{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T13:01:08Z","timestamp":1762866068812,"version":"3.44.0"},"reference-count":44,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["T32HL007734"],"award-info":[{"award-number":["T32HL007734"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","award":["12GRNT9510001"],"award-info":[{"award-number":["12GRNT9510001"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001333","name":"Carl and Ruth Shapiro Family Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001333","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","journalofsurgicalresearch.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Surgical Research"],"published-print":{"date-parts":[[2013,1]]},"DOI":"10.1016\/j.jss.2012.08.043","type":"journal-article","created":{"date-parts":[[2012,9,6]],"date-time":"2012-09-06T13:31:32Z","timestamp":1346938292000},"page":"175-182","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"title":["Impact of uremia on human adipose tissue phenotype"],"prefix":"10.1016","volume":"179","author":[{"given":"Karen J.","family":"Ho","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui","family":"Xue","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christine R.","family":"Mauro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Binh","family":"Nguyen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peng","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming","family":"Tao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael A.","family":"Seidman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven M.","family":"Brunelli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charles Keith","family":"Ozaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jss.2012.08.043_bib1","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.2174\/1381612033455152","article-title":"Adipobiology of disease: adipokines and adipokine-targeted pharmacology","volume":"9","author":"Chaldakov","year":"2003","journal-title":"Curr Pharm Des"},{"key":"10.1016\/j.jss.2012.08.043_bib2","doi-asserted-by":"crossref","first-page":"2094","DOI":"10.1172\/JCI45887","article-title":"Adipose tissue remodeling and obesity","volume":"121","author":"Sun","year":"2011","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jss.2012.08.043_bib3","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.mce.2009.08.018","article-title":"Adipose tissue as an endocrine organ","volume":"316","author":"Galic","year":"2010","journal-title":"Mol Cell Endocrinol"},{"key":"10.1016\/j.jss.2012.08.043_bib4","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1097\/MOL.0b013e3283346ccc","article-title":"The distinction of metabolically \u2018healthy\u2019 from \u2018unhealthy\u2019 obese individuals","volume":"21","author":"Bluher","year":"2010","journal-title":"Curr Opin Lipidol"},{"key":"10.1016\/j.jss.2012.08.043_bib5","doi-asserted-by":"crossref","first-page":"1306","DOI":"10.1016\/j.jvs.2011.11.135","article-title":"Class I obesity is paradoxically associated with decreased risk of postoperative stroke after carotid endarterectomy","volume":"55","author":"Jackson","year":"2012","journal-title":"J Vasc Surg"},{"key":"10.1016\/j.jss.2012.08.043_bib6","doi-asserted-by":"crossref","first-page":"481","DOI":"10.5858\/2007-131-481-TROPFI","article-title":"The role of periadventitial fat in atherosclerosis","volume":"131","author":"Vela","year":"2007","journal-title":"Arch Pathol Lab Med"},{"key":"10.1016\/j.jss.2012.08.043_bib7","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1161\/CIRCRESAHA.108.182998","article-title":"Proinflammatory phenotype of perivascular adipocytes: influence of high-fat feeding","volume":"104","author":"Chatterjee","year":"2009","journal-title":"Circ Res"},{"key":"10.1016\/j.jss.2012.08.043_bib8","doi-asserted-by":"crossref","first-page":"1576","DOI":"10.1161\/ATVBAHA.110.207175","article-title":"Endovascular injury induces rapid phenotypic changes in perivascular adipose tissue","volume":"30","author":"Takaoka","year":"2010","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.jss.2012.08.043_bib9","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1111\/j.1365-2796.2010.02293.x","article-title":"Increased expression of pro-inflammatory genes in abdominal subcutaneous fat in advanced chronic kidney disease patients","volume":"269","author":"Witasp","year":"2011","journal-title":"J Intern Med"},{"key":"10.1016\/j.jss.2012.08.043_bib10","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1007\/s00508-010-1409-y","article-title":"Increased proinflammatory cytokine production in adipose tissue of obese patients with chronic kidney disease","volume":"122","author":"Teplan","year":"2010","journal-title":"Wien Klin Wochenschr"},{"key":"10.1016\/j.jss.2012.08.043_bib11","doi-asserted-by":"crossref","first-page":"E690","DOI":"10.1152\/ajpendo.00034.2007","article-title":"Subcutaneous adipose tissue exerts proinflammatory cytokines after minimal trauma in humans","volume":"293","author":"Pachler","year":"2007","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"10.1016\/j.jss.2012.08.043_bib12","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1038\/oby.2010.227","article-title":"Lipid-heparin infusion suppresses the IL-10 response to trauma in subcutaneous adipose tissue in humans","volume":"19","author":"Ikeoka","year":"2011","journal-title":"Obesity (Silver Spring)"},{"key":"10.1016\/j.jss.2012.08.043_bib13","doi-asserted-by":"crossref","first-page":"E1782","DOI":"10.1210\/jc.2011-1577","article-title":"Adipose tissue dysregulation in patients with metabolic syndrome","volume":"96","author":"Bremer","year":"2011","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.jss.2012.08.043_bib14","doi-asserted-by":"crossref","first-page":"S112","DOI":"10.1053\/ajkd.1998.v32.pm9820470","article-title":"Clinical epidemiology of cardiovascular disease in chronic renal disease","volume":"32","author":"Foley","year":"1998","journal-title":"Am J Kidney Dis"},{"key":"10.1016\/j.jss.2012.08.043_bib15","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1046\/j.1525-139X.2003.160271.x","article-title":"Clinical epidemiology of cardiac disease in dialysis patients: left ventricular hypertrophy, ischemic heart disease, and cardiac failure","volume":"16","author":"Foley","year":"2003","journal-title":"Semin Dial"},{"key":"10.1016\/j.jss.2012.08.043_bib16","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/S0140-6736(00)02456-9","article-title":"Premature cardiovascular disease in chronic renal failure","volume":"356","author":"Baigent","year":"2000","journal-title":"Lancet"},{"key":"10.1016\/j.jss.2012.08.043_bib17","doi-asserted-by":"crossref","first-page":"2619","DOI":"10.1093\/ndt\/gfn070","article-title":"Plasma adiponectin levels and clinical outcomes among haemodialysis patients","volume":"23","author":"Rao","year":"2008","journal-title":"Nephrol Dial Transplant"},{"key":"10.1016\/j.jss.2012.08.043_bib18","doi-asserted-by":"crossref","first-page":"163","DOI":"10.5414\/CNP61163","article-title":"Factors associated with serum leptin in patients with chronic kidney disease","volume":"61","author":"Menon","year":"2004","journal-title":"Clin Nephrol"},{"key":"10.1016\/j.jss.2012.08.043_bib19","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1111\/j.1440-1797.2007.00782.x","article-title":"Elevated resistin is related to inflammation and residual renal function in haemodialysed patients","volume":"12","author":"Malyszko","year":"2007","journal-title":"Nephrology (Carlton)"},{"key":"10.1016\/j.jss.2012.08.043_bib20","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1093\/ndt\/gfi084","article-title":"Circulating resistin concentrations in children depend on renal function","volume":"21","author":"Nusken","year":"2006","journal-title":"Nephrol Dial Transplant"},{"key":"10.1016\/j.jss.2012.08.043_bib21","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1111\/j.1365-2265.2007.02743.x","article-title":"Implications of resistin plasma levels in subjects undergoing coronary angiography","volume":"66","author":"Pilz","year":"2007","journal-title":"Clinical endocrinology"},{"key":"10.1016\/j.jss.2012.08.043_bib22","doi-asserted-by":"crossref","first-page":"1524","DOI":"10.1046\/j.1523-1755.2002.00600.x","article-title":"The elephant in uremia: oxidant stress as a unifying concept of cardiovascular disease in uremia","volume":"62","author":"Himmelfarb","year":"2002","journal-title":"Kidney Int"},{"key":"10.1016\/j.jss.2012.08.043_bib23","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1046\/j.1523-1755.2001.059002407.x","article-title":"End-stage renal disease, atherosclerosis, and cardiovascular mortality: is C-reactive protein the missing link?","volume":"59","author":"Arici","year":"2001","journal-title":"Kidney Int"},{"key":"10.1016\/j.jss.2012.08.043_bib24","first-page":"S16","article-title":"Epidemiology of cardiovascular disease in chronic renal disease","volume":"9","author":"Foley","year":"1998","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.jss.2012.08.043_bib25","doi-asserted-by":"crossref","first-page":"1585","DOI":"10.2215\/CJN.01930408","article-title":"Accelerated atherosclerotic calcification and Monckeberg's sclerosis: a continuum of advanced vascular pathology in chronic kidney disease","volume":"3","author":"McCullough","year":"2008","journal-title":"Clin J Am Soc Nephrol"},{"key":"10.1016\/j.jss.2012.08.043_bib26","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1038\/ki.2011.178","article-title":"Novel inflammatory mechanisms of accelerated atherosclerosis in kidney disease","volume":"80","author":"Swaminathan","year":"2011","journal-title":"Kidney Int"},{"key":"10.1016\/j.jss.2012.08.043_bib27","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1056\/NEJM197403282901301","article-title":"Accelerated atherosclerosis in prolonged maintenance hemodialysis","volume":"290","author":"Lindner","year":"1974","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jss.2012.08.043_bib28","doi-asserted-by":"crossref","first-page":"1838","DOI":"10.1046\/j.1523-1755.2003.00287.x","article-title":"Body size and outcomes on peritoneal dialysis in the United States","volume":"64","author":"Snyder","year":"2003","journal-title":"Kidney Int"},{"key":"10.1016\/j.jss.2012.08.043_bib29","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1016\/S0272-6386(03)00916-8","article-title":"A population-based study of the incidence and outcomes of diagnosed chronic kidney disease","volume":"42","author":"Drey","year":"2003","journal-title":"Am J Kidney Dis"},{"key":"10.1016\/j.jss.2012.08.043_bib30","doi-asserted-by":"crossref","first-page":"2186","DOI":"10.1016\/j.transproceed.2003.08.001","article-title":"Plasma adiponectin concentration before and after successful kidney transplantation","volume":"35","author":"Chudek","year":"2003","journal-title":"Transplant Proc"},{"key":"10.1016\/j.jss.2012.08.043_bib31","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1111\/j.1525-139X.2009.00583.x","article-title":"Resistin as a cardiovascular and atherosclerotic risk factor and uremic toxin","volume":"22","author":"Cohen","year":"2009","journal-title":"Semin Dial"},{"key":"10.1016\/j.jss.2012.08.043_bib32","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1038\/sj.ijo.0803793","article-title":"Circulating adiponectin levels associate with inflammatory markers, insulin resistance and metabolic syndrome independent of obesity","volume":"32","author":"Hung","year":"2008","journal-title":"Int J Obes (Lond)"},{"key":"10.1016\/j.jss.2012.08.043_bib33","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1517\/14796678.1.1.39","article-title":"Adiposopathy: sick fat causes high blood sugar, high blood pressure and dyslipidemia","volume":"1","author":"Bays","year":"2005","journal-title":"Future Cardiol"},{"key":"10.1016\/j.jss.2012.08.043_bib34","doi-asserted-by":"crossref","first-page":"2461","DOI":"10.1016\/j.jacc.2011.02.038","article-title":"Adiposopathy is \u201csick fat\u201d a cardiovascular disease?","volume":"57","author":"Bays","year":"2011","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jss.2012.08.043_bib35","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1038\/sj.ijo.0800428","article-title":"Removal of endogenous leptin from the circulation by the kidney","volume":"21","author":"Cumin","year":"1997","journal-title":"Int J Obes Relat Metab Disord"},{"key":"10.1016\/j.jss.2012.08.043_bib36","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1038\/sj.ki.5000182","article-title":"Leptin and inflammation-associated cachexia in chronic kidney disease","volume":"69","author":"Mak","year":"2006","journal-title":"Kidney international"},{"key":"10.1016\/j.jss.2012.08.043_bib37","doi-asserted-by":"crossref","first-page":"1659","DOI":"10.1172\/JCI22521","article-title":"Role of leptin and melanocortin signaling in uremia-associated cachexia","volume":"115","author":"Cheung","year":"2005","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jss.2012.08.043_bib38","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/S0272-6386(03)00409-8","article-title":"Increased resistin blood levels are not associated with insulin resistance in patients with renal disease","volume":"42","author":"Kielstein","year":"2003","journal-title":"Am J Kidney Dis"},{"key":"10.1016\/j.jss.2012.08.043_bib39","doi-asserted-by":"crossref","first-page":"3052","DOI":"10.1161\/hc5001.101061","article-title":"Plasma leptin and the risk of cardiovascular disease in the west of Scotland coronary prevention study (WOSCOPS)","volume":"104","author":"Wallace","year":"2001","journal-title":"Circulation"},{"key":"10.1016\/j.jss.2012.08.043_bib40","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1161\/01.ATV.0000208363.85388.8f","article-title":"Comparison of circulating adiponectin and proinflammatory markers regarding their association with metabolic syndrome in Japanese men","volume":"26","author":"Matsushita","year":"2006","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.jss.2012.08.043_bib41","doi-asserted-by":"crossref","first-page":"1730","DOI":"10.1001\/jama.291.14.1730","article-title":"Plasma adiponectin levels and risk of myocardial infarction in men","volume":"291","author":"Pischon","year":"2004","journal-title":"JAMA"},{"key":"10.1016\/j.jss.2012.08.043_bib42","doi-asserted-by":"crossref","first-page":"534","DOI":"10.2337\/diabetes.54.2.534","article-title":"Adiponectin and future coronary heart disease events among men with type 2 diabetes","volume":"54","author":"Schulze","year":"2005","journal-title":"Diabetes"},{"key":"10.1016\/j.jss.2012.08.043_bib43","doi-asserted-by":"crossref","first-page":"2300","DOI":"10.1093\/eurheartj\/ehl153","article-title":"Adiponectin is an independent predictor of all-cause mortality, cardiac mortality, and myocardial infarction in patients presenting with chest pain","volume":"27","author":"Cavusoglu","year":"2006","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jss.2012.08.043_bib44","doi-asserted-by":"crossref","first-page":"4277","DOI":"10.1210\/jc.2006-0836","article-title":"Adiponectin and mortality in patients undergoing coronary angiography","volume":"91","author":"Pilz","year":"2006","journal-title":"J Clin Endocrinol Metab"}],"container-title":["Journal of Surgical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022480412007895?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022480412007895?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T14:41:29Z","timestamp":1758379289000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022480412007895"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,1]]},"references-count":44,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2013,1]]}},"alternative-id":["S0022480412007895"],"URL":"https:\/\/doi.org\/10.1016\/j.jss.2012.08.043","relation":{},"ISSN":["0022-4804"],"issn-type":[{"type":"print","value":"0022-4804"}],"subject":[],"published":{"date-parts":[[2013,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Impact of uremia on human adipose tissue phenotype","name":"articletitle","label":"Article Title"},{"value":"Journal of Surgical Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jss.2012.08.043","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}