{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T04:38:18Z","timestamp":1775018298239,"version":"3.50.1"},"reference-count":38,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2015,8,1]],"date-time":"2015-08-01T00:00:00Z","timestamp":1438387200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","journalofsurgicalresearch.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Surgical Research"],"published-print":{"date-parts":[[2015,8]]},"DOI":"10.1016\/j.jss.2015.02.061","type":"journal-article","created":{"date-parts":[[2015,3,19]],"date-time":"2015-03-19T18:27:37Z","timestamp":1426789657000},"page":"419-426","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"title":["Hydrogen sulphide as a novel therapy to ameliorate cyclosporine nephrotoxicity"],"prefix":"10.1016","volume":"197","author":[{"given":"Gwyn","family":"Lee","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah A.","family":"Hosgood","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meeta S.","family":"Patel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael L.","family":"Nicholson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jss.2015.02.061_bib1","doi-asserted-by":"crossref","first-page":"269","DOI":"10.5301\/jn.5000174","article-title":"Pathogenesis of calcineurin inhibitor-induced hypertension","volume":"25","author":"Hoorn","year":"2012","journal-title":"J Nephrol"},{"key":"10.1016\/j.jss.2015.02.061_bib2","first-page":"480","article-title":"Acute cyclosporine-induced renal vasoconstriction is mediated by endothelin-1","volume":"114","author":"Bloom","year":"1993","journal-title":"Surgery"},{"key":"10.1016\/j.jss.2015.02.061_bib3","doi-asserted-by":"crossref","first-page":"8979","DOI":"10.3390\/ijms15058979","article-title":"Transition from cyclosporine-induced renal dysfunction to nephrotoxicity in an in\u00a0vivo rat model","volume":"15","author":"Sereno","year":"2014","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.jss.2015.02.061_bib4","doi-asserted-by":"crossref","first-page":"4210","DOI":"10.1172\/JCI45161","article-title":"Cellular pathophysiology of ischemic acute kidney injury","volume":"121","author":"Bonventre","year":"2011","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jss.2015.02.061_bib5","doi-asserted-by":"crossref","first-page":"3","DOI":"10.2174\/1871529X1401140724093505","article-title":"Renal endothelial dysfunction in acute kidney ischemia reperfusion injury","volume":"14","author":"Basile","year":"2014","journal-title":"Cardiovasc Hematol Disord Drug Targets"},{"key":"10.1016\/j.jss.2015.02.061_bib6","doi-asserted-by":"crossref","first-page":"E413","DOI":"10.5489\/cuaj.1694","article-title":"Hydrogen sulfide treatment ameliorates long-term renal dysfunction resulting from prolonged warm renal ischemia-reperfusion injury","volume":"8","author":"Lobb","year":"2014","journal-title":"Can Urol Assoc J"},{"key":"10.1016\/j.jss.2015.02.061_bib7","doi-asserted-by":"crossref","DOI":"10.1016\/j.niox.2014.01.002","article-title":"The physiological role of hydrogen sulfide and beyond","author":"Kimura","year":"2014","journal-title":"Nitric Oxide"},{"key":"10.1016\/j.jss.2015.02.061_bib8","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1038\/nrd2425","article-title":"Hydrogen sulphide and its therapeutic potential","volume":"6","author":"Szabo","year":"2007","journal-title":"Nat Rev Drug Discov"},{"key":"10.1016\/j.jss.2015.02.061_bib9","doi-asserted-by":"crossref","first-page":"1518","DOI":"10.1016\/j.bbapap.2011.02.004","article-title":"PLP-dependent H(2)S biogenesis","volume":"1814","author":"Singh","year":"2011","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.jss.2015.02.061_bib10","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1681\/ASN.2012030268","article-title":"Cystathionine gamma-lyase protects against renal ischemia\/reperfusion by modulating oxidative stress","volume":"24","author":"Bos","year":"2013","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.jss.2015.02.061_bib11","doi-asserted-by":"crossref","first-page":"e112","DOI":"10.1016\/j.thromres.2013.07.010","article-title":"The anti-thrombotic effect of hydrogen sulfide is partly mediated by an upregulation of nitric oxide synthases","volume":"132","author":"Kram","year":"2013","journal-title":"Thromb Res"},{"key":"10.1016\/j.jss.2015.02.061_bib12","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1097\/FTD.0b013e3181d46386","article-title":"Multisite analytical evaluation of the Abbott ARCHITECT cyclosporine assay","volume":"32","author":"Wallemacq","year":"2010","journal-title":"Ther Drug Monit"},{"key":"10.1016\/j.jss.2015.02.061_bib13","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1002\/bjs.5324","article-title":"Leucocyte depletion improves renal function during reperfusion using an experimental isolated haemoperfused organ preservation system","volume":"93","author":"Harper","year":"2006","journal-title":"Br J Surg"},{"key":"10.1016\/j.jss.2015.02.061_bib14","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1002\/bjs.5381","article-title":"Effects of arterial pressure in an experimental isolated haemoperfused porcine kidney preservation system","volume":"93","author":"Hosgood","year":"2006","journal-title":"Br J Surg"},{"key":"10.1016\/j.jss.2015.02.061_bib15","doi-asserted-by":"crossref","first-page":"2279","DOI":"10.1111\/j.1600-6143.2011.03754.x","article-title":"Delayed graft function in the kidney transplant","volume":"11","author":"Siedlecki","year":"2011","journal-title":"Am J Transplant"},{"key":"10.1016\/j.jss.2015.02.061_bib16","doi-asserted-by":"crossref","first-page":"2508","DOI":"10.1111\/j.1523-1755.2005.00726.x","article-title":"Cyclosporine A and NAC on the inducible nitric oxide synthase expression and nitric oxide synthesis in rat renal artery cultured cells","volume":"68","author":"Lessio","year":"2005","journal-title":"Kidney Int"},{"key":"10.1016\/j.jss.2015.02.061_bib17","doi-asserted-by":"crossref","first-page":"1457","DOI":"10.1097\/01.TP.0000121196.71904.E0","article-title":"Oral cyclosporine but not tacrolimus reduces renal transplant blood flow","volume":"77","author":"Nankivell","year":"2004","journal-title":"Transplantation"},{"key":"10.1016\/j.jss.2015.02.061_bib18","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1046\/j.1440-1681.2002.03736.x","article-title":"Cyclosporine A protects against apoptosis in ischaemic\/reperfused rat kidneys","volume":"29","author":"Zhu","year":"2002","journal-title":"Clin Exp Pharmacol Physiol"},{"key":"10.1016\/j.jss.2015.02.061_bib19","doi-asserted-by":"crossref","first-page":"e13","DOI":"10.1017\/erm.2014.14","article-title":"Mitochondria-targeted therapies for acute kidney injury","volume":"16","author":"Tabara","year":"2014","journal-title":"Expert Rev Mol Med"},{"key":"10.1016\/j.jss.2015.02.061_bib20","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1007\/s00011-011-0400-z","article-title":"Annexin A1 protein attenuates cyclosporine-induced renal hemodynamics changes and macrophage infiltration in rats","volume":"61","author":"Araujo","year":"2012","journal-title":"Inflamm Res"},{"key":"10.1016\/j.jss.2015.02.061_bib21","doi-asserted-by":"crossref","first-page":"1738","DOI":"10.1016\/j.transproceed.2012.04.025","article-title":"Cilostazol and diltiazem attenuate cyclosporine-induced nephrotoxicity in rats","volume":"44","author":"Gokce","year":"2012","journal-title":"Transplant Proc"},{"key":"10.1016\/j.jss.2015.02.061_bib22","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1124\/jpet.105.096917","article-title":"Theophylline improves early allograft function in rat kidney transplantation","volume":"317","author":"Grenz","year":"2006","journal-title":"J\u00a0Pharmacol Exp Ther"},{"key":"10.1016\/j.jss.2015.02.061_bib23","doi-asserted-by":"crossref","first-page":"571","DOI":"10.3727\/096368911X605501","article-title":"Carbamylated erythropoietin ameliorates cyclosporine nephropathy without stimulating erythropoiesis","volume":"21","author":"Abe","year":"2012","journal-title":"Cell Transplant"},{"key":"10.1016\/j.jss.2015.02.061_bib24","doi-asserted-by":"crossref","first-page":"F78","DOI":"10.1152\/ajprenal.00077.2007","article-title":"Renal ischemia-reperfusion injury is prevented by the mineralocorticoid receptor blocker spironolactone","volume":"293","author":"Mejia-Vilet","year":"2007","journal-title":"Am J Physiol Renal Physiol"},{"key":"10.1016\/j.jss.2015.02.061_bib25","doi-asserted-by":"crossref","first-page":"87","DOI":"10.3389\/fendo.2013.00087","article-title":"Production of hydrogen sulfide from d-cysteine and its therapeutic potential","volume":"4","author":"Shibuya","year":"2013","journal-title":"Front Endocrinol (Lausanne)"},{"key":"10.1016\/j.jss.2015.02.061_bib26","doi-asserted-by":"crossref","first-page":"E1187","DOI":"10.1111\/j.1464-410X.2012.11526.x","article-title":"Supplemental hydrogen sulphide protects transplant kidney function and prolongs recipient survival after prolonged cold ischaemia-reperfusion injury by mitigating renal graft apoptosis and inflammation","volume":"110","author":"Lobb","year":"2012","journal-title":"BJU Int"},{"key":"10.1016\/j.jss.2015.02.061_bib27","doi-asserted-by":"crossref","first-page":"1665","DOI":"10.1002\/bjs.8956","article-title":"Effects of hydrogen sulphide in an experimental model of renal ischaemia-reperfusion injury","volume":"99","author":"Hunter","year":"2012","journal-title":"Br J Surg"},{"key":"10.1016\/j.jss.2015.02.061_bib28","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1002\/bjs.6856","article-title":"Hydrogen sulphide ameliorates ischaemia-reperfusion injury in an experimental model of non-heart-beating donor kidney transplantation","volume":"97","author":"Hosgood","year":"2010","journal-title":"Br J Surg"},{"key":"10.1016\/j.jss.2015.02.061_bib29","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1124\/jpet.110.166637","article-title":"Hypoxia in the renal medulla: implications for hydrogen sulfide signaling","volume":"334","author":"Beltowski","year":"2010","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1016\/j.jss.2015.02.061_bib30","doi-asserted-by":"crossref","first-page":"1989","DOI":"10.1016\/j.bbadis.2013.06.015","article-title":"Involvement of hydrogen sulfide and homocysteine transsulfuration pathway in the progression of kidney fibrosis after ureteral obstruction","volume":"1832","author":"Jung","year":"2013","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.jss.2015.02.061_bib31","doi-asserted-by":"crossref","first-page":"1998","DOI":"10.1016\/j.bbadis.2013.07.001","article-title":"Activation of ERK accelerates repair of renal tubular epithelial cells, whereas it inhibits progression of fibrosis following ischemia\/reperfusion injury","volume":"1832","author":"Jang","year":"2013","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.jss.2015.02.061_bib32","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1007\/s00424-007-0321-4","article-title":"Cardioprotection induced by hydrogen sulfide preconditioning involves activation of ERK and PI3K\/Akt pathways","volume":"455","author":"Hu","year":"2008","journal-title":"Pflugers Arch"},{"key":"10.1016\/j.jss.2015.02.061_bib33","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1038\/bmt.2013.139","article-title":"Higher therapeutic CsA levels early post transplantation reduce risk of acute GVHD and improves survival","volume":"49","author":"Rogosheske","year":"2014","journal-title":"Bone Marrow Transplant"},{"key":"10.1016\/j.jss.2015.02.061_bib34","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1097\/SHK.0b013e3181f0dc91","article-title":"Effects of intravenous sulfide during porcine aortic occlusion-induced kidney ischemia\/reperfusion injury","volume":"35","author":"Simon","year":"2011","journal-title":"Shock"},{"key":"10.1016\/j.jss.2015.02.061_bib35","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.jss.2012.08.001","article-title":"The conditioning effect of ex\u00a0vivo normothermic perfusion in an experimental kidney model","volume":"182","author":"Hosgood","year":"2013","journal-title":"J Surg Res"},{"key":"10.1016\/j.jss.2015.02.061_bib36","doi-asserted-by":"crossref","first-page":"1366","DOI":"10.1038\/ncomms2371","article-title":"A novel pathway for the production of hydrogen sulfide from D-cysteine in mammalian cells","volume":"4","author":"Shibuya","year":"2013","journal-title":"Nat Commun"},{"key":"10.1016\/j.jss.2015.02.061_bib37","doi-asserted-by":"crossref","first-page":"17977","DOI":"10.1073\/pnas.0705710104","article-title":"Hydrogen sulfide mediates the vasoactivity of garlic","volume":"104","author":"Benavides","year":"2007","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jss.2015.02.061_bib38","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1016\/j.bcp.2012.10.019","article-title":"Biology and therapeutic potential of hydrogen sulfide and hydrogen sulfide-releasing chimeras","volume":"85","author":"Kashfi","year":"2013","journal-title":"Biochem Pharmacol"}],"container-title":["Journal of Surgical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022480415001730?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022480415001730?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,5,3]],"date-time":"2022-05-03T15:36:56Z","timestamp":1651592216000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022480415001730"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,8]]},"references-count":38,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2015,8]]}},"alternative-id":["S0022480415001730"],"URL":"https:\/\/doi.org\/10.1016\/j.jss.2015.02.061","relation":{},"ISSN":["0022-4804"],"issn-type":[{"value":"0022-4804","type":"print"}],"subject":[],"published":{"date-parts":[[2015,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Hydrogen sulphide as a novel therapy to ameliorate cyclosporine nephrotoxicity","name":"articletitle","label":"Article Title"},{"value":"Journal of Surgical Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jss.2015.02.061","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}