{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T20:21:29Z","timestamp":1788294089173,"version":"build-2803163510"},"reference-count":62,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2016,6,1]],"date-time":"2016-06-01T00:00:00Z","timestamp":1464739200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","journalofsurgicalresearch.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Surgical Research"],"published-print":{"date-parts":[[2016,6]]},"DOI":"10.1016\/j.jss.2016.03.027","type":"journal-article","created":{"date-parts":[[2016,3,24]],"date-time":"2016-03-24T06:47:46Z","timestamp":1458802066000},"page":"348-359","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":46,"title":["Gastroprotective effects of sulforaphane and thymoquinone against acetylsalicylic acid\u2013induced gastric ulcer in rats"],"prefix":"10.1016","volume":"203","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9342-1706","authenticated-orcid":false,"given":"Sezgin","family":"Zeren","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7587-7267","authenticated-orcid":false,"given":"Zulfu","family":"Bayhan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatma Emel","family":"Kocak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cengiz","family":"Kocak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raziye","family":"Akc\u0131lar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeynep","family":"Bayat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hasan","family":"Simsek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sukru Aydin","family":"Duzgun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jss.2016.03.027_bib1","first-page":"1118","article-title":"A pharmacological review on natural antiulcer agents","volume":"4","author":"Rao","year":"2013","journal-title":"J Glob Trends Pharm Sci"},{"key":"10.1016\/j.jss.2016.03.027_bib2","doi-asserted-by":"crossref","first-page":"99","DOI":"10.25004\/IJPSDR.2010.02023","article-title":"Clinical manifestations, causes and management strategies of peptic ulcer disease","volume":"2","author":"Pahwa","year":"2010","journal-title":"Int J Pharm Sci Drug Res"},{"key":"10.1016\/j.jss.2016.03.027_bib3","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.1016\/S0140-6736(09)60938-7","article-title":"Peptic ulcer disease","volume":"374","author":"Malfertheiner","year":"2009","journal-title":"Lancet"},{"key":"10.1016\/j.jss.2016.03.027_bib4","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1053\/gast.2000.16497","article-title":"Mechanisms of NSAID-induced gastrointestinal injury defined using mutant mice","volume":"119","author":"Beck","year":"2000","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jss.2016.03.027_bib5","first-page":"57","article-title":"Gastric mucosa re-epithelisation, oxidative stress and apoptosis during healing of acetic acid-induced ulceration in thyroxine treatment and thyroidectomy on rats","volume":"2","author":"Adeniyi","year":"2014","journal-title":"J Afr Ass Physiol Sci"},{"key":"10.1016\/j.jss.2016.03.027_bib6","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/j.etp.2010.11.005","article-title":"Protective effect of sulforaphane against oxidative stress: recent advances","volume":"64","author":"Guerrero-Beltr\u00e1n","year":"2012","journal-title":"Exp Toxicol Pathol"},{"key":"10.1016\/j.jss.2016.03.027_bib7","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.fct.2015.03.020","article-title":"Sulforaphane protects against acetaminophen-induced hepatotoxicity","volume":"80","author":"Noh","year":"2015","journal-title":"Food Chem Toxicol"},{"key":"10.1016\/j.jss.2016.03.027_bib8","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.phrs.2015.03.011","article-title":"Thymoquinone and its therapeutic potentials","volume":"95-96","author":"Darakhshan","year":"2015","journal-title":"Pharmacol Res"},{"key":"10.1016\/j.jss.2016.03.027_bib9","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1007\/s00204-005-0037-1","article-title":"The antioxidative and antihistaminic effect of Nigella sativa and its major constituent, thymoquinone on ethanol-induced gastric mucosal damage","volume":"80","author":"Kanter","year":"2006","journal-title":"Arch Toxicol"},{"key":"10.1016\/j.jss.2016.03.027_bib10","doi-asserted-by":"crossref","first-page":"421","DOI":"10.4103\/0976-9668.160026","article-title":"Protective effects of ginger and marshmallow extracts on indomethacin-induced peptic ulcer in rats","volume":"6","author":"Zaghlool","year":"2015","journal-title":"J Nat Sci Biol Med"},{"key":"10.1016\/j.jss.2016.03.027_bib11","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1016\/j.dld.2007.04.002","article-title":"COXIBs and non-selective NSAIDs in the gastroenterological setting: what should patients and physicians do?","volume":"39","author":"Lazzaroni","year":"2007","journal-title":"Dig Liver Dis"},{"key":"10.1016\/j.jss.2016.03.027_bib12","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1155\/2013\/796405","article-title":"In\u00a0vivo models used for evaluation of potential antigastroduodenal ulcer agents","volume":"2013","author":"Adinortey","year":"2013","journal-title":"Ulcers"},{"key":"10.1016\/j.jss.2016.03.027_bib13","series-title":"Guide for the Care and Use of Laboratory Animals","first-page":"248","year":"2010"},{"key":"10.1016\/j.jss.2016.03.027_bib14","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/j.nutres.2005.06.004","article-title":"The protective effect of thymoquinone on ethanol-induced acute gastric damage in the rat","volume":"25","author":"Aslan","year":"2005","journal-title":"Nutr Res"},{"key":"10.1016\/j.jss.2016.03.027_bib15","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/S0011-393X(10)80003-7","article-title":"Effects of \u03b2-glucan pretreatment on acetylsalicylic acid-induced gastric damage: an experimental study in rats","volume":"71","author":"Ozkan","year":"2010","journal-title":"Curr Ther Res Clin Exp"},{"key":"10.1016\/j.jss.2016.03.027_bib16","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.1016\/0016-5085(88)90661-0","article-title":"Histology of alcoholic hemorrhagic \u201cgastritis\u201d: a prospective evaluation","volume":"94","author":"Laine","year":"1988","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jss.2016.03.027_bib17","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.clinbiochem.2003.10.014","article-title":"A novel automated method to measure total antioxidant response against potent free radical reactions","volume":"37","author":"Erel","year":"2004","journal-title":"Clin Biochem"},{"key":"10.1016\/j.jss.2016.03.027_bib18","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1016\/j.clinbiochem.2005.08.008","article-title":"A new automated colorimetric method for measuring total oxidant status","volume":"38","author":"Erel","year":"2005","journal-title":"Clin Biochem"},{"key":"10.1016\/j.jss.2016.03.027_bib19","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1016\/j.clinbiochem.2014.09.026","article-title":"A novel and automated assay for thiol\/disulphide homeostasis","volume":"47","author":"Erel","year":"2014","journal-title":"Clin Biochem"},{"key":"10.1016\/j.jss.2016.03.027_bib20","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.jss.2014.12.040","article-title":"Effects of ukrain in rats with intestinal ischemia and reperfusion","volume":"195","author":"Akcilar","year":"2015","journal-title":"J Surg Res"},{"key":"10.1016\/j.jss.2016.03.027_bib21","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/0003-2697(76)90527-3","article-title":"A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding","volume":"72","author":"Bradford","year":"1976","journal-title":"Anal Biochem"},{"key":"10.1016\/j.jss.2016.03.027_bib22","first-page":"444","article-title":"Oxidative stress implications in experimental gastric ulcer induced by indomethacin","volume":"65","author":"Adriana","year":"2008","journal-title":"Bull UASVM, Vet Med"},{"key":"10.1016\/j.jss.2016.03.027_bib23","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1152\/physrev.00040.2012","article-title":"Oxidative stress: an essential factor in the pathogenesis of gastrointestinal mucosal diseases","volume":"94","author":"Bhattacharyya","year":"2014","journal-title":"Physiol Rev"},{"key":"10.1016\/j.jss.2016.03.027_bib24","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1016\/j.ejphar.2007.09.041","article-title":"Healing properties of malabaricone B and malabaricone C, against indomethacin-induced gastric ulceration and mechanism of action","volume":"578","author":"Banerjee","year":"2008","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.jss.2016.03.027_bib25","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1186\/s12906-015-0923-x","article-title":"Ulcer healing and mechanism(s) of action involved in the gastroprotective activity of fractions obtained from Syngonanthus arthrotrichus and Syngonanthus bisulcatus","volume":"15","author":"Batista","year":"2015","journal-title":"BMC Complement Altern Med"},{"key":"10.1016\/j.jss.2016.03.027_bib26","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1016\/S0076-6879(94)33044-1","article-title":"Measurement of protein thiol groups and glutathione in plasma","volume":"233","author":"Hu","year":"1994","journal-title":"Meth Enzymol"},{"key":"10.1016\/j.jss.2016.03.027_bib27","doi-asserted-by":"crossref","first-page":"6662","DOI":"10.3748\/wjg.v11.i42.6662","article-title":"Gastroprotective activity of Nigella sativa L oil and its constituent, thymoquinone against acute alcohol-induced gastric mucosal injury in rats","volume":"11","author":"Kanter","year":"2005","journal-title":"World J Gastroenterol"},{"key":"10.1016\/j.jss.2016.03.027_bib28","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.ejphar.2012.09.042","article-title":"Thymoquinone: novel gastroprotective mechanisms","volume":"697","author":"Magdy","year":"2012","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.jss.2016.03.027_bib29","doi-asserted-by":"crossref","first-page":"1532","DOI":"10.2174\/138161211796196945","article-title":"Sulforaphane enhances protection and repair of gastric mucosa against oxidative stress in\u00a0vitro, and demonstrates anti-inflammatory effects on Helicobacter pylori-infected gastric mucosae in mice and human subjects","volume":"17","author":"Yanaka","year":"2011","journal-title":"Curr Pharm Des"},{"key":"10.1016\/j.jss.2016.03.027_bib30","doi-asserted-by":"crossref","first-page":"486","DOI":"10.5009\/gnl14040","article-title":"The effects of broccoli sprout extract containing sulforaphane on lipid peroxidation and Helicobacter pylori infection in the gastric mucosa","volume":"9","author":"Chang","year":"2015","journal-title":"Gut Liver"},{"key":"10.1016\/j.jss.2016.03.027_bib31","first-page":"157","article-title":"Sulforaphane protects small intestinal mucosa from aspirin\/NSAID-induced injury by enhancing host defense systems against oxidative stress and by inhibiting mucosal invasion of anaerobic enterobacteria","volume":"19","author":"Yanaka","year":"2013","journal-title":"Curr Pharm Des"},{"key":"10.1016\/j.jss.2016.03.027_bib32","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1053\/j.gastro.2008.05.030","article-title":"Gastric mucosal defense and cytoprotection: bench to bedside","volume":"135","author":"Laine","year":"2008","journal-title":"Gastroenterology"},{"issue":"Suppl 2","key":"10.1016\/j.jss.2016.03.027_bib33","first-page":"89","article-title":"Physiological mediators in nonsteroidal anti-inflammatory drugs (NSAIDs)-induced impairment of gastric mucosal defense and adaptation. Focus on nitric oxide and lipoxins","volume":"59","author":"Brzozowski","year":"2008","journal-title":"J Physiol Pharmacol"},{"key":"10.1016\/j.jss.2016.03.027_bib34","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1159\/000108590","article-title":"Dual action of nitric oxide in the pathogenesis of ischemia\/reperfusion-induced mucosal injury in mouse stomach","volume":"75","author":"Kobata","year":"2007","journal-title":"Digestion"},{"key":"10.1016\/j.jss.2016.03.027_bib35","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1038\/sj.bjp.0707396","article-title":"Building a better aspirin: gaseous solutions to a century-old problem","volume":"152","author":"Wallace","year":"2007","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.jss.2016.03.027_bib36","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1006\/phrs.2001.0801","article-title":"Protective role of nitric oxide in indomethacin-induced gastric ulceration by a mechanism independent of gastric acid secretion","volume":"43","author":"Khattab","year":"2001","journal-title":"Pharmacol Res"},{"key":"10.1016\/j.jss.2016.03.027_bib37","doi-asserted-by":"crossref","first-page":"2178","DOI":"10.3748\/wjg.v17.i17.2178","article-title":"Asymmetric dimethylarginine: a novel biomarker of gastric mucosal injury?","volume":"17","author":"Zhang","year":"2011","journal-title":"World J Gastroenterol"},{"key":"10.1016\/j.jss.2016.03.027_bib38","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1139\/Y08-003","article-title":"Role of endogenous nitric oxide synthase inhibitor in gastric mucosal injury","volume":"86","author":"Wang","year":"2008","journal-title":"Can J Physiol Pharmacol"},{"key":"10.1016\/j.jss.2016.03.027_bib39","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1046\/j.1440-1681.2002.03607.x","article-title":"L-arginine protects against stress-induced gastric mucosal lesions by preserving gastric mucus","volume":"29","author":"Ohta","year":"2002","journal-title":"Clin Exp Pharmacol Physiol"},{"key":"10.1016\/j.jss.2016.03.027_bib40","first-page":"515","article-title":"Asymmetric dimethylarginine, an endogenous inhibitor of nitric oxide synthase, interacts with gastric oxidative metabolism and enhances stress-induced gastric lesions","volume":"63","author":"Kwiecien","year":"2012","journal-title":"J Physiol Pharmacol"},{"key":"10.1016\/j.jss.2016.03.027_bib41","doi-asserted-by":"crossref","first-page":"4946","DOI":"10.3390\/ijms15034946","article-title":"Exogenous asymmetric dimethylarginine (ADMA) in pathogenesis of ischemia-reperfusion-induced gastric lesions: interaction with protective nitric oxide (NO) and calcitonin gene-related peptide (CGRP)","volume":"15","author":"Magierowski","year":"2014","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.jss.2016.03.027_bib42","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1139\/Y08-073","article-title":"Reduction of asymmetric dimethylarginine in the protective effects of rutaecarpine on gastric mucosal injury","volume":"86","author":"Liu","year":"2008","journal-title":"Can J Physiol Pharmacol"},{"key":"10.1016\/j.jss.2016.03.027_bib43","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.advenzreg.2006.01.007","article-title":"Nrf2-Keap1 regulation of cellular defense mechanisms against electrophiles and reactive oxygen species","volume":"46","author":"Kobayashi","year":"2006","journal-title":"Adv Enzyme Regul"},{"key":"10.1016\/j.jss.2016.03.027_bib44","doi-asserted-by":"crossref","first-page":"4283","DOI":"10.3748\/wjg.v17.i38.4283","article-title":"Heme oxygenase-1 system and gastrointestinal inflammation: a short review","volume":"17","author":"Zhu","year":"2011","journal-title":"World J Gastroenterol"},{"key":"10.1016\/j.jss.2016.03.027_bib45","doi-asserted-by":"crossref","first-page":"G460","DOI":"10.1152\/ajpgi.00204.2007","article-title":"Adaptive HNE-Nrf2-HO-1 pathway against oxidative stress is associated with acute gastric mucosal lesions","volume":"295","author":"Ueda","year":"2008","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1016\/j.jss.2016.03.027_bib46","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1080\/003655202753387293","article-title":"Expression and immunolocalization of heat shock proteins in the healing of gastric ulcers in rats","volume":"37","author":"Guo","year":"2002","journal-title":"Scand J Gastroenterol"},{"key":"10.1016\/j.jss.2016.03.027_bib47","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1097\/MPG.0b013e3182334fdf","article-title":"Heme oxygenase-1 is protective against nonsteroidal anti-inflammatory drug-induced gastric ulcers","volume":"54","author":"Uc","year":"2012","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"10.1016\/j.jss.2016.03.027_bib48","doi-asserted-by":"crossref","first-page":"313","DOI":"10.33549\/physiolres.932834","article-title":"Activation of Nrf2 by ischemic preconditioning and sulforaphane in renal ischemia\/reperfusion injury: a comparative experimental study","volume":"64","author":"Shokeir","year":"2015","journal-title":"Physiol Res"},{"key":"10.1016\/j.jss.2016.03.027_bib49","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1016\/j.phrs.2009.11.009","article-title":"Sulforaphane protects ischemic injury of hearts through antioxidant pathway and mitochondrial K(ATP) channels","volume":"61","author":"Piao","year":"2010","journal-title":"Pharmacol Res"},{"key":"10.1016\/j.jss.2016.03.027_bib50","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1007\/s12072-014-9604-y","article-title":"Sulforaphane reduces apoptosis and oncosis along with protecting liver injury-induced ischemic reperfusion by activating the Nrf2\/ARE pathway","volume":"9","author":"Chi","year":"2015","journal-title":"Hepatol Int"},{"key":"10.1016\/j.jss.2016.03.027_bib51","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.neulet.2005.09.065","article-title":"Sulforaphane reduces infarct volume following focal cerebral ischemia in rodents","volume":"393","author":"Zhao","year":"2006","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.jss.2016.03.027_bib52","first-page":"211","article-title":"Apoptosis in gastric mucosa with stress-induced gastric ulcers","volume":"50","author":"Konturek","year":"1999","journal-title":"J Physiol Pharmacol"},{"key":"10.1016\/j.jss.2016.03.027_bib53","doi-asserted-by":"crossref","first-page":"1421","DOI":"10.1211\/jpp.58.10.0001","article-title":"NSAID injury to the gastrointestinal tract: evidence that NSAIDs interact with phospholipids to weaken the hydrophobic surface barrier and induce the formation of unstable pores in membranes","volume":"58","author":"Lichtenberger","year":"2006","journal-title":"J Pharm Pharmacol"},{"key":"10.1016\/j.jss.2016.03.027_bib54","doi-asserted-by":"crossref","first-page":"3776","DOI":"10.1016\/j.bbagen.2013.03.013","article-title":"Inhibition of TNF-\u03b1, and NF-\u03baB and JNK pathways accounts for the prophylactic action of the natural phenolic, allylpyrocatechol against indomethacin gastropathy","volume":"1830","author":"Yadav","year":"2013","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.jss.2016.03.027_bib55","doi-asserted-by":"crossref","first-page":"e86686","DOI":"10.1371\/journal.pone.0086686","article-title":"The gastroprotective effect of menthol: involvement of anti-apoptotic, antioxidant and anti-inflammatory activities","volume":"9","author":"Rozza","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.jss.2016.03.027_bib56","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1016\/S2221-1691(13)60180-X","article-title":"Study on the antiulcer effects of Veronicastrum axillare on gastric ulcer in rats induced by ethanol based on tumor necrosis factor-\u03b1 (TNF-\u03b1) and endothelin-1 (ET-1)","volume":"3","author":"Du","year":"2013","journal-title":"Asian Pac J Trop Biomed"},{"key":"10.1016\/j.jss.2016.03.027_bib57","first-page":"171","article-title":"Beneficial effects of thymoquinone and omega-3 on intestinal ischemia\/reperfusion-induced renal dysfunction in rats","volume":"52","author":"Fayez","year":"2014","journal-title":"Bull Fac Pharm (Cairo Univ)"},{"key":"10.1016\/j.jss.2016.03.027_bib58","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1016\/j.bbagen.2007.01.002","article-title":"Thymoquinone attenuates proinflammatory responses in lipopolysaccharide-activated mast cells by modulating NF-kappaB nuclear transactivation","volume":"1770","author":"El Gazzar","year":"2007","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.jss.2016.03.027_bib59","first-page":"388","article-title":"Thymoquinone inhibits the activation of NF-\u03baB in the brain and spinal cord of experimental autoimmune encephalomyelitis","volume":"41","author":"Mohamed","year":"2005","journal-title":"Biomed Sci Instrum"},{"key":"10.1016\/j.jss.2016.03.027_bib60","doi-asserted-by":"crossref","first-page":"32008","DOI":"10.1074\/jbc.M104794200","article-title":"Nuclear factor kappa B is a molecular target for sulforaphane-mediated anti-inflammatory mechanisms","volume":"276","author":"Heiss","year":"2001","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jss.2016.03.027_bib61","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1016\/j.jnutbio.2011.02.004","article-title":"Sulforaphane, a natural constituent of broccoli, prevents cell death and inflammation in nephropathy","volume":"23","author":"Guerrero-Beltr\u00e1n","year":"2012","journal-title":"J Nutr Biochem"},{"key":"10.1016\/j.jss.2016.03.027_bib62","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.taap.2008.11.007","article-title":"Sulforaphane protects against cytokine- and streptozotocin-induced beta-cell damage by suppressing the NF-kappaB pathway","volume":"235","author":"Song","year":"2009","journal-title":"Toxicol Appl Pharmacol"}],"container-title":["Journal of Surgical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S002248041600127X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S002248041600127X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T19:16:28Z","timestamp":1748805388000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S002248041600127X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,6]]},"references-count":62,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2016,6]]}},"alternative-id":["S002248041600127X"],"URL":"https:\/\/doi.org\/10.1016\/j.jss.2016.03.027","relation":{},"ISSN":["0022-4804"],"issn-type":[{"value":"0022-4804","type":"print"}],"subject":[],"published":{"date-parts":[[2016,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Gastroprotective effects of sulforaphane and thymoquinone against acetylsalicylic acid\u2013induced gastric ulcer in rats","name":"articletitle","label":"Article Title"},{"value":"Journal of Surgical Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jss.2016.03.027","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}