formation of nitric oxide-derived oxidants by myeloperoxidase in monocytes","volume":"85","author":"Hazen","year":"1999","journal-title":"Circ Res"},{"key":"10.1016\/j.jss.2005.10.008_bib21","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1111\/j.1432-1033.1990.tb19358.x","article-title":"The role of myeloperoxidase in the oxidation of biologically active polyhydroxyphenols (substituted catechols)","volume":"193","author":"Metodiewa","year":"1990","journal-title":"Eur J Biochem"},{"key":"10.1016\/j.jss.2005.10.008_bib22","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1080\/10623320490482619","article-title":"Peroxynitrite and vascular endothelial dysfunction in diabetes mellitus","volume":"11","author":"Zou","year":"2004","journal-title":"Endothelium"},{"key":"10.1016\/j.jss.2005.10.008_bib23","first-page":"778","article-title":"Nitrated and oxidized plasma proteins in smokers and lung cancer patients","volume":"61","author":"Pignatelli","year":"2001","journal-title":"Cancer Res"},{"key":"10.1016\/j.jss.2005.10.008_bib24","doi-asserted-by":"crossref","first-page":"1146","DOI":"10.1002\/bjs.4690","article-title":"Increased nitrotyrosine production in patients undergoing abdominal aortic aneurysm repair","volume":"91","author":"Troxler","year":"2004","journal-title":"Br J Surg"},{"key":"10.1016\/j.jss.2005.10.008_bib25","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1053\/j.ajkd.2004.04.034","article-title":"Tyrosine nitration in plasma proteins from patients undergoing hemodialysis","volume":"44","author":"Mitrogianni","year":"2004","journal-title":"Am J Kidney Dis"},{"key":"10.1016\/j.jss.2005.10.008_bib26","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1172\/JCI0215021","article-title":"Myeloperoxidase produces nitrating oxidants in vivo","volume":"109","author":"Gaut","year":"2002","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jss.2005.10.008_bib27","doi-asserted-by":"crossref","first-page":"2375","DOI":"10.1097\/00004872-200312000-00027","article-title":"Distribution of nitric oxide synthases and nitrotyrosine in the kidney of spontaneously hypertensive rats","volume":"21","author":"Fernandez","year":"2003","journal-title":"J Hypertens"},{"key":"10.1016\/j.jss.2005.10.008_bib28","doi-asserted-by":"crossref","first-page":"2466","DOI":"10.1097\/01.ASN.0000088024.72216.2E","article-title":"Chronic renal failure accelerates atherogenesis in apolipoprotein E-deficient mice","volume":"14","author":"Bro","year":"2003","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.jss.2005.10.008_bib29","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1097\/00000542-200210000-00021","article-title":"Myeloperoxidase-associated tyrosine nitration after intratracheal administration of lipopolysaccharide in rats","volume":"97","author":"Hataishi","year":"2002","journal-title":"Anesthesiology"},{"key":"10.1016\/j.jss.2005.10.008_bib30","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.neulet.2004.04.008","article-title":"Morphological and functional changes induced by the amino acid analogue 3-nitrotyrosine in mouse neuroblastoma and rat glioma cell lines","volume":"363","author":"Zedda","year":"2004","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.jss.2005.10.008_bib31","first-page":"269","article-title":"Stimulation of nerve growth factor expression in astrocytes by peroxynitrite","volume":"18","author":"Vargas","year":"2004","journal-title":"In Vivo"},{"key":"10.1016\/j.jss.2005.10.008_bib32","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1111\/j.1365-2222.2004.01968.x","article-title":"Urinary 3-bromotyrosine and 3-chlorotyrosine concentrations in asthmatic patients","volume":"34","author":"Mita","year":"2004","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.jss.2005.10.008_bib33","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1203\/01.PDR.0000050655.25689.CE","article-title":"3-Chlorotyrosine as a marker of protein damage by myeloperoxidase in tracheal aspirates from preterm infants","volume":"53","author":"Buss","year":"2003","journal-title":"Pediatr Res"},{"key":"10.1016\/j.jss.2005.10.008_bib34","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1002\/mrm.20242","article-title":"NMR analysis of neutrophil activation in sputum samples from patients with cystic fibrosis","volume":"52","author":"Saude","year":"2004","journal-title":"Magn Reson Med"},{"key":"10.1016\/j.jss.2005.10.008_bib35","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1016\/S0891-5849(01)00697-9","article-title":"Myeloperoxidase-catalyzed 3-chlorotyrosine formation in dialysis patients","volume":"31","author":"Himmelfarb","year":"2001","journal-title":"Free Radic Biol Med"},{"key":"10.1016\/j.jss.2005.10.008_bib36","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.1016\/j.jaci.2004.09.027","article-title":"Urinary eicosanoid and tyrosine derivative concentrations in patients with vasculitides","volume":"114","author":"Higashi","year":"2004","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jss.2005.10.008_bib37","doi-asserted-by":"crossref","first-page":"11961","DOI":"10.1073\/pnas.211190298","article-title":"Neutrophils employ the myeloperoxidase system to generate antimicrobial brominating and chlorinating oxidants during sepsis","volume":"98","author":"Gaut","year":"2001","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.jss.2005.10.008_bib38","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1161\/01.ATV.0000013785.03265.5C","article-title":"Vitamin C protects against hypochlorous acid-induced glutathione depletion and DNA base and protein damage in human vascular smooth muscle cells","volume":"22","author":"Jenner","year":"2002","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.jss.2005.10.008_bib39","doi-asserted-by":"crossref","first-page":"30463","DOI":"10.1074\/jbc.M202331200","article-title":"Human neutrophils use the myeloperoxidase-hydrogen peroxide-chloride system to chlorinate but not nitrate bacterial proteins during phagocytosis","volume":"277","author":"Rosen","year":"2002","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jss.2005.10.008_bib40","doi-asserted-by":"crossref","first-page":"9757","DOI":"10.1074\/jbc.M106134200","article-title":"Chlorination of bacterial and neutrophil proteins during phagocytosis and killing of Staphylococcus aureus","volume":"277","author":"Chapman","year":"2002","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jss.2005.10.008_bib41","doi-asserted-by":"crossref","first-page":"34621","DOI":"10.1074\/jbc.274.49.34621","article-title":"Mass spectrometric quantification of 3-nitrotyrosine, ortho-tyrosine, and o,o\u2032-dityrosine in brain tissue of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated mice, a model of oxidative stress in Parkinson\u2019s disease","volume":"274","author":"Pennathur","year":"1999","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jss.2005.10.008_bib42","doi-asserted-by":"crossref","first-page":"19950","DOI":"10.1074\/jbc.271.33.19950","article-title":"Human phagocytes employ the myeloperoxidase-hydrogen peroxide system to synthesize dityrosine, trityrosine, pulcherosine, and isodityrosine by a tyrosyl radical-dependent pathway","volume":"271","author":"Jacob","year":"1996","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jss.2005.10.008_bib43","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1067\/mpd.2000.107512","article-title":"Increased oxidative stress in kwashiorkor","volume":"137","author":"Manary","year":"2000","journal-title":"J Pediatr"},{"key":"10.1016\/j.jss.2005.10.008_bib44","doi-asserted-by":"crossref","first-page":"L537","DOI":"10.1152\/ajplung.2000.279.3.L537","article-title":"Myeloperoxidase and protein oxidation in cystic fibrosis","volume":"279","author":"Van Der Vliet","year":"2000","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"10.1016\/j.jss.2005.10.008_bib45","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1042\/bj20020964","article-title":"Comparison of nitration and oxidation of tyrosine in advanced human carotid plaque proteins","volume":"370","author":"Morton","year":"2003","journal-title":"Biochem J"},{"key":"10.1016\/j.jss.2005.10.008_bib46","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1161\/01.CIR.0000080895.05158.8B","article-title":"Statins promote potent systemic antioxidant effects through specific inflammatory pathways","volume":"108","author":"Shishehbor","year":"2003","journal-title":"Circulation"},{"key":"10.1016\/j.jss.2005.10.008_bib47","doi-asserted-by":"crossref","first-page":"4799","DOI":"10.1021\/bi035946a","article-title":"Kinetic analysis of the reactions of hypobromous acid with protein components","volume":"43","author":"Pattison","year":"2004","journal-title":"Biochemistry"},{"key":"10.1016\/j.jss.2005.10.008_bib48","doi-asserted-by":"crossref","first-page":"1609","DOI":"10.1016\/S0024-3205(02)02443-8","article-title":"Lemon flavonoid, eriocitrin, suppresses exercise-induced oxidative damage in rat liver","volume":"72","author":"Minato","year":"2003","journal-title":"Life Sci"},{"key":"10.1016\/j.jss.2005.10.008_bib49","doi-asserted-by":"crossref","first-page":"243","DOI":"10.5551\/jat.9.243","article-title":"The protective effects of tetrahydrocurcumin on oxidative stress in cholesterol-fed rabbits","volume":"9","author":"Naito","year":"2002","journal-title":"J Atheroscler Thromb"},{"key":"10.1016\/j.jss.2005.10.008_bib50","first-page":"R128","article-title":"Oxidized amino acids in the urine of aging rats","volume":"276","author":"Leeuwenburgh","year":"1999","journal-title":"Am J Physiol"},{"key":"10.1016\/j.jss.2005.10.008_bib51","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.brainres.2004.01.017","article-title":"Histochemical features of stress-induced aggregates in alpha-synuclein overexpressing cells","volume":"1004","author":"Matsuzaki","year":"2004","journal-title":"Brain Res"},{"key":"10.1016\/j.jss.2005.10.008_bib52","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1172\/JCI10072","article-title":"Eosinophil-dependent bromination in the pathogenesis of asthma","volume":"105","author":"Heinecke","year":"2000","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jss.2005.10.008_bib53","doi-asserted-by":"crossref","first-page":"25933","DOI":"10.1074\/jbc.274.36.25933","article-title":"Eosinophil peroxidase nitrates protein tyrosyl residues. Implications for oxidative damage by nitrating intermediates in eosinophilic inflammatory disorders","volume":"274","author":"Wu","year":"1999","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jss.2005.10.008_bib54","first-page":"E1","article-title":"Antioxidant effects of statins","volume":"9","author":"Stoll","year":"2005","journal-title":"Timely Top Med Cardiovasc Dis"},{"key":"10.1016\/j.jss.2005.10.008_bib55","doi-asserted-by":"crossref","first-page":"1675","DOI":"10.1001\/jama.289.13.1675","article-title":"Association of nitrotyrosine levels with cardiovascular disease and modulation by statin therapy","volume":"289","author":"Shishehbor","year":"2003","journal-title":"JAMA"},{"key":"10.1016\/j.jss.2005.10.008_bib56","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/S0167-4838(00)00112-6","article-title":"Comparison of HOCl traps with myeloperoxidase inhibitors in prevention of low density lipoprotein oxidation","volume":"1481","author":"Jerlich","year":"2000","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.jss.2005.10.008_bib57","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1189\/jlb.1103595","article-title":"Oxygen radical-induced natural killer cell dysfunction","volume":"75","author":"Betten","year":"2004","journal-title":"J Leuk Biol"},{"key":"10.1016\/j.jss.2005.10.008_bib58","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1179\/135100000101535744","article-title":"Myeloperoxidase-catalyzed chlorination of histamine by stimulated neutrophils","volume":"5","author":"Thomas","year":"2000","journal-title":"Redox Rep"}],"container-title":["Journal of Surgical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022480405005445?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022480405005445?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,4,11]],"date-time":"2020-04-11T15:32:17Z","timestamp":1586619137000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022480405005445"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,6]]},"references-count":58,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2006,6]]}},"alternative-id":["S0022480405005445"],"URL":"https:\/\/doi.org\/10.1016\/j.jss.2005.10.008","relation":{},"ISSN":["0022-4804"],"issn-type":[{"value":"0022-4804","type":"print"}],"subject":[],"published":{"date-parts":[[2006,6]]}}}