{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T12:52:04Z","timestamp":1789044724795,"version":"build-2803163510"},"reference-count":53,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,12,1]],"date-time":"2019-12-01T00:00:00Z","timestamp":1575158400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,12,1]],"date-time":"2019-12-01T00:00:00Z","timestamp":1575158400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","journalofsurgicalresearch.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Surgical Research"],"published-print":{"date-parts":[[2019,12]]},"DOI":"10.1016\/j.jss.2019.06.006","type":"journal-article","created":{"date-parts":[[2019,7,11]],"date-time":"2019-07-11T11:39:48Z","timestamp":1562845188000},"page":"312-323","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":30,"special_numbering":"C","title":["Reactive Oxygen Species Scavenging Potential Contributes to Hypertrophic Scar Formation"],"prefix":"10.1016","volume":"244","author":[{"given":"Bonnie C.","family":"Carney","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason H.","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rhett A.","family":"Kent","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maha","family":"Rummani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdulnaser","family":"Alkhalil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren T.","family":"Moffatt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dean S.","family":"Rosenthal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey W.","family":"Shupp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jss.2019.06.006_bib1","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1046\/j.1524-4725.1999.98257.x","article-title":"Keloids and hypertrophic scars","volume":"25","author":"English","year":"1999","journal-title":"Dermatol Surg"},{"key":"10.1016\/j.jss.2019.06.006_bib2","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1007\/s12079-013-0195-5","article-title":"The molecular mechanism of hypertrophic scar","volume":"7","author":"Zhu","year":"2013","journal-title":"J Cell Commun Signal"},{"key":"10.1016\/j.jss.2019.06.006_bib3","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1159\/000339613","article-title":"Wound repair and regeneration","volume":"49","author":"Reinke","year":"2012","journal-title":"Eur Surg Res"},{"key":"10.1016\/j.jss.2019.06.006_bib4","doi-asserted-by":"crossref","first-page":"3029","DOI":"10.1021\/acs.chemrev.5b00407","article-title":"Superoxide ion: generation and chemical implications","volume":"116","author":"Hayyan","year":"2016","journal-title":"Chem Rev"},{"key":"10.1016\/j.jss.2019.06.006_bib5","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1146\/annurev.pa.23.040183.001323","article-title":"Superoxide radical: an endogenous toxicant","volume":"23","author":"Fridovich","year":"1983","journal-title":"Annu Rev Pharmacol Toxicol"},{"key":"10.1016\/j.jss.2019.06.006_bib6","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.biocel.2006.07.001","article-title":"Free radicals and antioxidants in normal physiological functions and human disease","volume":"39","author":"Valko","year":"2007","journal-title":"Int J Biochem Cell Biol"},{"key":"10.1016\/j.jss.2019.06.006_bib7","doi-asserted-by":"crossref","first-page":"6049","DOI":"10.1016\/S0021-9258(18)63504-5","article-title":"Superoxide dismutase. An enzymic function for erythrocuprein (hemocuprein)","volume":"244","author":"McCord","year":"1969","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jss.2019.06.006_bib8","doi-asserted-by":"crossref","first-page":"1531","DOI":"10.1161\/CIRCULATIONAHA.105.605519","article-title":"Nitroso-redox interactions in the cardiovascular system","volume":"114","author":"Zimmet","year":"2006","journal-title":"Circulation"},{"key":"10.1016\/j.jss.2019.06.006_bib9","doi-asserted-by":"crossref","first-page":"5753","DOI":"10.1016\/S0021-9258(18)91929-0","article-title":"The reduction of cytochrome c by milk xanthine oxidase","volume":"243","author":"McCord","year":"1968","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jss.2019.06.006_bib10","doi-asserted-by":"crossref","first-page":"107","DOI":"10.3109\/14764172.2012.758380","article-title":"Skin and antioxidants","volume":"15","author":"Poljsak","year":"2013","journal-title":"J Cosmet Laser Ther"},{"key":"10.1016\/j.jss.2019.06.006_bib11","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1177\/1534735413490235","article-title":"The use of antioxidants in radiotherapy-induced skin toxicity","volume":"13","author":"Amber","year":"2014","journal-title":"Integr Cancer Ther"},{"key":"10.1016\/j.jss.2019.06.006_bib12","doi-asserted-by":"crossref","first-page":"2484","DOI":"10.1161\/01.CIR.0000137969.87365.05","article-title":"Gene therapy of endothelial nitric oxide synthase and manganese superoxide dismutase restores delayed wound healing in type 1 diabetic mice","volume":"110","author":"Luo","year":"2004","journal-title":"Circulation"},{"key":"10.1016\/j.jss.2019.06.006_bib13","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.2353\/ajpath.2006.060119","article-title":"Peroxiredoxin 6 is a potent cytoprotective enzyme in the epidermis","volume":"169","author":"Kumin","year":"2006","journal-title":"Am J Pathol"},{"key":"10.1016\/j.jss.2019.06.006_bib14","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1097\/BCR.0000000000000413","article-title":"Elastin is differentially regulated by pressure therapy in a porcine model of hypertrophic scar","volume":"38","author":"Carney","year":"2017","journal-title":"J Burn Care Res"},{"key":"10.1016\/j.jss.2019.06.006_bib15","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.jss.2015.10.040","article-title":"Compression therapy affects collagen type balance in hypertrophic scar","volume":"201","author":"Tejiram","year":"2016","journal-title":"J Surg Res"},{"key":"10.1016\/j.jss.2019.06.006_bib16","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1097\/BCR.0000000000000154","article-title":"A multimodal assessment of melanin and melanocyte activity in abnormally pigmented hypertrophic scar","volume":"36","author":"Travis","year":"2015","journal-title":"J Burn Care Res"},{"key":"10.1016\/j.jss.2019.06.006_bib17","first-page":"e29","article-title":"A translational animal model for scar compression therapy using an automated pressure delivery system","volume":"15","author":"Alkhalil","year":"2015","journal-title":"Eplasty"},{"key":"10.1016\/j.jss.2019.06.006_bib18","doi-asserted-by":"crossref","first-page":"5747","DOI":"10.1210\/en.2008-0355","article-title":"Sex dimorphism in wound healing: the roles of sex steroids and macrophage migration inhibitory factor","volume":"149","author":"Gilliver","year":"2008","journal-title":"Endocrinology"},{"key":"10.1016\/j.jss.2019.06.006_bib19","doi-asserted-by":"crossref","first-page":"e125","DOI":"10.1097\/BCR.0000000000000097","article-title":"Biphasic presence of fibrocytes in a porcine hypertrophic scar model","volume":"36","author":"Travis","year":"2015","journal-title":"J Burn Care Res"},{"key":"10.1016\/j.jss.2019.06.006_bib20","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1038\/laban.164","article-title":"A fitted neoprene garment to cover dressings in swine models","volume":"42","author":"Mino","year":"2012","journal-title":"Lab Anim (NY)"},{"key":"10.1016\/j.jss.2019.06.006_bib21","doi-asserted-by":"crossref","first-page":"1245049","DOI":"10.1155\/2016\/1245049","article-title":"Role of ROS and RNS sources in physiological and pathological conditions","volume":"2016","author":"Di Meo","year":"2016","journal-title":"Oxid Med Cell Longev"},{"key":"10.1016\/j.jss.2019.06.006_bib22","doi-asserted-by":"crossref","first-page":"e39","DOI":"10.1161\/RES.0000000000000110","article-title":"Measurement of reactive oxygen species, reactive nitrogen species, and redox-dependent signaling in the cardiovascular system: a scientific statement from the American Heart Association","volume":"119","author":"Griendling","year":"2016","journal-title":"Circ Res"},{"key":"10.1016\/j.jss.2019.06.006_bib23","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1093\/jbcr\/iry045","article-title":"Pigmentation diathesis of hypertrophic scar: an examination of known signaling pathways to elucidate the molecular pathophysiology of injury-related dyschromia","volume":"40","author":"Carney","year":"2019","journal-title":"J Burn Care Res"},{"key":"10.1016\/j.jss.2019.06.006_bib24","doi-asserted-by":"crossref","first-page":"e90425","DOI":"10.1371\/journal.pone.0090425","article-title":"Transcriptomic analysis of the effects of a fish oil enriched diet on murine brains","volume":"9","author":"Hammamieh","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.jss.2019.06.006_bib25","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1086\/685547","article-title":"Reactive oxygen species-associated molecular signature predicts survival in patients with sepsis","volume":"6","author":"Bime","year":"2016","journal-title":"Pulm Circ"},{"key":"10.1016\/j.jss.2019.06.006_bib26","first-page":"e45","article-title":"Reduction of a multidrug-resistant pathogen and associated virulence factors in a burn wound infection model: further understanding of the effectiveness of a hydroconductive dressing","volume":"14","author":"Carney","year":"2014","journal-title":"Eplasty"},{"key":"10.1016\/j.jss.2019.06.006_bib27","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1097\/BCR.0b013e3181667557","article-title":"Is there an ideal animal model to study hypertrophic scarring?","volume":"29","author":"Ramos","year":"2008","journal-title":"J Burn Care Res"},{"key":"10.1016\/j.jss.2019.06.006_bib28","doi-asserted-by":"crossref","first-page":"e259","DOI":"10.1097\/BCR.0000000000000167","article-title":"Advances in research in animal models of burn-related hypertrophic scarring","volume":"36","author":"Domergue","year":"2015","journal-title":"J Burn Care Res"},{"key":"10.1016\/j.jss.2019.06.006_bib29","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1097\/BCR.0000000000000548","article-title":"Scar management following burn injury","volume":"38","author":"Tredget","year":"2017","journal-title":"J Burn Care Res"},{"key":"10.1016\/j.jss.2019.06.006_bib30","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1097\/00005373-199001000-00010","article-title":"Systemic lipid peroxidation and inflammation induced by thermal injury persists into the post-resuscitation period","volume":"30","author":"Demling","year":"1990","journal-title":"J Trauma"},{"key":"10.1016\/j.jss.2019.06.006_bib31","first-page":"85","article-title":"Early postburn lipid peroxidation: effect of ibuprofen and allopurinol","volume":"107","author":"Demling","year":"1990","journal-title":"Surgery"},{"key":"10.1016\/j.jss.2019.06.006_bib32","first-page":"6","article-title":"Burns, endothelial dysfunction, and oxidative stress: the role of antioxidants","volume":"22","author":"Sahib","year":"2009","journal-title":"Ann Burns Fire Disasters"},{"key":"10.1016\/j.jss.2019.06.006_bib33","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1096\/fj.11-192484","article-title":"Down-regulation of glutatione S-transferase alpha 4 (hGSTA4) in the muscle of thermally injured patients is indicative of susceptibility to bacterial infection","volume":"26","author":"Apidianakis","year":"2012","journal-title":"FASEB J"},{"key":"10.1016\/j.jss.2019.06.006_bib34","doi-asserted-by":"crossref","first-page":"R153","DOI":"10.1186\/cc5084","article-title":"Reduction of nosocomial pneumonia after major burns by trace element supplementation: aggregation of two randomised trials","volume":"10","author":"Berger","year":"2006","journal-title":"Crit Care"},{"key":"10.1016\/j.jss.2019.06.006_bib35","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/j.saa.2017.05.055","article-title":"The role of topically applied l-ascorbic acid in ex-vivo examination of burn-injured human skin","volume":"185","author":"Pielesz","year":"2017","journal-title":"Spectrochim Acta A Mol Biomol Spectrosc"},{"key":"10.1016\/j.jss.2019.06.006_bib36","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1093\/ajcn\/85.5.1301","article-title":"Trace element supplementation after major burns increases burned skin trace element concentrations and modulates local protein metabolism but not whole-body substrate metabolism","volume":"85","author":"Berger","year":"2007","journal-title":"Am J Clin Nutr"},{"key":"10.1016\/j.jss.2019.06.006_bib37","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1093\/ajcn\/68.2.365","article-title":"Trace element supplementation modulates pulmonary infection rates after major burns: a double-blind, placebo-controlled trial","volume":"68","author":"Berger","year":"1998","journal-title":"Am J Clin Nutr"},{"key":"10.1016\/j.jss.2019.06.006_bib38","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1097\/BCR.0b013e3181b487a8","article-title":"Supplementation of vitamin E, vitamin C, and zinc attenuates oxidative stress in burned children: a randomized, double-blind, placebo-controlled pilot study","volume":"30","author":"Barbosa","year":"2009","journal-title":"J Burn Care Res"},{"key":"10.1016\/j.jss.2019.06.006_bib39","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1097\/SHK.0b013e3182758759","article-title":"gamma-tocopherol nebulization decreases oxidative stress, arginase activity, and collagen deposition after burn and smoke inhalation in the ovine model","volume":"38","author":"Yamamoto","year":"2012","journal-title":"Shock"},{"key":"10.1016\/j.jss.2019.06.006_bib40","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1097\/SHK.0b013e3182459482","article-title":"Nebulization with gamma-tocopherol ameliorates acute lung injury after burn and smoke inhalation in the ovine model","volume":"37","author":"Yamamoto","year":"2012","journal-title":"Shock"},{"key":"10.1016\/j.jss.2019.06.006_bib41","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1097\/00004630-199209000-00009","article-title":"Effects of high-dose vitamin C administration on postburn microvascular fluid and protein flux","volume":"13","author":"Matsuda","year":"1992","journal-title":"J Burn Care Rehabil"},{"key":"10.1016\/j.jss.2019.06.006_bib42","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1097\/00004630-199111000-00007","article-title":"Reduced fluid volume requirement for resuscitation of third-degree burns with high-dose vitamin C","volume":"12","author":"Matsuda","year":"1991","journal-title":"J Burn Care Rehabil"},{"key":"10.1016\/j.jss.2019.06.006_bib43","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1097\/00004630-199311000-00007","article-title":"The effects of high-dose vitamin C therapy on postburn lipid peroxidation","volume":"14","author":"Matsuda","year":"1993","journal-title":"J Burn Care Rehabil"},{"key":"10.1016\/j.jss.2019.06.006_bib44","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1097\/BCR.0b013e318204b336","article-title":"Resuscitation after severe burn injury using high-dose ascorbic acid: a retrospective review","volume":"32","author":"Kahn","year":"2011","journal-title":"J Burn Care Res"},{"key":"10.1016\/j.jss.2019.06.006_bib45","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1097\/BCR.0b013e3181e4d6ee","article-title":"Burn resuscitation index: a simple method for calculating fluid resuscitation in the burn patient","volume":"31","author":"Kahn","year":"2010","journal-title":"J Burn Care Res"},{"key":"10.1016\/j.jss.2019.06.006_bib46","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1016\/j.ccc.2016.06.003","article-title":"Vitamin C in burn resuscitation","volume":"32","author":"Rizzo","year":"2016","journal-title":"Crit Care Clin"},{"key":"10.1016\/j.jss.2019.06.006_bib47","first-page":"1","article-title":"Antioxidant and trace element supplementation reduce the inflammatory response in Critically Ill burn patients","volume":"39","author":"Rehou","year":"2018","journal-title":"J Burn Care Res"},{"key":"10.1016\/j.jss.2019.06.006_bib48","first-page":"199","article-title":"Effect of antioxidants on the incidence of wound infection in burn patients","volume":"23","author":"Sahib","year":"2010","journal-title":"Ann Burns Fire Disasters"},{"key":"10.1016\/j.jss.2019.06.006_bib49","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1111\/j.1067-1927.2005.00065.x","article-title":"Oxidative stress in chronic venous leg ulcers","volume":"13","author":"Wlaschek","year":"2005","journal-title":"Wound Repair Regen"},{"key":"10.1016\/j.jss.2019.06.006_bib50","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1007\/978-1-4939-2522-3_7","article-title":"Detecting reactive oxygen species by immunohistochemistry","volume":"1292","author":"Liou","year":"2015","journal-title":"Methods Mol Biol"},{"issue":"Suppl 1","key":"10.1016\/j.jss.2019.06.006_bib51","first-page":"S32","article-title":"Review of the female Duroc\/Yorkshire pig model of human fibroproliferative scarring","volume":"15","author":"Zhu","year":"2007","journal-title":"Wound Repair Regen"},{"key":"10.1016\/j.jss.2019.06.006_bib52","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1111\/wrr.12562","article-title":"Scar formation following excisional and burn injuries in a red Duroc pig model","volume":"25","author":"Blackstone","year":"2017","journal-title":"Wound Repair Regen"},{"key":"10.1016\/j.jss.2019.06.006_bib53","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1097\/BCR.0b013e3182839aca","article-title":"Donor site healing dynamics: molecular, histological, and noninvasive imaging assessment in a porcine model","volume":"34","author":"Mauskar","year":"2013","journal-title":"J Burn Care Res"}],"container-title":["Journal of Surgical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022480419303932?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022480419303932?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T14:47:08Z","timestamp":1758379628000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022480419303932"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,12]]},"references-count":53,"alternative-id":["S0022480419303932"],"URL":"https:\/\/doi.org\/10.1016\/j.jss.2019.06.006","relation":{},"ISSN":["0022-4804"],"issn-type":[{"value":"0022-4804","type":"print"}],"subject":[],"published":{"date-parts":[[2019,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Reactive Oxygen Species Scavenging Potential Contributes to Hypertrophic Scar Formation","name":"articletitle","label":"Article Title"},{"value":"Journal of Surgical Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jss.2019.06.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}