{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T10:31:27Z","timestamp":1778668287559,"version":"3.51.4"},"reference-count":31,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,2,1]],"date-time":"2018-02-01T00:00:00Z","timestamp":1517443200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","journalofsurgicalresearch.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Surgical Research"],"published-print":{"date-parts":[[2018,2]]},"DOI":"10.1016\/j.jss.2017.09.047","type":"journal-article","created":{"date-parts":[[2017,11,1]],"date-time":"2017-11-01T21:31:21Z","timestamp":1509571881000},"page":"85-92","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["AK03, a new recombinant fibrinogenase prevents abdominal adhesions in a rat model without systemic side effects"],"prefix":"10.1016","volume":"222","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6064-7859","authenticated-orcid":false,"given":"Roman Marius","family":"Eickhoff","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"Kroh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Klaus","family":"R\u00fcbsamen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Heise","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcel","family":"Binneb\u00f6sel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Uwe","family":"Klinge","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ulf Peter","family":"Neumann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian Daniel","family":"Klink","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jss.2017.09.047_bib1","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1159\/000050149","article-title":"Peritoneal adhesions: etiology, pathophysiology, and clinical significance. Recent advances in prevention and management","volume":"18","author":"Liakakos","year":"2001","journal-title":"Dig Surg"},{"issue":"Pt 1","key":"10.1016\/j.jss.2017.09.047_bib2","first-page":"27","article-title":"Peritoneal adhesions. Incidence, cause, and prevention","volume":"24","author":"Menzies","year":"1992","journal-title":"Surg Annu"},{"key":"10.1016\/j.jss.2017.09.047_bib3","first-page":"23","article-title":"Small bowel obstruction and its management","volume":"74","author":"Asbun","year":"1989","journal-title":"Int Surg"},{"key":"10.1016\/j.jss.2017.09.047_bib4","doi-asserted-by":"crossref","first-page":"222","DOI":"10.4240\/wjgs.v8.i3.222","article-title":"Adhesive small bowel adhesions obstruction: evolutions in diagnosis, management and prevention","volume":"8","author":"Catena","year":"2016","journal-title":"World J Gastrointest Surg"},{"key":"10.1016\/j.jss.2017.09.047_bib5","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1007\/s00423-007-0198-x","article-title":"Morphology, quality, and composition in mature human peritoneal adhesions","volume":"393","author":"Binnebosel","year":"2008","journal-title":"Langenbecks Arch Surg"},{"key":"10.1016\/j.jss.2017.09.047_bib6","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/1471-2482-11-13","article-title":"The inpatient burden of abdominal and gynecological adhesiolysis in the US","volume":"11","author":"Sikirica","year":"2011","journal-title":"BMC Surg"},{"key":"10.1016\/j.jss.2017.09.047_bib7","doi-asserted-by":"crossref","first-page":"4545","DOI":"10.3748\/wjg.v17.i41.4545","article-title":"Pathophysiology and prevention of postoperative peritoneal adhesions","volume":"17","author":"Arung","year":"2011","journal-title":"World J Gastroenterol"},{"key":"10.1016\/j.jss.2017.09.047_bib8","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1007\/s00423-011-0740-8","article-title":"Chronological evaluation of inflammatory mediators during peritoneal adhesion formation using a rat model","volume":"396","author":"Binnebosel","year":"2011","journal-title":"Langenbecks Arch Surg"},{"issue":"Suppl 2","key":"10.1016\/j.jss.2017.09.047_bib9","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1111\/j.1463-1318.2007.01345.x","article-title":"Biology of the peritoneum in normal homeostasis and after surgical trauma","volume":"9","author":"van der Wal","year":"2007","journal-title":"Colorectal Dis"},{"key":"10.1016\/j.jss.2017.09.047_bib10","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.fertnstert.2004.06.060","article-title":"A role for the fibrinolytic system in postsurgical adhesion formation","volume":"83","author":"Hellebrekers","year":"2005","journal-title":"Fertil Steril"},{"key":"10.1016\/j.jss.2017.09.047_bib11","doi-asserted-by":"crossref","first-page":"2015","DOI":"10.1093\/humrep\/der135","article-title":"Gynaecological endoscopic evaluation of 4% icodextrin solution: a European, multicentre, double-blind, randomized study of the efficacy and safety in the reduction of de novo adhesions after laparoscopic gynaecological surgery","volume":"26","author":"Trew","year":"2011","journal-title":"Hum Reprod"},{"key":"10.1016\/j.jss.2017.09.047_bib12","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/S0140-6736(13)61687-6","article-title":"Benefits and harms of adhesion barriers for abdominal surgery: a systematic review and meta-analysis","volume":"383","author":"ten Broek","year":"2014","journal-title":"Lancet"},{"key":"10.1016\/j.jss.2017.09.047_bib13","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1186\/1471-2482-13-34","article-title":"Influence of 4% icodextrin solution on peritoneal tissue response and adhesion formation","volume":"13","author":"Klink","year":"2013","journal-title":"BMC Surg"},{"key":"10.1016\/j.jss.2017.09.047_bib14","article-title":"Tissue response to five commercially available peritoneal adhesion barriers-A systematic histological evaluation","author":"Schmitt","year":"2017","journal-title":"J Biomed Mater Res B Appl Biomater"},{"key":"10.1016\/j.jss.2017.09.047_bib15","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1007\/s11605-011-1736-y","article-title":"P.O.P.A. study: prevention of postoperative abdominal adhesions by icodextrin 4% solution after laparotomy for adhesive small bowel obstruction. A prospective randomized controlled trial","volume":"16","author":"Catena","year":"2012","journal-title":"J Gastrointest Surg"},{"key":"10.1016\/j.jss.2017.09.047_bib16","first-page":"863","article-title":"The effect of intraperitoneal Malayan pit-viper venom on adhesion formation and peritoneal healing","volume":"57","author":"Ashby","year":"1970","journal-title":"Br J Surg"},{"key":"10.1016\/j.jss.2017.09.047_bib17","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1006\/jsre.1996.0081","article-title":"Adhesion prevention with ancrod released via a tissue-adherent hydrogel","volume":"61","author":"Chowdhury","year":"1996","journal-title":"J Surg Res"},{"key":"10.1016\/j.jss.2017.09.047_bib18","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1002\/micr.1920080406","article-title":"A model for sidewall adhesions in the rabbit: reduction by an absorbable barrier","volume":"8","author":"Diamond","year":"1987","journal-title":"Microsurgery"},{"key":"10.1016\/j.jss.2017.09.047_bib19","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1046\/j.1365-2141.2003.04256.x","article-title":"Guidelines on fibrinogen assays","volume":"121","author":"Mackie","year":"2003","journal-title":"Br J Haematol"},{"key":"10.1016\/j.jss.2017.09.047_bib20","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.amjsurg.2010.02.008","article-title":"Prevention of postoperative peritoneal adhesions: a review of the literature","volume":"201","author":"Schnuriger","year":"2011","journal-title":"Am J Surg"},{"key":"10.1016\/j.jss.2017.09.047_bib21","doi-asserted-by":"crossref","first-page":"1266","DOI":"10.1016\/j.fertnstert.2006.05.023","article-title":"Innovative barriers for peritoneal adhesion prevention: liquid or solid? A rat uterine horn model","volume":"86","author":"Wallwiener","year":"2006","journal-title":"Fertil Steril"},{"key":"10.1016\/j.jss.2017.09.047_bib22","doi-asserted-by":"crossref","first-page":"1","DOI":"10.7150\/ijms.8870","article-title":"High reproducibility of adhesion formation in rat with meso-stitch approximation of injured cecum and abdominal wall","volume":"12","author":"Poehnert","year":"2015","journal-title":"Int J Med Sci"},{"key":"10.1016\/j.jss.2017.09.047_bib23","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1080\/00015458.2010.11680569","article-title":"A comparison of three fibrinolytic agents in prevention of intra-abdominal adhesions","volume":"110","author":"Topal","year":"2010","journal-title":"Acta Chir Belg"},{"key":"10.1016\/j.jss.2017.09.047_bib24","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/S0140-6736(87)90764-1","article-title":"Ultrafiltration with an isosmotic solution during long peritoneal dialysis exchanges","volume":"2","author":"Mistry","year":"1987","journal-title":"Lancet"},{"key":"10.1016\/j.jss.2017.09.047_bib25","doi-asserted-by":"crossref","first-page":"31","DOI":"10.3109\/08941939709032122","article-title":"Reduction of adhesion formation by intraperitoneal administration of anti-inflammatory peptide 2","volume":"10","author":"Rodgers","year":"1997","journal-title":"J Invest Surg"},{"key":"10.1016\/j.jss.2017.09.047_bib26","doi-asserted-by":"crossref","first-page":"1503","DOI":"10.1097\/01.LAB.0000035024.75914.39","article-title":"Wound healing involves induction of cyclooxygenase-2 expression in rat skin","volume":"82","author":"Futagami","year":"2002","journal-title":"Lab Invest"},{"key":"10.1016\/j.jss.2017.09.047_bib27","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1111\/j.1538-7836.2010.04156.x","article-title":"COX-1(+\/\u2212)COX-2(\u2212\/\u2212) genotype in mice is associated with shortened time to carotid artery occlusion through\u00a0increased PAI-1","volume":"9","author":"Riehl","year":"2011","journal-title":"J Thromb Haemost"},{"key":"10.1016\/j.jss.2017.09.047_bib28","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/j.tcm.2005.07.004","article-title":"Two-way interactions between inflammation and coagulation","volume":"15","author":"Levi","year":"2005","journal-title":"Trends Cardiovasc Med"},{"key":"10.1016\/j.jss.2017.09.047_bib29","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1055\/s-0038-1645963","article-title":"Possible role of fibrinogen in the aggregation of white blood cells","volume":"58","author":"Berliner","year":"1987","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.jss.2017.09.047_bib30","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/0268-9499(88)90065-3","article-title":"Effect of fibrinogen-clotting enzymes on secretion of plasminogen activators from cultured human endothelial cells","volume":"2","author":"Soszka","year":"1988","journal-title":"Fibrinolysis"},{"key":"10.1016\/j.jss.2017.09.047_bib31","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1091\/mbc.12.1.85","article-title":"Structure and\u00a0function of a vimentin-associated matrix adhesion\u00a0in endothelial cells","volume":"12","author":"Gonzales","year":"2001","journal-title":"Mol Biol Cell"}],"container-title":["Journal of Surgical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S002248041730642X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S002248041730642X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,9,5]],"date-time":"2019-09-05T08:26:18Z","timestamp":1567671978000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S002248041730642X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,2]]},"references-count":31,"alternative-id":["S002248041730642X"],"URL":"https:\/\/doi.org\/10.1016\/j.jss.2017.09.047","relation":{},"ISSN":["0022-4804"],"issn-type":[{"value":"0022-4804","type":"print"}],"subject":[],"published":{"date-parts":[[2018,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"AK03, a new recombinant fibrinogenase prevents abdominal adhesions in a rat model without systemic side effects","name":"articletitle","label":"Article Title"},{"value":"Journal of Surgical Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jss.2017.09.047","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}