{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T01:43:26Z","timestamp":1792719806522,"version":"4.5.0"},"reference-count":37,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2014,3,1]],"date-time":"2014-03-01T00:00:00Z","timestamp":1393632000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,3,1]],"date-time":"2014-03-01T00:00:00Z","timestamp":1393632000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","journalofsurgicalresearch.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Surgical Research"],"published-print":{"date-parts":[[2014,3]]},"DOI":"10.1016\/j.jss.2013.09.031","type":"journal-article","created":{"date-parts":[[2013,9,29]],"date-time":"2013-09-29T04:17:05Z","timestamp":1380428225000},"page":"162-168","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"title":["The effects of iloprost on ischemia-reperfusion injury in skeletal muscles in a rodent model"],"prefix":"10.1016","volume":"187","author":[{"given":"Tuba","family":"Avci","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dilek","family":"Erer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aysegul","family":"Kucuk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasin","family":"Ozt\u00fcrk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Murat","family":"Tosun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gursel L.","family":"Oktar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mustafa","family":"Arslan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erkan","family":"Iriz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mustafa","family":"Kavutcu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tolga","family":"Tatar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jss.2013.09.031_bib1","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/S0022-4804(03)00094-5","article-title":"Attenuation of ischemia\/reperfusion injury by N-acetylcysteine in a rat hind limb model","volume":"111","author":"Koksal","year":"2003","journal-title":"J Surg Res"},{"key":"10.1016\/j.jss.2013.09.031_bib2","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1161\/01.RES.86.2.117","article-title":"Cellular and molecular dissection of reperfusion injury ROS within and without","volume":"86","author":"Semenza","year":"2000","journal-title":"Circ Res"},{"key":"10.1016\/j.jss.2013.09.031_bib3","doi-asserted-by":"crossref","first-page":"862","DOI":"10.5606\/tgkdc.dergisi.2012.167","article-title":"Ischemic preconditioning and N-acetylcysteine in a rat model of skeletal muscle ischemia-reperfusion: does antioxidant therapy have an impact on ischemic preconditioning","volume":"20","author":"Gurcun","year":"2012","journal-title":"Turkish J Thorac Cardiovasc Surg"},{"key":"10.1016\/j.jss.2013.09.031_bib4","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/S1078-5884(97)80191-8","article-title":"Post-ischaemic organ dysfunction: a review","volume":"14","author":"Homer-Vanniasinkam","year":"1997","journal-title":"Eur J Vasc Endovasc Surg"},{"key":"10.1016\/j.jss.2013.09.031_bib5","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/S0090-6980(01)00131-9","article-title":"Novel mode of action of iloprost: in\u00a0vitro down-regulation of endothelial cell adhesion molecules","volume":"65","author":"Della Bella","year":"2001","journal-title":"Prostaglandins Other Lipid Mediat"},{"key":"10.1016\/j.jss.2013.09.031_bib6","doi-asserted-by":"crossref","first-page":"889","DOI":"10.2165\/00003495-199243060-00008","article-title":"Iloprost. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential in peripheral vascular disease, myocardial ischaemia and extracorporeal circulation procedures","volume":"43","author":"Grant","year":"1992","journal-title":"Drugs"},{"key":"10.1016\/j.jss.2013.09.031_bib7","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1006\/jsre.1993.1183","article-title":"Inhibition of intestinal lipid peroxidation does not minimize morphological damage","volume":"55","author":"Van Ye","year":"1993","journal-title":"J Surg Res"},{"key":"10.1016\/j.jss.2013.09.031_bib8","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1002\/(SICI)1098-2825(1996)10:1<17::AID-JCLA4>3.0.CO;2-I","article-title":"Activities of total, cytoplasmic and mitochondrial superoxide dismutase enzymes in sera and pleural fluids from patient with lung cancer","volume":"10","author":"Durak","year":"1996","journal-title":"J Clin Lab Anal"},{"key":"10.1016\/j.jss.2013.09.031_bib9","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/j.cardiores.2003.11.033","article-title":"Molecular determinants of responses to myocardial ischemia\/reperfusion injury: focus on hypoxia-inducible and heat shock factors","volume":"61","author":"Chi","year":"2004","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.jss.2013.09.031_bib10","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1016\/S0002-9610(98)00198-6","article-title":"Reperfusion injury delays healing of intestinal anastomosis in a rat","volume":"176","author":"Kuzu","year":"1998","journal-title":"Am J Surgery"},{"key":"10.1016\/j.jss.2013.09.031_bib11","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1002\/bjs.1800810504","article-title":"Ischemia-reperfusion injury","volume":"81","author":"Grace","year":"1994","journal-title":"Br J Surg"},{"key":"10.1016\/j.jss.2013.09.031_bib12","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/S0039-6109(16)45628-8","article-title":"Reperfusion injury","volume":"72","author":"Zimmerman","year":"1992","journal-title":"Surg Clin North Am"},{"key":"10.1016\/j.jss.2013.09.031_bib13","first-page":"H1567","article-title":"Myocardial ischemia-reperfusion injury is exacerbated in absence of endothelial cell nitric oxide synthase","volume":"276","author":"Jones","year":"1999","journal-title":"Am J Physiol"},{"key":"10.1016\/j.jss.2013.09.031_bib14","doi-asserted-by":"crossref","first-page":"171","DOI":"10.6061\/clinics\/2012(02)13","article-title":"The protective effect of cilostazol on isolated rabbit femoral arteries under conditions of ischemia and reperfusion: the role of the nitric oxide pathway","volume":"67","author":"Santos","year":"2012","journal-title":"Clinics"},{"key":"10.1016\/j.jss.2013.09.031_bib15","doi-asserted-by":"crossref","first-page":"2742","DOI":"10.1161\/01.CIR.101.23.2742","article-title":"Attenuation of myocardial ischemia\/reperfusion injury by superinduction of inducible nitric oxide synthase","volume":"101","author":"Kanno","year":"2000","journal-title":"Circulation"},{"key":"10.1016\/j.jss.2013.09.031_bib16","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1161\/01.RES.78.1.65","article-title":"Nitric oxide attenuates neutrophil-mediated myocardial contractile dysfunction after ischemia and reperfusion","volume":"78","author":"Pabla","year":"1996","journal-title":"Circ Res"},{"key":"10.1016\/j.jss.2013.09.031_bib17","doi-asserted-by":"crossref","first-page":"11507","DOI":"10.1073\/pnas.96.20.11507","article-title":"The late phase of ischemic preconditioning is abrogated by targeted disruption of the inducible NO synthase gene","volume":"96","author":"Guo","year":"1999","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.jss.2013.09.031_bib18","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1038\/sj.bjp.0702368","article-title":"Pharmacological evidence that inducible nitric oxide synthase is a mediator of delayed preconditioning","volume":"126","author":"Imagawa","year":"1999","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.jss.2013.09.031_bib19","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1161\/01.CIR.98.5.441","article-title":"Nitric oxide synthase is the mediator of late preconditioning against myocardial infarction in conscious rabbits","volume":"98","author":"Takano","year":"1998","journal-title":"Circulation"},{"key":"10.1016\/j.jss.2013.09.031_bib20","doi-asserted-by":"crossref","first-page":"2157","DOI":"10.1161\/01.CIR.99.16.2157","article-title":"Essential role of inducible nitricoxide synthase in monophosphoryl lipid A-induced late cardioprotection: evidence from pharmacological inhibition and gene knockout mice","volume":"99","author":"Xi","year":"1999","journal-title":"Circulation"},{"key":"10.1016\/j.jss.2013.09.031_bib21","doi-asserted-by":"crossref","first-page":"3032","DOI":"10.1161\/01.CIR.0000018745.11739.9B","article-title":"S-nitroso human serum albumin treatment reduces ischemia\/reperfusion injury in skeletal muscle via nitric oxide release","volume":"105","author":"Hallstrom","year":"2002","journal-title":"Circulation"},{"key":"10.1016\/j.jss.2013.09.031_bib22","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1038\/labinvest.3780047","article-title":"Localization of inducible nitric oxide synthase to mast cells during ischemia\/reperfusion injury of skeletal muscle","volume":"80","author":"Messina","year":"2000","journal-title":"Lab Invest"},{"key":"10.1016\/j.jss.2013.09.031_bib23","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1006\/jmcc.1999.1050","article-title":"Infarct size and nitric oxide synthase in murine myocardium","volume":"32","author":"Sumeray","year":"2000","journal-title":"J Mol Cell Cardiol"},{"key":"10.1016\/j.jss.2013.09.031_bib24","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/0741-5214(90)90331-4","article-title":"Iloprost infusion decreases skeletal muscle ischemia-reperfusion injury","volume":"11","author":"Belkin","year":"1990","journal-title":"J Vasc Surg"},{"key":"10.1016\/j.jss.2013.09.031_bib25","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1146\/annurev.physiol.61.1.243","article-title":"Heat-shock proteins, molecular chaperones, and the stress response: evolutionary and ecological physiology","volume":"61","author":"Feder","year":"1999","journal-title":"Annu Rev Physiol"},{"key":"10.1016\/j.jss.2013.09.031_bib26","doi-asserted-by":"crossref","first-page":"C404","DOI":"10.1152\/ajpcell.00051.2002","article-title":"Redox signaling of cardiac HSF1 DNA binding","volume":"283","author":"Paroo","year":"2002","journal-title":"Am J Physiol Cell Physiol"},{"key":"10.1016\/j.jss.2013.09.031_bib27","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1172\/JCI11205","article-title":"Protective responses in the ischemic myocardium","volume":"106","author":"Williams","year":"2000","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jss.2013.09.031_bib28","first-page":"17","article-title":"The heat-shock\u00a0response: regulation and function of heat-shock proteins and molecular chaperones","volume":"32","author":"Morimoto","year":"1997","journal-title":"Essays Biochem"},{"key":"10.1016\/j.jss.2013.09.031_bib29","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1038\/355033a0","article-title":"Protein folding in the cell","volume":"355","author":"Gething","year":"1992","journal-title":"Nature"},{"key":"10.1016\/j.jss.2013.09.031_bib30","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1161\/01.CIR.85.2.769","article-title":"Heat shock protein induction in rat hearts. A role for improved myocardial salvage after ischemia and reperfusion?","volume":"85","author":"Donnelly","year":"1992","journal-title":"Circulation"},{"key":"10.1016\/j.jss.2013.09.031_bib31","doi-asserted-by":"crossref","unstructured":"Heads RJ, Latchman DS, Yellon DM. The molecular basis of adaptation to ischemia in the heart: the role of stress proteins and anti-oxidants in the ischemic and reperfused heart. EXS;76:383.","DOI":"10.1007\/978-3-0348-8988-9_23"},{"key":"10.1016\/j.jss.2013.09.031_bib32","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/0024-3205(91)90550-U","article-title":"The biological significance of malondialdehyde determination in the assessment of tissue oxidative stress","volume":"48","author":"Valenzuela","year":"1991","journal-title":"Life Sci"},{"key":"10.1016\/j.jss.2013.09.031_bib33","first-page":"182","article-title":"Iloprost and pentoxifylline attenuate ischemia-reperfusion injury in skeletal muscle in rabbit model","volume":"14","author":"Emrecan","year":"2008","journal-title":"Ulus Travma Acil Cerrahi Derg"},{"key":"10.1016\/j.jss.2013.09.031_bib34","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/2047-783X-17-14","article-title":"Protective effects of hyperbaric oxygen and iloprost on ischemia\/reperfusion-induced lung injury in a rabbit model","volume":"17","author":"Bozok","year":"2012","journal-title":"Eur J Med Res"},{"key":"10.1016\/j.jss.2013.09.031_bib35","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1510\/icvts.2007.161356","article-title":"The influence of levosimendan and iloprost on renal ischemia-reperfusion: an experimental study","volume":"7","author":"Yakut","year":"2008","journal-title":"Interact Cardiovasc Thorac Surg"},{"key":"10.1016\/j.jss.2013.09.031_bib36","first-page":"516","article-title":"Effects of ischemic preconditioning and iloprost on myocardial ischemia-reperfusion damage in rats","volume":"6","author":"Ay","year":"2013","journal-title":"Int J Clin Exp Med"},{"key":"10.1016\/j.jss.2013.09.031_bib37","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1038\/sc.2010.76","article-title":"Effects of iloprost and piracetam in spinal cord ischemia-reperfusion injury in the rabbit","volume":"49","author":"Kalkan","year":"2011","journal-title":"Spinal Cord"}],"container-title":["Journal of Surgical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022480413009050?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022480413009050?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T14:41:56Z","timestamp":1758379316000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022480413009050"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,3]]},"references-count":37,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2014,3]]}},"alternative-id":["S0022480413009050"],"URL":"https:\/\/doi.org\/10.1016\/j.jss.2013.09.031","relation":{},"ISSN":["0022-4804"],"issn-type":[{"value":"0022-4804","type":"print"}],"subject":[],"published":{"date-parts":[[2014,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The effects of iloprost on ischemia-reperfusion injury in skeletal muscles in a rodent model","name":"articletitle","label":"Article Title"},{"value":"Journal of Surgical Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jss.2013.09.031","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}