{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T06:01:36Z","timestamp":1761976896511,"version":"build-2065373602"},"reference-count":34,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2014,3,1]],"date-time":"2014-03-01T00:00:00Z","timestamp":1393632000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,3,1]],"date-time":"2014-03-01T00:00:00Z","timestamp":1393632000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100005405","name":"American Surgical Association Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005405","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","journalofsurgicalresearch.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Surgical Research"],"published-print":{"date-parts":[[2014,3]]},"DOI":"10.1016\/j.jss.2013.09.030","type":"journal-article","created":{"date-parts":[[2013,10,7]],"date-time":"2013-10-07T12:00:56Z","timestamp":1381147256000},"page":"230-236","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"title":["Ghrelin decreases motor deficits after traumatic brain injury"],"prefix":"10.1016","volume":"187","author":[{"given":"Nicole E.","family":"Lopez","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lindsay","family":"Gaston","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karina R.","family":"Lopez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne Marie","family":"Hageny","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James","family":"Putnam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brian","family":"Eliceiri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raul","family":"Coimbra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vishal","family":"Bansal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jss.2013.09.030_bib1","unstructured":"F. M.Traumatic brain injury in the united states: emergency department visits, hospitalizations and deaths 2002\u20132006. 2010;."},{"key":"10.1016\/j.jss.2013.09.030_bib2","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1097\/00001199-199912000-00009","article-title":"Traumatic brain injury in the united states: a public health perspective","volume":"14","author":"Thurman","year":"1999","journal-title":"J Head Trauma Rehabil"},{"key":"10.1016\/j.jss.2013.09.030_bib3","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1097\/01.WCB.0000111614.19196.04","article-title":"Pathophysiology of cerebral ischemia and brain trauma: similarities and differences","volume":"24","author":"Bramlett","year":"2004","journal-title":"J Cereb Blood Flow Metab"},{"key":"10.1016\/j.jss.2013.09.030_bib4","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1089\/089771502753754037","article-title":"Clinical trials in head injury","volume":"19","author":"Narayan","year":"2002","journal-title":"J Neurotrauma"},{"key":"10.1016\/j.jss.2013.09.030_bib5","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1046\/j.1440-1681.2002.03609.x","article-title":"Salvaging the ischaemic penumbra: more than just reperfusion?","volume":"29","author":"Phan","year":"2002","journal-title":"Clin Exp Pharmacol Physiol"},{"key":"10.1016\/j.jss.2013.09.030_bib6","doi-asserted-by":"crossref","DOI":"10.1186\/cc6887","article-title":"Improved outcomes from the administration of progesterone for patients with acute severe traumatic brain injury: a randomized controlled trial","volume":"12","author":"Xiao","year":"2008","journal-title":"Crit Care"},{"key":"10.1016\/j.jss.2013.09.030_bib7","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1186\/1472-6793-9-17","article-title":"Both ischemic preconditioning and ghrelin administration protect hippocampus from ischemia\/reperfusion and upregulate uncoupling protein-2","volume":"9","author":"Liu","year":"2009","journal-title":"BMC Physiol"},{"key":"10.1016\/j.jss.2013.09.030_bib8","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1016\/j.bbrc.2007.05.192","article-title":"Ghrelin protects cortical neuron against focal ischemia\/reperfusion in rats","volume":"359","author":"Miao","year":"2007","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.jss.2013.09.030_bib9","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1089\/neu.2009.1210","article-title":"The anti-inflammatory and neuroprotective effects of ghrelin in subarachnoid hemorrhage-induced oxidative brain damage in rats","volume":"27","author":"Ersahin","year":"2010","journal-title":"J Neurotrauma"},{"key":"10.1016\/j.jss.2013.09.030_bib10","doi-asserted-by":"crossref","first-page":"3815","DOI":"10.1210\/en.2009-1416","article-title":"Inhibition of apoptotic cell death by ghrelin improves functional recovery after spinal cord injury","volume":"151","author":"Lee","year":"2010","journal-title":"Endocrinology"},{"key":"10.1016\/j.jss.2013.09.030_bib11","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1089\/neu.2011.2053","article-title":"Ghrelin prevents disruption of the blood-brain barrier after traumatic brain injury","volume":"29","author":"Lopez","year":"2012","journal-title":"J Neurotrauma"},{"key":"10.1016\/j.jss.2013.09.030_bib12","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.brainres.2012.10.031","article-title":"Early ghrelin treatment attenuates disruption of the blood brain barrier and apoptosis after traumatic brain injury through a ucp-2 mechanism","volume":"1489","author":"Lopez","year":"2012","journal-title":"Brain Res"},{"key":"10.1016\/j.jss.2013.09.030_bib13","doi-asserted-by":"crossref","first-page":"2255","DOI":"10.1089\/neu.2010.1372","article-title":"The hormone ghrelin prevents traumatic brain injury induced intestinal dysfunction","volume":"27","author":"Bansal","year":"2010","journal-title":"J Neurotrauma"},{"key":"10.1016\/j.jss.2013.09.030_bib14","first-page":"1059","article-title":"Stimulating the central nervous system to prevent intestinal dysfunction after traumatic brain injury","volume":"68","author":"Bansal","year":"2010","journal-title":"J Trauma"},{"key":"10.1016\/j.jss.2013.09.030_bib15","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1038\/35013070","article-title":"Vagus nerve stimulation attenuates the systemic inflammatory response to endotoxin","volume":"405","author":"Borovikova","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.jss.2013.09.030_bib16","first-page":"1349","article-title":"Efferent vagal nerve stimulation attenuates gut barrier injury after burn: modulation of intestinal occludin expression","volume":"68","author":"Costantini","year":"2010","journal-title":"J Trauma"},{"key":"10.1016\/j.jss.2013.09.030_bib17","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1007\/s10753-011-9307-7","article-title":"Vagal stimulation modulates inflammation through a ghrelin mediated mechanism in traumatic brain injury","volume":"35","author":"Bansal","year":"2012","journal-title":"Inflammation"},{"key":"10.1016\/j.jss.2013.09.030_bib18","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1177\/0269881105051524","article-title":"The mouse beam walking assay offers improved sensitivity over the mouse rotarod in determining motor coordination deficits induced by benzodiazepines","volume":"19","author":"Stanley","year":"2005","journal-title":"J Psychopharmacol"},{"key":"10.1016\/j.jss.2013.09.030_bib19","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1186\/1742-2094-4-17","article-title":"Acute and delayed neuroinflammatory response following experimental penetrating ballistic brain injury in the rat","volume":"4","author":"Williams","year":"2007","journal-title":"J Neuroinflammation"},{"key":"10.1016\/j.jss.2013.09.030_bib20","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.neulet.2009.01.067","article-title":"Ghrelin protects against cell death of hippocampal neurons in pilocarpine-induced seizures in rats","volume":"453","author":"Xu","year":"2009","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.jss.2013.09.030_bib21","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1677\/JOE-10-0040","article-title":"Ghrelin attenuates kainic acid-induced neuronal cell death in the mouse hippocampus","volume":"205","author":"Lee","year":"2010","journal-title":"J Endocrinol"},{"key":"10.1016\/j.jss.2013.09.030_bib22","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1124\/jpet.102.034827","article-title":"Extent and direction of ghrelin transport across the blood-brain barrier is determined by its unique primary structure","volume":"302","author":"Banks","year":"2002","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1016\/j.jss.2013.09.030_bib23","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1210\/en.2006-0991","article-title":"Ghrelin inhibits apoptosis in hypothalamic neuronal cells during oxygen-glucose deprivation","volume":"148","author":"Chung","year":"2007","journal-title":"Endocrinology"},{"key":"10.1016\/j.jss.2013.09.030_bib24","doi-asserted-by":"crossref","DOI":"10.1152\/ajpendo.00508.2011","article-title":"Ghrelin-mediated sympathoinhibition and suppression of inflammation in sepsis","volume":"302","author":"Cheyuo","year":"2012","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"10.1016\/j.jss.2013.09.030_bib25","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1097\/SHK.0b013e3181f48a37","article-title":"Ghrelin suppresses inflammation and neuronal nitric oxide synthase in focal cerebral ischemia via the vagus nerve","volume":"35","author":"Cheyuo","year":"2011","journal-title":"Shock"},{"key":"10.1016\/j.jss.2013.09.030_bib26","doi-asserted-by":"crossref","first-page":"2225","DOI":"10.1016\/j.peptides.2011.09.019","article-title":"Role of\u00a0ghrelin system in neuroprotection and cognitive functions: Implications in alzheimer's disease","volume":"32","author":"Gahete","year":"2011","journal-title":"Peptides"},{"key":"10.1016\/j.jss.2013.09.030_bib27","doi-asserted-by":"crossref","first-page":"186","DOI":"10.2119\/molmed.00390","article-title":"Ghrelin attenuates brain injury after traumatic brain injury and uncontrolled hemorrhagic shock in rats","volume":"18","author":"Qi","year":"2012","journal-title":"Mol Med"},{"key":"10.1016\/j.jss.2013.09.030_bib28","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1159\/000054680","article-title":"A role of ghrelin in neuroendocrine and behavioral responses to stress in mice","volume":"74","author":"Asakawa","year":"2001","journal-title":"Neuroendocrinology"},{"key":"10.1016\/j.jss.2013.09.030_bib29","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1016\/j.psyneuen.2007.04.010","article-title":"The acute ghrelin response to a psychological stress challenge does not predict the post-stress urge to eat","volume":"32","author":"Rouach","year":"2007","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.jss.2013.09.030_bib30","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1097\/01.CCM.0B013E3181611F5AA","article-title":"Endotoxin increases plasma leptin and ghrelin levels in dogs","volume":"36","author":"Yilmaz","year":"2008","journal-title":"Crit Care Med"},{"key":"10.1016\/j.jss.2013.09.030_bib31","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/j.ghir.2007.11.005","article-title":"Changes in total ghrelin within the somatotropic axis in severe burn patients: comparison of those with inhalation injury and those without inhalation injury","volume":"18","author":"Lee","year":"2008","journal-title":"Growth Horm IGF Res"},{"key":"10.1016\/j.jss.2013.09.030_bib32","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1007\/DCR.0b013e3181b54166","article-title":"The ghrelin agonist tzp-101 for management of postoperative ileus after partial colectomy: a randomized, dose-ranging, placebo-controlled clinical trial","volume":"53","author":"Popescu","year":"2010","journal-title":"Dis Colon Rectum"},{"key":"10.1016\/j.jss.2013.09.030_bib33","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1097\/DCR.0b013e31829196d0","article-title":"Safety and efficacy of ulimorelin administered postoperatively to accelerate recovery of gastrointestinal motility following partial bowel resection: results of two randomized, placebo-controlled phase 3 trials","volume":"56","author":"Shaw","year":"2013","journal-title":"Dis Colon Rectum"},{"key":"10.1016\/j.jss.2013.09.030_bib34","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1038\/nn1656","article-title":"Ghrelin controls hippocampal spine synapse density and memory performance","volume":"9","author":"Diano","year":"2006","journal-title":"Nat Neurosci"}],"container-title":["Journal of Surgical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022480413009049?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022480413009049?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T14:40:27Z","timestamp":1758379227000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022480413009049"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,3]]},"references-count":34,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2014,3]]}},"alternative-id":["S0022480413009049"],"URL":"https:\/\/doi.org\/10.1016\/j.jss.2013.09.030","relation":{},"ISSN":["0022-4804"],"issn-type":[{"type":"print","value":"0022-4804"}],"subject":[],"published":{"date-parts":[[2014,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Ghrelin decreases motor deficits after traumatic brain injury","name":"articletitle","label":"Article Title"},{"value":"Journal of Surgical Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jss.2013.09.030","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}