{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T05:34:13Z","timestamp":1788327253233,"version":"build-2803163510"},"reference-count":36,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T00:00:00Z","timestamp":1612137600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,10,29]],"date-time":"2020-10-29T00:00:00Z","timestamp":1603929600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","journalofsurgicalresearch.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Surgical Research"],"published-print":{"date-parts":[[2021,2]]},"DOI":"10.1016\/j.jss.2020.10.009","type":"journal-article","created":{"date-parts":[[2020,11,11]],"date-time":"2020-11-11T04:43:40Z","timestamp":1605069820000},"page":"324-331","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":23,"special_numbering":"C","title":["Direct Oral Anticoagulants Are a Potential Alternative to Low-Molecular-Weight Heparin for Thromboprophylaxis in Trauma Patients Sustaining Lower Extremity Fractures"],"prefix":"10.1016","volume":"258","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7387-1769","authenticated-orcid":false,"given":"Charlie J.","family":"Nederpelt","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kerry A.","family":"Breen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Majed W.","family":"el Hechi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pieta","family":"Krijnen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Menno V.","family":"Huisman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9952-3079","authenticated-orcid":false,"given":"Inger B.","family":"Schipper","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haytham M.A.","family":"Kaafarani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin G.","family":"Rosenthal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jss.2020.10.009_bib1","doi-asserted-by":"crossref","first-page":"1573","DOI":"10.1302\/0301-620X.94B11.28955","article-title":"The effects of rivaroxaban on the complications of surgery after total hip or knee replacement: results from the RECORD programme","volume":"94","author":"Lassen","year":"2012","journal-title":"J Bone Joint Surg Br"},{"key":"10.1016\/j.jss.2020.10.009_bib2","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1302\/0301-620X.91B5.21691","article-title":"Oral rivaroxaban for the prevention of symptomatic venous thromboembolism after elective hip and knee replacement","volume":"91","author":"Eriksson","year":"2009","journal-title":"J Bone Joint Surg Br"},{"key":"10.1016\/j.jss.2020.10.009_bib3","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1007\/s00402-017-2697-8","article-title":"A comparison of apixaban and dabigatran etexilate for thromboprophylaxis following hip and knee replacement surgery","volume":"137","author":"Mayer","year":"2017","journal-title":"Arch Orthop Trauma Surg"},{"key":"10.1016\/j.jss.2020.10.009_bib4","first-page":"897","article-title":"Dabigatran etexilate and LMWH for the prevention of venous thromboembolism in 532 patients undergoing hip surgery","volume":"19","author":"Bonarelli","year":"2015","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"10.1016\/j.jss.2020.10.009_bib5","doi-asserted-by":"crossref","first-page":"e3675","DOI":"10.1136\/bmj.e3675","article-title":"Dabigatran, rivaroxaban, or apixaban versus enoxaparin for thromboprophylaxis after total hip or knee replacement: systematic review, meta-analysis, and indirect treatment comparisons","volume":"344","author":"Gomez-Outes","year":"2012","journal-title":"BMJ"},{"key":"10.1016\/j.jss.2020.10.009_bib6","doi-asserted-by":"crossref","first-page":"395","DOI":"10.2174\/1874325001105010395","article-title":"Oral thromboprophylaxis following total hip or knee replacement: review and multicentre experience with dabigatran etexilate","volume":"5","author":"Kendoff","year":"2011","journal-title":"Open Orthop J"},{"key":"10.1016\/j.jss.2020.10.009_bib7","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1586\/17474086.2013.853430","article-title":"The use of novel oral anticoagulants for thromboprophylaxis after elective major orthopedic surgery","volume":"6","author":"Rachidi","year":"2013","journal-title":"Expert Rev Hematol"},{"key":"10.1016\/j.jss.2020.10.009_bib8","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1067\/msy.2001.114558","article-title":"Venous thromboembolism in trauma patients: a review","volume":"130","author":"Rogers","year":"2001","journal-title":"Surgery"},{"key":"10.1016\/j.jss.2020.10.009_bib9","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1053\/j.seminhematol.2007.02.004","article-title":"Epidemiology and risk factors for venous thrombosis","volume":"44","author":"Cushman","year":"2007","journal-title":"Semin Hematol"},{"key":"10.1016\/j.jss.2020.10.009_bib10","doi-asserted-by":"crossref","first-page":"1601","DOI":"10.1056\/NEJM199412153312401","article-title":"A prospective study of venous thromboembolism after major trauma","volume":"331","author":"Geerts","year":"1994","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jss.2020.10.009_bib11","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.jss.2016.08.072","article-title":"A simplified stratification system for venous thromboembolism risk in severely injured trauma patients","volume":"207","author":"Meizoso","year":"2017","journal-title":"J Surg Res"},{"key":"10.1016\/j.jss.2020.10.009_bib12","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1001\/jamasurg.2016.3116","article-title":"Association of mechanism of injury with risk for venous thromboembolism after trauma","volume":"152","author":"Karcutskie","year":"2017","journal-title":"JAMA Surg"},{"key":"10.1016\/j.jss.2020.10.009_bib13","doi-asserted-by":"crossref","first-page":"313","DOI":"10.2174\/1874325001509010313","article-title":"Methods and guidelines for venous thromboembolism prevention in polytrauma patients with pelvic and acetabular fractures","volume":"9","author":"Chana-Rodriguez","year":"2015","journal-title":"Open Orthop J"},{"key":"10.1016\/j.jss.2020.10.009_bib14","first-page":"CD008303","article-title":"Thromboprophylaxis for trauma patients","volume":"3","author":"Barrera","year":"2013","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.jss.2020.10.009_bib15","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1056\/NEJM199609053351003","article-title":"A comparison of low-dose heparin with low-molecular-weight heparin as prophylaxis against venous thromboembolism after major trauma","volume":"335","author":"Geerts","year":"1996","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jss.2020.10.009_bib16","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1097\/TA.0000000000001321","article-title":"Effectiveness of low-molecular-weight heparin versus unfractionated heparin to prevent pulmonary embolism following major trauma: a propensity-matched analysis","volume":"82","author":"Byrne","year":"2017","journal-title":"J Trauma Acute Care Surg"},{"issue":"2 Suppl l","key":"10.1016\/j.jss.2020.10.009_bib17","article-title":"Antithrombotic therapy for VTE disease: Antithrombotic therapy and prevention of thrombosis, 9th ed: American College of chest physicians Evidence-based clinical practice guidelines","volume":"141","author":"Kearon","year":"2012","journal-title":"Chest"},{"key":"10.1016\/j.jss.2020.10.009_bib18","doi-asserted-by":"crossref","first-page":"e1001885","DOI":"10.1371\/journal.pmed.1001885","article-title":"The REporting of studies Conducted using Observational Routinely-collected health Data (RECORD) statement","volume":"12","author":"Benchimol","year":"2015","journal-title":"PLoS Med"},{"key":"10.1016\/j.jss.2020.10.009_bib19","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1111\/j.1538-7836.2009.03678.x","article-title":"Definition of major bleeding in clinical investigations of antihemostatic medicinal products in surgical patients","volume":"8","author":"Schulman","year":"2010","journal-title":"J Thromb Haemost"},{"key":"10.1016\/j.jss.2020.10.009_bib20","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1111\/j.1538-7836.2005.01204.x","article-title":"Subcommittee on Control of Anticoagulation of the S, Standardization Committee of the International Society on T, Haemostasis. Definition of major bleeding in clinical investigations of antihemostatic medicinal products in non-surgical patients","volume":"3","author":"Schulman","year":"2005","journal-title":"J Thromb Haemost"},{"key":"10.1016\/j.jss.2020.10.009_bib21","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1186\/s12959-015-0067-8","article-title":"Oral dabigatran etexilate versus enoxaparin for venous thromboembolism prevention after total hip arthroplasty: pooled analysis of two phase 3 randomized trials","volume":"13","author":"Eriksson","year":"2015","journal-title":"Thromb J"},{"key":"10.1016\/j.jss.2020.10.009_bib22","doi-asserted-by":"crossref","first-page":"2178","DOI":"10.1111\/j.1538-7836.2007.02748.x","article-title":"Oral dabigatran etexilate vs. subcutaneous enoxaparin for the prevention of venous thromboembolism after total knee replacement: the RE-MODEL randomized trial","volume":"5","author":"Eriksson","year":"2007","journal-title":"J Thromb Haemost"},{"key":"10.1016\/j.jss.2020.10.009_bib23","first-page":"CD004179","article-title":"Anticoagulants (extended duration) for prevention of venous thromboembolism following total hip or knee replacement or hip fracture repair","volume":"3","author":"Forster","year":"2016","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.jss.2020.10.009_bib24","doi-asserted-by":"crossref","first-page":"2765","DOI":"10.1056\/NEJMoa0800374","article-title":"Rivaroxaban versus enoxaparin for thromboprophylaxis after hip arthroplasty","volume":"358","author":"Eriksson","year":"2008","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jss.2020.10.009_bib25","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1056\/NEJMoa0810773","article-title":"Apixaban or enoxaparin for thromboprophylaxis after knee replacement","volume":"361","author":"Lassen","year":"2009","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jss.2020.10.009_bib26","doi-asserted-by":"crossref","first-page":"2487","DOI":"10.1056\/NEJMoa1006885","article-title":"Apixaban versus enoxaparin for thromboprophylaxis after hip replacement","volume":"363","author":"Lassen","year":"2010","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jss.2020.10.009_bib27","doi-asserted-by":"crossref","first-page":"1916","DOI":"10.1056\/NEJMoa1913808","article-title":"Rivaroxaban or enoxaparin in nonmajor orthopedic surgery","volume":"382","author":"Samama","year":"2020","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jss.2020.10.009_bib28","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.jamcollsurg.2018.09.023","article-title":"Direct oral anticoagulants vs low-molecular-weight heparin for thromboprophylaxis in nonoperative pelvic fractures","volume":"228","author":"Hamidi","year":"2019","journal-title":"J Am Coll Surg"},{"key":"10.1016\/j.jss.2020.10.009_bib29","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1186\/s13018-019-1124-y","article-title":"A comparative cost-effectiveness analysis of mechanical and pharmacological VTE prophylaxis after lower limb arthroplasty in Australia","volume":"14","author":"Torrejon Torres","year":"2019","journal-title":"J Orthop Surg Res"},{"key":"10.1016\/j.jss.2020.10.009_bib30","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1160\/TH10-01-0071","article-title":"Cost-effectiveness of rivaroxaban versus enoxaparin for the prevention of postsurgical venous thromboembolism in Canada","volume":"104","author":"Diamantopoulos","year":"2010","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.jss.2020.10.009_bib31","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1586\/erp.11.65","article-title":"Cost-effectiveness of rivaroxaban versus heparins for prevention of venous thromboembolism after total hip or knee surgery in Sweden","volume":"11","author":"Ryttberg","year":"2011","journal-title":"Expert Rev Pharmacoecon Outcomes Res"},{"key":"10.1016\/j.jss.2020.10.009_bib32","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1160\/TH12-12-0919","article-title":"Cost-effectiveness impact of rivaroxaban versus new and existing prophylaxis for the prevention of venous thromboembolism after total hip or knee replacement surgery in France, Italy and Spain","volume":"110","author":"Monreal","year":"2013","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.jss.2020.10.009_bib33","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1056\/NEJMoa1111096","article-title":"Rivaroxaban for thromboprophylaxis in acutely ill medical patients","volume":"368","author":"Cohen","year":"2013","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jss.2020.10.009_bib34","doi-asserted-by":"crossref","first-page":"1326","DOI":"10.1056\/NEJMoa1814051","article-title":"Full study report of andexanet\u00a0alfa for bleeding associated with factor Xa inhibitors","volume":"380","author":"Connolly","year":"2019","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jss.2020.10.009_bib35","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1056\/NEJMoa1707278","article-title":"Idarucizumab for dabigatran reversal - full cohort analysis","volume":"377","author":"Pollack","year":"2017","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jss.2020.10.009_bib36","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1378\/chest.10-0134","article-title":"A novel user-friendly score (HAS-BLED) to assess 1-year risk of major bleeding in patients with atrial fibrillation: the Euro Heart Survey","volume":"138","author":"Pisters","year":"2010","journal-title":"Chest"}],"updated-by":[{"DOI":"10.1016\/j.jss.2021.03.019","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000}}],"container-title":["Journal of Surgical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022480420307277?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022480420307277?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,12,11]],"date-time":"2020-12-11T04:05:07Z","timestamp":1607659507000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022480420307277"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2]]},"references-count":36,"alternative-id":["S0022480420307277"],"URL":"https:\/\/doi.org\/10.1016\/j.jss.2020.10.009","relation":{"erratum":[{"id-type":"doi","id":"10.1016\/j.jss.2021.03.019","asserted-by":"object"}]},"ISSN":["0022-4804"],"issn-type":[{"value":"0022-4804","type":"print"}],"subject":[],"published":{"date-parts":[[2021,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Direct Oral Anticoagulants Are a Potential Alternative to Low-Molecular-Weight Heparin for Thromboprophylaxis in Trauma Patients Sustaining Lower Extremity Fractures","name":"articletitle","label":"Article Title"},{"value":"Journal of Surgical Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jss.2020.10.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}