{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T14:22:04Z","timestamp":1778768524241,"version":"3.51.4"},"reference-count":21,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,9,1]],"date-time":"2019-09-01T00:00:00Z","timestamp":1567296000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","journalofsurgicalresearch.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Surgical Research"],"published-print":{"date-parts":[[2019,9]]},"DOI":"10.1016\/j.jss.2019.03.034","type":"journal-article","created":{"date-parts":[[2019,4,28]],"date-time":"2019-04-28T09:55:06Z","timestamp":1556445306000},"page":"254-263","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"special_numbering":"C","title":["The Role of Phospho-c-Jun N-Terminal Kinase Expression on hepatocyte Necrosis and Autophagy in the Cholestatic Liver"],"prefix":"10.1016","volume":"241","author":[{"given":"Bong Jun","family":"Kwak","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ho Joong","family":"Choi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ok-Hee","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kee-Hwan","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Young Kyoung","family":"You","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tae Yoon","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph","family":"Ahn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Say-June","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jss.2019.03.034_bib1","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/j.dld.2010.03.015","article-title":"Bile salts and cholestasis","volume":"42","author":"Maillette de Buy Wenniger","year":"2010","journal-title":"Dig Liver Dis"},{"key":"10.1016\/j.jss.2019.03.034_bib2","doi-asserted-by":"crossref","first-page":"1541","DOI":"10.1016\/j.bbrc.2017.11.202","article-title":"Impaired autophagy promotes bile acid-induced hepatic injury and accumulation of ubiquitinated proteins","volume":"495","author":"Kim","year":"2018","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.jss.2019.03.034_bib3","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1093\/toxsci\/kft246","article-title":"Suppression of autophagic flux by bile acids in hepatocytes","volume":"137","author":"Manley","year":"2014","journal-title":"Toxicol Sci"},{"key":"10.1016\/j.jss.2019.03.034_bib4","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1186\/2045-3701-4-47","article-title":"Activation of autophagy protects against cholestasis-induced hepatic injury","volume":"4","author":"Gao","year":"2014","journal-title":"Cell Biosci"},{"key":"10.1016\/j.jss.2019.03.034_bib5","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1111\/j.1440-1711.2006.01454.x","article-title":"Insulin-like growth factor-1 and TNF-alpha regulate autophagy through c-jun N-terminal kinase and Akt pathways in human atherosclerotic vascular smooth cells","volume":"84","author":"Jia","year":"2006","journal-title":"Immunol Cell Biol"},{"key":"10.1016\/j.jss.2019.03.034_bib6","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/S0092-8674(00)00116-1","article-title":"Signal transduction by the JNK group of MAP kinases","volume":"103","author":"Davis","year":"2000","journal-title":"Cell"},{"key":"10.1016\/j.jss.2019.03.034_bib7","first-page":"F85","article-title":"Regulation and function of the JNK subgroup of MAP kinases","volume":"1333","author":"Minden","year":"1997","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.jss.2019.03.034_bib8","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1179\/135100001101536085","article-title":"Signalling apoptosis: a radical approach","volume":"6","author":"Carmody","year":"2001","journal-title":"Redox Rep"},{"key":"10.1016\/j.jss.2019.03.034_bib9","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/S0891-5849(00)00302-6","article-title":"Triggering and modulation of apoptosis by oxidative stress","volume":"29","author":"Chandra","year":"2000","journal-title":"Free Radic Biol Med"},{"key":"10.1016\/j.jss.2019.03.034_bib10","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1152\/physrev.00018.2001","article-title":"Free radicals in the physiological control of cell function","volume":"82","author":"Droge","year":"2002","journal-title":"Physiol Rev"},{"key":"10.1016\/j.jss.2019.03.034_bib11","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1016\/j.freeradbiomed.2005.10.056","article-title":"JNK signaling pathway is a key modulator in cell death mediated by reactive oxygen and nitrogen species","volume":"40","author":"Shen","year":"2006","journal-title":"Free Radic Biol Med"},{"key":"10.1016\/j.jss.2019.03.034_bib12","doi-asserted-by":"crossref","first-page":"5914","DOI":"10.1128\/MCB.24.13.5914-5922.2004","article-title":"Essential roles of receptor-interacting protein and TRAF2 in oxidative stress-induced cell death","volume":"24","author":"Shen","year":"2004","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.jss.2019.03.034_bib13","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1177\/0023677214567748","article-title":"Induction of experimental obstructive cholestasis in mice","volume":"49","author":"Tag","year":"2015","journal-title":"Lab Anim"},{"key":"10.1016\/j.jss.2019.03.034_bib14","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1038\/labinvest.2016.128","article-title":"Automated evaluation of liver fibrosis in thioacetamide, carbon tetrachloride, and bile duct ligation rodent models using second-harmonic generation\/two-photon excited fluorescence microscopy","volume":"97","author":"Liu","year":"2017","journal-title":"Lab Invest"},{"key":"10.1016\/j.jss.2019.03.034_bib15","doi-asserted-by":"crossref","first-page":"19445","DOI":"10.1038\/srep19445","article-title":"Adiponectin-derived active peptide ADP355 exerts anti-inflammatory and anti-fibrotic activities in thioacetamide-induced liver injury","volume":"6","author":"Wang","year":"2016","journal-title":"Sci Rep"},{"key":"10.1016\/j.jss.2019.03.034_bib16","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1080\/08916930701356978","article-title":"HMGB1: a signal of necrosis","volume":"40","author":"Raucci","year":"2007","journal-title":"Autoimmunity"},{"key":"10.1016\/j.jss.2019.03.034_bib17","doi-asserted-by":"crossref","first-page":"869390","DOI":"10.1155\/2014\/869390","article-title":"Autophagy: a multifaceted partner in liver fibrosis","volume":"2014","author":"Mallat","year":"2014","journal-title":"Biomed Res Int"},{"key":"10.1016\/j.jss.2019.03.034_bib18","doi-asserted-by":"crossref","first-page":"1623","DOI":"10.1111\/apt.14678","article-title":"Review article: therapeutic bile acids and the risks for\u00a0hepatotoxicity","volume":"47","author":"Ashby","year":"2018","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1016\/j.jss.2019.03.034_bib19","doi-asserted-by":"crossref","first-page":"2905","DOI":"10.1101\/gad.1223004","article-title":"JNK potentiates TNF-stimulated necrosis by increasing the production of cytotoxic reactive oxygen species","volume":"18","author":"Ventura","year":"2004","journal-title":"Genes Dev"},{"key":"10.1016\/j.jss.2019.03.034_bib20","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1007\/s00005-012-0205-y","article-title":"Autophagy, apoptosis, mitoptosis and necrosis: interdependence between those pathways and effects on cancer","volume":"61","author":"Chaabane","year":"2013","journal-title":"Arch Immunol Ther Exp (Warsz)"},{"key":"10.1016\/j.jss.2019.03.034_bib21","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1093\/embo-reports\/kve046","article-title":"ASK1 is required for sustained activations of JNK\/p38 MAP kinases and apoptosis","volume":"2","author":"Tobiume","year":"2001","journal-title":"Embo Rep"}],"container-title":["Journal of Surgical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022480419301507?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022480419301507?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,6,29]],"date-time":"2019-06-29T02:28:09Z","timestamp":1561775289000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022480419301507"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9]]},"references-count":21,"alternative-id":["S0022480419301507"],"URL":"https:\/\/doi.org\/10.1016\/j.jss.2019.03.034","relation":{},"ISSN":["0022-4804"],"issn-type":[{"value":"0022-4804","type":"print"}],"subject":[],"published":{"date-parts":[[2019,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The Role of Phospho-c-Jun N-Terminal Kinase Expression on hepatocyte Necrosis and Autophagy in the Cholestatic Liver","name":"articletitle","label":"Article Title"},{"value":"Journal of Surgical Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jss.2019.03.034","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}