{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T15:40:15Z","timestamp":1790005215039,"version":"4.0.1"},"reference-count":32,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2008,11,1]],"date-time":"2008-11-01T00:00:00Z","timestamp":1225497600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2008,11,1]],"date-time":"2008-11-01T00:00:00Z","timestamp":1225497600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["30471696"],"award-info":[{"award-number":["30471696"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["30500473"],"award-info":[{"award-number":["30500473"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["30772098"],"award-info":[{"award-number":["30772098"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002338","name":"Ministry of Education of the People's Republic of China","doi-asserted-by":"publisher","award":["20050631001"],"award-info":[{"award-number":["20050631001"]}],"id":[{"id":"10.13039\/501100002338","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005230","name":"Natural Science Foundation of Chongqing","doi-asserted-by":"publisher","award":["2005BB5242"],"award-info":[{"award-number":["2005BB5242"]}],"id":[{"id":"10.13039\/501100005230","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","journalofsurgicalresearch.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Surgical Research"],"published-print":{"date-parts":[[2008,11]]},"DOI":"10.1016\/j.jss.2007.12.759","type":"journal-article","created":{"date-parts":[[2008,1,11]],"date-time":"2008-01-11T11:03:15Z","timestamp":1200049395000},"page":"34-39","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":53,"title":["Up-Regulation of IRAK-M is Essential for Endotoxin Tolerance Induced by a Low Dose of Lipopolysaccharide in Kupffer Cells"],"prefix":"10.1016","volume":"150","author":[{"given":"Zuo-Jin","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu-Nan","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xu-Hong","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fa-Liang","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xian-Feng","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hai-Bo","family":"You","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian-Ping","family":"Gong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jss.2007.12.759_bib1","doi-asserted-by":"crossref","first-page":"2487","DOI":"10.2174\/092986706778201675","article-title":"Toll-like receptor (TLR) response tolerance: A key physiological \u201cdamage limitation\u201d effect and an important potential opportunity for therapy","volume":"13","author":"Broad","year":"2006","journal-title":"Curr Med Chem"},{"key":"10.1016\/j.jss.2007.12.759_bib2","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1111\/j.1365-2567.2006.02485.x","article-title":"Toll-like receptor interactions: Tolerance of MyD88-dependent cytokines but enhancement of MyD88-independent interferon-\u03b2 production","volume":"120","author":"Broad","year":"2007","journal-title":"Immunology"},{"key":"10.1016\/j.jss.2007.12.759_bib3","doi-asserted-by":"crossref","first-page":"5564","DOI":"10.4049\/jimmunol.164.11.5564","article-title":"Inhibition of lipopolysaccharide-induced signal transduction in endotoxin-tolerized mouse macrophages: Dysregulation of cytokine, chemokine, and toll-like receptor 2 and 4 gene expression","volume":"164","author":"Medvedev","year":"2000","journal-title":"J Immunol"},{"key":"10.1016\/j.jss.2007.12.759_bib4","doi-asserted-by":"crossref","first-page":"5161","DOI":"10.4049\/jimmunol.166.8.5161","article-title":"Induction of cross-tolerance by lipopolysaccharide and highly purified lipoteichoic acid via different Toll-like receptors independent of paracrine mediators","volume":"166","author":"Makhlouf","year":"2001","journal-title":"J Immunol"},{"key":"10.1016\/j.jss.2007.12.759_bib5","first-page":"201","article-title":"Infection, fever, and exogenous and endogenous pyrogens: Some concepts have changed","volume":"10","author":"Dinarello","year":"2004","journal-title":"J Endotoxin Res"},{"key":"10.1016\/j.jss.2007.12.759_bib6","first-page":"133","article-title":"Tolerance to microbial TLR ligands: Molecular mechanisms and relevance to disease","volume":"12","author":"Medvedev","year":"2006","journal-title":"J Endotoxin Res"},{"key":"10.1016\/j.jss.2007.12.759_bib7","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.pharmthera.2003.08.003","article-title":"Molecular mechanisms of macrophage activation and deactivation by lipopolysaccharide: Roles of the receptor complex","volume":"100","author":"Fujihara","year":"2003","journal-title":"Pharmacol Ther"},{"key":"10.1016\/j.jss.2007.12.759_bib8","first-page":"276","article-title":"IRAK-4: The key molecule of TLR\/IL-1R common signal transduction system","volume":"36","author":"Liu","year":"2005","journal-title":"Prog Physiol Sci"},{"key":"10.1016\/j.jss.2007.12.759_bib9","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/S0092-8674(02)00827-9","article-title":"IRAK-M is a negative regulator of toll-like receptor signaling","volume":"110","author":"Kobayashi","year":"2002","journal-title":"Cell"},{"key":"10.1016\/j.jss.2007.12.759_bib10","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1097\/01.shk.0000191377.78144.d9","article-title":"Activation of the liver X receptor protects against hepatic injury in endotoxemia by suppressing Kupffer cell activation","volume":"25","author":"Wang","year":"2006","journal-title":"Shock"},{"key":"10.1016\/j.jss.2007.12.759_bib11","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1016\/j.bbadis.2007.03.010","article-title":"Proinflammatory cytokines from Kupffer cells down-regulate hepatocyte expression of adrenomedullin binding protein-1","volume":"1772","author":"Jacob","year":"2007","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.jss.2007.12.759_bib12","doi-asserted-by":"crossref","first-page":"7S","DOI":"10.1097\/01.ALC.0000078610.78390.2A","article-title":"Dalteparin sodium prevents liver injury due to lipopolysaccharide in rat through suppression of tumor necrosis factor-alpha production by Kupffer cells","volume":"27","author":"Tsukada","year":"2003","journal-title":"Alcohol Clin Exp Res"},{"key":"10.1016\/j.jss.2007.12.759_bib13","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.jhep.2004.09.019","article-title":"Kupffer cell depletion with liposomal clodronate prevents suppression of Ntcp expression in endotoxin-treated rats","volume":"42","author":"Sturm","year":"2005","journal-title":"J Hepatol"},{"key":"10.1016\/j.jss.2007.12.759_bib14","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1002\/jcp.20860","article-title":"The role of MAPK in Kupffer cell toll-like receptor (TLR) 2-TLR4-, and TLR9-mediated signaling following trauma-hemorrhage","volume":"210","author":"Thobe","year":"2007","journal-title":"J Cell Physiol"},{"key":"10.1016\/j.jss.2007.12.759_bib15","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1111\/j.1478-3231.2006.01325.x","article-title":"Endotoxin tolerance in human intrahepatic biliary epithelial cells is induced by up-regulation of IRAK-M","volume":"26","author":"Harada","year":"2006","journal-title":"Liver Int"},{"key":"10.1016\/j.jss.2007.12.759_bib16","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.1111\/j.1745-7254.2006.00413.x","article-title":"Glycine blunts transplantative liver ischemia-reperfusion injury by down-regulating interleukin 1 receptor associated kinase-4","volume":"27","author":"Liu","year":"2006","journal-title":"Acta Pharmacol Sin"},{"key":"10.1016\/j.jss.2007.12.759_bib17","doi-asserted-by":"crossref","first-page":"1448","DOI":"10.1136\/gut.52.10.1448","article-title":"CD40 expression on human pancreatic duct cells: Role in nuclear factor-\u03baB activation and production of pro-inflammatory cytokines","volume":"52","author":"Gelbmann","year":"2003","journal-title":"Gut"},{"key":"10.1016\/j.jss.2007.12.759_bib18","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1034\/j.1600-0528.2002.017404.x","article-title":"The liver as a crucial organ in the first line of host defense: The roles of Kupffer cells, natural killer (NK) cells, and NK1.1 Ag+ T cells in T helper 1 immune responses","volume":"174","author":"Seki","year":"2000","journal-title":"Immunol Rev"},{"key":"10.1016\/j.jss.2007.12.759_bib19","doi-asserted-by":"crossref","first-page":"2007","DOI":"10.1007\/s10620-006-9141-1","article-title":"Protective effects of nafamostat mesylate on liver injury induced by lipopolysaccharide in rats: Possible involvement of CD14 and TLR-4 down-regulation on Kupffer cells","volume":"51","author":"Miyaso","year":"2006","journal-title":"Dig Dis Sci"},{"key":"10.1016\/j.jss.2007.12.759_bib20","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1677\/joe.1.06585","article-title":"Inactivation of Kupffer cells by gadolinium administration prevents lipopolysaccharide-induced decrease in liver insulin-like growth factor-I and IGF-binding protein-3 gene expression","volume":"188","author":"Granado","year":"2006","journal-title":"J Endocrinol"},{"key":"10.1016\/j.jss.2007.12.759_bib21","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1006\/bbrc.2000.3738","article-title":"Tolerance and sensitization to endotoxin in Kupffer cells caused by acute ethanol involve interleukin-1 receptor associated kinase","volume":"277","author":"Yamashina","year":"2000","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.jss.2007.12.759_bib22","first-page":"2532","article-title":"Sepsis-induced suppression of lung innate immunity is mediated by IRAK-M","volume":"116","author":"Deng","year":"2006","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jss.2007.12.759_bib23","doi-asserted-by":"crossref","first-page":"5209","DOI":"10.4049\/jimmunol.169.9.5209","article-title":"Dysregulation of LPS-induced toll-like receptor 4-MyD88 complex formation and IL-1 receptor-associated kinase 1 activation in endotoxin-tolerant cells","volume":"169","author":"Medvedev","year":"2002","journal-title":"J Immunol"},{"key":"10.1016\/j.jss.2007.12.759_bib24","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1179\/096805104225003997","article-title":"Molecular mechanisms of endotoxin tolerance","volume":"10","author":"Fan","year":"2004","journal-title":"J Endotoxin Res"},{"key":"10.1016\/j.jss.2007.12.759_bib25","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1189\/jlb.0905505","article-title":"Bacterial lipoprotein-induced self-tolerance and cross-tolerance to LPS are associated with reduced IRAK-1 expression and MyD88-IRAK complex formation","volume":"79","author":"Li","year":"2006","journal-title":"J Leukoc Biol"},{"key":"10.1016\/j.jss.2007.12.759_bib26","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/S1097-2765(03)00053-4","article-title":"Functional diversity and regulation of different interleukin-1 receptor-associated kinase (IRAK) family members","volume":"11","author":"Janssens","year":"2003","journal-title":"Mol Cell"},{"key":"10.1016\/j.jss.2007.12.759_bib27","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.jhep.2006.02.013","article-title":"Up-regulation of TNF-\u03b1 production signaling pathways in monocytes from patients with advanced cirrhosis: Possible role of Akt and IRAK-M","volume":"45","author":"Tazi","year":"2006","journal-title":"J Hepatol"},{"key":"10.1016\/j.jss.2007.12.759_bib28","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1111\/j.1600-065X.2006.00435.x","article-title":"Cellular and molecular mechanisms of liver tolerance","volume":"213","author":"Crispe","year":"2006","journal-title":"Immunol Rev"},{"key":"10.1016\/j.jss.2007.12.759_bib29","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1097\/01.qco.0000224817.35105.7d","article-title":"Pathophysiology of interleukin-1 receptor-associated kinase-M: Implications in refractory state","volume":"19","author":"Lopez-Collazo","year":"2006","journal-title":"Curr Opin Infect Dis"},{"key":"10.1016\/j.jss.2007.12.759_bib30","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1097\/00024382-200115040-00007","article-title":"Signal transduction events in Chinese hamster ovary cells expressing human CD14; effect of endotoxin desensitization","volume":"15","author":"Ferlito","year":"2001","journal-title":"Shock"},{"key":"10.1016\/j.jss.2007.12.759_bib31","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1189\/jlb.0106053","article-title":"Endotoxin tolerance attenuates LPS-induced TLR4 mobilization to lipid rafts: A condition reversed by PKC activation","volume":"80","author":"Cuschieri","year":"2006","journal-title":"J Leukoc Biol"},{"key":"10.1016\/j.jss.2007.12.759_bib32","doi-asserted-by":"crossref","first-page":"6280","DOI":"10.4049\/jimmunol.170.12.6280","article-title":"Differential activation of NF-\u03baB, AP-1, and C\/EBP in endotoxin-tolerant rats: Mechanisms for in vivo regulation of glomerular RANTES\/CCL5 expression","volume":"170","author":"Pocock","year":"2003","journal-title":"J Immunol"}],"container-title":["Journal of Surgical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022480407024055?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022480407024055?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T14:37:32Z","timestamp":1758379052000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022480407024055"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,11]]},"references-count":32,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2008,11]]}},"alternative-id":["S0022480407024055"],"URL":"https:\/\/doi.org\/10.1016\/j.jss.2007.12.759","relation":{},"ISSN":["0022-4804"],"issn-type":[{"value":"0022-4804","type":"print"}],"subject":[],"published":{"date-parts":[[2008,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Up-Regulation of IRAK-M is Essential for Endotoxin Tolerance Induced by a Low Dose of Lipopolysaccharide in Kupffer Cells","name":"articletitle","label":"Article Title"},{"value":"Journal of Surgical Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jss.2007.12.759","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2008 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}