{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T11:16:57Z","timestamp":1788779817905,"version":"build-2803163510"},"reference-count":31,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,12,1]],"date-time":"2019-12-01T00:00:00Z","timestamp":1575158400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,12,1]],"date-time":"2019-12-01T00:00:00Z","timestamp":1575158400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","journalofsurgicalresearch.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Surgical Research"],"published-print":{"date-parts":[[2019,12]]},"DOI":"10.1016\/j.jss.2019.06.023","type":"journal-article","created":{"date-parts":[[2019,7,3]],"date-time":"2019-07-03T17:56:41Z","timestamp":1562176601000},"page":"63-68","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":26,"special_numbering":"C","title":["UCH-L1 is a Poor Serum Biomarker of Murine Traumatic Brain Injury After Polytrauma"],"prefix":"10.1016","volume":"244","author":[{"given":"Mackenzie C.","family":"Morris","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aron","family":"Bercz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grace M.","family":"Niziolek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farzaan","family":"Kassam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rose","family":"Veile","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lou Ann","family":"Friend","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy A.","family":"Pritts","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy T.","family":"Makley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael D.","family":"Goodman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jss.2019.06.023_bib2","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1089\/neu.2008.0586","article-title":"Classification of traumatic brain injury for targeted therapies","volume":"25","author":"Saatman","year":"2008","journal-title":"J Neurotrauma"},{"key":"10.1016\/j.jss.2019.06.023_bib3","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/S0140-6736(78)90415-4","article-title":"Serum-myelin-basic-protein assay in diagnosis and prognosis of patients with head injury","volume":"1","author":"Thomas","year":"1978","journal-title":"Lancet"},{"key":"10.1016\/j.jss.2019.06.023_bib4","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/0090-3019(95)80012-6","article-title":"Diagnostic significance of serum neuron-specific enolase and myelin basic protein assay in patients with acute head injury","volume":"43","author":"Yamazaki","year":"1995","journal-title":"Surg Neurol"},{"key":"10.1016\/j.jss.2019.06.023_bib5","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/j.jemermed.2007.11.032","article-title":"The prognostic value of neuron-specific enolase in head trauma patients","volume":"38","author":"Meric","year":"2010","journal-title":"J Emerg Med"},{"key":"10.1016\/j.jss.2019.06.023_bib6","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1080\/02688699647104","article-title":"Neuron-specific enolase as an aid to outcome prediction in head injury","volume":"10","author":"Ross","year":"1996","journal-title":"Br J Neurosurg"},{"key":"10.1016\/j.jss.2019.06.023_bib7","doi-asserted-by":"crossref","first-page":"76","DOI":"10.3109\/02699052.2011.635360","article-title":"Accuracy of the S100beta protein as a marker of brain damage in traumatic brain injury","volume":"26","author":"Egea-Guerrero","year":"2012","journal-title":"Brain Inj"},{"key":"10.1016\/j.jss.2019.06.023_bib8","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/j.resuscitation.2008.11.021","article-title":"Predicting outcome after severe traumatic brain injury using the serum S100B biomarker: results using a single (24h) time-point","volume":"80","author":"Rainey","year":"2009","journal-title":"Resuscitation"},{"key":"10.1016\/j.jss.2019.06.023_bib9","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1097\/01.TA.0000096644.08735.72","article-title":"Effects of head and extracranial injuries on serum protein S100B levels in trauma patients","volume":"56","author":"Savola","year":"2004","journal-title":"J Trauma"},{"key":"10.1016\/j.jss.2019.06.023_bib10","doi-asserted-by":"crossref","first-page":"1428","DOI":"10.1212\/WNL.0b013e318253d5c7","article-title":"GFAP and S100B in the acute phase of mild traumatic brain injury","volume":"78","author":"Metting","year":"2012","journal-title":"Neurology"},{"key":"10.1016\/j.jss.2019.06.023_bib11","doi-asserted-by":"crossref","first-page":"1786","DOI":"10.1212\/WNL.0b013e3181fd62d2","article-title":"GFAP and S100B are biomarkers of traumatic brain injury: an observational cohort study","volume":"75","author":"Vos","year":"2010","journal-title":"Neurology"},{"key":"10.1016\/j.jss.2019.06.023_bib12","first-page":"91","article-title":"The immunolocalization of protein gene product 9.5 using rabbit polyclonal and mouse monoclonal antibodies","volume":"69","author":"Wilson","year":"1988","journal-title":"Br J Exp Pathol"},{"key":"10.1016\/j.jss.2019.06.023_bib13","doi-asserted-by":"crossref","first-page":"13256","DOI":"10.1074\/jbc.M314124200","article-title":"Oxidative modifications and down-regulation of ubiquitin carboxyl-terminal hydrolase L1 associated with idiopathic Parkinson's and Alzheimer's diseases","volume":"279","author":"Choi","year":"2004","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jss.2019.06.023_bib14","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1089\/neu.2015.3873","article-title":"Acute Temporal Profiles of serum levels of UCH-L1 and GFAP and Relationships to neuronal and Astroglial Pathology following traumatic brain injury in rats","volume":"32","author":"Huang","year":"2015","journal-title":"J Neurotrauma"},{"key":"10.1016\/j.jss.2019.06.023_bib15","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1001\/jamaneurol.2016.0039","article-title":"Time Course and diagnostic accuracy of glial and neuronal blood biomarkers GFAP and UCH-L1 in a large cohort of trauma patients with and without mild traumatic brain injury","volume":"73","author":"Papa","year":"2016","journal-title":"JAMA Neurol"},{"key":"10.1016\/j.jss.2019.06.023_bib16","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1089\/neu.2013.3040","article-title":"Acute biomarkers of traumatic brain injury: relationship between plasma levels of ubiquitin C-terminal hydrolase-L1 and glial fibrillary acidic protein","volume":"31","author":"Diaz-Arrastia","year":"2014","journal-title":"J Neurotrauma"},{"key":"10.1016\/j.jss.2019.06.023_bib17","first-page":"666","article-title":"Clinical utility of serum levels of ubiquitin C-terminal hydrolase as a biomarker for severe traumatic brain injury","volume":"70","author":"Mondello","year":"2012","journal-title":"Neurosurgery"},{"key":"10.1016\/j.jss.2019.06.023_bib18","doi-asserted-by":"crossref","first-page":"1427","DOI":"10.1089\/neu.2016.4442","article-title":"Glial fibrillary acidic protein and ubiquitin C-terminal hydrolase-L1 are not specific biomarkers for mild CT-negative traumatic brain injury","volume":"34","author":"Posti","year":"2017","journal-title":"J Neurotrauma"},{"key":"10.1016\/j.jss.2019.06.023_bib19","doi-asserted-by":"crossref","first-page":"641","DOI":"10.2174\/1570159X14666160309123554","article-title":"Neuroprotection by estrogen and progesterone in traumatic brain injury and spinal cord injury","volume":"14","author":"Brotfain","year":"2016","journal-title":"Curr Neuropharmacol"},{"key":"10.1016\/j.jss.2019.06.023_bib20","doi-asserted-by":"crossref","first-page":"1328","DOI":"10.1038\/nprot.2009.148","article-title":"Mouse closed head injury model induced by a weight-drop device","volume":"4","author":"Flierl","year":"2009","journal-title":"Nat Protoc"},{"key":"10.1016\/j.jss.2019.06.023_bib21","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1016\/j.jss.2013.03.075","article-title":"A murine model of mild traumatic brain injury exhibiting cognitive and motor deficits","volume":"184","author":"Yang","year":"2013","journal-title":"J Surg Res"},{"key":"10.1016\/j.jss.2019.06.023_bib22","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1097\/SHK.0000000000001056","article-title":"Platelet function changes in a time-dependent manner following traumatic brain injury in a murine model","volume":"50","author":"Martin","year":"2017","journal-title":"Shock"},{"key":"10.1016\/j.jss.2019.06.023_bib23","doi-asserted-by":"crossref","first-page":"H1468","DOI":"10.1152\/ajpheart.00006.2016","article-title":"Plasma syndecan-1 and heparan sulfate correlate with microvascular glycocalyx degradation in hemorrhaged rats after different resuscitation fluids","volume":"310","author":"Torres Filho","year":"2016","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"10.1016\/j.jss.2019.06.023_bib24","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/02699052.2017.1382717","article-title":"The diagnostic values of UCH-L1 in traumatic brain injury: a meta-analysis","volume":"32","author":"Shahjouei","year":"2018","journal-title":"Brain Inj"},{"key":"10.1016\/j.jss.2019.06.023_bib25","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1097\/SLA.0b013e318226113d","article-title":"A high admission syndecan-1 level, a marker of endothelial glycocalyx degradation, is associated with inflammation, protein C depletion, fibrinolysis, and increased mortality in trauma patients","volume":"254","author":"Johansson","year":"2011","journal-title":"Ann Surg"},{"key":"10.1016\/j.jss.2019.06.023_bib26","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.jcrc.2016.06.027","article-title":"Plasma syndecan-1 levels identify a cohort of patients with severe sepsis at high risk for intubation after large-volume intravenous fluid resuscitation","volume":"36","author":"Puskarich","year":"2016","journal-title":"J Crit Care"},{"key":"10.1016\/j.jss.2019.06.023_bib27","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/10409230590918577","article-title":"Relating structure to mechanism in creatine kinase","volume":"40","author":"McLeish","year":"2005","journal-title":"Crit Rev Biochem Mol Biol"},{"key":"10.1016\/j.jss.2019.06.023_bib28","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1097\/TA.0b013e31827a0a36","article-title":"Serum creatine kinase levels are associated with extremity compartment syndrome","volume":"74","author":"Valdez","year":"2013","journal-title":"J Trauma Acute Care Surg"},{"key":"10.1016\/j.jss.2019.06.023_bib29","first-page":"104","article-title":"Serum glial fibrillary acidic protein is a highly specific biomarker for traumatic brain injury in humans compared with S-100B and neuron-specific enolase","volume":"69","author":"Honda","year":"2010","journal-title":"J Trauma"},{"key":"10.1016\/j.jss.2019.06.023_bib30","doi-asserted-by":"crossref","first-page":"e106680","DOI":"10.1371\/journal.pone.0106680","article-title":"The prognostic value of serum neuron-specific enolase in traumatic brain injury: systematic review and meta-analysis","volume":"9","author":"Cheng","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.jss.2019.06.023_bib31","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.nbd.2013.07.017","article-title":"Plasma levels of neuron specific enolase quantify the extent of neuronal injury in murine models of ischemic stroke and multiple sclerosis","volume":"59","author":"Gelderblom","year":"2013","journal-title":"Neurobiol Dis"},{"key":"10.1016\/j.jss.2019.06.023_bib32","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.jss.2010.05.055","article-title":"Hypobaric hypoxia exacerbates the neuroinflammatory response to traumatic brain injury","volume":"165","author":"Goodman","year":"2011","journal-title":"J Surg Res"}],"container-title":["Journal of Surgical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S002248041930410X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S002248041930410X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T14:45:11Z","timestamp":1758379511000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S002248041930410X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,12]]},"references-count":31,"alternative-id":["S002248041930410X"],"URL":"https:\/\/doi.org\/10.1016\/j.jss.2019.06.023","relation":{},"ISSN":["0022-4804"],"issn-type":[{"value":"0022-4804","type":"print"}],"subject":[],"published":{"date-parts":[[2019,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"UCH-L1 is a Poor Serum Biomarker of Murine Traumatic Brain Injury After Polytrauma","name":"articletitle","label":"Article Title"},{"value":"Journal of Surgical Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jss.2019.06.023","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}