{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T11:17:38Z","timestamp":1759058258983,"version":"3.44.0"},"reference-count":35,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81270436","81671503"],"award-info":[{"award-number":["81270436","81671503"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","journalofsurgicalresearch.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Surgical Research"],"published-print":{"date-parts":[[2019,1]]},"DOI":"10.1016\/j.jss.2018.08.006","type":"journal-article","created":{"date-parts":[[2018,8,29]],"date-time":"2018-08-29T13:01:35Z","timestamp":1535547695000},"page":"173-182","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"special_numbering":"C","title":["The Expression of Shh, Ptch1, and Gli1 in the Developing Caudal Spinal Cord of Fetal Rats With Anorectal Malformations"],"prefix":"10.1016","volume":"233","author":[{"given":"Zhonghua","family":"Yang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linlin","family":"Gao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huimin","family":"Jia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuzuo","family":"Bai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weilin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jss.2018.08.006_bib1","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1016\/S0022-3468(86)80515-2","article-title":"Normal and abnormal development of the anorectum","volume":"21","author":"van der Putte","year":"1986","journal-title":"J Pediatr Surg"},{"key":"10.1016\/j.jss.2018.08.006_bib2","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.ejmg.2007.04.002","article-title":"Associated malformations in patients with anorectal anomalies","volume":"50","author":"Stoll","year":"2007","journal-title":"Eur J Med Genet"},{"key":"10.1016\/j.jss.2018.08.006_bib3","doi-asserted-by":"crossref","first-page":"2273","DOI":"10.1016\/j.jpedsurg.2012.09.017","article-title":"Anomalies associated with anorectal malformations according to the Krickenbeck anatomic classification","volume":"479","author":"Nah","year":"2012","journal-title":"J Pediatr Surg"},{"key":"10.1016\/j.jss.2018.08.006_bib4","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1002\/bdra.20576","article-title":"Defective development of sensory neurons innervating the levator ani muscle in fetal rats with anorectal malformation","volume":"85","author":"Guan","year":"2009","journal-title":"Birth Defects Res A Clin Mol Teratol"},{"key":"10.1016\/j.jss.2018.08.006_bib5","doi-asserted-by":"crossref","first-page":"1544","DOI":"10.1016\/j.jpedsurg.2007.04.034","article-title":"Quantitative analysis of sacral parasympathetic nucleus innervating the rectum in rats with anorectal malformation","volume":"42","author":"Jia","year":"2007","journal-title":"J Pediatr Surg"},{"key":"10.1016\/j.jss.2018.08.006_bib6","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1016\/S0022-3468(03)00401-9","article-title":"Deficient motor innervation of the sphincter mechanism in fetal rats with anorectal malformation: a quantitative study by fluorogold retrograde tracing","volume":"38","author":"Yuan","year":"2003","journal-title":"J Pediatr Surg"},{"key":"10.1016\/j.jss.2018.08.006_bib7","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1007\/s00383-004-1212-9","article-title":"Abnormalities of the vertebral column and ribs associated with anorectal malformations","volume":"20","author":"Qi","year":"2004","journal-title":"Pediatr Surg Int"},{"key":"10.1016\/j.jss.2018.08.006_bib8","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1016\/0022-3468(93)90687-G","article-title":"Anorectal anomaly neuropathological changes in the sacral spinal cord","volume":"28","author":"Li","year":"1993","journal-title":"J Pediatr Surg"},{"key":"10.1016\/j.jss.2018.08.006_bib9","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1016\/0022-3468(90)90357-F","article-title":"Sensory nerve endings in puborectalis and anal region normal findings in the newborn and changes in anorectal anomalies","volume":"25","author":"Li","year":"1990","journal-title":"J Pediatr Surg"},{"key":"10.1016\/j.jss.2018.08.006_bib10","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.1016\/j.jpedsurg.2013.10.022","article-title":"Bowel symptoms in children with anorectal malformation - a follow-up with a gender and age perspective","volume":"49","author":"Stenstrom","year":"2014","journal-title":"J Pediatr Surg"},{"key":"10.1016\/j.jss.2018.08.006_bib11","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/0092-8674(93)90248-O","article-title":"Control of cell pattern in the neural tube motor neuron induction by diffusible factors from notochord and floor plate","volume":"73","author":"Yamada","year":"1993","journal-title":"Cell"},{"key":"10.1016\/j.jss.2018.08.006_bib12","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1016\/0092-8674(91)90247-V","article-title":"Control of cell pattern in the developing nervous system polarizing activity of the floor plate and notochord","volume":"64","author":"Yamada","year":"1991","journal-title":"Cell"},{"key":"10.1016\/j.jss.2018.08.006_bib13","doi-asserted-by":"crossref","first-page":"293","DOI":"10.3389\/fncel.2014.00293","article-title":"Motor neurons and the generation of spinal motor neuron diversity","volume":"8","author":"Stifani","year":"2014","journal-title":"Front Cell Neurosci"},{"key":"10.1016\/j.jss.2018.08.006_bib14","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1016\/S0002-9297(07)62934-6","article-title":"The sonic hedgehog\u2013patched\u2013Gli pathway in human development and disease","volume":"67","author":"Villavicencio","year":"2000","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.jss.2018.08.006_bib15","doi-asserted-by":"crossref","first-page":"4759","DOI":"10.3892\/mmr.2016.5139","article-title":"Hedgehog gene polymorphisms are associated with the risk of Hirschsprung's disease and anorectal malformation in a Chinese population","volume":"13","author":"Gao","year":"2016","journal-title":"Mol Med Rep"},{"key":"10.1016\/j.jss.2018.08.006_bib16","doi-asserted-by":"crossref","first-page":"1400","DOI":"10.1016\/j.jpedsurg.2014.03.007","article-title":"Hypermethylation of SHH in the pathogenesis of congenital anorectal malformations","volume":"49","author":"Huang","year":"2014","journal-title":"J Pediatr Surg"},{"key":"10.1016\/j.jss.2018.08.006_bib17","doi-asserted-by":"crossref","first-page":"1842","DOI":"10.1177\/147323000903700620","article-title":"Downregulation of SHH\/BMP4 signalling in human anorectal malformations","volume":"37","author":"Zhang","year":"2009","journal-title":"J Int Med Res"},{"key":"10.1016\/j.jss.2018.08.006_bib18","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1053\/jpsu.2002.34996","article-title":"Clarification of the processes that lead to anorectal malformations in the ETU-induced rat model of imperforate anus","volume":"37","author":"Qi","year":"2002","journal-title":"J Pediatr Surg"},{"key":"10.1016\/j.jss.2018.08.006_bib19","doi-asserted-by":"crossref","first-page":"2195","DOI":"10.1016\/j.jpedsurg.2010.06.020","article-title":"Embryonic development of the internal anal sphincter in rats with anorectal malformations","volume":"45","author":"Zhang","year":"2010","journal-title":"J Pediatr Surg"},{"key":"10.1016\/j.jss.2018.08.006_bib20","doi-asserted-by":"crossref","first-page":"2041","DOI":"10.1016\/j.jpedsurg.2006.08.035","article-title":"Sonic hedgehog, BMP4, and Hox genes in the development of anorectal malformations in Ethylenethiourea-exposed fetal rats","volume":"41","author":"Mandhan","year":"2006","journal-title":"J Pediatr Surg"},{"key":"10.1016\/j.jss.2018.08.006_bib21","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1016\/j.jpedsurg.2009.10.094","article-title":"Spinal dysraphism with anorectal malformation: lumbosacral magnetic resonance imaging evaluation of 120 patients","volume":"45","author":"Kim","year":"2010","journal-title":"J Pediatr Surg"},{"key":"10.1016\/j.jss.2018.08.006_bib22","first-page":"35","article-title":"Anorectal malformations","volume":"4","author":"Pe\u00f1a","year":"1995","journal-title":"Semin Pediatr Surg"},{"key":"10.1016\/j.jss.2018.08.006_bib23","doi-asserted-by":"crossref","first-page":"3160","DOI":"10.1007\/s11064-017-2354-1","article-title":"Spatiotemporal expression of Bcl-2\/Bax and neural cell apoptosis in the developing lumbosacral spinal cord of rat fetuses with anorectal malformations","volume":"42","author":"Yang","year":"2017","journal-title":"Neurochem Res"},{"key":"10.1016\/j.jss.2018.08.006_bib24","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1242\/dev.012054","article-title":"Wnt canonical pathway restricts graded Shh\/Gli patterning activity through the regulation of Gli3 expression","volume":"135","author":"Alvarez-Medina","year":"2008","journal-title":"Development"},{"key":"10.1016\/j.jss.2018.08.006_bib25","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/S0166-2236(96)01046-6","article-title":"Bone morphogenetic proteins in the nervous system","volume":"20","author":"Mehler","year":"1997","journal-title":"Trends Neurosci"},{"key":"10.1016\/j.jss.2018.08.006_bib26","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1016\/S0092-8674(00)80802-8","article-title":"A sonic hedgehog\u2013independent, retinoid-activated pathway of neurogenesis in the ventral spinal cord","volume":"97","author":"Pierani","year":"1999","journal-title":"Cell"},{"key":"10.1016\/j.jss.2018.08.006_bib27","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1002\/bdra.20686","article-title":"The relationship between sonic Hedgehog signaling, cilia, and neural tube defects","volume":"88","author":"Murdoch","year":"2010","journal-title":"Birth Defects Res A Clin Mol Teratol"},{"key":"10.1016\/j.jss.2018.08.006_bib28","doi-asserted-by":"crossref","first-page":"1594","DOI":"10.1242\/dev.090845","article-title":"Floor plate-derived sonic hedgehog regulates glial and ependymal cell fates in the developing spinal cord","volume":"140","author":"Yu","year":"2013","journal-title":"Development"},{"key":"10.1016\/j.jss.2018.08.006_bib29","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/j.neuron.2009.03.022","article-title":"Sonic hedgehog guides axons through a noncanonical, Src-family-kinase-dependent signaling pathway","volume":"62","author":"Yam","year":"2009","journal-title":"Neuron"},{"key":"10.1016\/j.jss.2018.08.006_bib30","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.celrep.2013.12.003","article-title":"Gli protein activity is controlled by multi-site phosphorylation in vertebrate Hedgehog signaling","volume":"6","author":"Niewiadomski","year":"2014","journal-title":"Cell Rep"},{"key":"10.1016\/j.jss.2018.08.006_bib31","doi-asserted-by":"crossref","first-page":"2537","DOI":"10.1242\/dev.124.13.2537","article-title":"Gli1 is a target of Sonic hedgehog that induces ventral neural tube development","volume":"124","author":"Lee","year":"1997","journal-title":"Development"},{"key":"10.1016\/j.jss.2018.08.006_bib32","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/j.cell.2004.07.023","article-title":"Dynamic changes in the response of cells to positive hedgehog signaling during mouse limb patterning","volume":"118","author":"Ahn","year":"2004","journal-title":"Cell"},{"key":"10.1016\/j.jss.2018.08.006_bib33","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1016\/j.yexcr.2012.03.006","article-title":"Neurotrophins and cell death","volume":"318","author":"Ichim","year":"2012","journal-title":"Exp Cell Res"},{"key":"10.1016\/j.jss.2018.08.006_bib34","doi-asserted-by":"crossref","first-page":"1452","DOI":"10.1016\/j.jpedsurg.2008.02.059","article-title":"Embryonic development of the striated muscle complex in rats with anorectal malformations","volume":"43","author":"Zhang","year":"2008","journal-title":"J Pediatr Surg"},{"key":"10.1016\/j.jss.2018.08.006_bib35","doi-asserted-by":"crossref","first-page":"1884","DOI":"10.1016\/j.jpedsurg.2009.02.004","article-title":"Apoptosis during the development of pelvic floor muscle in anorectal malformation rats","volume":"44","author":"Chen","year":"2009","journal-title":"J Pediatr Surg"}],"container-title":["Journal of Surgical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022480418305705?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022480418305705?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T14:43:39Z","timestamp":1758379419000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022480418305705"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1]]},"references-count":35,"alternative-id":["S0022480418305705"],"URL":"https:\/\/doi.org\/10.1016\/j.jss.2018.08.006","relation":{},"ISSN":["0022-4804"],"issn-type":[{"type":"print","value":"0022-4804"}],"subject":[],"published":{"date-parts":[[2019,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The Expression of Shh, Ptch1, and Gli1 in the Developing Caudal Spinal Cord of Fetal Rats With Anorectal Malformations","name":"articletitle","label":"Article Title"},{"value":"Journal of Surgical Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jss.2018.08.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}