{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T11:31:43Z","timestamp":1787311903707,"version":"build-2736575974"},"reference-count":66,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,4,1]],"date-time":"2019-04-01T00:00:00Z","timestamp":1554076800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Liver Regenerative Medicine"},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R21AG052822-01A1"],"award-info":[{"award-number":["R21AG052822-01A1"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","journalofsurgicalresearch.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Surgical Research"],"published-print":{"date-parts":[[2019,4]]},"DOI":"10.1016\/j.jss.2018.11.047","type":"journal-article","created":{"date-parts":[[2018,12,17]],"date-time":"2018-12-17T07:34:02Z","timestamp":1545032042000},"page":"172-183","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":44,"special_numbering":"C","title":["GABA, \u03b3-Aminobutyric Acid, Protects Against Severe Liver Injury"],"prefix":"10.1016","volume":"236","author":[{"given":"Toshiyuki","family":"Hata","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatima","family":"Rehman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomohide","family":"Hori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justin H.","family":"Nguyen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jss.2018.11.047_bib1","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1126\/science.1082874","article-title":"GABA and its agonists improved visual cortical function in senescent monkeys","volume":"300","author":"Leventhal","year":"2003","journal-title":"Science"},{"key":"10.1016\/j.jss.2018.11.047_bib2","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1038\/nature04404","article-title":"GABA regulates synaptic integration of newly generated neurons in the adult brain","volume":"439","author":"Ge","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.jss.2018.11.047_bib3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.tins.2006.11.001","article-title":"GABA sets the tempo for activity-dependent adult neurogenesis","volume":"30","author":"Ge","year":"2007","journal-title":"Trends Neurosci"},{"key":"10.1016\/j.jss.2018.11.047_bib4","first-page":"171","article-title":"GABA's control of stem and cancer cell proliferation in adult neural and peripheral niches","volume":"24","author":"Young","year":"2009","journal-title":"Physiology (Bethesda)"},{"key":"10.1016\/j.jss.2018.11.047_bib5","doi-asserted-by":"crossref","first-page":"11692","DOI":"10.1073\/pnas.1102715108","article-title":"GABA exerts protective and regenerative effects on islet beta cells and reverses diabetes","volume":"108","author":"Soltani","year":"2011","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jss.2018.11.047_bib6","doi-asserted-by":"crossref","first-page":"4197","DOI":"10.2337\/db14-0153","article-title":"GABA promotes human beta-cell proliferation and modulates glucose homeostasis","volume":"63","author":"Purwana","year":"2014","journal-title":"Diabetes"},{"key":"10.1016\/j.jss.2018.11.047_bib7","doi-asserted-by":"crossref","first-page":"3760","DOI":"10.2337\/db13-0931","article-title":"gamma-Aminobutyric acid regulates both the survival and replication of human beta-cells","volume":"62","author":"Tian","year":"2013","journal-title":"Diabetes"},{"key":"10.1016\/j.jss.2018.11.047_bib8","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.cell.2016.11.002","article-title":"Long-term GABA administration induces alpha cell-mediated beta-like cell neogenesis","volume":"168","author":"Ben-Othman","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.jss.2018.11.047_bib9","doi-asserted-by":"crossref","first-page":"1520","DOI":"10.3389\/fpsyg.2015.01520","article-title":"Neurotransmitters as food supplements: the effects of GABA on brain and behavior","volume":"6","author":"Boonstra","year":"2015","journal-title":"Front Psychol"},{"key":"10.1016\/j.jss.2018.11.047_bib10","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1038\/nature06488","article-title":"Histone H2AX-dependent GABA(A) receptor regulation of stem cell proliferation","volume":"451","author":"Andang","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.jss.2018.11.047_bib11","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/0920-1211(92)90030-W","article-title":"Chemical models of epilepsy with some reference to their applicability in the development of anticonvulsants","volume":"12","author":"De Deyn","year":"1992","journal-title":"Epilepsy Res"},{"key":"10.1016\/j.jss.2018.11.047_bib12","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/S0197-0186(03)00041-X","article-title":"Potential mechanisms of enhanced GABA-mediated inhibitory neurotransmission in liver failure","volume":"43","author":"Jones","year":"2003","journal-title":"Neurochem Int"},{"key":"10.1016\/j.jss.2018.11.047_bib13","doi-asserted-by":"crossref","first-page":"G12","DOI":"10.1152\/ajpgi.00513.2002","article-title":"Increasing cell membrane potential and GABAergic activity inhibits malignant hepatocyte growth","volume":"285","author":"Sun","year":"2003","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1016\/j.jss.2018.11.047_bib14","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1002\/hep.21562","article-title":"Decreased hepatocyte membrane potential differences and GABAA-beta3 expression in human hepatocellular carcinoma","volume":"45","author":"Minuk","year":"2007","journal-title":"Hepatology"},{"key":"10.1016\/j.jss.2018.11.047_bib15","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/0016-5085(93)90854-6","article-title":"The effect of gamma-aminobutyric acid on hepatic regenerative activity following partial hepatectomy in rats","volume":"104","author":"Minuk","year":"1993","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jss.2018.11.047_bib16","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1016\/S0168-8278(98)80160-8","article-title":"The effects of ethanol and gamma aminobutyric acid alone and in combination on hepatic regenerative activity in the rat","volume":"29","author":"Zhang","year":"1998","journal-title":"J Hepatol"},{"key":"10.1016\/j.jss.2018.11.047_bib17","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/S1386-6346(01)00092-4","article-title":"Hepatic GABA(A) receptor functional regulation during rat liver cell proliferation","volume":"21","author":"Biju","year":"2001","journal-title":"Hepatol Res"},{"key":"10.1016\/j.jss.2018.11.047_bib18","doi-asserted-by":"crossref","first-page":"6145","DOI":"10.1166\/jnn.2012.6194","article-title":"Evaluation of GABA-chitosan nanoparticle induced cell signaling activation during liver regeneration after partial hepatectomy","volume":"12","author":"Shilpa","year":"2012","journal-title":"J Nanosci Nanotechnol"},{"key":"10.1016\/j.jss.2018.11.047_bib19","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1002\/hep.26308","article-title":"GABA induces the differentiation of small into large cholangiocytes by activation of Ca(2+)\/CaMK I-dependent adenylyl cyclase 8","volume":"58","author":"Mancinelli","year":"2013","journal-title":"Hepatology"},{"key":"10.1016\/j.jss.2018.11.047_bib20","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1152\/ajpgi.00344.2016","article-title":"Protective roles of hepatic GABA signaling in acute liver injury of rats","volume":"312","author":"Wang","year":"2017","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1016\/j.jss.2018.11.047_bib21","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.bbrc.2017.07.015","article-title":"Rescuing fluoride-induced damages in liver with gamma aminobutyric acid","volume":"491","author":"Yang","year":"2017","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.jss.2018.11.047_bib22","doi-asserted-by":"crossref","first-page":"149123","DOI":"10.1155\/2013\/149123","article-title":"Pretreatment of small-for-size grafts in\u00a0vivo by gamma -aminobutyric acid receptor regulation against oxidative stress-induced injury in rat split orthotopic liver transplantation","volume":"2013","author":"Hori","year":"2013","journal-title":"Int J Hepatol"},{"key":"10.1016\/j.jss.2018.11.047_bib23","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1111\/j.1872-034X.2012.01030.x","article-title":"Effect of specific activation of gamma-aminobutyric acid receptor in\u00a0vivo on oxidative stress-induced damage after extended hepatectomy","volume":"42","author":"Gardner","year":"2012","journal-title":"Hepatol Res"},{"key":"10.1016\/j.jss.2018.11.047_bib24","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1038\/nm1101-1202","article-title":"Inhibition of matrix metalloproteinases blocks lethal hepatitis and apoptosis induced by tumor necrosis factor and allows safe antitumor therapy","volume":"7","author":"Wielockx","year":"2001","journal-title":"Nat Med"},{"key":"10.1016\/j.jss.2018.11.047_bib25","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1038\/jcbfm.2013.45","article-title":"TIMP-1 attenuates blood-brain barrier permeability in mice with acute liver failure","volume":"33","author":"Chen","year":"2013","journal-title":"J Cereb Blood Flow Metab"},{"key":"10.1016\/j.jss.2018.11.047_bib26","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1016\/j.jhep.2005.09.019","article-title":"Matrix metalloproteinase-9 contributes to brain extravasation and edema in fulminant hepatic failure mice","volume":"44","author":"Nguyen","year":"2006","journal-title":"J Hepatol"},{"key":"10.1016\/j.jss.2018.11.047_bib27","doi-asserted-by":"crossref","first-page":"7391","DOI":"10.1073\/pnas.0609757104","article-title":"Selective chemical probe inhibitor of Stat3, identified through structure-based virtual screening, induces antitumor activity","volume":"104","author":"Siddiquee","year":"2007","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jss.2018.11.047_bib28","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1038\/nmeth.2089","article-title":"NIH image to ImageJ: 25 years of image analysis","volume":"9","author":"Schneider","year":"2012","journal-title":"Nat Methods"},{"key":"10.1016\/j.jss.2018.11.047_bib29","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.fct.2014.02.005","article-title":"Subchronic toxicity evaluation of gamma-aminobutyric acid (GABA) in rats","volume":"68","author":"Takeshima","year":"2014","journal-title":"Food Chem Toxicol"},{"key":"10.1016\/j.jss.2018.11.047_bib30","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/0026-0495(82)90029-4","article-title":"Effects of gamma aminobutyric acid (GABA) and muscimol on endocrine pancreatic function in man","volume":"31","author":"Cavagnini","year":"1982","journal-title":"Metabolism"},{"key":"10.1016\/j.jss.2018.11.047_bib31","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1249\/mss.0b013e318158b518","article-title":"Growth hormone isoform responses to GABA ingestion at rest and after exercise","volume":"40","author":"Powers","year":"2008","journal-title":"Med Sci Sports Exerc"},{"key":"10.1016\/j.jss.2018.11.047_bib32","doi-asserted-by":"crossref","first-page":"1899","DOI":"10.1101\/gad.13.15.1899","article-title":"BCL-2 family members and the mitochondria in apoptosis","volume":"13","author":"Gross","year":"1999","journal-title":"Genes Dev"},{"key":"10.1016\/j.jss.2018.11.047_bib33","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.devcel.2011.06.017","article-title":"Mitochondria in apoptosis: Bcl-2 family members and mitochondrial dynamics","volume":"21","author":"Martinou","year":"2011","journal-title":"Dev Cell"},{"key":"10.1016\/j.jss.2018.11.047_bib34","doi-asserted-by":"crossref","first-page":"1210","DOI":"10.1002\/hep.21604","article-title":"Met signals hepatocyte survival by preventing Fas-triggered FLIP degradation in a PI3k-Akt-dependent manner","volume":"45","author":"Moumen","year":"2007","journal-title":"Hepatology"},{"key":"10.1016\/j.jss.2018.11.047_bib35","doi-asserted-by":"crossref","first-page":"2129","DOI":"10.1038\/onc.2011.407","article-title":"Manganese superoxide dismutase is a mitochondrial fidelity protein that protects polgamma against UV-induced inactivation","volume":"31","author":"Bakthavatchalu","year":"2012","journal-title":"Oncogene"},{"key":"10.1016\/j.jss.2018.11.047_bib36","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.ab.2013.07.018","article-title":"A spectrophotometric coupled enzyme assay to measure the activity of succinate dehydrogenase","volume":"442","author":"Jones","year":"2013","journal-title":"Anal Biochem"},{"key":"10.1016\/j.jss.2018.11.047_bib37","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/j.cmet.2015.02.008","article-title":"The GABA transaminase, ABAT, is essential for mitochondrial nucleoside metabolism","volume":"21","author":"Besse","year":"2015","journal-title":"Cell Metab"},{"key":"10.1016\/j.jss.2018.11.047_bib38","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1002\/stem.573","article-title":"GABAA receptor signaling induces osmotic swelling and cell cycle activation of neonatal prominin+ precursors","volume":"29","author":"Cesetti","year":"2011","journal-title":"Stem Cells"},{"key":"10.1016\/j.jss.2018.11.047_bib39","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1172\/JCI200317970","article-title":"Stat3 protects against Fas-induced liver injury by redox-dependent and -independent mechanisms","volume":"112","author":"Haga","year":"2003","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jss.2018.11.047_bib40","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1172\/JCI19974","article-title":"Hepatoprotection via the IL-6\/Stat3 pathway","volume":"112","author":"Taub","year":"2003","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jss.2018.11.047_bib41","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1126\/science.1164551","article-title":"Function of mitochondrial Stat3 in cellular respiration","volume":"323","author":"Wegrzyn","year":"2009","journal-title":"Science"},{"key":"10.1016\/j.jss.2018.11.047_bib42","first-page":"e1158379","article-title":"IL-6\/STAT3 signaling in mice with dysfunctional type-2 ryanodine receptor","volume":"4","author":"Huang","year":"2015","journal-title":"JAKSTAT"},{"key":"10.1016\/j.jss.2018.11.047_bib43","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1038\/onc.2008.448","article-title":"The STAT3 inhibitor NSC 74859 is effective in hepatocellular cancers with disrupted TGF-beta signaling","volume":"28","author":"Lin","year":"2009","journal-title":"Oncogene"},{"key":"10.1016\/j.jss.2018.11.047_bib44","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1007\/s10545-016-9927-z","article-title":"Mitochondrial dysfunction in liver failure requiring transplantation","volume":"39","author":"Lane","year":"2016","journal-title":"J Inherit Metab Dis"},{"key":"10.1016\/j.jss.2018.11.047_bib45","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1055\/s-2007-985071","article-title":"Liver disease in mitochondrial disorders","volume":"27","author":"Lee","year":"2007","journal-title":"Semin Liver Dis"},{"key":"10.1016\/j.jss.2018.11.047_bib46","doi-asserted-by":"crossref","first-page":"1443","DOI":"10.1002\/hep.1840210531","article-title":"Rapid activation of the Stat3 transcription complex in liver regeneration","volume":"21","author":"Cressman","year":"1995","journal-title":"Hepatology"},{"key":"10.1016\/j.jss.2018.11.047_bib47","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1002\/jcp.21172","article-title":"Liver regeneration","volume":"213","author":"Michalopoulos","year":"2007","journal-title":"J Cell Physiol"},{"key":"10.1016\/j.jss.2018.11.047_bib48","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1084\/jem.189.1.63","article-title":"STAT3 is required for the gp130-mediated full activation of the c-myc gene","volume":"189","author":"Kiuchi","year":"1999","journal-title":"J Exp Med"},{"key":"10.1016\/j.jss.2018.11.047_bib49","doi-asserted-by":"crossref","first-page":"1354","DOI":"10.1002\/hep.23430","article-title":"Interplay of hepatic and myeloid signal transducer and activator of transcription 3 in facilitating liver regeneration via tempering innate immunity","volume":"51","author":"Wang","year":"2010","journal-title":"Hepatology"},{"key":"10.1016\/j.jss.2018.11.047_bib50","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1016\/j.jhep.2004.08.019","article-title":"Stat3 confers resistance against hypoxia\/reoxygenation-induced oxidative injury in hepatocytes through upregulation of Mn-SOD","volume":"41","author":"Terui","year":"2004","journal-title":"J Hepatol"},{"key":"10.1016\/j.jss.2018.11.047_bib51","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1007\/s00534-010-0304-2","article-title":"Molecular mechanisms of liver regeneration and protection for treatment of liver dysfunction and diseases","volume":"18","author":"Fujiyoshi","year":"2011","journal-title":"J Hepatobiliary Pancreat Sci"},{"key":"10.1016\/j.jss.2018.11.047_bib52","doi-asserted-by":"crossref","first-page":"30404","DOI":"10.1038\/srep30404","article-title":"Autocrine activity of BDNF induced by the STAT3 signaling pathway causes prolonged TrkB activation and promotes human non-small-cell lung cancer proliferation","volume":"6","author":"Chen","year":"2016","journal-title":"Sci Rep"},{"key":"10.1016\/j.jss.2018.11.047_bib53","doi-asserted-by":"crossref","first-page":"2","DOI":"10.2353\/ajpath.2010.090675","article-title":"Liver regeneration after partial hepatectomy: critical analysis of mechanistic dilemmas","volume":"176","author":"Michalopoulos","year":"2010","journal-title":"Am J Pathol"},{"issue":"Suppl 1","key":"10.1016\/j.jss.2018.11.047_bib54","doi-asserted-by":"crossref","first-page":"S13","DOI":"10.1002\/lt.24309","article-title":"Small for size: laboratory perspective","volume":"21","author":"Clavien","year":"2015","journal-title":"Liver Transpl"},{"key":"10.1016\/j.jss.2018.11.047_bib55","doi-asserted-by":"crossref","first-page":"35659","DOI":"10.1038\/srep35659","article-title":"Oxytocin modulates GABAAR subunits to confer neuroprotection in stroke in\u00a0vitro","volume":"6","author":"Kaneko","year":"2016","journal-title":"Sci Rep"},{"key":"10.1016\/j.jss.2018.11.047_bib56","doi-asserted-by":"crossref","first-page":"536","DOI":"10.7150\/ijbs.7.536","article-title":"Signal transducer and activator of transcription 3 in liver diseases: a novel therapeutic target","volume":"7","author":"Wang","year":"2011","journal-title":"Int J Biol Sci"},{"key":"10.1016\/j.jss.2018.11.047_bib57","doi-asserted-by":"crossref","first-page":"260","DOI":"10.3389\/fphar.2015.00260","article-title":"Study of GABA in healthy volunteers: pharmacokinetics and pharmacodynamics","volume":"6","author":"Li","year":"2015","journal-title":"Front Pharmacol"},{"key":"10.1016\/j.jss.2018.11.047_bib58","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1002\/lt.23693","article-title":"Endogenous signal transducer and activator of transcription 3 is required for the protection of hepatocytes against warm ischemia\/reperfusion injury","volume":"19","author":"Lou","year":"2013","journal-title":"Liver Transpl"},{"key":"10.1016\/j.jss.2018.11.047_bib59","doi-asserted-by":"crossref","first-page":"e0134874","DOI":"10.1371\/journal.pone.0134874","article-title":"Factors associated with mortality and graft failure in liver transplants: a hierarchical approach","volume":"10","author":"Haddad","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.jss.2018.11.047_bib60","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1111\/j.1600-6143.2006.01242.x","article-title":"Characteristics associated with liver graft failure: the concept of a donor risk index","volume":"6","author":"Feng","year":"2006","journal-title":"Am J Transpl"},{"key":"10.1016\/j.jss.2018.11.047_bib61","first-page":"127","article-title":"A decade of liver transplantation at Mayo Clinic in Florida","author":"Nguyen","year":"2008","journal-title":"Clin Transpl"},{"key":"10.1016\/j.jss.2018.11.047_bib62","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1002\/lt.23684","article-title":"Decadal analysis of deceased organ donation in Spain and the United States linking an increased donation rate and the utilization of older donors","volume":"19","author":"Halldorson","year":"2013","journal-title":"Liver Transpl"},{"key":"10.1016\/j.jss.2018.11.047_bib63","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1097\/TP.0000000000000806","article-title":"Use of elderly allografts in liver transplantation","volume":"100","author":"Paterno","year":"2016","journal-title":"Transplantation"},{"key":"10.1016\/j.jss.2018.11.047_bib64","doi-asserted-by":"crossref","first-page":"1188","DOI":"10.1038\/gt.2013.53","article-title":"Liver-directed adeno-associated virus serotype 8 gene transfer rescues a lethal murine model of citrullinemia type 1","volume":"20","author":"Chandler","year":"2013","journal-title":"Gene Ther"},{"key":"10.1016\/j.jss.2018.11.047_bib65","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1038\/labinvest.3700630","article-title":"Role of STAT3 in liver regeneration: survival, DNA synthesis, inflammatory reaction and liver mass recovery","volume":"87","author":"Moh","year":"2007","journal-title":"Lab Invest"},{"key":"10.1016\/j.jss.2018.11.047_bib66","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1002\/hep.24469","article-title":"Canonical notch pathway protects hepatocytes from ischemia\/reperfusion injury in mice by repressing reactive oxygen species production through JAK2\/STAT3 signaling","volume":"54","author":"Yu","year":"2011","journal-title":"Hepatology"}],"container-title":["Journal of Surgical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022480418308424?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022480418308424?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,11,17]],"date-time":"2020-11-17T19:50:54Z","timestamp":1605642654000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022480418308424"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,4]]},"references-count":66,"alternative-id":["S0022480418308424"],"URL":"https:\/\/doi.org\/10.1016\/j.jss.2018.11.047","relation":{},"ISSN":["0022-4804"],"issn-type":[{"value":"0022-4804","type":"print"}],"subject":[],"published":{"date-parts":[[2019,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"GABA, \u03b3-Aminobutyric Acid, Protects Against Severe Liver Injury","name":"articletitle","label":"Article Title"},{"value":"Journal of Surgical Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jss.2018.11.047","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}