{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,26]],"date-time":"2025-06-26T23:44:40Z","timestamp":1750981480537},"reference-count":33,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2010,8,1]],"date-time":"2010-08-01T00:00:00Z","timestamp":1280620800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Surgical Research"],"published-print":{"date-parts":[[2010,8]]},"DOI":"10.1016\/j.jss.2010.02.023","type":"journal-article","created":{"date-parts":[[2010,3,17]],"date-time":"2010-03-17T09:14:08Z","timestamp":1268817248000},"page":"e9-e17","source":"Crossref","is-referenced-by-count":13,"title":["PTHrP 1-141 and 1-86 Increase In Vitro Bone Formation"],"prefix":"10.1016","volume":"162","author":[{"suffix":"III","given":"Blake Eason","family":"Hildreth","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jillian L.","family":"Werbeck","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nandu K.","family":"Thudi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiyun","family":"Deng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas J.","family":"Rosol","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ramiro E.","family":"Toribio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jss.2010.02.023_bib1","doi-asserted-by":"crossref","first-page":"7151","DOI":"10.1016\/S0021-9258(18)48217-8","article-title":"Identification of a novel 17,000-dalton parathyroid hormone-like adenylate cyclase-stimulating protein from a tumor associated with humoral hypercalcemia of malignancy","volume":"262","author":"Burtis","year":"1987","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jss.2010.02.023_bib2","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1023\/A:1018700502518","article-title":"Parathyroid hormone-related protein: A developmental regulatory molecule necessary for mammary gland development","volume":"4","author":"Dunbar","year":"1999","journal-title":"J Mammary Gland Biol Neoplasia"},{"key":"10.1016\/j.jss.2010.02.023_bib3","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1210\/me.8.2.139","article-title":"Antisense-mediated inhibition of parathyroid hormone-related peptide (PTHrP) production in a keratinocyte cell line impedes differentiation","volume":"8","author":"Kaiser","year":"1994","journal-title":"Mol Endocrinol"},{"key":"10.1016\/j.jss.2010.02.023_bib4","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.1210\/endo-125-3-1204","article-title":"Parathyroid hormone-related peptide transiently increases cytosolic calcium in osteoblast-like cells: Comparison with parathyroid hormone","volume":"125","author":"Civitelli","year":"1989","journal-title":"Endocrinology"},{"key":"10.1016\/j.jss.2010.02.023_bib5","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1146\/annurev.physiol.60.1.431","article-title":"The physiology of parathyroid hormone-related protein: An emerging role as a developmental factor","volume":"60","author":"Wysolmerski","year":"1998","journal-title":"Annu Rev Physiol"},{"key":"10.1016\/j.jss.2010.02.023_bib6","doi-asserted-by":"crossref","first-page":"15233","DOI":"10.1073\/pnas.93.26.15233","article-title":"Parathyroid hormone-related peptide (PTHrP) regulates fetal-placental calcium transport through a receptor distinct from the PTH\/PTHrP receptor","volume":"93","author":"Kovacs","year":"1996","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.jss.2010.02.023_bib7","doi-asserted-by":"crossref","first-page":"4064","DOI":"10.1128\/MCB.15.8.4064","article-title":"Nucleolar localization of parathyroid hormone-related peptide enhances survival of chondrocytes under conditions that promote apoptotic cell death","volume":"15","author":"Henderson","year":"1995","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.jss.2010.02.023_bib8","doi-asserted-by":"crossref","first-page":"13630","DOI":"10.1073\/pnas.94.25.13630","article-title":"Opposing mitogenic and anti-mitogenic actions of parathyroid hormone-related protein in vascular smooth muscle cells: A critical role for nuclear targeting","volume":"94","author":"Massfelder","year":"1997","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.jss.2010.02.023_bib9","doi-asserted-by":"crossref","first-page":"3424","DOI":"10.1210\/endo-129-6-3424","article-title":"A potent inhibitor of osteoclastic bone resorption within a highly conserved pentapeptide region of parathyroid hormone-related protein; PTHrP [107-111]","volume":"129","author":"Fenton","year":"1991","journal-title":"Endocrinology"},{"key":"10.1016\/j.jss.2010.02.023_bib10","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1023\/A:1026526703898","article-title":"PTH and PTHrP effects on the skeleton","volume":"1","author":"Karaplis","year":"2000","journal-title":"Rev Endocr Metab Disord"},{"key":"10.1016\/j.jss.2010.02.023_bib11","doi-asserted-by":"crossref","first-page":"2166","DOI":"10.1210\/jc.2007-2781","article-title":"Randomized trial of once-weekly PTH (1-84) on bone mineral density and remodelling","volume":"93","author":"Black","year":"2008","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.jss.2010.02.023_bib12","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1002\/jcp.21547","article-title":"Parathyroid hormone-related protein (107-139) increases human osteoblastic cell survival by activation of vascular endothelial growth factor receptor-2","volume":"217","author":"Alonso","year":"2008","journal-title":"J Cell Physiol"},{"key":"10.1016\/j.jss.2010.02.023_bib13","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1007\/s00223-006-0099-y","article-title":"Transient exposure to PTHrP (107-139) exerts anabolic effects through vascular endothelial growth factor receptor 2 in human osteoblastic cells in vitro","volume":"79","author":"de Gort\u00e1zar","year":"2006","journal-title":"Calcif Tissue Int"},{"key":"10.1016\/j.jss.2010.02.023_bib14","doi-asserted-by":"crossref","first-page":"1766","DOI":"10.1359\/JBMR.050608","article-title":"Exogenous PTH-related protein and PTH improve mineral and skeletal status in 25-hydroxyvitamin D-1alpha-hydroxylase and PTH double knockout mice","volume":"20","author":"Xue","year":"2005","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.jss.2010.02.023_bib15","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1056\/NEJM200001203420306","article-title":"The physiology of parathyroid hormone-related protein","volume":"342","author":"Strewler","year":"2000","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jss.2010.02.023_bib16","doi-asserted-by":"crossref","first-page":"3554","DOI":"10.1210\/en.2003-1695","article-title":"Parathyroid hormone-related peptide is required for increased trabecular bone volume in parathyroid hormone-null mice","volume":"145","author":"Miao","year":"2004","journal-title":"Endocrinology"},{"key":"10.1016\/j.jss.2010.02.023_bib17","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1359\/jbmr.060211","article-title":"Full length or fragments in hormone studies?","volume":"21","author":"Martin","year":"2006","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.jss.2010.02.023_bib18","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1007\/s004670000343","article-title":"Role of parathyroid hormone-related peptide and Indian hedgehog in skeletal development","volume":"14","author":"J\u00fcppner","year":"2000","journal-title":"Pediatr Nephrol"},{"key":"10.1016\/j.jss.2010.02.023_bib19","doi-asserted-by":"crossref","first-page":"S49","DOI":"10.1016\/j.injury.2007.02.010","article-title":"New technologies for the enhancement of skeletal repair","volume":"38","author":"Axelrad","year":"2007","journal-title":"Injury"},{"key":"10.1016\/j.jss.2010.02.023_bib20","first-page":"4040","article-title":"An experimental model of bone metastasis by human lung cancer cells: The role of parathyroid hormone-related protein in bone metastasis","volume":"56","author":"Iguchi","year":"1996","journal-title":"Cancer Res"},{"key":"10.1016\/j.jss.2010.02.023_bib21","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1023\/A:1006598422203","article-title":"LCC15-MB: A vimentin-positive human breast cancer cell line from a femoral bone metastasis","volume":"17","author":"Thompson","year":"1999","journal-title":"Clin Exp Metastasis"},{"key":"10.1016\/j.jss.2010.02.023_bib22","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1139\/o99-005","article-title":"Advances in the osteoblast lineage","volume":"76","author":"Aubin","year":"1998","journal-title":"Biochem Cell Biol"},{"key":"10.1016\/j.jss.2010.02.023_bib23","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1101\/gad.8.3.277","article-title":"Lethal skeletal dysplasia from targeted disruption of the parathyroid hormone-related peptide gene","volume":"8","author":"Karaplis","year":"1994","journal-title":"Genes Dev"},{"key":"10.1016\/j.jss.2010.02.023_bib24","doi-asserted-by":"crossref","first-page":"13689","DOI":"10.1073\/pnas.94.25.13689","article-title":"Targeted expression of constitutively active receptors for parathyroid hormone and parathyroid hormone-related peptide delays endochondral bone formation and rescues mice that lack parathyroid hormone-related peptide","volume":"94","author":"Schipani","year":"1997","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.jss.2010.02.023_bib25","doi-asserted-by":"crossref","first-page":"20309","DOI":"10.1073\/pnas.0805690105","article-title":"Severe growth retardation and early lethality in mice lacking the nuclear localization sequence and C-terminus of PTH-related protein","volume":"105","author":"Miao","year":"2008","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.jss.2010.02.023_bib26","doi-asserted-by":"crossref","first-page":"1504","DOI":"10.1359\/jbmr.1999.14.9.1504","article-title":"Anabolic or catabolic responses of MC3T3-E1 osteoblastic cells to parathyroid hormone depend on time and duration of treatment","volume":"14","author":"Schiller","year":"1999","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.jss.2010.02.023_bib27","doi-asserted-by":"crossref","first-page":"4607","DOI":"10.1210\/en.138.11.4607","article-title":"The effects of programmed administration of human parathyroid hormone fragment (1-34) on bone histomorphometry and serum chemistry in rats","volume":"138","author":"Dobnig","year":"1997","journal-title":"Endocrinology"},{"key":"10.1016\/j.jss.2010.02.023_bib28","doi-asserted-by":"crossref","first-page":"2961","DOI":"10.1172\/JCI119491","article-title":"Parathyroid hormone exerts disparate effects on osteoblast differentiation depending on exposure time in rat osteoblastic cells","volume":"99","author":"Ishizuya","year":"1997","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jss.2010.02.023_bib29","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1016\/S8756-3282(02)00685-3","article-title":"Parathyroid hormone-related protein (PTHrP)-(1-139) isoform is efficiently secreted in vitro and enhances breast cancer metastasis to bone in vivo","volume":"30","author":"Guise","year":"2002","journal-title":"Bone"},{"key":"10.1016\/j.jss.2010.02.023_bib30","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1385\/ENDO:15:2:217","article-title":"Comparative tissue distribution of the processing enzymes \u201cprohormone thiol protease,\u201d and prohormone convertases 1 and 2, in human PTHrP-producing cell lines and mammalian neuroendocrine tissues","volume":"15","author":"Deftos","year":"2001","journal-title":"Endocrine"},{"key":"10.1016\/j.jss.2010.02.023_bib31","doi-asserted-by":"crossref","first-page":"7586","DOI":"10.1074\/jbc.M007400200","article-title":"Stimulation of extracellular signal-regulated kinases and proliferation in rat\u00a0osteoblastic cells by parathyroid hormone is protein kinase C-dependent","volume":"276","author":"Swarthout","year":"2001","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jss.2010.02.023_bib32","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1359\/jbmr.1999.14.6.915","article-title":"Stimulation of osteoblast proliferation by C-terminal fragments of parathyroid hormone related-protein","volume":"14","author":"Cornish","year":"1999","journal-title":"J Bone Min Res"},{"key":"10.1016\/j.jss.2010.02.023_bib33","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1210\/jc.80.1.60","article-title":"Comparison of the pharmacokinetics of parenteral parathyroid hormone-(1-34) [PTH-(1-34)] and PTH-related peptide-(1-34) in healthy young humans","volume":"80","author":"Fraher","year":"1995","journal-title":"J\u00a0Clin Endocrinol Metab"}],"container-title":["Journal of Surgical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022480410001150?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022480410001150?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,10,24]],"date-time":"2021-10-24T22:27:59Z","timestamp":1635114479000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022480410001150"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,8]]},"references-count":33,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2010,8]]}},"alternative-id":["S0022480410001150"],"URL":"https:\/\/doi.org\/10.1016\/j.jss.2010.02.023","relation":{},"ISSN":["0022-4804"],"issn-type":[{"value":"0022-4804","type":"print"}],"subject":[],"published":{"date-parts":[[2010,8]]}}}