{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,18]],"date-time":"2026-01-18T06:58:56Z","timestamp":1768719536166,"version":"3.49.0"},"reference-count":38,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","journalofsurgicalresearch.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Surgical Research"],"published-print":{"date-parts":[[2020,12]]},"DOI":"10.1016\/j.jss.2020.07.003","type":"journal-article","created":{"date-parts":[[2020,8,16]],"date-time":"2020-08-16T23:01:21Z","timestamp":1597618881000},"page":"663-672","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"special_numbering":"C","title":["Inflammation Drives MicroRNAs to Limit Hepatocyte Bile Acid Transport in Murine Biliary Atresia"],"prefix":"10.1016","volume":"256","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0968-7390","authenticated-orcid":false,"given":"Mark W.","family":"Azeltine","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8212-9558","authenticated-orcid":false,"given":"Emily J.","family":"Chavez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3036-254X","authenticated-orcid":false,"given":"Kelsey M.","family":"Nemec","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8000-704X","authenticated-orcid":false,"given":"Joseph M.","family":"Bednarek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rengasamy","family":"Asokan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natarajan","family":"Balasubramaniyan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos","family":"Zgheib","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cara L.","family":"Mack","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan P.","family":"Roach","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jss.2020.07.003_bib1","doi-asserted-by":"crossref","first-page":"656","DOI":"10.3346\/jkms.2017.32.4.656","article-title":"Epidemiology of biliary atresia in Korea","volume":"32","author":"Lee","year":"2017","journal-title":"J Korean Med Sci"},{"key":"10.1016\/j.jss.2020.07.003_bib2","doi-asserted-by":"crossref","first-page":"e951","DOI":"10.1542\/peds.2008-3108","article-title":"Biliary atresia screening: why, when, and how?","volume":"123","author":"Sokol","year":"2009","journal-title":"Pediatrics"},{"key":"10.1016\/j.jss.2020.07.003_bib3","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1111\/j.1440-1746.2007.05114.x","article-title":"Epidemiological features of biliary atresia in Taiwan, a national study 1996-2003","volume":"23","author":"Tiao","year":"2008","journal-title":"J Gastroenterol Hepatol"},{"key":"10.1016\/j.jss.2020.07.003_bib4","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1016\/j.jpeds.2007.05.051","article-title":"Biliary atresia: the Canadian experience","volume":"151","author":"Schreiber","year":"2007","journal-title":"J Pediatr"},{"key":"10.1016\/j.jss.2020.07.003_bib5","doi-asserted-by":"crossref","first-page":"1280","DOI":"10.1542\/peds.2008-1949","article-title":"Impact of age at Kasai operation on its results in late childhood and adolescence: a rational basis for biliary atresia screening","volume":"123","author":"Serinet","year":"2009","journal-title":"Pediatrics"},{"key":"10.1016\/j.jss.2020.07.003_bib6","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1002\/hep.21790","article-title":"Screening and outcomes in biliary atresia: summary of a National Institutes of Health Workshop","volume":"46","author":"Sokol","year":"2007","journal-title":"Hepatology"},{"key":"10.1016\/j.jss.2020.07.003_bib7","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1002\/lt.24640","article-title":"Biliary atresia: indications and timing of liver transplantation and optimization of pretransplant care","volume":"23","author":"Sundaram","year":"2017","journal-title":"Liver Transpl"},{"key":"10.1016\/j.jss.2020.07.003_bib8","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1097\/SLA.0b013e3182300950","article-title":"The anatomic pattern of biliary atresia identified at time of Kasai hepatoportoenterostomy and early postoperative clearance of jaundice are significant predictors of transplant-free survival","volume":"254","author":"Superina","year":"2011","journal-title":"Ann Surg"},{"key":"10.1016\/j.jss.2020.07.003_bib9","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1097\/00000658-199809000-00014","article-title":"Long-term results of pediatric liver transplantation","volume":"228","author":"Goss","year":"1998","journal-title":"Ann Surg"},{"key":"10.1016\/j.jss.2020.07.003_bib10","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1007\/s00431-008-0774-2","article-title":"Incidence of hepatotropic viruses in biliary atresia","volume":"168","author":"Rauschenfels","year":"2009","journal-title":"Eur J Pediatr"},{"key":"10.1016\/j.jss.2020.07.003_bib11","doi-asserted-by":"crossref","first-page":"1398","DOI":"10.1016\/j.jpedsurg.2015.04.006","article-title":"Evidence for viral infection as a causative factor of human biliary atresia","volume":"50","author":"Saito","year":"2015","journal-title":"J Pediatr Surg"},{"key":"10.1016\/j.jss.2020.07.003_bib12","doi-asserted-by":"crossref","first-page":"1890","DOI":"10.1002\/hep.30051","article-title":"Cytokine-producing B cells promote immune-mediated bile duct injury in murine biliary atresia","volume":"68","author":"Bednarek","year":"2018","journal-title":"Hepatology"},{"key":"10.1016\/j.jss.2020.07.003_bib13","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1002\/hep.25662","article-title":"Regulatory T cells control the CD8 adaptive immune response at the time of ductal obstruction in experimental biliary atresia","volume":"56","author":"Lages","year":"2012","journal-title":"Hepatology"},{"key":"10.1016\/j.jss.2020.07.003_bib14","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1002\/hep.28851","article-title":"The dendritic cell-T helper 17-macrophage axis controls cholangiocyte injury and disease progression in murine and human biliary atresia","volume":"65","author":"Lages","year":"2017","journal-title":"Hepatology"},{"key":"10.1016\/j.jss.2020.07.003_bib15","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.clim.2005.01.012","article-title":"Armed CD4+ Th1 effector cells and activated macrophages participate in bile duct injury in murine biliary atresia","volume":"115","author":"Mack","year":"2005","journal-title":"Clin Immunol"},{"key":"10.1016\/j.jss.2020.07.003_bib16","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1203\/PDR.0b013e318170a6b5","article-title":"Expression of hepatocyte transporters and nuclear receptors in children with early and late-stage biliary atresia","volume":"63","author":"Chen","year":"2008","journal-title":"Pediatr Res"},{"key":"10.1016\/j.jss.2020.07.003_bib17","doi-asserted-by":"crossref","first-page":"A-832","DOI":"10.1016\/S0016-5085(09)63833-6","article-title":"Hepatobiliary transport regulation in the development of murine biliary atresia","volume":"136","author":"Yang","year":"2009","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jss.2020.07.003_bib18","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1203\/PDR.0b013e3181b454a4","article-title":"Inflammation mediated down-regulation of hepatobiliary transporters contributes to intrahepatic cholestasis and liver damage in murine biliary atresia","volume":"66","author":"Yang","year":"2009","journal-title":"Pediatr Res"},{"key":"10.1016\/j.jss.2020.07.003_bib19","doi-asserted-by":"crossref","first-page":"1795","DOI":"10.3390\/ijms17111795","article-title":"Function and regulation of MicroRNAs and their potential as biomarkers in paediatric liver disease","volume":"17","author":"Calvopina","year":"2016","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.jss.2020.07.003_bib20","doi-asserted-by":"crossref","first-page":"280","DOI":"10.3390\/ijms17030280","article-title":"MicroRNAs as biomarkers for liver disease and hepatocellular carcinoma","volume":"17","author":"Hayes","year":"2016","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.jss.2020.07.003_bib21","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1097\/MPG.0b013e318264e648","article-title":"Circulating MicroRNA is a biomarker of biliary atresia","volume":"55","author":"Zahm","year":"2012","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"10.1016\/j.jss.2020.07.003_bib22","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1158\/1541-7786.MCR-11-0473","article-title":"Downregulation of human farnesoid X receptor by miR-421 promotes proliferation and migration of hepatocellular carcinoma cells","volume":"10","author":"Zhang","year":"2012","journal-title":"Mol Cancer Res"},{"key":"10.1016\/j.jss.2020.07.003_bib23","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1038\/ncb0309-228","article-title":"Many roads to maturity: MicroRNA biogenesis pathways and their regulation","volume":"11","author":"Winter","year":"2009","journal-title":"Nat Cell Biol"},{"key":"10.1016\/j.jss.2020.07.003_bib24","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1097\/MPG.0b013e318244148b","article-title":"MicroRNA profiling identifies miR-29 as a regulator of disease-associated pathways in experimental biliary atresia","volume":"54","author":"Hand","year":"2012","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"10.1016\/j.jss.2020.07.003_bib25","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1261\/rna.038968.113","article-title":"Synthetic pre-microRNAs reveal dual-strand activity of miR-34a on TNF-","volume":"20","author":"Guennewig","year":"2014","journal-title":"RNA"},{"key":"10.1016\/j.jss.2020.07.003_bib26","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1126\/science.1141229","article-title":"Regulation of the germinal center response by MicroRNA-155","volume":"316","author":"Thai","year":"2007","journal-title":"Science"},{"key":"10.1016\/j.jss.2020.07.003_bib27","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1038\/pr.2017.87","article-title":"MicroRNA-155 modulates bile duct inflammation by targeting the suppressor of cytokine signaling 1 in biliary atresia","volume":"82","author":"Zhao","year":"2017","journal-title":"Pediatr Res"},{"key":"10.1016\/j.jss.2020.07.003_bib28","doi-asserted-by":"crossref","first-page":"865","DOI":"10.4049\/jimmunol.169.2.865","article-title":"B cell progenitors are arrested in maturation but have intact VDJ recombination in the absence of ig-\u03b1 and ig-\u03b2","volume":"169","author":"Pelanda","year":"2002","journal-title":"J Immunol"},{"key":"10.1016\/j.jss.2020.07.003_bib29","doi-asserted-by":"crossref","first-page":"e73644","DOI":"10.1371\/journal.pone.0073644","article-title":"B cell deficient mice are protected from biliary obstruction in the rotavirus-induced mouse model of biliary atresia","volume":"8","author":"Feldman","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.jss.2020.07.003_bib30","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2-\u0394\u0394CT method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"10.1016\/j.jss.2020.07.003_bib31","doi-asserted-by":"crossref","first-page":"8157","DOI":"10.1038\/s41598-018-26383-8","article-title":"Obeticholic acid protects against hepatocyte death and liver fibrosis in a murine model of nonalcoholic steatohepatitis","volume":"8","author":"Goto","year":"2018","journal-title":"Sci Rep"},{"key":"10.1016\/j.jss.2020.07.003_bib32","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.jhep.2012.08.002","article-title":"Bile acid transporters and regulatory nuclear receptors in the liver and beyond","volume":"58","author":"Halilbasic","year":"2013","journal-title":"J Hepatol"},{"key":"10.1016\/j.jss.2020.07.003_bib33","first-page":"G1124","article-title":"Upregulation of a basolateral FXR-dependent bile acid efflux transporter OST\u03b1-OST\u03b2 in cholestasis in humans and rodents","volume":"290","author":"Boyer","year":"2006","journal-title":"Am J Physiol Liver Physiol"},{"key":"10.1016\/j.jss.2020.07.003_bib34","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1186\/s13578-017-0161-7","article-title":"The roles of microRNA families in hepatic fibrosis","volume":"7","author":"Jiang","year":"2017","journal-title":"Cell Biosci"},{"key":"10.1016\/j.jss.2020.07.003_bib35","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.bbrc.2014.02.065","article-title":"microRNA-222\u00a0modulates liver fibrosis in a murine model of biliary\u00a0atresia","volume":"446","author":"Shen","year":"2014","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.jss.2020.07.003_bib36","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1111\/liv.12919","article-title":"microRNA changes in liver tissue associated with fibrosis progression in patients with hepatitis C","volume":"36","author":"Van Keuren-Jensen","year":"2016","journal-title":"Liver Int"},{"key":"10.1016\/j.jss.2020.07.003_bib37","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1055\/s-0030-1253225","article-title":"Nuclear receptor regulation of the adaptive response of bile acid transporters in cholestasis","volume":"30","author":"Wagner","year":"2010","journal-title":"Semin Liver Dis"},{"key":"10.1016\/j.jss.2020.07.003_bib38","doi-asserted-by":"crossref","first-page":"33453","DOI":"10.1038\/srep33453","article-title":"FXR agonist obeticholic acid reduces hepatic inflammation and fibrosis in a rat model of toxic cirrhosis","volume":"6","author":"Verbeke","year":"2016","journal-title":"Sci Rep"}],"container-title":["Journal of Surgical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022480420304583?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022480420304583?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T14:53:44Z","timestamp":1758380024000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022480420304583"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12]]},"references-count":38,"alternative-id":["S0022480420304583"],"URL":"https:\/\/doi.org\/10.1016\/j.jss.2020.07.003","relation":{},"ISSN":["0022-4804"],"issn-type":[{"value":"0022-4804","type":"print"}],"subject":[],"published":{"date-parts":[[2020,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Inflammation Drives MicroRNAs to Limit Hepatocyte Bile Acid Transport in Murine Biliary Atresia","name":"articletitle","label":"Article Title"},{"value":"Journal of Surgical Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jss.2020.07.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}