{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T22:51:25Z","timestamp":1759963885421},"reference-count":40,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2012,4,1]],"date-time":"2012-04-01T00:00:00Z","timestamp":1333238400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Surgical Research"],"published-print":{"date-parts":[[2012,4]]},"DOI":"10.1016\/j.jss.2011.11.004","type":"journal-article","created":{"date-parts":[[2011,11,23]],"date-time":"2011-11-23T19:53:45Z","timestamp":1322078025000},"page":"e47-e52","source":"Crossref","is-referenced-by-count":14,"title":["Berberine Inhibits Lipopolysaccharide- and Polyethylene Particle-Induced Mouse Calvarial Osteolysis In\u00a0Vivo"],"prefix":"10.1016","volume":"173","author":[{"given":"Xiaoxiao","family":"Zhou","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoqing","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bingchen","family":"An","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhen\u2019an","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jss.2011.11.004_bib1","doi-asserted-by":"crossref","first-page":"1276","DOI":"10.1016\/j.bone.2006.12.053","article-title":"Comparison of the roles of IL-1, IL-6, and TNF\u03b1 in cell culture and murine models of aseptic loosening","volume":"40","author":"Taki","year":"2007","journal-title":"Bone"},{"key":"10.1016\/j.jss.2011.11.004_bib2","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1002\/jor.1100170603","article-title":"Measurement and removal of adherent endotoxin from titanium particles and implant surfaces","volume":"17","author":"Ragab","year":"1999","journal-title":"J Orthop Res"},{"key":"10.1016\/j.jss.2011.11.004_bib3","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1302\/0301-620X.84B5.11775","article-title":"Bone-resorptive effects of endotoxin-contaminated high-density polyethylene particles spontaneously eliminated in\u00a0vivo","volume":"84","author":"Skoglund","year":"2002","journal-title":"J Bone Joint Surg Br"},{"key":"10.1016\/j.jss.2011.11.004_bib4","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1002\/jor.20289","article-title":"The balance between endotoxin accumulation and clearance during particle-induced osteolysis in murine calvaria","volume":"25","author":"Tatro","year":"2007","journal-title":"J Orthop Res"},{"key":"10.1016\/j.jss.2011.11.004_bib5","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1128\/MMBR.60.2.316-341.1996","article-title":"Bacterial modulins: A novel class of virulence factors which cause host tissue pathology by inducing cytokine synthesis","volume":"60","author":"Henderson","year":"1996","journal-title":"Microbiol Rev"},{"key":"10.1016\/j.jss.2011.11.004_bib6","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1002\/jab.770050202","article-title":"Incidence of infection and analysis of contributing factors in revision joint arthroplasty over a two-year period","volume":"5","author":"Merritt","year":"1994","journal-title":"J Appl Biomater"},{"key":"10.1016\/j.jss.2011.11.004_bib7","doi-asserted-by":"crossref","first-page":"3281","DOI":"10.1128\/JCM.37.10.3281-3290.1999","article-title":"Detection of prosthetic hip infection at revision arthroplasty by immunofluorescence microscopy and PCR amplification of the bacterial 16S rRNA gene","volume":"37","author":"Tunney","year":"1999","journal-title":"J Clin Microbiol"},{"key":"10.1016\/j.jss.2011.11.004_bib8","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1302\/0301-620X.79B4.7420","article-title":"Antibiotic prophylaxis in total hip arthroplasty. Review of 10,905 primary cemented total hip replacements reported to the Norwegian arthroplasty register, 1987 to 1995","volume":"79","author":"Espehaug","year":"1997","journal-title":"J Bone Joint Surg Br"},{"key":"10.1016\/j.jss.2011.11.004_bib9","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1038\/35081178","article-title":"Natural products and plant disease resistance","volume":"411","author":"Dixon","year":"2001","journal-title":"Nature"},{"key":"10.1016\/j.jss.2011.11.004_bib10","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1016\/j.bbrc.2006.11.043","article-title":"Berberine alters the processing of Alzheimer\u2019s amyloid precursor protein to decrease A- secretion","volume":"352","author":"Asai","year":"2007","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.jss.2011.11.004_bib11","first-page":"94","article-title":"Berberine: Therapeutic potential of an alkaloid found in several medicinal plants","volume":"2","author":"Birdsall","year":"1997","journal-title":"Altern Med Rev"},{"key":"10.1016\/j.jss.2011.11.004_bib12","doi-asserted-by":"crossref","first-page":"2256","DOI":"10.2337\/db06-0006","article-title":"Berberine, a natural plant product, activates AMP-activated protein kinase with beneficial metabolic effects in diabetic and insulin-resistant states","volume":"55","author":"Lee","year":"2006","journal-title":"Diabetes"},{"key":"10.1016\/j.jss.2011.11.004_bib13","doi-asserted-by":"crossref","first-page":"1344","DOI":"10.1038\/nm1135","article-title":"Berberine is a novel cholesterol-lowering drug working through a unique mechanism distinct from statins","volume":"10","author":"Kong","year":"2004","journal-title":"Nat Med"},{"key":"10.1016\/j.jss.2011.11.004_bib14","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1211\/0022357011775901","article-title":"Inhibition of chemical carcinogenesis by berberine in rats and mice","volume":"53","author":"Anis","year":"2001","journal-title":"J Pharm Pharmacol"},{"key":"10.1016\/j.jss.2011.11.004_bib15","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1158\/1535-7163.MCT-05-0448","article-title":"Berberine, a natural product, induces G1\u2013 phase cell cycle arrest and caspase-3-dependent apoptosis in human prostate carcinoma cells","volume":"5","author":"Mantena","year":"2006","journal-title":"Mol Cancer Ther"},{"key":"10.1016\/j.jss.2011.11.004_bib16","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1111\/j.1601-0825.2000.tb00142.x","article-title":"Coptidis rhizoma inhibits growth and proteases of oral bacteria","volume":"6","author":"Hu","year":"2000","journal-title":"Oral Dis"},{"key":"10.1016\/j.jss.2011.11.004_bib17","doi-asserted-by":"crossref","first-page":"1809","DOI":"10.1055\/s-0030-1250040","article-title":"Preventive effects of berberine on glucocorticoid-induced osteoporosis in rats","volume":"76","author":"Xu","year":"2010","journal-title":"Planta Med"},{"key":"10.1016\/j.jss.2011.11.004_bib18","doi-asserted-by":"crossref","first-page":"1562","DOI":"10.1016\/j.bmcl.2006.12.085","article-title":"Antiviral activity of berberine and related compounds against human cytomegalovirus","volume":"17","author":"Hayashi","year":"2007","journal-title":"Bioorg Med Chem Lett"},{"key":"10.1016\/j.jss.2011.11.004_bib19","doi-asserted-by":"crossref","first-page":"3913","DOI":"10.1016\/j.bmcl.2006.05.033","article-title":"Synthesis of 13-(substituted benzyl) berberine and berberrubine derivatives as antifungal agents","volume":"16","author":"Park","year":"2006","journal-title":"Bioorg Med Chem Lett"},{"key":"10.1016\/j.jss.2011.11.004_bib20","doi-asserted-by":"crossref","first-page":"771","DOI":"10.3109\/08923979909007141","article-title":"Influence of berberine on T-cell mediated immunity","volume":"21","author":"Ivanovska","year":"1999","journal-title":"Immunopharmacol Immunotoxicol"},{"key":"10.1016\/j.jss.2011.11.004_bib21","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1016\/S0192-0561(96)00047-1","article-title":"Study on the anti-inflammatory action of Berberis vulgaris root extract, alkaloid fractions and pure alkaloids","volume":"18","author":"Ivanovska","year":"1996","journal-title":"Int J Immunopharmacol"},{"key":"10.1016\/j.jss.2011.11.004_bib22","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/S0162-3109(99)00189-7","article-title":"Suppression of experimental autoimmune tubulointerstitial nephritis in BALB\/c mice by berberine","volume":"48","author":"Marinova","year":"2000","journal-title":"Immunopharmacology"},{"key":"10.1016\/j.jss.2011.11.004_bib23","first-page":"476","article-title":"Different Phagocytosis Reaction of Macrophages on UHMWPE and Ti-6AI-4V Particles","volume":"26","author":"Mao","year":"2006","journal-title":"Journal of Shanghai Jiaotong University (Medical Science)"},{"key":"10.1016\/j.jss.2011.11.004_bib24","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1002\/jor.21002","article-title":"Promotion of bone formation by naringin in a titanium particle-induced diabetic murine calvarial osteolysis model","volume":"28","author":"Zhou","year":"2010","journal-title":"J Orthop Res"},{"key":"10.1016\/j.jss.2011.11.004_bib25","doi-asserted-by":"crossref","first-page":"1905","DOI":"10.1359\/JBMR.040919","article-title":"Sesquiterpene lactone parthenolide blocks lipopolysaccharide-induced osteolysis through the suppression of NF-\u043aB activity","volume":"19","author":"Yip","year":"2004","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.jss.2011.11.004_bib26","doi-asserted-by":"crossref","first-page":"461","DOI":"10.5507\/bp.2005.080","article-title":"Antiproliferative activity of berberine in\u00a0vitro and in\u00a0vivo","volume":"149","author":"Letasiov\u00e1","year":"2005","journal-title":"Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub"},{"key":"10.1016\/j.jss.2011.11.004_bib27","doi-asserted-by":"crossref","first-page":"1803","DOI":"10.1016\/j.biomaterials.2004.06.010","article-title":"The decrease of particle-induced osteolysis after a single dose of bisphosphonate","volume":"26","author":"von Knoch","year":"2005","journal-title":"Biomaterials"},{"key":"10.1016\/j.jss.2011.11.004_bib28","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1002\/jbmr.5650020617","article-title":"Bone histomorphometry: Standardization of nomenclature, symbols and units. Report of the ASMBR histomorphometry nomenclature committee","volume":"2","author":"Parfitt","year":"1987","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.jss.2011.11.004_bib29","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.2106\/00004623-199507000-00008","article-title":"Tissue in-growth and differentiation in the bone-harvest chamber in the presence of cobaltchromium-alloy and high-density-polyethylene particles","volume":"77","author":"Goodman","year":"1995","journal-title":"J Bone Joint Surg Am"},{"key":"10.1016\/j.jss.2011.11.004_bib30","doi-asserted-by":"crossref","first-page":"1086","DOI":"10.2106\/00004623-199307000-00017","article-title":"Current concepts in orthopaedic biomaterials and implant fixation","volume":"75","author":"Friedman","year":"1994","journal-title":"J Bone Joint Surg Am"},{"key":"10.1016\/j.jss.2011.11.004_bib31","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1302\/0301-620X.84B5.11775","article-title":"Bone-resorptive effects of endotoxin-contaminated high-density polyethylene particles spontaneously eliminated in\u00a0vivo","volume":"84","author":"Skoglund","year":"2002","journal-title":"J Bone Joint Surg Br"},{"key":"10.1016\/j.jss.2011.11.004_bib32","doi-asserted-by":"crossref","first-page":"2371","DOI":"10.1128\/IAI.64.7.2371-2380.1996","article-title":"Bacterially induced bone destruction: Mechanisms and misconceptions","volume":"64","author":"Nair","year":"1996","journal-title":"Infect Immune"},{"key":"10.1016\/j.jss.2011.11.004_bib33","doi-asserted-by":"crossref","first-page":"2085","DOI":"10.1126\/science.282.5396.2085","article-title":"Defective LPS signaling in C3H\/HeJ and C57BL\/10ScCr mice: Mutations in Tlr4 gene","volume":"282","author":"Poltorak","year":"1998","journal-title":"Science"},{"key":"10.1016\/j.jss.2011.11.004_bib34","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1210\/en.134.2.831","article-title":"Granulocyte macrophage colony stimulating factor suppresses lipopolysaccharide-induced osteoclast-like cell formation in mouse bone marrow cultures","volume":"134","author":"Shuto","year":"1994","journal-title":"Endocrinology"},{"key":"10.1016\/j.jss.2011.11.004_bib35","doi-asserted-by":"crossref","first-page":"1516","DOI":"10.4049\/jimmunol.169.3.1516","article-title":"Stimulation by toll-like receptors inhibits osteoclast differentiation","volume":"169","author":"Takami","year":"2002","journal-title":"J Immunol"},{"key":"10.1016\/j.jss.2011.11.004_bib36","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.1002\/jor.20917","article-title":"Berberine inhibits Staphylococcus epidermidis adhesion and biofilm formation on the surface of titanium alloy","volume":"27","author":"Wang","year":"2009","journal-title":"J Orthop Res"},{"key":"10.1016\/j.jss.2011.11.004_bib37","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.ijantimicag.2008.10.033","article-title":"Effect of berberine on Staphylococcus epidermidis biofilm formation","volume":"34","author":"Wang","year":"2009","journal-title":"Int J Antimicrob Agents"},{"key":"10.1016\/j.jss.2011.11.004_bib38","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1248\/bpb.22.391","article-title":"The effect of kampo formulae on bone resorption in\u00a0vitro and in\u00a0vivo. II. Detailed study of berberine","volume":"22","author":"Li","year":"1999","journal-title":"Biol Pharm Bull"},{"key":"10.1016\/j.jss.2011.11.004_bib39","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.ejphar.2007.11.013","article-title":"Berberine inhibits RANKL-induced osteoclast formation and survival through suppressing the NF-\u043aB and Akt pathways","volume":"580","author":"Hu","year":"2008","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.jss.2011.11.004_bib40","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/S0736-0266(00)00033-4","article-title":"Rapid repair of titanium particle-induced osteolysis is dramatically reduced in aged mice","volume":"19","author":"Kaar","year":"2001","journal-title":"J Orthop Res"}],"container-title":["Journal of Surgical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022480411009188?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022480411009188?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,6,27]],"date-time":"2020-06-27T22:50:39Z","timestamp":1593298239000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022480411009188"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,4]]},"references-count":40,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2012,4]]}},"alternative-id":["S0022480411009188"],"URL":"https:\/\/doi.org\/10.1016\/j.jss.2011.11.004","relation":{},"ISSN":["0022-4804"],"issn-type":[{"value":"0022-4804","type":"print"}],"subject":[],"published":{"date-parts":[[2012,4]]}}}