{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T16:44:19Z","timestamp":1776962659546,"version":"3.51.4"},"reference-count":34,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,8,1]],"date-time":"2020-08-01T00:00:00Z","timestamp":1596240000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,8,1]],"date-time":"2020-08-01T00:00:00Z","timestamp":1596240000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","journalofsurgicalresearch.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Surgical Research"],"published-print":{"date-parts":[[2020,8]]},"DOI":"10.1016\/j.jss.2019.11.032","type":"journal-article","created":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T05:34:56Z","timestamp":1585719296000},"page":"80-88","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"special_numbering":"C","title":["Efficacy of Flurbiprofen for Postoperative Pain in Chinese Surgical Patients: A Meta-Analysis"],"prefix":"10.1016","volume":"252","author":[{"given":"Mingyang","family":"Sun","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuhui","family":"Cong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Enqiang","family":"Chang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mengrong","family":"Miao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiaqiang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jss.2019.11.032_bib1","doi-asserted-by":"crossref","first-page":"1537","DOI":"10.1016\/S0140-6736(19)30352-6","article-title":"Transition from acute to chronic pain after surgery","volume":"393","author":"Glare","year":"2019","journal-title":"Lancet"},{"key":"10.1016\/j.jss.2019.11.032_bib2","doi-asserted-by":"crossref","first-page":"2729","DOI":"10.2147\/JPR.S94650","article-title":"Gender, genetics, and analgesia: understanding the differences in response to pain relief","volume":"11","author":"Packiasabapathy","year":"2018","journal-title":"J Pain Res"},{"key":"10.1016\/j.jss.2019.11.032_bib3","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1111\/j.1365-2125.2006.02781.x","article-title":"Evaluation of flurbiprofen urinary ratios as in\u00a0vivo indices for CYP2C9 activity","volume":"63","author":"Zgheib","year":"2007","journal-title":"Br J Clin Pharmacol"},{"key":"10.1016\/j.jss.2019.11.032_bib4","doi-asserted-by":"crossref","first-page":"2643","DOI":"10.2147\/JPR.S147691","article-title":"A retrospective study on analgesic requirements for thoracoscopic surgery postoperative pain","volume":"10","author":"Kuroda","year":"2017","journal-title":"J Pain Res"},{"key":"10.1016\/j.jss.2019.11.032_bib5","first-page":"1607","article-title":"Analgesic effect of parecoxib and flurbiprofen axetil for patients undergoing laparoscopic cholecystectomy and their influences on platelet aggregation","volume":"123","author":"Ji","year":"2010","journal-title":"Chin Med J (Engl)"},{"key":"10.1016\/j.jss.2019.11.032_bib6","doi-asserted-by":"crossref","first-page":"1935","DOI":"10.1001\/jama.1995.03530240045039","article-title":"Preparing, maintaining, and disseminating systematic reviews of the effects of health care","volume":"274","author":"Bero","year":"1995","journal-title":"JAMA"},{"key":"10.1016\/j.jss.2019.11.032_bib7","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1046\/j.1445-2197.2003.02748.x","article-title":"Methodological index for non-randomized studies (minors): development and validation of a new instrument","volume":"73","author":"Slim","year":"2003","journal-title":"ANZ J Surg"},{"key":"10.1016\/j.jss.2019.11.032_bib8","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/0197-2456(86)90046-2","article-title":"Meta-analysis in clinical trials","volume":"7","author":"DerSimonian","year":"1986","journal-title":"Control Clin Trials"},{"key":"10.1016\/j.jss.2019.11.032_bib9","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1002\/sim.1186","article-title":"Quantifying heterogeneity in a meta-analysis","volume":"21","author":"Higgins","year":"2002","journal-title":"Stat Med"},{"key":"10.1016\/j.jss.2019.11.032_bib10","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1007\/s00540-011-1192-6","article-title":"Flurbiprofen axetil enhances analgesic effect of fentanyl associated with increase in \u03b2-endorphin levels","volume":"25","author":"Liu","year":"2011","journal-title":"J Anesth"},{"key":"10.1016\/j.jss.2019.11.032_bib11","doi-asserted-by":"crossref","first-page":"433","DOI":"10.7150\/ijms.8.433","article-title":"Lack of preemptive analgesia by intravenous flurbiprofen in thyroid gland surgery: a randomized, double-blind and placebo-controlled clinical trial","volume":"8","author":"Zhang","year":"2011","journal-title":"Int J Med Sci"},{"key":"10.1016\/j.jss.2019.11.032_bib12","first-page":"579","article-title":"Preemptive analgesic effects of flurbiprofen axetil in patients undergoing radical resection of esophageal carcinoma via the left thoracic approach","volume":"125","author":"Wang","year":"2012","journal-title":"Chin Med J (Engl)"},{"key":"10.1016\/j.jss.2019.11.032_bib13","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1186\/1749-8090-7-98","article-title":"Intravenous flurbiprofen for post-thymectomy pain relief in patients with myasthenia gravis","volume":"7","author":"Su","year":"2012","journal-title":"J Cardiothorac Surg"},{"key":"10.1016\/j.jss.2019.11.032_bib14","first-page":"653","article-title":"Effect of perioperative intravenous flurbiprofen axetil on chronic postmastectomy pain","volume":"38","author":"Sun","year":"2013","journal-title":"Zhong Nan Da Xue Xue Bao Yi Xue Ban"},{"key":"10.1016\/j.jss.2019.11.032_bib15","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1007\/s12013-014-0482-7","article-title":"Effects of flurbiprofen axetil on postoperative analgesia and cytokines in peripheral blood of thoracotomy patients","volume":"72","author":"Zhou","year":"2015","journal-title":"Cell Biochem Biophys"},{"key":"10.1016\/j.jss.2019.11.032_bib16","doi-asserted-by":"crossref","first-page":"16469","DOI":"10.4238\/2015.December.9.18","article-title":"Effects of flurbiprofen axetil on postoperative serum IL-2 and IL-6 levels in patients with colorectal cancer","volume":"14","author":"Jiang","year":"2015","journal-title":"Genet Mol Res"},{"key":"10.1016\/j.jss.2019.11.032_bib17","doi-asserted-by":"crossref","first-page":"2622","DOI":"10.3892\/etm.2016.3687","article-title":"Protective effects of dexmedetomidine combined with flurbiprofen axetil on remifentanil-induced hyperalgesia: a randomized controlled trial","volume":"12","author":"Yu","year":"2016","journal-title":"Exp Ther Med"},{"key":"10.1016\/j.jss.2019.11.032_bib18","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1097\/AJP.0000000000000416","article-title":"Preoperative but not postoperative flurbiprofen axetil alleviates remifentanil-induced hyperalgesia after laparoscopic gynecological surgery: a prospective, randomized, double-blinded, trial","volume":"33","author":"Zhang","year":"2017","journal-title":"Clin J Pain"},{"key":"10.1016\/j.jss.2019.11.032_bib19","first-page":"1875","article-title":"Analgesic effect of flurbiprofen axetil in treatment of single hole thoracoscopic surgery for pneumothorax","volume":"30","author":"Huang","year":"2017","journal-title":"Pak J Pharm Sci"},{"key":"10.1016\/j.jss.2019.11.032_bib20","first-page":"1895","article-title":"Analgesic effect of different dosage of Flurbiprofen axetil in laparoscopic cholecystectomy in comparison with other analgesic drugs","volume":"30","author":"Luo","year":"2017","journal-title":"Pak J Pharm Sci"},{"key":"10.1016\/j.jss.2019.11.032_bib21","doi-asserted-by":"crossref","first-page":"2148","DOI":"10.3892\/etm.2017.4717","article-title":"Postoperative benefits of dexmedetomidine combined with flurbiprofen axetil after thyroid surgery","volume":"14","author":"Ma","year":"2017","journal-title":"Exp Ther Med"},{"key":"10.1016\/j.jss.2019.11.032_bib22","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1213\/ANE.0000000000002025","article-title":"Flurbiprofen axetil provides effective analgesia without changing the pregnancy rate in ultrasound-guided transvaginal oocyte retrieval: a double-blind randomized controlled trial","volume":"125","author":"Zhao","year":"2017","journal-title":"Anesth Analg"},{"key":"10.1016\/j.jss.2019.11.032_bib23","doi-asserted-by":"crossref","first-page":"e12391","DOI":"10.1097\/MD.0000000000012391","article-title":"Comparison of perioperative flurbiprofen axetil or celecoxib administration for pain management after total-knee arthroplasty: a retrospective study","volume":"97","author":"Xiao","year":"2018","journal-title":"Medicine (Baltimore)"},{"key":"10.1016\/j.jss.2019.11.032_bib24","doi-asserted-by":"crossref","first-page":"867","DOI":"10.2147\/JPR.S153456","article-title":"Perioperative analgesia with a buprenorphine transdermal patch for hallux valgus surgery: a prospective, randomized, controlled study","volume":"11","author":"Xu","year":"2018","journal-title":"J Pain Res"},{"key":"10.1016\/j.jss.2019.11.032_bib25","first-page":"354","article-title":"Preoperative intravenous flurbiprofen reduces postoperative pain and inflammatory cytokines in elderly patients after hip arthroplasty","volume":"17","author":"Zhou","year":"2019","journal-title":"Exp Ther Med"},{"key":"10.1016\/j.jss.2019.11.032_bib26","doi-asserted-by":"crossref","first-page":"659","DOI":"10.2147\/JPR.S187020","article-title":"Intraoperative administration of intravenous flurbiprofen axetil with nalbuphine reduces postoperative pain after orbital decompression: a single-center, prospective randomized controlled trial","volume":"12","author":"Ye","year":"2019","journal-title":"J Pain Res"},{"key":"10.1016\/j.jss.2019.11.032_bib27","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.2147\/DDDT.S199897","article-title":"Effects of dezocine for the prevention of postoperative catheter-related bladder discomfort: a prospective randomized trial","volume":"13","author":"Zhang","year":"2019","journal-title":"Drug Des Devel Ther"},{"key":"10.1016\/j.jss.2019.11.032_bib28","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1007\/s00540-017-2409-0","article-title":"Preoperative flurbiprofen axetil administration for acute postoperative pain: a meta-analysis of randomized controlled trials","volume":"31","author":"Wang","year":"2017","journal-title":"J Anesth"},{"key":"10.1016\/j.jss.2019.11.032_bib29","doi-asserted-by":"crossref","first-page":"669","DOI":"10.5414\/CP202027","article-title":"Flurbiprofen improves dysfunction of T-lymphocyte subsets and natural killer cells in cancer patients receiving post-operative morphine analgesia","volume":"52","author":"Shen","year":"2014","journal-title":"Int J Clin Pharmacol Ther"},{"key":"10.1016\/j.jss.2019.11.032_bib30","doi-asserted-by":"crossref","first-page":"35","DOI":"10.3109\/09273948.2015.1032308","article-title":"Flurbiprofen: a nonselective cyclooxygenase (COX) inhibitor for treatment of noninfectious, non-necrotizing anterior scleritis","volume":"24","author":"Agrawal","year":"2016","journal-title":"Ocul Immunol Inflamm"},{"key":"10.1016\/j.jss.2019.11.032_bib31","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1080\/13543784.2017.1260544","article-title":"Investigational drugs targeting the prostaglandin E2 signaling pathway for the treatment of inflammatory pain","volume":"26","author":"Gr\u00f6sch","year":"2017","journal-title":"Expert Opin Investig Drugs"},{"key":"10.1016\/j.jss.2019.11.032_bib32","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.jclinane.2006.05.028","article-title":"Preadministration of flurbiprofen suppresses prostaglandin production and postoperative pain in orthopedic patients undergoing tourniquet inflation","volume":"19","author":"Takada","year":"2007","journal-title":"J Clin Anesth"},{"key":"10.1016\/j.jss.2019.11.032_bib33","doi-asserted-by":"crossref","first-page":"59","DOI":"10.3389\/fsurg.2018.00059","article-title":"Comparing the efficacy of IV ibuprofen and ketorolac in the management of postoperative pain following arthroscopic knee surgery. A randomized double-blind active comparator pilot study","volume":"5","author":"Uribe","year":"2018","journal-title":"Front Surg"},{"key":"10.1016\/j.jss.2019.11.032_bib34","article-title":"Comparing ketorolac with ibuprofen for postoperative pain: a randomized clinical trial","author":"Dwarica","year":"2019","journal-title":"Female Pelvic Med Reconstr Surg"}],"container-title":["Journal of Surgical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022480419308376?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022480419308376?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T14:48:27Z","timestamp":1758379707000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022480419308376"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8]]},"references-count":34,"alternative-id":["S0022480419308376"],"URL":"https:\/\/doi.org\/10.1016\/j.jss.2019.11.032","relation":{},"ISSN":["0022-4804"],"issn-type":[{"value":"0022-4804","type":"print"}],"subject":[],"published":{"date-parts":[[2020,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Efficacy of Flurbiprofen for Postoperative Pain in Chinese Surgical Patients: A Meta-Analysis","name":"articletitle","label":"Article Title"},{"value":"Journal of Surgical Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jss.2019.11.032","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}