{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T11:49:59Z","timestamp":1768564199420,"version":"3.49.0"},"reference-count":43,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2014,6,1]],"date-time":"2014-06-01T00:00:00Z","timestamp":1401580800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Surgical Research"],"published-print":{"date-parts":[[2014,6]]},"DOI":"10.1016\/j.jss.2014.01.049","type":"journal-article","created":{"date-parts":[[2014,1,30]],"date-time":"2014-01-30T11:05:44Z","timestamp":1391079944000},"page":"81-88","source":"Crossref","is-referenced-by-count":37,"title":["Expression and prognostic significance of p21-activated kinase 6 in hepatocellular carcinoma"],"prefix":"10.1016","volume":"189","author":[{"given":"Hongwei","family":"Chen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinlin","family":"Miao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongchen","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chunhua","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junliang","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianxin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xia","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongying","family":"Qiao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jss.2014.01.049_bib1","doi-asserted-by":"crossref","first-page":"1907","DOI":"10.1016\/S0140-6736(03)14964-1","article-title":"Hepatocellular carcinoma","volume":"362","author":"Llovet","year":"2003","journal-title":"Lancet"},{"key":"10.1016\/j.jss.2014.01.049_bib2","doi-asserted-by":"crossref","first-page":"74","DOI":"10.3322\/canjclin.55.2.74","article-title":"Global cancer statistics, 2002","volume":"55","author":"Parkin","year":"2005","journal-title":"CA Cancer J Clin"},{"key":"10.1016\/j.jss.2014.01.049_bib3","doi-asserted-by":"crossref","first-page":"S294","DOI":"10.1111\/j.1440-1746.1997.tb00513.x","article-title":"Epidemiological characteristics and risk factors of hepatocellular carcinoma","volume":"12","author":"Chen","year":"1997","journal-title":"J Gastroenterol Hepatol"},{"key":"10.1016\/j.jss.2014.01.049_bib4","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1038\/ng0802-339","article-title":"Molecular pathogenesis of human hepatocellular carcinoma","volume":"31","author":"Thorgeirsson","year":"2002","journal-title":"Nat Genet"},{"key":"10.1016\/j.jss.2014.01.049_bib5","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/S1535-6108(04)00058-3","article-title":"Focus on hepatocellular carcinoma","volume":"5","author":"Bruix","year":"2004","journal-title":"Cancer Cell"},{"key":"10.1016\/j.jss.2014.01.049_bib6","doi-asserted-by":"crossref","first-page":"1763","DOI":"10.1053\/gast.2001.24798","article-title":"Genetic alterations associated with hepatocellular carcinomas define distinct pathways of hepatocarcinogenesis","volume":"120","author":"Laurent-Puig","year":"2001","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jss.2014.01.049_bib7","doi-asserted-by":"crossref","first-page":"4554","DOI":"10.1002\/cncr.24494","article-title":"p53-induced RING-H2 protein, a novel marker for poor survival in hepatocellular carcinoma after hepatic resection","volume":"115","author":"Wang","year":"2009","journal-title":"Cancer"},{"key":"10.1016\/j.jss.2014.01.049_bib8","first-page":"237","article-title":"Hepatocellular carcinoma: current management and recent advances","volume":"7","author":"Lau","year":"2008","journal-title":"Hepatobiliary Pancreat Dis Int"},{"key":"10.1016\/j.jss.2014.01.049_bib9","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1038\/367040a0","article-title":"A brain serine\/threonine protein kinase activated by Cdc42 and Rac1","volume":"367","author":"Manser","year":"1994","journal-title":"Nature"},{"key":"10.1016\/j.jss.2014.01.049_bib10","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1126\/science.7618083","article-title":"Regulation of human leukocyte p21-activated kinases through G protein\u2013coupled receptors","volume":"269","author":"Knaus","year":"1995","journal-title":"Science"},{"key":"10.1016\/j.jss.2014.01.049_bib11","doi-asserted-by":"crossref","first-page":"1970","DOI":"10.1002\/j.1460-2075.1995.tb07189.x","article-title":"A novel serine kinase activated by rac1\/CDC42Hs-dependent autophosphorylation is related to PAK65 and STE20","volume":"14","author":"Martin","year":"1995","journal-title":"EMBO J"},{"key":"10.1016\/j.jss.2014.01.049_bib12","doi-asserted-by":"crossref","first-page":"23633","DOI":"10.1074\/jbc.273.37.23633","article-title":"A novel regulator of p21-activated kinases","volume":"273","author":"Bagrodia","year":"1998","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jss.2014.01.049_bib13","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1002\/jcp.10167","article-title":"Emerging functions of p21-activated kinases in human cancer cells","volume":"193","author":"Kumar","year":"2002","journal-title":"J Cell Physiol"},{"key":"10.1016\/j.jss.2014.01.049_bib14","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1146\/annurev.biochem.72.121801.161742","article-title":"Biology of the p21-activated kinases","volume":"72","author":"Bokoch","year":"2003","journal-title":"Annu Rev Biochem"},{"key":"10.1016\/j.jss.2014.01.049_bib15","doi-asserted-by":"crossref","first-page":"4343","DOI":"10.1242\/jcs.01392","article-title":"The genetics of Pak","volume":"117","author":"Hofmann","year":"2004","journal-title":"J\u00a0Cell Sci"},{"key":"10.1016\/j.jss.2014.01.049_bib16","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1038\/nrc1892","article-title":"p21-activated kinases in cancer","volume":"6","author":"Kumar","year":"2006","journal-title":"Nat Rev Cancer"},{"key":"10.1016\/j.jss.2014.01.049_bib17","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1042\/BJ20091173","article-title":"The emerging importance of group II PAKs","volume":"425","author":"Wells","year":"2010","journal-title":"Biochem J"},{"key":"10.1016\/j.jss.2014.01.049_bib18","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1016\/S1357-2725(01)00158-3","article-title":"p21-activated kinases: three more join the Pak","volume":"34","author":"Jaffer","year":"2002","journal-title":"Int J Biochem Cell Biol"},{"key":"10.1016\/j.jss.2014.01.049_bib19","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1042\/BJ20041638","article-title":"PAK and other Rho-associated kinases\u2013effectors with surprisingly diverse mechanisms of regulation","volume":"386","author":"Zhao","year":"2005","journal-title":"Biochem J"},{"key":"10.1016\/j.jss.2014.01.049_bib20","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1042\/BC20070109","article-title":"A tale of two Paks","volume":"100","author":"Arias-Romero","year":"2008","journal-title":"Biol Cell"},{"key":"10.1016\/j.jss.2014.01.049_bib21","doi-asserted-by":"crossref","first-page":"3448","DOI":"10.1158\/1078-0432.CCR-03-0210","article-title":"Pak-1 expression increases with progression of colorectal carcinomas to metastasis","volume":"10","author":"Carter","year":"2004","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.jss.2014.01.049_bib22","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1159\/000134699","article-title":"Detailed map of a region commonly amplified at 11q13-->q14 in human breast carcinoma","volume":"79","author":"Bekri","year":"1997","journal-title":"Cytogenet Cell Genet"},{"key":"10.1016\/j.jss.2014.01.049_bib23","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1002\/ijc.25005","article-title":"Differential expression and phosphorylation of Pak1 and Pak2 in ovarian cancer: effects on prognosis and cell invasion","volume":"127","author":"Siu","year":"2010","journal-title":"Int J Cancer"},{"key":"10.1016\/j.jss.2014.01.049_bib24","doi-asserted-by":"crossref","first-page":"3601","DOI":"10.1158\/0008-5472.CAN-06-3994","article-title":"P21-activated protein kinase is overexpressed in hepatocellular carcinoma and enhances cancer metastasis involving c-Jun NH2-terminal kinase activation and paxillin phosphorylation","volume":"67","author":"Ching","year":"2007","journal-title":"Cancer Res"},{"key":"10.1016\/j.jss.2014.01.049_bib25","doi-asserted-by":"crossref","first-page":"36238","DOI":"10.1074\/jbc.M002138200","article-title":"Regulatable expression of p21-activated kinase-1 promotes anchorage-independent growth and abnormal organization of mitotic spindles in human epithelial breast cancer cells","volume":"275","author":"Vadlamudi","year":"2000","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.jss.2014.01.049_bib26","doi-asserted-by":"crossref","first-page":"12041","DOI":"10.1074\/jbc.275.16.12041","article-title":"Regulation of microfilament reorganization and invasiveness of breast cancer cells by kinase dead p21-activated kinase-1","volume":"275","author":"Adam","year":"2000","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.jss.2014.01.049_bib27","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1111\/jgh.12150","article-title":"P21-activated kinase-2 is a critical mediator of transforming growth factor-beta-induced hepatoma cell migration","volume":"28","author":"Sato","year":"2013","journal-title":"J\u00a0Gastroenterol Hepatol"},{"key":"10.1016\/j.jss.2014.01.049_bib28","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1038\/436792a","article-title":"Colorectal cancer: mutations in a signalling pathway","volume":"436","author":"Parsons","year":"2005","journal-title":"Nature"},{"key":"10.1016\/j.jss.2014.01.049_bib29","doi-asserted-by":"crossref","first-page":"1793","DOI":"10.4161\/cbt.7.11.6840","article-title":"Copy number alterations in pancreatic cancer identify recurrent PAK4 amplification","volume":"7","author":"Chen","year":"2008","journal-title":"Cancer Biol Ther"},{"key":"10.1016\/j.jss.2014.01.049_bib30","doi-asserted-by":"crossref","first-page":"1663","DOI":"10.1242\/jcs.055707","article-title":"PAK4: a pluripotent kinase that regulates prostate cancer cell adhesion","volume":"123","author":"Wells","year":"2010","journal-title":"J Cell Sci"},{"key":"10.1016\/j.jss.2014.01.049_bib31","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1093\/carcin\/bgr033","article-title":"Overexpressed PAK4 promotes proliferation, migration and invasion of choriocarcinoma","volume":"32","author":"Zhang","year":"2011","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.jss.2014.01.049_bib32","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1002\/ijc.24428","article-title":"P21-activated kinase 5 is overexpressed during colorectal cancer progression and regulates colorectal carcinoma cell adhesion and migration","volume":"125","author":"Gong","year":"2009","journal-title":"Int J Cancer"},{"key":"10.1016\/j.jss.2014.01.049_bib33","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1038\/aps.2013.31","article-title":"P21-activated kinase 5 plays essential roles in the proliferation and tumorigenicity of human hepatocellular carcinoma","volume":"35","author":"Fang","year":"2014","journal-title":"Acta Pharmacol Sin"},{"key":"10.1016\/j.jss.2014.01.049_bib34","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1210\/mend.16.1.0753","article-title":"AR and ER interaction with a p21-activated kinase (PAK6)","volume":"16","author":"Lee","year":"2002","journal-title":"Mol Endocrinol"},{"key":"10.1016\/j.jss.2014.01.049_bib35","doi-asserted-by":"crossref","first-page":"15345","DOI":"10.1074\/jbc.M010311200","article-title":"Androgen receptor specifically interacts with a novel p21-activated kinase, PAK6","volume":"276","author":"Yang","year":"2001","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jss.2014.01.049_bib36","doi-asserted-by":"crossref","first-page":"1510","DOI":"10.1002\/pros.20787","article-title":"Increased PAK6 expression in prostate cancer and identification of PAK6 associated proteins","volume":"68","author":"Kaur","year":"2008","journal-title":"Prostate"},{"key":"10.1016\/j.jss.2014.01.049_bib37","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.1016\/j.urology.2008.09.041","article-title":"Knockdown of p21-activated kinase 6 inhibits prostate cancer growth and enhances chemosensitivity to docetaxel","volume":"73","author":"Wen","year":"2009","journal-title":"Urology"},{"key":"10.1016\/j.jss.2014.01.049_bib38","doi-asserted-by":"crossref","first-page":"401","DOI":"10.3727\/096504010X12644422320744","article-title":"Distinct DNA methylation profiles between adenocarcinoma and squamous cell carcinoma of human uterine cervix","volume":"18","author":"Lee","year":"2010","journal-title":"Oncol Res"},{"key":"10.1016\/j.jss.2014.01.049_bib39","first-page":"5679","article-title":"Molecular signature associated with bone marrow micrometastasis in human breast cancer","volume":"63","author":"Woelfle","year":"2003","journal-title":"Cancer Res"},{"key":"10.1016\/j.jss.2014.01.049_bib40","doi-asserted-by":"crossref","first-page":"1609","DOI":"10.1053\/gast.2002.33411","article-title":"Hepatocellular carcinoma: diagnosis and treatment","volume":"122","author":"Befeler","year":"2002","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jss.2014.01.049_bib41","doi-asserted-by":"crossref","first-page":"1859","DOI":"10.1002\/1097-0142(19930915)72:6<1859::AID-CNCR2820720612>3.0.CO;2-A","article-title":"The assessment of proliferating cell nuclear antigen immunohistochemical staining in small hepatocellular carcinoma and its relationship to histologic characteristics and prognosis","volume":"72","author":"Kitamoto","year":"1993","journal-title":"Cancer"},{"key":"10.1016\/j.jss.2014.01.049_bib42","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1016\/j.ejca.2007.01.004","article-title":"Prognostic molecular markers in hepatocellular carcinoma: a systematic review","volume":"43","author":"Mann","year":"2007","journal-title":"Eur J Cancer"},{"key":"10.1016\/j.jss.2014.01.049_bib43","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1038\/nrc1934","article-title":"Hepatocellular carcinoma pathogenesis: from genes to environment","volume":"6","author":"Farazi","year":"2006","journal-title":"Nat Rev Cancer"}],"container-title":["Journal of Surgical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022480414000894?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022480414000894?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,8,7]],"date-time":"2019-08-07T00:38:01Z","timestamp":1565138281000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022480414000894"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,6]]},"references-count":43,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2014,6]]}},"alternative-id":["S0022480414000894"],"URL":"https:\/\/doi.org\/10.1016\/j.jss.2014.01.049","relation":{},"ISSN":["0022-4804"],"issn-type":[{"value":"0022-4804","type":"print"}],"subject":[],"published":{"date-parts":[[2014,6]]}}}