{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T18:46:58Z","timestamp":1768416418663,"version":"3.49.0"},"reference-count":31,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2009,12,1]],"date-time":"2009-12-01T00:00:00Z","timestamp":1259625600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Surgical Research"],"published-print":{"date-parts":[[2009,12]]},"DOI":"10.1016\/j.jss.2008.08.021","type":"journal-article","created":{"date-parts":[[2008,10,13]],"date-time":"2008-10-13T05:28:00Z","timestamp":1223875680000},"page":"208-215","source":"Crossref","is-referenced-by-count":19,"title":["17\u03b2-Estradiol Activates Adenosine A2a Receptor After Subarachnoid Hemorrhage"],"prefix":"10.1016","volume":"157","author":[{"given":"Chih-Lung","family":"Lin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aaron S.","family":"Dumont","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yee-Jean","family":"Tsai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jih-Hui","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kao-Ping","family":"Chang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aij-Lie","family":"Kwan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi-Ren","family":"Hong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shen-Long","family":"Howng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jss.2008.08.021_bib1","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1111\/j.1750-3639.2002.tb00447.x","article-title":"Neuronal apoptosis in the dentate gyrus in humans with subarachnoid hemorrhage and cerebral hypoxia","volume":"12","author":"Nau","year":"2002","journal-title":"Brain Pathol"},{"key":"10.1016\/j.jss.2008.08.021_bib2","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1038\/sj.jcbfm.9600283","article-title":"Mechanisms of early brain injury after subarachnoid hemorrhage","volume":"26","author":"Cahill","year":"2006","journal-title":"J Cereb Blood Flow Metab"},{"key":"10.1016\/j.jss.2008.08.021_bib3","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1159\/000080096","article-title":"Racial disparities in subarachnoid hemorrhage mortality: Los Angeles County, California, 1985-1998","volume":"23","author":"Schievink","year":"2004","journal-title":"Neuroepidemiology"},{"key":"10.1016\/j.jss.2008.08.021_bib4","doi-asserted-by":"crossref","first-page":"43","DOI":"10.3171\/jns.1996.84.1.0043","article-title":"Gender-related differences in aneurysmal subarachnoid hemorrhage","volume":"84","author":"Kongable","year":"1996","journal-title":"J Neurosurg"},{"key":"10.1016\/j.jss.2008.08.021_bib5","doi-asserted-by":"crossref","first-page":"2115","DOI":"10.1523\/JNEUROSCI.22-06-02115.2002","article-title":"Estrogen protects against global ischemia-induced neuronal death and prevents activation of apoptotic signaling cascades in the hippocampal CA1","volume":"22","author":"Jover","year":"2002","journal-title":"J Neurosci"},{"key":"10.1016\/j.jss.2008.08.021_bib6","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1111\/j.1532-5415.1996.tb01400.x","article-title":"Estrogen replacement therapy in older women: A neuropsychological and brain MRI study","volume":"44","author":"Schmidt","year":"1996","journal-title":"J Am Geriatr Soc"},{"key":"10.1016\/j.jss.2008.08.021_bib7","first-page":"1054","article-title":"17beta-estradiol inhibits endothelin-1 production and attenuates cerebral vasospasm after experimental subarachnoid hemorrhage","volume":"231","author":"Lin","year":"2006","journal-title":"Exp Biol Med"},{"key":"10.1016\/j.jss.2008.08.021_bib8","doi-asserted-by":"crossref","first-page":"298","DOI":"10.3171\/jns.2006.104.2.298","article-title":"The effect of 17beta-estradiol in attenuating experimental subarachnoid hemorrhage-induced cerebral vasospasm","volume":"104","author":"Lin","year":"2006","journal-title":"J Neurosurg"},{"key":"10.1016\/j.jss.2008.08.021_bib9","doi-asserted-by":"crossref","first-page":"3025","DOI":"10.1161\/01.STR.0000249008.18669.5a","article-title":"17beta-Estradiol inhibits subarachnoid hemorrhage-induced inducible nitric oxide synthase gene expression by interfering with the nuclear factor kappa B transactivation","volume":"37","author":"Shih","year":"2006","journal-title":"Stroke"},{"key":"10.1016\/j.jss.2008.08.021_bib10","doi-asserted-by":"crossref","first-page":"436","DOI":"10.3171\/jns.2007.106.3.436","article-title":"Attenuation of experimental subarachnoid hemorrhage\u2013induced cerebral vasospasm by the adenosine A2A receptor agonist CGS 21680","volume":"106","author":"Lin","year":"2007","journal-title":"J Neurosurg"},{"key":"10.1016\/j.jss.2008.08.021_bib11","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1067\/mva.2002.123091","article-title":"Adenosine A2A analogue ATL-146e reduces systemic tumor necrosing factor-alpha and spinal cord capillary platelet-endothelial cell adhesion molecule-1 expression after spinal cord ischemia","volume":"35","author":"Cassada","year":"2002","journal-title":"J Vasc Surg"},{"key":"10.1016\/j.jss.2008.08.021_bib12","first-page":"G285","article-title":"Protection from ischemic liver injury by activation of A2A adenosine receptors during reperfusion: Inhibition of chemokine induction","volume":"286","author":"Day","year":"2004","journal-title":"Am J Physiol"},{"key":"10.1016\/j.jss.2008.08.021_bib13","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1053\/ajkd.2001.26888","article-title":"Systemic adenosine given after ischemia protects renal function via A(2a) adenosine receptor activation","volume":"38","author":"Lee","year":"2001","journal-title":"Am J Kidney Dis"},{"key":"10.1016\/j.jss.2008.08.021_bib14","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1097\/01.shk.0000235137.13152.44","article-title":"Attenuation of reperfusion lung injury and apoptosis by A2A adenosine receptor activation is associated with modulation of Bcl-2 and Bax expression and activation of extracellular signal-regulated kinases","volume":"27","author":"Rivo","year":"2007","journal-title":"Shock"},{"key":"10.1016\/j.jss.2008.08.021_bib15","doi-asserted-by":"crossref","first-page":"2926","DOI":"10.4049\/jimmunol.158.6.2926","article-title":"Adenosine A2a receptor activation delays apoptosis in human neutrophils","volume":"158","author":"Walker","year":"1997","journal-title":"J Immunol"},{"key":"10.1016\/j.jss.2008.08.021_bib16","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1002\/jlb.67.4.529","article-title":"Theophylline induces neutrophil apoptosis through adenosine A2A receptor antagonism","volume":"67","author":"Yasui","year":"2000","journal-title":"J Leukoc Bio"},{"key":"10.1016\/j.jss.2008.08.021_bib17","doi-asserted-by":"crossref","first-page":"1773","DOI":"10.1172\/JCI118976","article-title":"Direct preconditioning of cultured chick ventricular myocytes. Novel functions of cardiac adenosine A2a and A3 receptors","volume":"98","author":"Strickler","year":"1996","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jss.2008.08.021_bib18","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1080\/08941930490269646","article-title":"The role of MAP kinases in trauma and ischemia-reperfusion","volume":"17","author":"Lai","year":"2004","journal-title":"J Invest Surg"},{"key":"10.1016\/j.jss.2008.08.021_bib19","doi-asserted-by":"crossref","first-page":"5792","DOI":"10.1074\/jbc.272.9.5792","article-title":"Stimulation of the mitogen-activated protein kinase via the A2A-adenosine receptor in primary human endothelial cells","volume":"272","author":"Sexl","year":"1997","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jss.2008.08.021_bib20","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1007\/BF03160021","article-title":"Involvement of adenosine in ischemic and postischemic calcium regulation","volume":"18","author":"Andine","year":"1993","journal-title":"Mol Chem Neuropathol"},{"key":"10.1016\/j.jss.2008.08.021_bib21","doi-asserted-by":"crossref","first-page":"1704","DOI":"10.1210\/endo-94-6-1704","article-title":"Plasma concentration of LH, FSH, prolactin, progesterone and estradiol-17beta throughout the 4-day estrous cycle of the rat","volume":"94","author":"Butcher","year":"1974","journal-title":"Endocrinology"},{"key":"10.1016\/j.jss.2008.08.021_bib22","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1038\/sj.jcbfm.9600069","article-title":"Role of p53 and apoptosis in cerebral vasospasm after experimental subarachnoid hemorrhage","volume":"25","author":"Zhou","year":"2005","journal-title":"J Cereb Blood Flow Metab"},{"key":"10.1016\/j.jss.2008.08.021_bib23","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1161\/01.STR.16.4.591","article-title":"Subarachnoid hemorrhage: Epidemiology, diagnosis, management, and outcome","volume":"16","author":"Bonita","year":"1985","journal-title":"Stroke"},{"key":"10.1016\/j.jss.2008.08.021_bib24","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1161\/01.STR.27.3.504","article-title":"Subarachnoid injections of lysed blood induce the hsp70 stress gene and produce DNA fragmentation in focal areas of the rat brain","volume":"27","author":"Matz","year":"1996","journal-title":"Stroke"},{"key":"10.1016\/j.jss.2008.08.021_bib25","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.3171\/jns.2005.102.6.1046","article-title":"Delayed cell death related to acute cerebral blood flow changes following subarachnoid hemorrhage in the rat brain","volume":"102","author":"Prunell","year":"2005","journal-title":"J Neurosurg"},{"key":"10.1016\/j.jss.2008.08.021_bib26","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1097\/00000542-200411000-00015","article-title":"Activation of A3 adenosine receptors attenuates lung injury after in vivo reperfusion","volume":"101","author":"Rivo","year":"2004","journal-title":"Anesthesiology"},{"key":"10.1016\/j.jss.2008.08.021_bib27","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1016\/j.jtcvs.2003.04.001","article-title":"Mitogen-activated protein kinase pathways and cardiac surgery","volume":"127","author":"Khan","year":"2004","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1016\/j.jss.2008.08.021_bib28","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1124\/mol.58.3.477","article-title":"Human adenosine A(1), A(2A), A(2B), and A(3) receptors expressed in Chinese hamster ovary cells all mediate the phosphorylation of extracellular-regulated kinase 1\/2","volume":"58","author":"Schulte","year":"2000","journal-title":"Mol Pharmacol"},{"key":"10.1016\/j.jss.2008.08.021_bib29","doi-asserted-by":"crossref","first-page":"25833","DOI":"10.1074\/jbc.274.36.25833","article-title":"Activation of mitogen-activated protein kinase by the A(2A)-adenosine receptor via a rap1-dependent and via a p21(ras)-dependent pathway","volume":"274","author":"Seidel","year":"1999","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jss.2008.08.021_bib30","doi-asserted-by":"crossref","first-page":"33930","DOI":"10.1074\/jbc.M201206200","article-title":"Essential role of cAMP-response element-binding protein activation by A2A adenosine receptors in rescuing the nerve growth factor-induced neurite outgrowth impaired by blockage of the MAPK cascade","volume":"277","author":"Cheng","year":"2002","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jss.2008.08.021_bib31","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1096\/fj.02-0807fje","article-title":"17beta-estradiol activates ICI 182,780-sensitive estrogen receptors and cyclic GMP-dependent thioredoxin expression for neuroprotection","volume":"17","author":"Lee","year":"2003","journal-title":"FASEB J"}],"container-title":["Journal of Surgical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022480408005465?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022480408005465?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T15:21:12Z","timestamp":1709306472000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022480408005465"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,12]]},"references-count":31,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2009,12]]}},"alternative-id":["S0022480408005465"],"URL":"https:\/\/doi.org\/10.1016\/j.jss.2008.08.021","relation":{},"ISSN":["0022-4804"],"issn-type":[{"value":"0022-4804","type":"print"}],"subject":[],"published":{"date-parts":[[2009,12]]}}}