{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T18:45:05Z","timestamp":1773168305849,"version":"3.50.1"},"reference-count":32,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,6,1]],"date-time":"2018-06-01T00:00:00Z","timestamp":1527811200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","journalofsurgicalresearch.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Surgical Research"],"published-print":{"date-parts":[[2018,6]]},"DOI":"10.1016\/j.jss.2018.01.025","type":"journal-article","created":{"date-parts":[[2018,2,10]],"date-time":"2018-02-10T05:33:34Z","timestamp":1518240814000},"page":"15-23","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"special_numbering":"C","title":["Prognostic value of neoadjuvant treatment response in locally advanced rectal cancer"],"prefix":"10.1016","volume":"226","author":[{"given":"Yvonne H.","family":"Sada","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hop S.","family":"Tran Cao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"George J.","family":"Chang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Avo","family":"Artinyan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benjamin L.","family":"Musher","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brandon G.","family":"Smaglo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nader N.","family":"Massarweh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jss.2018.01.025_bib1","doi-asserted-by":"crossref","first-page":"7","DOI":"10.3322\/caac.21332","article-title":"Cancer statistics, 2016","volume":"66","author":"Siegel","year":"2016","journal-title":"CA Cancer J Clin"},{"key":"10.1016\/j.jss.2018.01.025_bib2","doi-asserted-by":"crossref","first-page":"4558","DOI":"10.1200\/JCO.2012.42.8771","article-title":"Clinical outcome of the ACCORD 12\/0405 PRODIGE 2 randomized trial in rectal cancer","volume":"30","author":"Gerard","year":"2012","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.jss.2018.01.025_bib3","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/S1470-2045(15)00467-2","article-title":"Watch-and-wait approach versus surgical resection after chemoradiotherapy for patients with rectal cancer (the OnCoRe project): a propensity-score matched cohort analysis","volume":"17","author":"Renehan","year":"2016","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.jss.2018.01.025_bib4","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1016\/S1470-2045(15)00159-X","article-title":"Oxaliplatin added to fluorouracil-based preoperative chemoradiotherapy and postoperative chemotherapy of locally advanced rectal cancer (the German CAO\/ARO\/AIO-04 study): final results of the multicentre, open-label, randomised, phase 3 trial","volume":"16","author":"Rodel","year":"2015","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.jss.2018.01.025_bib5","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1200\/JCO.2013.51.7904","article-title":"Neoadjuvant chemotherapy without routine use of radiation therapy for patients with locally advanced rectal cancer: a pilot trial","volume":"32","author":"Schrag","year":"2014","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.jss.2018.01.025_bib6","doi-asserted-by":"crossref","first-page":"3300","DOI":"10.1200\/JCO.2016.66.6198","article-title":"Modified FOLFOX6 with or without radiation versus fluorouracil and leucovorin with radiation in neoadjuvant treatment of locally advanced rectal cancer: initial results of the Chinese FOWARC multicenter, open-label, randomized three-arm phase III trial","volume":"34","author":"Deng","year":"2016","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.jss.2018.01.025_bib7","doi-asserted-by":"crossref","first-page":"4231","DOI":"10.1002\/cncr.28331","article-title":"Quantified pathologic response assessed as residual tumor burden is a predictor of recurrence-free survival in patients with rectal cancer who undergo resection after neoadjuvant chemoradiotherapy","volume":"119","author":"Agarwal","year":"2013","journal-title":"Cancer"},{"key":"10.1016\/j.jss.2018.01.025_bib8","doi-asserted-by":"crossref","first-page":"1554","DOI":"10.1200\/JCO.2013.54.3769","article-title":"Tumor regression grading after preoperative chemoradiotherapy for locally advanced rectal carcinoma revisited: updated results of the CAO\/ARO\/AIO-94 trial","volume":"32","author":"Fokas","year":"2014","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.jss.2018.01.025_bib9","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1097\/00000421-200104000-00001","article-title":"Improved overall survival among responders to preoperative chemoradiation for locally advanced rectal cancer","volume":"24","author":"Janjan","year":"2001","journal-title":"Am J Clin Oncol"},{"key":"10.1016\/j.jss.2018.01.025_bib10","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1016\/S1470-2045(10)70172-8","article-title":"Long-term outcome in patients with a pathological complete response after chemoradiation for rectal cancer: a pooled analysis of individual patient data","volume":"11","author":"Maas","year":"2010","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.jss.2018.01.025_bib11","doi-asserted-by":"crossref","first-page":"1770","DOI":"10.1200\/JCO.2011.39.7901","article-title":"Neoadjuvant treatment response as an early response indicator for patients with rectal cancer","volume":"30","author":"Park","year":"2012","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.jss.2018.01.025_bib12","doi-asserted-by":"crossref","first-page":"3753","DOI":"10.1200\/JCO.2011.34.9068","article-title":"Magnetic resonance imaging-detected tumor response for locally advanced rectal cancer predicts survival outcomes: MERCURY experience","volume":"29","author":"Patel","year":"2011","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.jss.2018.01.025_bib13","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1097\/SLA.0b013e3181f3f1b1","article-title":"Pathologic complete response of primary tumor following preoperative chemoradiotherapy for locally advanced rectal cancer: long-term outcomes and prognostic significance of pathologic nodal status (KROG 09-01)","volume":"252","author":"Yeo","year":"2010","journal-title":"Ann Surg"},{"key":"10.1016\/j.jss.2018.01.025_bib14","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1002\/cncr.30261","article-title":"Poor compliance with adjuvant chemotherapy use associated with poorer survival in patients with rectal cancer: an NCDB analysis","volume":"123","author":"Xu","year":"2017","journal-title":"Cancer"},{"key":"10.1016\/j.jss.2018.01.025_bib15","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1007\/s003840050072","article-title":"Pathological features of rectal cancer after preoperative radiochemotherapy","volume":"12","author":"Dworak","year":"1997","journal-title":"Int J Colorectal Dis"},{"key":"10.1016\/j.jss.2018.01.025_bib16","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1111\/j.1463-1318.2007.01424.x","article-title":"Pathologic response assessed by Mandard grade is a better prognostic factor than down staging for disease-free survival after preoperative radiochemotherapy for advanced rectal cancer","volume":"10","author":"Suarez","year":"2008","journal-title":"Colorectal Dis"},{"key":"10.1016\/j.jss.2018.01.025_bib17","doi-asserted-by":"crossref","DOI":"10.1093\/jnci\/dju248","article-title":"Comparison of tumor regression grade systems for locally advanced rectal cancer after multimodality treatment","volume":"106","author":"Trakarnsanga","year":"2014","journal-title":"J Natl Cancer Inst"},{"key":"10.1016\/j.jss.2018.01.025_bib18","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1200\/JCO.2009.23.9194","article-title":"Revised tumor and node categorization for rectal cancer based on surveillance, epidemiology, and end results and rectal pooled analysis outcomes","volume":"28","author":"Gunderson","year":"2010","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.jss.2018.01.025_bib19","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1016\/S0140-6736(94)92206-3","article-title":"Role of circumferential margin involvement in the local recurrence of rectal cancer","volume":"344","author":"Adam","year":"1994","journal-title":"Lancet"},{"key":"10.1016\/j.jss.2018.01.025_bib20","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1007\/BF02050539","article-title":"Prognostic value of positive lymph nodes in rectal cancer","volume":"35","author":"Moran","year":"1992","journal-title":"Dis Colon Rectum"},{"key":"10.1016\/j.jss.2018.01.025_bib21","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1016\/S0140-6736(09)60485-2","article-title":"Effect of the plane of surgery achieved on local recurrence in patients with operable rectal cancer: a prospective study using data from the MRC CR07 and NCIC-CTG CO16 randomised clinical trial","volume":"373","author":"Quirke","year":"2009","journal-title":"Lancet"},{"key":"10.1016\/j.jss.2018.01.025_bib22","doi-asserted-by":"crossref","first-page":"8688","DOI":"10.1200\/JCO.2005.02.1329","article-title":"Prognostic significance of tumor regression after preoperative chemoradiotherapy for rectal cancer","volume":"23","author":"Rodel","year":"2005","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.jss.2018.01.025_bib23","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/S1470-2045(11)70097-3","article-title":"Preoperative radiotherapy combined with total mesorectal excision for resectable rectal cancer: 12-year follow-up of the multicentre, randomised controlled TME trial","volume":"12","author":"van Gijn","year":"2011","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.jss.2018.01.025_bib24","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/S1470-2045(13)70599-0","article-title":"Fluorouracil-based adjuvant chemotherapy after preoperative chemoradiotherapy in rectal cancer: long-term results of the EORTC 22921 randomised study","volume":"15","author":"Bosset","year":"2014","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.jss.2018.01.025_bib25","doi-asserted-by":"crossref","first-page":"1356","DOI":"10.1093\/annonc\/mdu147","article-title":"Chronicle: results of a randomised phase III trial in locally advanced rectal cancer after neoadjuvant chemoradiation randomising postoperative adjuvant capecitabine plus oxaliplatin (XELOX) versus control","volume":"25","author":"Glynne-Jones","year":"2014","journal-title":"Ann Oncol"},{"key":"10.1016\/j.jss.2018.01.025_bib26","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1093\/annonc\/mdu560","article-title":"Adjuvant chemotherapy for rectal cancer patients treated with preoperative (chemo)radiotherapy and total mesorectal excision: a Dutch Colorectal Cancer Group (DCCG) randomized phase III trial","volume":"26","author":"Breugom","year":"2015","journal-title":"Ann Oncol"},{"key":"10.1016\/j.jss.2018.01.025_bib27","doi-asserted-by":"crossref","first-page":"1409","DOI":"10.1200\/JCO.1995.13.6.1409","article-title":"Relationship of acute gastrointestinal toxicity and the volume of irradiated small bowel in patients receiving combined modality therapy for rectal cancer","volume":"13","author":"Minsky","year":"1995","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.jss.2018.01.025_bib28","doi-asserted-by":"crossref","first-page":"1731","DOI":"10.1056\/NEJMoa040694","article-title":"Preoperative versus postoperative chemoradiotherapy for rectal cancer","volume":"351","author":"Sauer","year":"2004","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jss.2018.01.025_bib29","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/S1053-4296(03)00051-1","article-title":"The impact of radiation on functional outcomes in patients with rectal cancer and sphincter preservation","volume":"13","author":"Temple","year":"2003","journal-title":"Semin Radiat Oncol"},{"key":"10.1016\/j.jss.2018.01.025_bib30","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1002\/cncr.30410","article-title":"Can we eliminate neoadjuvant chemoradiotherapy in favor of neoadjuvant multiagent chemotherapy for select stage II\/III rectal adenocarcinomas: analysis of the National Cancer Database","volume":"123","author":"Cassidy","year":"2016","journal-title":"Cancer"},{"key":"10.1016\/j.jss.2018.01.025_bib31","doi-asserted-by":"crossref","first-page":"4177","DOI":"10.1200\/JCO.2008.21.7018","article-title":"Comparison of commission on cancer-approved and -nonapproved hospitals\u00a0in the United States: implications for studies that use the National Cancer Data Base","volume":"27","author":"Bilimoria","year":"2009","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.jss.2018.01.025_bib32","doi-asserted-by":"crossref","first-page":"1759","DOI":"10.1245\/s10434-013-2901-1","article-title":"Comparison of cases captured in the national cancer data base with those in population-based central cancer registries","volume":"20","author":"Lerro","year":"2013","journal-title":"Ann Surg Oncol"}],"container-title":["Journal of Surgical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022480418300337?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022480418300337?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,8,24]],"date-time":"2018-08-24T01:03:30Z","timestamp":1535072610000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022480418300337"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,6]]},"references-count":32,"alternative-id":["S0022480418300337"],"URL":"https:\/\/doi.org\/10.1016\/j.jss.2018.01.025","relation":{},"ISSN":["0022-4804"],"issn-type":[{"value":"0022-4804","type":"print"}],"subject":[],"published":{"date-parts":[[2018,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Prognostic value of neoadjuvant treatment response in locally advanced rectal cancer","name":"articletitle","label":"Article Title"},{"value":"Journal of Surgical Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jss.2018.01.025","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}