{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T16:02:12Z","timestamp":1792252932044,"version":"4.4.0"},"reference-count":25,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81201994"],"award-info":[{"award-number":["81201994"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journalofsurgicalresearch.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Surgical Research"],"published-print":{"date-parts":[[2015,1]]},"DOI":"10.1016\/j.jss.2014.06.055","type":"journal-article","created":{"date-parts":[[2014,7,5]],"date-time":"2014-07-05T04:15:33Z","timestamp":1404533733000},"page":"255-264","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":76,"title":["Interferon alpha-inducible protein 27 promotes epithelial\u2013mesenchymal transition and induces ovarian tumorigenicity and stemness"],"prefix":"10.1016","volume":"193","author":[{"given":"Shuqin","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junfeng","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Man","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guoxuan","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xing","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongping","family":"Xia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang","family":"Tao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jss.2014.06.055_bib1","doi-asserted-by":"crossref","first-page":"183","DOI":"10.3322\/caac.20113","article-title":"Recent progress in the diagnosis and treatment of ovarian cancer","volume":"61","author":"Jelovac","year":"2011","journal-title":"CA Cancer J Clin"},{"key":"10.1016\/j.jss.2014.06.055_bib2","doi-asserted-by":"crossref","first-page":"296","DOI":"10.3389\/fonc.2013.00296","article-title":"Current status and evolution of preclinical drug development models of epithelial ovarian cancer","volume":"3","author":"Konstantinopoulos","year":"2013","journal-title":"Front Oncol"},{"key":"10.1016\/j.jss.2014.06.055_bib3","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1038\/nature10166","article-title":"Integrated genomic analyses of ovarian carcinoma","volume":"474","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.jss.2014.06.055_bib4","doi-asserted-by":"crossref","first-page":"2686","DOI":"10.1200\/JCO.2008.19.2963","article-title":"Phase II evaluation of pemetrexed in the treatment of recurrent or persistent platinum-resistant ovarian or primary peritoneal carcinoma: a study of the Gynecologic Oncology Group","volume":"27","author":"Miller","year":"2009","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.jss.2014.06.055_bib5","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1186\/1757-2215-6-49","article-title":"Molecular profiling supports the role of epithelial-to-mesenchymal transition (EMT) in ovarian cancer metastasis","volume":"6","author":"Lili","year":"2013","journal-title":"J Ovarian Res"},{"key":"10.1016\/j.jss.2014.06.055_bib6","first-page":"4096","article-title":"Identification of a new interferon-\u03b1-inducible gene (p27) on human chromosome 14q32 and its expression in breast carcinoma","volume":"53","author":"Rasmussen","year":"1993","journal-title":"Cancer Res"},{"key":"10.1016\/j.jss.2014.06.055_bib7","doi-asserted-by":"crossref","first-page":"2605","DOI":"10.1002\/ijc.23799","article-title":"Transcriptional profiling identifies an interferon-associated host immune response in invasive squamous cell carcinoma of the skin","volume":"123","author":"Wenzel","year":"2008","journal-title":"Int J Cancer"},{"key":"10.1016\/j.jss.2014.06.055_bib8","doi-asserted-by":"crossref","first-page":"1552","DOI":"10.1093\/carcin\/bgm075","article-title":"Induction of a unique gene expression profile in primary human hepatocytes by hepatitis C virus core, NS3 and NS5A proteins","volume":"28","author":"Budhu","year":"2007","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.jss.2014.06.055_bib9","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1186\/1471-2407-10-576","article-title":"Identification of differentially expressed genes using an annealing control primer system in stage III serous ovarian carcinoma","volume":"10","author":"Kim","year":"2010","journal-title":"BMC Cancer"},{"key":"10.1016\/j.jss.2014.06.055_bib10","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta (CT)) method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"10.1016\/j.jss.2014.06.055_bib11","first-page":"75","article-title":"Epithelial\u2013mesenchymal transition in cancer metastasis: mechanisms, markers and strategies to overcome drug resistance in the clinic","volume":"1796","author":"Voulgari","year":"2009","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.jss.2014.06.055_bib12","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1038\/nrg1379","article-title":"MicroRNAs: small RNAs with a big role in gene regulation","volume":"5","author":"He","year":"2004","journal-title":"Nat Rev Genet"},{"key":"10.1016\/j.jss.2014.06.055_bib13","doi-asserted-by":"crossref","first-page":"716","DOI":"10.3390\/cancers30100716","article-title":"Cancer stem cells and epithelial-to-mesenchymal transition (EMT)-phenotypic cells: are they cousins or twins?","volume":"3","author":"Kong","year":"2011","journal-title":"Cancers"},{"key":"10.1016\/j.jss.2014.06.055_bib14","doi-asserted-by":"crossref","first-page":"1429","DOI":"10.1172\/JCI36183","article-title":"Biomarkers for epithelial-mesenchymal transitions","volume":"119","author":"Zeisberg","year":"2009","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jss.2014.06.055_bib15","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1111\/j.0022-202X.2004.22322.x","article-title":"Interferon \u03b1-inducible protein 27 (IFI27) is upregulated in psoriatic skin and certain epithelial cancers","volume":"122","author":"Suomela","year":"2004","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.jss.2014.06.055_bib16","doi-asserted-by":"crossref","first-page":"5947","DOI":"10.1046\/j.0014-2956.2001.02545.x","article-title":"The interferon alpha induced protein ISG12 is localized to the nuclear membrane","volume":"268","author":"Martensen","year":"2001","journal-title":"Eur J Biochem"},{"key":"10.1016\/j.jss.2014.06.055_bib17","doi-asserted-by":"crossref","first-page":"1833","DOI":"10.1242\/jcs.03450","article-title":"MicroRNAs in human cancer: from research to therapy","volume":"120","author":"Negrini","year":"2007","journal-title":"J Cell Science"},{"key":"10.1016\/j.jss.2014.06.055_bib18","doi-asserted-by":"crossref","first-page":"1570","DOI":"10.1038\/onc.2012.167","article-title":"Inhibition of autophagy and tumor growth in colon cancer by miR-502","volume":"32","author":"Zhai","year":"2013","journal-title":"Oncogene"},{"key":"10.1016\/j.jss.2014.06.055_bib19","doi-asserted-by":"crossref","first-page":"2085","DOI":"10.3892\/or.2014.3105","article-title":"Suppressive role of miR-502-5p in breast cancer via downregulation of TRAF2","volume":"31","author":"Sun","year":"2014","journal-title":"Oncol Rep"},{"key":"10.1016\/j.jss.2014.06.055_bib20","doi-asserted-by":"crossref","first-page":"6292","DOI":"10.1158\/1078-0432.CCR-09-0826","article-title":"An miR-502\u2013binding site single-nucleotide polymorphism in the 3\u2032-untranslated region of the SET8 gene is associated with early age of breast cancer onset","volume":"15","author":"Song","year":"2009","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.jss.2014.06.055_bib21","doi-asserted-by":"crossref","first-page":"1318","DOI":"10.1002\/ijc.27352","article-title":"A polymorphism at the miR-502 binding site in the 3\u2032-untranslated region of the histone methyltransferase SET8 is associated with hepatocellular carcinoma outcome","volume":"131","author":"Guo","year":"2012","journal-title":"Int J Cancer"},{"key":"10.1016\/j.jss.2014.06.055_bib22","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1093\/abbs\/gmt138","article-title":"Association of miR-502-binding site single nucleotide polymorphism in the 3\u2032-untranslated region of SET8 and TP53 codon 72 polymorphism with non-small cell lung cancer in Chinese population","volume":"46","author":"Yang","year":"2014","journal-title":"Acta biochimica et biophysica Sinica"},{"key":"10.1016\/j.jss.2014.06.055_bib23","doi-asserted-by":"crossref","first-page":"689","DOI":"10.3892\/etm.2012.469","article-title":"A polymorphism at the miR-502 binding site in the 3'untranslated region of the SET8 gene is associated with the outcome of small-cell lung cancer","volume":"3","author":"Ding","year":"2012","journal-title":"Exp Ther Med"},{"key":"10.1016\/j.jss.2014.06.055_bib24","doi-asserted-by":"crossref","first-page":"e77024","DOI":"10.1371\/journal.pone.0077024","article-title":"Genetic variation in a MicroRNA-502 minding site in SET8 gene confers clinical outcome of non-small cell lung cancer in a Chinese population","volume":"8","author":"Xu","year":"2013","journal-title":"PloS One"},{"key":"10.1016\/j.jss.2014.06.055_bib25","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1158\/0008-5472.CAN-08-2842","article-title":"Modulation of g protein signaling normalizes tumor vessels","volume":"69","author":"Manzur","year":"2009","journal-title":"Cancer Res"}],"container-title":["Journal of Surgical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022480414006337?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022480414006337?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,8,12]],"date-time":"2019-08-12T08:45:38Z","timestamp":1565599538000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022480414006337"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,1]]},"references-count":25,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015,1]]}},"alternative-id":["S0022480414006337"],"URL":"https:\/\/doi.org\/10.1016\/j.jss.2014.06.055","relation":{},"ISSN":["0022-4804"],"issn-type":[{"value":"0022-4804","type":"print"}],"subject":[],"published":{"date-parts":[[2015,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Interferon alpha-inducible protein 27 promotes epithelial\u2013mesenchymal transition and induces ovarian tumorigenicity and stemness","name":"articletitle","label":"Article Title"},{"value":"Journal of Surgical Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jss.2014.06.055","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}