{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T22:22:19Z","timestamp":1774390939765,"version":"3.50.1"},"reference-count":41,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2015,10,1]],"date-time":"2015-10-01T00:00:00Z","timestamp":1443657600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["RO1 (AR055843)"],"award-info":[{"award-number":["RO1 (AR055843)"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Department of Surgery, Division of Vascular and Endovascular Surgery"},{"name":"Henry & Nod Meyer Sundry Fund"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","journalofsurgicalresearch.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Surgical Research"],"published-print":{"date-parts":[[2015,10]]},"DOI":"10.1016\/j.jss.2015.04.008","type":"journal-article","created":{"date-parts":[[2015,4,11]],"date-time":"2015-04-11T11:38:10Z","timestamp":1428752290000},"page":"515-524","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"title":["Effect of limb demand ischemia on autophagy and morphology in mice"],"prefix":"10.1016","volume":"198","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5913-8571","authenticated-orcid":false,"given":"Hassan","family":"Albadawi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rahmi","family":"Oklu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John D.","family":"Milner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thuy P.","family":"Uong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyung-Jin","family":"Yoo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr.","given":"William G.","family":"Austen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael T.","family":"Watkins","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jss.2015.04.008_bib1","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1038\/ijo.2009.244","article-title":"The prognostic impact of general and abdominal obesity in peripheral arterial disease","volume":"34","author":"Giugliano","year":"2010","journal-title":"Int J Obes (Lond)"},{"key":"10.1016\/j.jss.2015.04.008_bib2","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1016\/j.jvs.2008.01.048","article-title":"The effect of metabolic syndrome components on exercise performance in patients with intermittent claudication","volume":"47","author":"Gardner","year":"2008","journal-title":"J Vasc Surg"},{"key":"10.1016\/j.jss.2015.04.008_bib3","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1016\/S0741-5214(03)00602-5","article-title":"Abnormal mitochondrial respiration in skeletal muscle in patients with peripheral arterial disease","volume":"38","author":"Pipinos","year":"2003","journal-title":"J Vasc Surg"},{"key":"10.1016\/j.jss.2015.04.008_bib4","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1016\/j.gaitpost.2012.05.004","article-title":"Patients with peripheral arterial disease exhibit reduced joint powers compared to velocity-matched controls","volume":"36","author":"Wurdeman","year":"2012","journal-title":"Gait Posture"},{"key":"10.1016\/j.jss.2015.04.008_bib5","doi-asserted-by":"crossref","first-page":"R290","DOI":"10.1152\/ajpregu.90374.2008","article-title":"Chronically ischemic mouse skeletal muscle exhibits myopathy in association with mitochondrial dysfunction and oxidative damage","volume":"295","author":"Pipinos","year":"2008","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"10.1016\/j.jss.2015.04.008_bib6","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1097\/SLA.0000000000000643","article-title":"Protein concentration and mitochondrial content in the gastrocnemius predicts mortality rates in patients with peripheral arterial disease","volume":"261","author":"Thompson","year":"2015","journal-title":"Ann Surg"},{"key":"10.1016\/j.jss.2015.04.008_bib7","doi-asserted-by":"crossref","first-page":"R291","DOI":"10.1152\/ajpregu.00525.2012","article-title":"Morphometric analysis of gastrocnemius muscle biopsies from patients with peripheral arterial disease: objective grading of muscle degeneration","volume":"305","author":"Cluff","year":"2013","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"10.1016\/j.jss.2015.04.008_bib8","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1161\/01.CIR.87.2.413","article-title":"Chronic changes in skeletal muscle histology and function in peripheral arterial disease","volume":"87","author":"Regensteiner","year":"1993","journal-title":"Circulation"},{"key":"10.1016\/j.jss.2015.04.008_bib9","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1186\/1479-5876-11-230","article-title":"Oxidative damage and myofiber degeneration in the gastrocnemius of patients with peripheral arterial disease","volume":"11","author":"Weiss","year":"2013","journal-title":"J Transl Med"},{"key":"10.1016\/j.jss.2015.04.008_bib10","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1172\/JCI37048","article-title":"Mitochondrial H2O2 emission and cellular redox state link excess fat intake to insulin resistance in both rodents and humans","volume":"119","author":"Anderson","year":"2009","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jss.2015.04.008_bib11","doi-asserted-by":"crossref","first-page":"194821","DOI":"10.1155\/2012\/194821","article-title":"Skeletal muscle mitochondria and aging: a review","volume":"2012","author":"Peterson","year":"2012","journal-title":"J Aging Res"},{"key":"10.1016\/j.jss.2015.04.008_bib12","doi-asserted-by":"crossref","first-page":"642038","DOI":"10.1155\/2012\/642038","article-title":"Mitochondrial dysregulation in the pathogenesis of diabetes: potential for mitochondrial biogenesis-mediated interventions","volume":"2012","author":"Joseph","year":"2012","journal-title":"Exp Diabetes Res"},{"key":"10.1016\/j.jss.2015.04.008_bib13","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.bbadis.2014.04.029","article-title":"Role of autophagy in metabolic syndrome-associated heart disease","volume":"1852","author":"Ren","year":"2015","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.jss.2015.04.008_bib14","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1007\/s11154-013-9272-6","article-title":"Autophagy as a crosstalk mediator of metabolic organs in regulation of energy metabolism","volume":"15","author":"Kim","year":"2014","journal-title":"Rev Endocr Metab Disord"},{"key":"10.1016\/j.jss.2015.04.008_bib15","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.yjmcc.2012.08.001","article-title":"Mitochondrial biogenesis and fragmentation as regulators of protein degradation in striated muscles","volume":"55","author":"Romanello","year":"2013","journal-title":"J Mol Cell Cardiol"},{"key":"10.1016\/j.jss.2015.04.008_bib16","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1016\/j.jss.2014.01.020","article-title":"Hind limb ischemia-reperfusion injury in diet-induced obese mice","volume":"190","author":"Albadawi","year":"2014","journal-title":"J Surg Res"},{"key":"10.1016\/j.jss.2015.04.008_bib17","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1016\/j.avsg.2009.12.003","article-title":"A functional murine model of hindlimb demand ischemia","volume":"24","author":"Peck","year":"2010","journal-title":"Ann Vasc Surg"},{"key":"10.1016\/j.jss.2015.04.008_bib18","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1016\/j.jss.2013.02.042","article-title":"Divergent systemic and local inflammatory response to hind limb demand ischemia in wild-type and ApoE\u2212\/\u2212 mice","volume":"183","author":"Crawford","year":"2013","journal-title":"J Surg Res"},{"key":"10.1016\/j.jss.2015.04.008_bib19","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.surg.2007.06.005","article-title":"Development of reproducible histologic injury severity scores: skeletal muscle reperfusion injury","volume":"143","author":"McCormack","year":"2008","journal-title":"Surgery"},{"key":"10.1016\/j.jss.2015.04.008_bib20","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1016\/j.ajpath.2013.12.020","article-title":"Altered macrophage phenotype transition impairs skeletal muscle regeneration","volume":"184","author":"Wang","year":"2014","journal-title":"Am J Pathol"},{"key":"10.1016\/j.jss.2015.04.008_bib21","doi-asserted-by":"crossref","first-page":"2503","DOI":"10.1016\/j.biocel.2004.05.009","article-title":"LC3 conjugation system in mammalian autophagy","volume":"36","author":"Tanida","year":"2004","journal-title":"Int J Biochem Cell Biol"},{"key":"10.1016\/j.jss.2015.04.008_bib22","doi-asserted-by":"crossref","first-page":"189794","DOI":"10.1155\/2012\/189794","article-title":"Alternative macroautophagic pathways","volume":"2012","author":"Juenemann","year":"2012","journal-title":"Int J Cell Biol"},{"key":"10.1016\/j.jss.2015.04.008_bib23","doi-asserted-by":"crossref","first-page":"307","DOI":"10.4161\/auto.6.2.11137","article-title":"Autophagy inhibition induces atrophy and myopathy in adult skeletal muscles","volume":"6","author":"Masiero","year":"2010","journal-title":"Autophagy"},{"key":"10.1016\/j.jss.2015.04.008_bib24","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1159\/000103376","article-title":"Expression of autophagy-associated genes in skeletal muscle: an experimental model of chloroquine-induced myopathy","volume":"74","author":"Kimura","year":"2007","journal-title":"Pathobiology"},{"key":"10.1016\/j.jss.2015.04.008_bib25","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1038\/aps.2013.144","article-title":"Exercise ameliorates the detrimental effect of chloroquine on skeletal muscles in mice via restoring autophagy flux","volume":"35","author":"Jiang","year":"2014","journal-title":"Acta Pharmacol Sin"},{"key":"10.1016\/j.jss.2015.04.008_bib26","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1007\/s40279-013-0140-z","article-title":"Autophagic cellular responses to physical exercise in skeletal muscle","volume":"44","author":"Tam","year":"2014","journal-title":"Sports Med"},{"key":"10.1016\/j.jss.2015.04.008_bib27","doi-asserted-by":"crossref","first-page":"1529","DOI":"10.1152\/japplphysiol.00952.2011","article-title":"Modulation of autophagy and ubiquitin-proteasome pathways during ultra-endurance running","volume":"112","author":"Jamart","year":"1985","journal-title":"J Appl Physiol"},{"key":"10.1016\/j.jss.2015.04.008_bib28","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/j.bbagen.2009.08.007","article-title":"Response of mitochondrial fusion and fission protein gene expression to exercise in rat skeletal muscle","volume":"1800","author":"Ding","year":"2010","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.jss.2015.04.008_bib29","doi-asserted-by":"crossref","first-page":"1890","DOI":"10.1111\/bph.12516","article-title":"Mitochondrial fusion and fission proteins: novel therapeutic targets for combating cardiovascular disease","volume":"171","author":"Hall","year":"2014","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.jss.2015.04.008_bib30","doi-asserted-by":"crossref","first-page":"C953","DOI":"10.1152\/ajpcell.00154.2006","article-title":"Fat accumulation with altered inflammation and regeneration in skeletal muscle of CCR2-\/- mice following ischemic injury","volume":"292","author":"Contreras-Shannon","year":"2007","journal-title":"Am J Physiol Cell Physiol"},{"key":"10.1016\/j.jss.2015.04.008_bib31","doi-asserted-by":"crossref","first-page":"5393","DOI":"10.1242\/jcs.01419","article-title":"Skeletal muscle satellite cells can spontaneously enter an alternative mesenchymal pathway","volume":"117","author":"Shefer","year":"2004","journal-title":"J Cell Sci"},{"key":"10.1016\/j.jss.2015.04.008_bib32","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1038\/nature07182","article-title":"PRDM16 controls a brown fat\/skeletal muscle switch","volume":"454","author":"Seale","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.jss.2015.04.008_bib33","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/j.cmet.2013.01.004","article-title":"MicroRNA-133 controls brown adipose determination in skeletal muscle satellite cells by targeting Prdm16","volume":"17","author":"Yin","year":"2013","journal-title":"Cell Metab"},{"key":"10.1016\/j.jss.2015.04.008_bib34","doi-asserted-by":"crossref","first-page":"3587","DOI":"10.1172\/JCI25151","article-title":"Reduced mitochondrial density and increased IRS-1 serine phosphorylation in muscle of insulin-resistant offspring of type 2 diabetic parents","volume":"115","author":"Morino","year":"2005","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jss.2015.04.008_bib35","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1038\/oby.2004.92","article-title":"Effects of weight loss and physical activity on muscle lipid content and droplet size","volume":"12","author":"He","year":"2004","journal-title":"Obes Res"},{"key":"10.1016\/j.jss.2015.04.008_bib36","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1097\/FJC.0000000000000170","article-title":"Saxagliptin restores vascular mitochondrial exercise response in the Goto-Kakizaki rat","volume":"65","author":"Keller","year":"2015","journal-title":"J Cardiovasc Pharmacol"},{"key":"10.1016\/j.jss.2015.04.008_bib37","doi-asserted-by":"crossref","first-page":"645891","DOI":"10.1100\/2012\/645891","article-title":"Exercise training prevents decrease in luminal capillary diameter of skeletal muscles in rats with type 2 diabetes","volume":"2012","author":"Morifuji","year":"2012","journal-title":"ScientificWorldJournal"},{"key":"10.1016\/j.jss.2015.04.008_bib38","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1186\/1475-2840-7-34","article-title":"Exercise training enhanced myocardial endothelial nitric oxide synthase (eNOS) function in diabetic Goto-Kakizaki (GK) rats","volume":"7","author":"Grijalva","year":"2008","journal-title":"Cardiovasc Diabetol"},{"key":"10.1016\/j.jss.2015.04.008_bib39","first-page":"1712","article-title":"Endurance exercise is protective for mice with mitochondrial myopathy","volume":"2009","author":"Wenz","year":"1985","journal-title":"J Appl Physiol"},{"key":"10.1016\/j.jss.2015.04.008_bib40","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1152\/physiol.00008.2006","article-title":"Mitochondrial uncoupling: a key contributor to reduced cardiac efficiency in diabetes","volume":"21","author":"Boudina","year":"2006","journal-title":"Physiology"},{"key":"10.1016\/j.jss.2015.04.008_bib41","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1016\/j.jacc.2012.08.1021","article-title":"Mitochondria as a therapeutic target in heart failure","volume":"61","author":"Bayeva","year":"2013","journal-title":"J Am Coll Cardiol"}],"container-title":["Journal of Surgical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022480415004059?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022480415004059?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,5,4]],"date-time":"2022-05-04T22:44:44Z","timestamp":1651704284000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022480415004059"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,10]]},"references-count":41,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2015,10]]}},"alternative-id":["S0022480415004059"],"URL":"https:\/\/doi.org\/10.1016\/j.jss.2015.04.008","relation":{},"ISSN":["0022-4804"],"issn-type":[{"value":"0022-4804","type":"print"}],"subject":[],"published":{"date-parts":[[2015,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effect of limb demand ischemia on autophagy and morphology in mice","name":"articletitle","label":"Article Title"},{"value":"Journal of Surgical Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jss.2015.04.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}