{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T05:45:31Z","timestamp":1769751931810,"version":"3.49.0"},"reference-count":31,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100004085","name":"Ministry of Education, Science and Technology","doi-asserted-by":"publisher","award":["NRF-2013R1A1A2007300"],"award-info":[{"award-number":["NRF-2013R1A1A2007300"]}],"id":[{"id":"10.13039\/501100004085","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","journalofsurgicalresearch.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Surgical Research"],"published-print":{"date-parts":[[2015,9]]},"DOI":"10.1016\/j.jss.2015.05.043","type":"journal-article","created":{"date-parts":[[2015,5,29]],"date-time":"2015-05-29T07:20:11Z","timestamp":1432884011000},"page":"228-236","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"title":["Melatonin attenuates hepatic ischemia through mitogen-activated protein kinase signaling"],"prefix":"10.1016","volume":"198","author":[{"given":"Sang-Ah","family":"Gim","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Phil-Ok","family":"Koh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jss.2015.05.043_bib1","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1146\/annurev.pharmtox.37.1.327","article-title":"Reperfusion injury after liver preservation for transplantation","volume":"37","author":"Lemasters","year":"1997","journal-title":"Annu Rev Pharmacol Toxicol"},{"key":"10.1016\/j.jss.2015.05.043_bib2","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/0022-4804(91)90101-Q","article-title":"Mechanism and prevention of ischemia-reperfusion-induced liver injury in rats","volume":"51","author":"Kobayashi","year":"1991","journal-title":"J Surg Res"},{"key":"10.1016\/j.jss.2015.05.043_bib3","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1002\/hep.1840130328","article-title":"Trolox protects rat hepatocytes against oxyradical damage and the ischemic rat liver from reperfusion injury","volume":"13","author":"Wu","year":"1991","journal-title":"Hepatology"},{"key":"10.1016\/j.jss.2015.05.043_bib4","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1111\/j.1600-079X.2006.00407.x","article-title":"One molecule, many derivatives: a never-ending interaction of melatonin with reactive oxygen and nitrogen species?","volume":"42","author":"Tan","year":"2007","journal-title":"J\u00a0Pineal Res"},{"key":"10.1016\/j.jss.2015.05.043_bib5","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1111\/jpi.12128","article-title":"Protective effects of melatonin in reducing oxidative stress and in preserving the fluidity of biological membranes: a review","volume":"56","author":"Garc\u00eda","year":"2014","journal-title":"J Pineal Res"},{"key":"10.1016\/j.jss.2015.05.043_bib6","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1159\/000014636","article-title":"Pharmacology and physiology of melatonin in the reduction of oxidative stress in\u00a0vivo","volume":"9","author":"Reiter","year":"2000","journal-title":"Biol Signals Recept"},{"key":"10.1016\/j.jss.2015.05.043_bib7","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1111\/jpi.12010","article-title":"On the free radical scavenging activities of melatonin's metabolites, AFMK and AMK","volume":"54","author":"Galano","year":"2013","journal-title":"J Pineal Res"},{"key":"10.1016\/j.jss.2015.05.043_bib8","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1007\/s00595-005-3027-2","article-title":"Protective effect of melatonin against ischemia\/reperfusion-induced oxidative remote organ injury in the rat","volume":"35","author":"Ka\u00e7maz","year":"2005","journal-title":"Surg Today"},{"key":"10.1016\/j.jss.2015.05.043_bib9","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1111\/j.1600-079X.2011.00879.x","article-title":"Melatonin prevents hepatic injury-induced decrease in Akt downstream targets phosphorylations","volume":"51","author":"Koh","year":"2011","journal-title":"J Pineal Res"},{"key":"10.1016\/j.jss.2015.05.043_bib10","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/S0014-2999(03)01643-1","article-title":"Protective effect of melatonin against mitochondrial injury induced by ischemia and reperfusion of rat liver","volume":"469","author":"Okatani","year":"2003","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.jss.2015.05.043_bib11","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1111\/j.1600-079X.2007.00504.x","article-title":"Cytoprotective effects of melatonin against necrosis and apoptosis induced by ischemia\/reperfusion injury in rat liver","volume":"44","author":"Kim","year":"2008","journal-title":"J Pineal Res"},{"key":"10.1016\/j.jss.2015.05.043_bib12","first-page":"153","article-title":"Mitogen-activated protein (MAP) kinase pathways: regulation and physiological functions","volume":"22","author":"Pearson","year":"2001","journal-title":"Endocr Rev"},{"key":"10.1016\/j.jss.2015.05.043_bib13","doi-asserted-by":"crossref","first-page":"1358","DOI":"10.1126\/science.286.5443.1358","article-title":"Cell survival promoted by the Ras-MAPK signaling pathway by transcription-dependent and -independent mechanisms","volume":"286","author":"Bonni","year":"1999","journal-title":"Science"},{"key":"10.1016\/j.jss.2015.05.043_bib14","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/S0960-9822(00)00310-9","article-title":"Rsk1 mediates a MEK\u2013MAP kinase cell survival signal","volume":"10","author":"Shimamura","year":"2000","journal-title":"Curr Biol"},{"key":"10.1016\/j.jss.2015.05.043_bib15","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/S0303-7207(99)00061-1","article-title":"Role and regulation of 90kDa ribosomal S6 kinase (RSK) in signal transduction","volume":"151","author":"Fr\u00f6din","year":"1999","journal-title":"Mol Cell Endocrinol"},{"key":"10.1016\/j.jss.2015.05.043_bib16","doi-asserted-by":"crossref","first-page":"1496","DOI":"10.1074\/jbc.273.3.1496","article-title":"Identification of regulatory phosphorylation sites in mitogen-activated protein kinase (MAPK)-activated protein kinase-1a\/p90rsk that are inducible by MAPK","volume":"273","author":"Dalby","year":"1998","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jss.2015.05.043_bib17","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/0092-8674(95)90411-5","article-title":"Bad, a heterodimeric partner for Bcl-XL and Bcl-2, displaces Bax and promotes cell death","volume":"80","author":"Yang","year":"1995","journal-title":"Cell"},{"key":"10.1016\/j.jss.2015.05.043_bib18","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1016\/S0092-8674(00)81382-3","article-title":"Serine phosphorylation of death agonist BAD in response to survival factor results in binding to 14-3-3 not BCL-x(L)","volume":"87","author":"Zha","year":"1996","journal-title":"Cell"},{"key":"10.1016\/j.jss.2015.05.043_bib19","doi-asserted-by":"crossref","first-page":"2058","DOI":"10.1074\/jbc.M207880200","article-title":"14-3-3 interacts directly with and negatively regulates pro-apoptotic Bax","volume":"278","author":"Nomura","year":"2002","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.jss.2015.05.043_bib20","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.freeradbiomed.2008.09.029","article-title":"Mouse model of liver ischemia and reperfusion injury: method for studying reactive oxygen and nitrogen metabolites in\u00a0vivo","volume":"46","author":"Abe","year":"2009","journal-title":"Free Radic Biol Med"},{"key":"10.1016\/j.jss.2015.05.043_bib21","doi-asserted-by":"crossref","first-page":"273","DOI":"10.5625\/lar.2012.28.4.273","article-title":"Ferulic acid modulates nitric oxide synthase expression in focal cerebral ischemia","volume":"28","author":"Koh","year":"2012","journal-title":"Lab Anim Res"},{"key":"10.1016\/j.jss.2015.05.043_bib22","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/S0006-291X(75)80292-0","article-title":"Protein degradation in isolated rat hepatocytes is inhibited by ammonia","volume":"66","author":"Seglen","year":"1975","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.jss.2015.05.043_bib23","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1111\/j.1600-079X.2010.00799.x","article-title":"Proteomic identification of proteins differentially expressed by melatonin in hepatic ischemia-reperfusion injury","volume":"49","author":"Cho","year":"2010","journal-title":"J Pineal Res"},{"key":"10.1016\/j.jss.2015.05.043_bib24","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1111\/j.1600-079X.2008.00596.x","article-title":"Melatonin protects from hepatic reperfusion injury through inhibition of IKK and JNK pathways and modification of cell proliferation","volume":"46","author":"Liang","year":"2009","journal-title":"J Pineal Res"},{"key":"10.1016\/j.jss.2015.05.043_bib25","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1111\/j.1600-079X.2012.00972.x","article-title":"Melatonin inhibits type 1 interferon signaling of toll-like receptor 4 via heme oxygenase-1 induction in hepatic ischemia\/reperfusion","volume":"53","author":"Kang","year":"2012","journal-title":"J Pineal Res"},{"key":"10.1016\/j.jss.2015.05.043_bib26","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1111\/j.1600-079X.2011.00858.x","article-title":"Melatonin protects liver against ischemia and reperfusion injury through inhibition of toll-like receptor signaling pathway","volume":"50","author":"Kang","year":"2011","journal-title":"J Pineal Res"},{"key":"10.1016\/j.jss.2015.05.043_bib27","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1002\/biof.5520170128","article-title":"Redox signaling and the MAP kinase pathways","volume":"17","author":"Torres","year":"2003","journal-title":"Biofactors"},{"key":"10.1016\/j.jss.2015.05.043_bib28","doi-asserted-by":"crossref","first-page":"947","DOI":"10.2741\/2116","article-title":"Melatonin role in the mitochondrial function","volume":"12","author":"Acuna-Castroviejo","year":"2007","journal-title":"Front Biosci"},{"key":"10.1016\/j.jss.2015.05.043_bib29","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1096\/fj.06-7859rev","article-title":"Phosphatase-mediated crosstalk between MAPK signaling pathways in the regulation of cell survival","volume":"22","author":"Junttila","year":"2008","journal-title":"FASEB J"},{"key":"10.1016\/j.jss.2015.05.043_bib30","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1042\/bj3260001","article-title":"Caspases: the executioners of apoptosis","volume":"326","author":"Cohen","year":"1997","journal-title":"Biochem J"},{"key":"10.1016\/j.jss.2015.05.043_bib31","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1038\/sj.cdd.4400476","article-title":"Emerging roles of caspase-3 in apoptosis","volume":"6","author":"Porter","year":"1999","journal-title":"Cell Death Differ"}],"container-title":["Journal of Surgical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S002248041500654X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S002248041500654X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,6,24]],"date-time":"2022-06-24T03:16:19Z","timestamp":1656040579000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S002248041500654X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,9]]},"references-count":31,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015,9]]}},"alternative-id":["S002248041500654X"],"URL":"https:\/\/doi.org\/10.1016\/j.jss.2015.05.043","relation":{},"ISSN":["0022-4804"],"issn-type":[{"value":"0022-4804","type":"print"}],"subject":[],"published":{"date-parts":[[2015,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Melatonin attenuates hepatic ischemia through mitogen-activated protein kinase signaling","name":"articletitle","label":"Article Title"},{"value":"Journal of Surgical Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jss.2015.05.043","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}