{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T16:16:11Z","timestamp":1783181771241,"version":"3.54.6"},"reference-count":47,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2007,5,1]],"date-time":"2007-05-01T00:00:00Z","timestamp":1177977600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Surgical Research"],"published-print":{"date-parts":[[2007,5]]},"DOI":"10.1016\/j.jss.2006.09.016","type":"journal-article","created":{"date-parts":[[2007,2,3]],"date-time":"2007-02-03T07:46:44Z","timestamp":1170488804000},"page":"113-120","source":"Crossref","is-referenced-by-count":13,"title":["Inhibition of Heme Oxygenase-1 Protects Against Tissue Injury in Carbon Tetrachloride Exposed Livers"],"prefix":"10.1016","volume":"139","author":[{"given":"Christian","family":"Eipel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michaela","family":"Eisold","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harald","family":"Schuett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brigitte","family":"Vollmar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jss.2006.09.016_bib1","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1080\/713611034","article-title":"Hepatotoxicity and mechanism of action of haloalkanes: Carbon tetrachloride as a toxicological model","volume":"33","author":"Weber","year":"2003","journal-title":"Crit Rev Toxicol"},{"key":"10.1016\/j.jss.2006.09.016_bib2","doi-asserted-by":"crossref","first-page":"4542","DOI":"10.1016\/S0021-9258(17)38535-6","article-title":"The formation of a novel free radical metabolite from CCl4 in the perfused rat liver and in vivo","volume":"261","author":"Connor","year":"1986","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jss.2006.09.016_bib3","doi-asserted-by":"crossref","first-page":"275","DOI":"10.3109\/03602538909103543","article-title":"Cytochrome P-450, reductive metabolism, and cell injury","volume":"20","author":"De Groot","year":"1989","journal-title":"Drug Metab Rev"},{"key":"10.1016\/j.jss.2006.09.016_bib4","doi-asserted-by":"crossref","first-page":"L1029","DOI":"10.1152\/ajplung.2000.279.6.L1029","article-title":"Heme oxygenase: Colors of defense against cellular stress","volume":"279","author":"Otterbein","year":"2000","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"10.1016\/j.jss.2006.09.016_bib5","doi-asserted-by":"crossref","first-page":"2557","DOI":"10.1096\/fasebj.2.10.3290025","article-title":"Heme oxygenase: Function, multiplicity, regulatory mechanisms, and clinical applications","volume":"2","author":"Maines","year":"1988","journal-title":"FASEB J"},{"key":"10.1016\/j.jss.2006.09.016_bib6","first-page":"370","article-title":"Regulation of heme oxygenase gene expression","volume":"25","author":"Shibahara","year":"1988","journal-title":"Semin Hematol"},{"key":"10.1016\/j.jss.2006.09.016_bib7","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1165\/ajrcmb.13.5.7576696","article-title":"Hemoglobin provides protection against lethal endotoxemia in rats: The role of heme oxygenase-1","volume":"13","author":"Otterbein","year":"1995","journal-title":"Am J Respir Cell Mol Biol"},{"key":"10.1016\/j.jss.2006.09.016_bib8","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1097\/00003246-200003000-00033","article-title":"Protective effect of heme oxygenase induction in ischemic acute renal failure","volume":"28","author":"Shimizu","year":"2000","journal-title":"Crit Care Med"},{"key":"10.1016\/j.jss.2006.09.016_bib9","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1053\/gast.2001.23249","article-title":"Carbon monoxide from heme catabolism protects against hepatobiliary dysfunction in endotoxin-treated rat liver","volume":"120","author":"Kyokane","year":"2001","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jss.2006.09.016_bib10","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1016\/S0006-2952(03)00444-1","article-title":"Protective role of heme oxygenase-1 induction in carbon tetrachloride-induced hepatotoxicity","volume":"66","author":"Nakahira","year":"2003","journal-title":"Biochem Pharmacol"},{"key":"10.1016\/j.jss.2006.09.016_bib11","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1161\/01.STR.26.6.1035","article-title":"Preischemic but not postischemic zinc protoporphyrin treatment reduces infarct size and edema accumulation after temporary focal cerebral ischemia in rats","volume":"26","author":"Kadoya","year":"1995","journal-title":"Stroke"},{"key":"10.1016\/j.jss.2006.09.016_bib12","doi-asserted-by":"crossref","first-page":"2299","DOI":"10.1161\/01.STR.27.12.2299","article-title":"Zinc protoporphyrin, zinc ion, and protoporphyrin reduce focal cerebral ischemia","volume":"27","author":"Zhao","year":"1996","journal-title":"Stroke"},{"key":"10.1016\/j.jss.2006.09.016_bib13","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1006\/taap.1993.1069","article-title":"The involvement of Kupffer cells in carbon tetrachloride toxicity","volume":"119","author":"Edwards","year":"1993","journal-title":"Toxicol Appl Pharmacol"},{"key":"10.1016\/j.jss.2006.09.016_bib14","doi-asserted-by":"crossref","first-page":"1544","DOI":"10.1002\/hep.510270612","article-title":"An intravital fluorescence microscopic study of hepatic microvascular and cellular derangements in developing cirrhosis in rats","volume":"27","author":"Vollmar","year":"1998","journal-title":"Hepatology"},{"key":"10.1016\/j.jss.2006.09.016_bib15","doi-asserted-by":"crossref","first-page":"G769","DOI":"10.1152\/ajpgi.00275.2003","article-title":"Impact of leukocytes and platelets in mediating hepatocyte apoptosis in a rat model of systemic endotoxemia","volume":"286","author":"Eipel","year":"2004","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1016\/j.jss.2006.09.016_bib16","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1096\/fj.02-0774com","article-title":"Inhibition of p53 protects liver tissue against endotoxin-induced apoptotic and necrotic cell death","volume":"17","author":"Schafer","year":"2003","journal-title":"FASEB J"},{"key":"10.1016\/j.jss.2006.09.016_bib17","doi-asserted-by":"crossref","first-page":"7365","DOI":"10.1016\/S0021-9258(18)53184-7","article-title":"Regulation of heme oxygenase and metallothionein gene expression by the heme analogs, cobalt-, and tin-protoporphyrin","volume":"268","author":"Smith","year":"1993","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jss.2006.09.016_bib18","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1096\/fj.02-0368com","article-title":"Heme oxygenase and nitric oxide synthase mediate cooling-associated protection against TNF-\u03b1-induced microcirculatory dysfunction and apoptotic cell death","volume":"17","author":"Amon","year":"2003","journal-title":"FASEB J"},{"key":"10.1016\/j.jss.2006.09.016_bib19","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1161\/01.ATV.0000118279.74056.8a","article-title":"Vascular heme oxygenase-1 induction suppresses microvascular thrombus formation in vivo","volume":"24","author":"Lindenblatt","year":"2004","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.jss.2006.09.016_bib20","first-page":"1421","article-title":"Hepatic microcirculatory perfusion failure is a determinant of liver dysfunction in warm ischemia-reperfusion","volume":"145","author":"Vollmar","year":"1994","journal-title":"Am J Pathol"},{"key":"10.1016\/j.jss.2006.09.016_bib21","first-page":"G786","article-title":"Impact of leukocyte-endothelial cell interaction in hepatic ischemia-reperfusion injury","volume":"267","author":"Vollmar","year":"1994","journal-title":"Am J Physiol"},{"key":"10.1016\/j.jss.2006.09.016_bib22","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1002\/jlb.62.6.710","article-title":"Immunomodulatory action of G-CSF in a rat model of endotoxin-induced liver injury: An intravital microscopic analysis of Kupffer cell and leukocyte response","volume":"62","author":"Vollmar","year":"1997","journal-title":"J Leukoc Biol"},{"key":"10.1016\/j.jss.2006.09.016_bib23","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1038\/nm0196-87","article-title":"Heme oxygenase: A novel target for the modulation of the inflammatory response","volume":"2","author":"Willis","year":"1996","journal-title":"Nat Med"},{"key":"10.1016\/j.jss.2006.09.016_bib24","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1165\/ajrcmb.15.1.8679227","article-title":"Heme oxygenase-1: Function, regulation, and implication of a novel stress-inducible protein in oxidant-induced lung injury","volume":"15","author":"Choi","year":"1996","journal-title":"Am J Respir Cell Mol Biol"},{"key":"10.1016\/j.jss.2006.09.016_bib25","first-page":"L268","article-title":"Mechanism of hemoglobin-induced protection against endotoxemia in rats: A ferritin-independent pathway","volume":"272","author":"Otterbein","year":"1997","journal-title":"Am J Physiol"},{"key":"10.1016\/j.jss.2006.09.016_bib26","doi-asserted-by":"crossref","first-page":"4295","DOI":"10.1074\/jbc.272.7.4295","article-title":"Induction of heme oxygenase-1 expression in vascular smooth muscle cells","volume":"272","author":"Yet","year":"1997","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jss.2006.09.016_bib27","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1161\/01.RES.85.8.663","article-title":"Induction of heme oxygenase-1 suppresses venular leukocyte adhesion elicited by oxidative stress: Role of bilirubin generated by the enzyme","volume":"85","author":"Hayashi","year":"1999","journal-title":"Circ Res"},{"key":"10.1016\/j.jss.2006.09.016_bib28","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/S0021-9258(17)42488-4","article-title":"Characterization of two constitutive forms of rat liver microsomal heme oxygenase","volume":"261","author":"Maines","year":"1986","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jss.2006.09.016_bib29","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1002\/hep.510270327","article-title":"Expression pattern of heme oxygenase isoenzymes 1 and 2 in normal and stress-exposed rat liver","volume":"27","author":"Bauer","year":"1998","journal-title":"Hepatology"},{"key":"10.1016\/j.jss.2006.09.016_bib30","doi-asserted-by":"crossref","first-page":"4185","DOI":"10.4049\/jimmunol.166.6.4185","article-title":"Carbon monoxide generated by heme oxygenase-1 suppresses the rejection of mouse-to-rat cardiac transplants","volume":"166","author":"Sato","year":"2001","journal-title":"J Immunol"},{"key":"10.1016\/j.jss.2006.09.016_bib31","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1097\/00000542-200209000-00025","article-title":"Carbon monoxide modulates endotoxin-induced microvascular leukocyte adhesion through platelet-dependent mechanisms","volume":"97","author":"Morisaki","year":"2002","journal-title":"Anesthesiology"},{"key":"10.1016\/j.jss.2006.09.016_bib32","doi-asserted-by":"crossref","first-page":"2431","DOI":"10.1172\/JCI118300","article-title":"Carbon monoxide: An endogenous modulator of sinusoidal tone in the perfused rat liver","volume":"96","author":"Suematsu","year":"1995","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jss.2006.09.016_bib33","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1006\/bbrc.1994.2811","article-title":"Carbon monoxide as an endogenous modulator of hepatic vascular perfusion","volume":"205","author":"Suematsu","year":"1994","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.jss.2006.09.016_bib34","first-page":"497","article-title":"Inhibition of platelet aggregation by carbon monoxide is mediated by activation of guanylate cyclase","volume":"32","author":"Brune","year":"1987","journal-title":"Mol Pharmacol"},{"key":"10.1016\/j.jss.2006.09.016_bib35","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1111\/j.1432-1033.1990.tb19276.x","article-title":"Activation of soluble guanylate cyclase by carbon monoxide and inhibition by superoxide anion","volume":"192","author":"Brune","year":"1990","journal-title":"Eur J Biochem"},{"key":"10.1016\/j.jss.2006.09.016_bib36","doi-asserted-by":"crossref","first-page":"2568","DOI":"10.1073\/pnas.92.7.2568","article-title":"Basis of guanylate cyclase activation by carbon monoxide","volume":"92","author":"Kharitonov","year":"1995","journal-title":"Proc Natl Acad Sci U.S.A."},{"key":"10.1016\/j.jss.2006.09.016_bib37","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1191\/1358863x02vm424ra","article-title":"Carbon monoxide and bile pigments: Surprising mediators of vascular function","volume":"7","author":"Durante","year":"2002","journal-title":"Vasc Med"},{"key":"10.1016\/j.jss.2006.09.016_bib38","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1016\/0003-9861(88)90492-4","article-title":"Rat liver cytochrome P-450b, P-420b, and P-420c are degraded to biliverdin by heme oxygenase","volume":"260","author":"Kutty","year":"1988","journal-title":"Arch Biochem Biophys"},{"key":"10.1016\/j.jss.2006.09.016_bib39","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1038\/87929","article-title":"Paradoxical rescue from ischemic lung injury by inhaled carbon monoxide driven by derepression of fibrinolysis","volume":"7","author":"Fujita","year":"2001","journal-title":"Nat Med"},{"key":"10.1016\/j.jss.2006.09.016_bib40","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1084\/jem.192.7.1015","article-title":"Carbon monoxide generated by heme oxygenase 1 suppresses endothelial cell apoptosis","volume":"192","author":"Brouard","year":"2000","journal-title":"J Exp Med"},{"key":"10.1016\/j.jss.2006.09.016_bib41","doi-asserted-by":"crossref","first-page":"1128","DOI":"10.1002\/hep.20450","article-title":"Cooperative effect of biliverdin and carbon monoxide on survival of mice in immune-mediated liver injury","volume":"40","author":"Sass","year":"2004","journal-title":"Hepatology"},{"key":"10.1016\/j.jss.2006.09.016_bib42","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1006\/faat.1996.2266","article-title":"Dichloromethane potentiation of carbon tetrachloride hepatotoxicity in rats","volume":"35","author":"Kim","year":"1997","journal-title":"Fundam Appl Toxicol"},{"key":"10.1016\/j.jss.2006.09.016_bib43","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1146\/annurev.pharmtox.37.1.517","article-title":"The heme oxygenase system: A regulator of second messenger gases","volume":"37","author":"Maines","year":"1997","journal-title":"Annu Rev Pharmacol Toxicol"},{"key":"10.1016\/j.jss.2006.09.016_bib44","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1002\/hep.510310102","article-title":"The heme oxygenase-carbon monoxide system: A regulator of hepatobiliary function","volume":"31","author":"Suematsu","year":"2000","journal-title":"Hepatology"},{"key":"10.1016\/j.jss.2006.09.016_bib45","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/S0891-5849(99)00223-3","article-title":"The heme synthesis and degradation pathways: Role in oxidant sensitivity","volume":"28","author":"Ryter","year":"2000","journal-title":"Free Radic Biol Med"},{"key":"10.1016\/j.jss.2006.09.016_bib46","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1042\/0264-6021:3570241","article-title":"Ferritin and the response to oxidative stress","volume":"357","author":"Orino","year":"2001","journal-title":"Biochem J"},{"key":"10.1016\/j.jss.2006.09.016_bib47","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1053\/jhep.2003.50386","article-title":"Heme oxygenase-1 and its reaction product, carbon monoxide, prevent inflammation-related apoptotic liver damage in mice","volume":"38","author":"Sass","year":"2003","journal-title":"Hepatology"}],"container-title":["Journal of Surgical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022480406004926?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022480406004926?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,8,8]],"date-time":"2021-08-08T09:02:23Z","timestamp":1628413343000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022480406004926"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,5]]},"references-count":47,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2007,5]]}},"alternative-id":["S0022480406004926"],"URL":"https:\/\/doi.org\/10.1016\/j.jss.2006.09.016","relation":{},"ISSN":["0022-4804"],"issn-type":[{"value":"0022-4804","type":"print"}],"subject":[],"published":{"date-parts":[[2007,5]]}}}