{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T22:13:24Z","timestamp":1759529604104},"reference-count":44,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2008,1,1]],"date-time":"2008-01-01T00:00:00Z","timestamp":1199145600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Surgical Research"],"published-print":{"date-parts":[[2008,1]]},"DOI":"10.1016\/j.jss.2007.03.054","type":"journal-article","created":{"date-parts":[[2007,7,31]],"date-time":"2007-07-31T15:11:58Z","timestamp":1185894718000},"page":"43-48","source":"Crossref","is-referenced-by-count":20,"title":["Bcl-2 Gene Silencing in Pediatric Epithelial Liver Tumors"],"prefix":"10.1016","volume":"144","author":[{"given":"Steven W.","family":"Warmann","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heike","family":"Frank","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heike","family":"Heitmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Ruck","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tina","family":"Herberts","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guido","family":"Seitz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00f6rg","family":"Fuchs","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jss.2007.03.054_bib1","doi-asserted-by":"crossref","first-page":"1795","DOI":"10.1002\/cncr.10858","article-title":"The role of the MDR1 gene in the development of multidrug resistance in human hepatoblastoma: Clinical course and in vivo model","volume":"95","author":"Warmann","year":"2002","journal-title":"Cancer"},{"key":"10.1016\/j.jss.2007.03.054_bib2","first-page":"3127","article-title":"Altered expression of resistance associated genes in hepatoblastoma xenografts incorporated into mice following treatment with Adriamycin or cisplatin","volume":"18","author":"Bader","year":"1998","journal-title":"Anticancer Res"},{"key":"10.1016\/j.jss.2007.03.054_bib3","first-page":"559","article-title":"Overexpression of multidrug resistance genes MDR1 and moat in human hepatocellular carcinoma and hepatoblastoma cell lines","volume":"15","author":"Minemura","year":"1999","journal-title":"Int J Oncol"},{"key":"10.1016\/j.jss.2007.03.054_bib4","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1089\/hum.2006.17.941","article-title":"Inhibition of ovarian tumor growth by gene therapy with recombinant soluble vascular endothelial growth factor receptor 2","volume":"17","author":"Wu","year":"2006","journal-title":"Hum Gene Ther"},{"key":"10.1016\/j.jss.2007.03.054_bib5","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1007\/s00383-005-1573-8","article-title":"In vitro gene targeting in human hepatoblastoma","volume":"22","author":"Warmann","year":"2006","journal-title":"Pediatr Surg Int"},{"key":"10.1016\/j.jss.2007.03.054_bib6","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.2174\/156802605774463105","article-title":"PNP anticancer gene therapy","volume":"5","author":"Zhang","year":"2005","journal-title":"Curr Topics Med Chem"},{"key":"10.1016\/j.jss.2007.03.054_bib7","doi-asserted-by":"crossref","first-page":"8079","DOI":"10.1158\/0008-5472.CAN-04-4402","article-title":"Synthetic anticancer gene medicine exploits intrinsic antitumor activity of cationic vector to cure established tumors","volume":"65","author":"Dufes","year":"2005","journal-title":"Cancer Res"},{"key":"10.1016\/j.jss.2007.03.054_bib8","doi-asserted-by":"crossref","first-page":"507","DOI":"10.2174\/1566524043360492","article-title":"Silencing of disease-related genes by small interfering RNAs","volume":"4","author":"Fuchs","year":"2004","journal-title":"Curr Mol Med"},{"key":"10.1016\/j.jss.2007.03.054_bib9","first-page":"270","article-title":"RNA interference: New mechanisms for targeted treatment?","volume":"7","author":"Woessmann","year":"2003","journal-title":"Rev Clin Exp Hematol"},{"key":"10.1016\/j.jss.2007.03.054_bib10","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/10408360500295626","article-title":"BCL2 family of apoptosis-related genes: Functions and clinical implications in cancer","volume":"43","author":"Thomadaki","year":"2006","journal-title":"Crit Rev Clin Lab Sci"},{"key":"10.1016\/j.jss.2007.03.054_bib11","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1586\/14737140.4.6.1157","article-title":"Anticancer drug development based on modulation of the Bcl-2 family core apoptosis mechanism","volume":"4","author":"Gardner","year":"2004","journal-title":"Expert Rev Anticancer Ther"},{"key":"10.1016\/j.jss.2007.03.054_bib12","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/S0165-5876(00)00305-0","article-title":"Evaluation of bcl-2 gene expression in papilloma of larynx in children","volume":"53","author":"Niedzielska","year":"2000","journal-title":"Int J Pediatr Otorhinolaryngol"},{"key":"10.1016\/j.jss.2007.03.054_bib13","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1080\/10611860500527947","article-title":"Bcl-2 siRNA induced apoptosis and increased sensitivity to 5-fluorouracil and HCPT in HepG2 cells","volume":"14","author":"Feng","year":"2006","journal-title":"J Drug Target"},{"key":"10.1016\/j.jss.2007.03.054_bib14","first-page":"1","article-title":"Establishment of a cell line and its clonal sublines from a patient with hepatoblastoma Doi I","volume":"76","year":"1976","journal-title":"Gann"},{"key":"10.1016\/j.jss.2007.03.054_bib15","first-page":"809","article-title":"Characterization of the continuous cell line HepT1 derived from a human hepatoblastoma","volume":"74","author":"Pietsch","year":"1996","journal-title":"Lab Invest"},{"key":"10.1016\/j.jss.2007.03.054_bib16","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1038\/282615a0","article-title":"Controlled synthesis of HBsAg in a differentiated human liver carcinoma-derived cell line","volume":"282","author":"Aden","year":"1979","journal-title":"Nature"},{"key":"10.1016\/j.jss.2007.03.054_bib17","first-page":"69","article-title":"The MTT assay to evaluate chemosensitivity","volume":"110","author":"Burton","year":"2005","journal-title":"Methods Mol Med"},{"key":"10.1016\/j.jss.2007.03.054_bib18","doi-asserted-by":"crossref","first-page":"8698","DOI":"10.1158\/0008-5472.CAN-05-3691","article-title":"Anti-angiogenic effect of TW37, a small-molecule inhibitor of Bcl-2","volume":"66","author":"Zeitlin","year":"2006","journal-title":"Cancer Res"},{"key":"10.1016\/j.jss.2007.03.054_bib19","first-page":"2183","article-title":"Up-regulation of Bcl-2 in microvascular endothelial cells enhances intratumoral angiogenesis and accelerates tumor growth","volume":"61","author":"Nor","year":"2001","journal-title":"Cancer Res"},{"key":"10.1016\/j.jss.2007.03.054_bib20","doi-asserted-by":"crossref","first-page":"5063","DOI":"10.1158\/0008-5472.CAN-05-0140","article-title":"Bcl-2 acts in a proangiogenic signaling pathway through nuclear factor-\u03baB and CXC chemokines","volume":"65","author":"Karl","year":"2005","journal-title":"Cancer Res"},{"key":"10.1016\/j.jss.2007.03.054_bib21","doi-asserted-by":"crossref","first-page":"4421","DOI":"10.1128\/MCB.01647-05","article-title":"Bcl2\u2019s flexible loop domain regulates p53 binding and survival","volume":"26","author":"Deng","year":"2006","journal-title":"Moll Cell Biol"},{"key":"10.1016\/j.jss.2007.03.054_bib22","first-page":"161","article-title":"Expression of genes involved with cell cycle control, cell growth, and chromatin modification are altered in hepatoblastomas","volume":"6","author":"Gray","year":"2000","journal-title":"Int J Mol Med"},{"key":"10.1016\/j.jss.2007.03.054_bib23","first-page":"2547","article-title":"A novel bispecific antisense oligonucleotide inhibiting both bcl-2 and bcl-xL expression efficiently induces apoptosis in tumor cells","volume":"6","author":"Zangemeister-Wittke","year":"2000","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.jss.2007.03.054_bib24","doi-asserted-by":"crossref","first-page":"1689","DOI":"10.1158\/1535-7163.MCT-05-0064","article-title":"A novel antisense oligonucleotide inhibiting several antiapoptotic Bcl-2 family members induces apoptosis and enhances chemosensitivity in androgen-independent human prostate cancer PC3 cells","volume":"4","author":"Yamanaka","year":"2005","journal-title":"Mol Cancer Ther"},{"key":"10.1016\/j.jss.2007.03.054_bib25","doi-asserted-by":"crossref","first-page":"7747","DOI":"10.1158\/1078-0432.CCR-04-0908","article-title":"Trastuzumab down-regulates Bcl-2 expression and potentiates apoptosis induction by Bcl-2\/Bcl-XL bispecific antisense oligonucleotides in HER-2 gene-amplified breast cancer cells","volume":"10","author":"Milella","year":"2004","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.jss.2007.03.054_bib26","doi-asserted-by":"crossref","first-page":"822","DOI":"10.4161\/cbt.4.8.1889","article-title":"RNA interference remarkably suppresses bcl-2 gene expression in cancer cells in vitro and in vivo","volume":"4","author":"Fu","year":"2005","journal-title":"Cancer Biol Ther"},{"key":"10.1016\/j.jss.2007.03.054_bib27","doi-asserted-by":"crossref","first-page":"1298","DOI":"10.1136\/gut.2004.056192","article-title":"Variants of bcl-2 specific siRNA for silencing antiapoptotic bcl-2 in pancreatic cancer","volume":"54","author":"Ocker","year":"2005","journal-title":"Gut"},{"key":"10.1016\/j.jss.2007.03.054_bib28","doi-asserted-by":"crossref","first-page":"11689","DOI":"10.1158\/0008-5472.CAN-05-3091","article-title":"Bcl-2\/adenovirus E1B 19 kDa interacting protein-3 knockdown enables growth of breast cancer metastases in the lung, liver, and bone","volume":"65","author":"Manka","year":"2005","journal-title":"Cancer Res"},{"key":"10.1016\/j.jss.2007.03.054_bib29","first-page":"159","article-title":"Differentiated treatment protocols for high- and standard-risk hepatoblastoma\u2014an interim report of the German Liver Tumor Study HB99","volume":"215","author":"Haberle","year":"2003","journal-title":"Klin Padiatr"},{"key":"10.1016\/j.jss.2007.03.054_bib30","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/j.ejca.2003.06.003","article-title":"Risk-adapted treatment for childhood hepatoblastoma","volume":"40","author":"Perilongo","year":"2004","journal-title":"Eur J Cancer"},{"key":"10.1016\/j.jss.2007.03.054_bib31","doi-asserted-by":"crossref","first-page":"2665","DOI":"10.1200\/JCO.2000.18.14.2665","article-title":"Randomized comparison of cisplatin\/vincristine\/fluorouracil and cisplatin\/continuous infusion doxorubicin for treatment of pediatric hepatoblastoma: A report from the Children\u2019s Cancer Group and the Pediatric Oncology Group","volume":"18","author":"Ortega","year":"2000","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.jss.2007.03.054_bib32","doi-asserted-by":"crossref","first-page":"3438","DOI":"10.1200\/JCO.2002.07.400","article-title":"Treatment of unresectable and metastatic hepatoblastoma: A Pediatric Oncology Group Phase II study","volume":"20","author":"Katzenstein","year":"2002","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.jss.2007.03.054_bib33","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1097\/01.pai.0000173052.37673.95","article-title":"Immunohistochemical analysis of embryonal sarcoma of the liver","volume":"14","author":"Kiani","year":"2006","journal-title":"Appl Immunohistochem Mol Morphol"},{"key":"10.1016\/j.jss.2007.03.054_bib34","doi-asserted-by":"crossref","first-page":"1938","DOI":"10.1002\/cncr.10898","article-title":"Quantitative analysis of apoptosis-related gene expression in hepatocellular carcinoma","volume":"95","author":"Ikeguchi","year":"2002","journal-title":"Cancer"},{"key":"10.1016\/j.jss.2007.03.054_bib35","first-page":"4607","article-title":"P-glycoprotein improves in vitro chemosensitivity in malignant pediatric liver tumors","volume":"23","author":"Warmann","year":"2003","journal-title":"Anticancer Res"},{"key":"10.1016\/j.jss.2007.03.054_bib36","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1177\/153537020623100516","article-title":"Nuclear accumulations of p53 and Mdm2 are accompanied by reductions in c-Abl and p300 in zinc-depleted human hepatoblastoma cells","volume":"231","author":"Alshatwi","year":"2006","journal-title":"Exp Biol Med"},{"issue":"Suppl.11","key":"10.1016\/j.jss.2007.03.054_bib37","doi-asserted-by":"crossref","first-page":"S210","DOI":"10.1038\/sj.cdd.4401520","article-title":"Atrial natriuretic peptide induces cell death in human hepatoblastoma (HepG2) through the involvement of NADPH oxidase","volume":"2","author":"Baldini","year":"2004","journal-title":"Cell Death Differ"},{"key":"10.1016\/j.jss.2007.03.054_bib38","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1007\/s00432-004-0589-0","article-title":"The tamoxifen-induced suppression of telomerase activity in the human hepatoblastoma cell lie HepG2: A result of post-translational regulation","volume":"131","author":"Brandt","year":"2005","journal-title":"J. Cancer Res Clin Oncol"},{"key":"10.1016\/j.jss.2007.03.054_bib39","doi-asserted-by":"crossref","first-page":"7059","DOI":"10.1158\/0008-5472.CAN-06-0325","article-title":"Cyclo-oxygenase-2 inhibition induces apoptosis signaling via death receptors and mitochondria in hepatocellular carcinoma","volume":"66","author":"Kern","year":"2006","journal-title":"Cancer Res"},{"key":"10.1016\/j.jss.2007.03.054_bib40","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.1002\/hep.21137","article-title":"Adenovirus-mediated transfer of siRNA against PTTG1 inhibits liver cancer cell growth in vitro and in vivo","volume":"43","author":"Cho-Rok","year":"2006","journal-title":"Hepatology"},{"key":"10.1016\/j.jss.2007.03.054_bib41","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1111\/j.1745-7254.2006.00247.x","article-title":"Inhibition of Bcl-2 expression by a novel tumor-specific RNA interference system increases chemosensitivity to 5-fluorouracil in HeLa cells","volume":"27","author":"Huang","year":"2006","journal-title":"Acta Pharmacol Sin"},{"key":"10.1016\/j.jss.2007.03.054_bib42","first-page":"715","article-title":"In vitro RNA interference against \u03b2-catenin inhibits the proliferation of pediatric hepatic tumors","volume":"28","author":"Sangkhathat","year":"2006","journal-title":"Int J Oncol"},{"key":"10.1016\/j.jss.2007.03.054_bib43","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1002\/path.1662","article-title":"Mutations and elevated transcriptional activity of conducting (AXIN2) in hepatoblastomas","volume":"204","author":"Koch","year":"2004","journal-title":"J Pathol"},{"key":"10.1016\/j.jss.2007.03.054_bib44","first-page":"269","article-title":"Childhood hepatoblastomas frequently carry a mutated degradation targeting box of the \u03b2-catenin gene","volume":"59","author":"Koch","year":"1999","journal-title":"Cancer Res"}],"container-title":["Journal of Surgical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022480407001898?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022480407001898?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T12:17:31Z","timestamp":1556713051000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022480407001898"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,1]]},"references-count":44,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2008,1]]}},"alternative-id":["S0022480407001898"],"URL":"https:\/\/doi.org\/10.1016\/j.jss.2007.03.054","relation":{},"ISSN":["0022-4804"],"issn-type":[{"value":"0022-4804","type":"print"}],"subject":[],"published":{"date-parts":[[2008,1]]}}}