{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T20:20:08Z","timestamp":1769026808381,"version":"3.49.0"},"reference-count":25,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100005927","name":"American Society of Colon and Rectal Surgeons","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005927","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","journalofsurgicalresearch.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Surgical Research"],"published-print":{"date-parts":[[2021,11]]},"DOI":"10.1016\/j.jss.2021.05.043","type":"journal-article","created":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T23:57:59Z","timestamp":1625183879000},"page":"397-403","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["COLQ and ARHGAP15 are Associated with Diverticular Disease and are Expressed in the Colon"],"prefix":"10.1016","volume":"267","author":[{"given":"Bryan P.","family":"Kline","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gregory S.","family":"Yochum","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0631-4110","authenticated-orcid":false,"given":"David L.","family":"Brinton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2688-8680","authenticated-orcid":false,"given":"Kathleen M.","family":"Schieffer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taelor","family":"Weaver","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leonard","family":"Harris","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sue","family":"Deiling","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4097-7348","authenticated-orcid":false,"given":"Arthur S.","family":"Berg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Walter A.","family":"Koltun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jss.2021.05.043_bib0001","doi-asserted-by":"crossref","first-page":"1521","DOI":"10.1056\/NEJM199805213382107","article-title":"Acute diverticulitis","volume":"338","author":"Ferzoco","year":"1998","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jss.2021.05.043_bib0002","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1053\/j.gastro.2018.08.063","article-title":"Burden and cost of gastrointestinal, liver, and pancreatic diseases in the United States: update 2018","volume":"156","author":"Peery","year":"2019","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jss.2021.05.043_bib0003","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1111\/j.1365-2036.2012.05069.x","article-title":"The genetic influence on diverticular disease\u2013a twin study","volume":"35","author":"Granlund","year":"2012","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1016\/j.jss.2021.05.043_bib0004","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1053\/j.gastro.2012.12.030","article-title":"Heritability and familial aggregation of diverticular disease: a population-based study of twins and siblings","volume":"144","author":"Strate","year":"2013","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jss.2021.05.043_bib0005","doi-asserted-by":"crossref","first-page":"15789","DOI":"10.1038\/ncomms15789","article-title":"Sequence variants in ARHGAP15, COLQ and FAM155A associate with diverticular disease and diverticulitis","volume":"8","author":"Sigurdsson","year":"2017","journal-title":"Nat Commun"},{"key":"10.1016\/j.jss.2021.05.043_bib0006","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1182\/blood-2010-12-324756","article-title":"The RacGAP ArhGAP15 is a master negative regulator of neutrophil functions","volume":"118","author":"Costa","year":"2011","journal-title":"Blood"},{"key":"10.1016\/j.jss.2021.05.043_bib0007","doi-asserted-by":"crossref","first-page":"22840","DOI":"10.1074\/jbc.272.36.22840","article-title":"The mammalian gene of acetylcholinesterase-associated collagen","volume":"272","author":"Krejci","year":"1997","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jss.2021.05.043_bib0008","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.cbi.2012.10.006","article-title":"Developmental consequences of the ColQ\/MuSK interactions","volume":"203","author":"Karmouch","year":"2013","journal-title":"Chem Biol Interact"},{"key":"10.1016\/j.jss.2021.05.043_bib0009","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1111\/iej.13060","article-title":"A biological study of supernumerary teeth derived dental pulp stem cells based on RNA-seq analysis","volume":"52","author":"Lu","year":"2018","journal-title":"Int Endod J"},{"key":"10.1016\/j.jss.2021.05.043_bib0010","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1038\/s41588-018-0203-z","article-title":"Genome-wide association analyses identify 39 new susceptibility loci for diverticular disease","volume":"50","author":"Maguire","year":"2018","journal-title":"Nat Genet"},{"key":"10.1016\/j.jss.2021.05.043_bib0011","doi-asserted-by":"crossref","DOI":"10.1136\/gutjnl-2018-317619","article-title":"Genome-wide association analysis of diverticular disease points towards neuromuscular, connective tissue and epithelial pathomechanisms","author":"Schafmayer","year":"2019","journal-title":"Gut"},{"key":"10.1016\/j.jss.2021.05.043_bib0012","doi-asserted-by":"crossref","first-page":"5735","DOI":"10.1093\/nar\/gkq363","article-title":"Identification of [beta]-catenin binding regions in colon cancer cells using ChIP0Seq","volume":"38","author":"Bottomly","year":"2010","journal-title":"Nucleic Acids Rs"},{"key":"10.1016\/j.jss.2021.05.043_bib0013","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1002\/bjs.18005021913","article-title":"Visceral diverticula and the Marfan syndrome","volume":"50","author":"Clunie","year":"1962","journal-title":"Br J Surg"},{"key":"10.1016\/j.jss.2021.05.043_bib0014","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1136\/gut.10.12.1004","article-title":"Gastrointestinal complications of the Ehlers-Danlos syndrome","volume":"10","author":"Beighton","year":"1969","journal-title":"Gut"},{"key":"10.1016\/j.jss.2021.05.043_bib0015","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1080\/17474124.2017.1294061","article-title":"Diverticular disease is associated with benign intra-abdominal cystic disease","volume":"11","author":"Wrafter","year":"2017","journal-title":"Expert Rev Gastroenterol Hepatol"},{"key":"10.1016\/j.jss.2021.05.043_bib0016","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1097\/DCR.0000000000001001","article-title":"A Variant of COL3A1 (rs3134646) is associated with risk of developing diverticulosis in white men","volume":"61","author":"Reichert","year":"2018","journal-title":"Dis Colon Rectum"},{"key":"10.1016\/j.jss.2021.05.043_bib0017","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1097\/SLA.0000000000000232","article-title":"The TNFSF15 gene single nucleotide polymorphism rs7848647 is associated with surgical diverticulitis","volume":"259","author":"Connelly","year":"2014","journal-title":"Ann Surg"},{"key":"10.1016\/j.jss.2021.05.043_bib0018","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1001\/jama.2013.282025","article-title":"Sigmoid diverticulitis: a systematic review","volume":"311","author":"Morris","year":"2014","journal-title":"Jama"},{"key":"10.1016\/j.jss.2021.05.043_bib0019","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1097\/DCR.0000000000000075","article-title":"Practice parameters for the treatment of sigmoid diverticulitis","volume":"57","author":"Feingold","year":"2014","journal-title":"Dis Colon Rectum"},{"key":"10.1016\/j.jss.2021.05.043_bib0020","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1038\/s41419-018-0707-6","article-title":"Decreased expression of ARHGAP15 promotes the development of colorectal cancer through PTEN\/AKT\/FOXO1 axis","volume":"9","author":"Pan","year":"2018","journal-title":"Cell Death Dis"},{"key":"10.1016\/j.jss.2021.05.043_bib0021","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/S0014-5793(03)00213-8","article-title":"ArhGAP15, a novel human RacGAP protein with GTPase binding property","volume":"539","author":"Seoh","year":"2003","journal-title":"FEBS Letters"},{"key":"10.1016\/j.jss.2021.05.043_bib0022","doi-asserted-by":"crossref","first-page":"9654","DOI":"10.1073\/pnas.95.16.9654","article-title":"Human endplate acetylcholinesterase deficiency caused by mutations in the collagen-like tail subunit (ColQ) of the asymmetric enzyme","volume":"95","author":"Ohno","year":"1998","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jss.2021.05.043_bib0023","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1136\/gut.29.2.218","article-title":"Sigmoid motility in diverticular disease and the irritable bowel syndrome","volume":"29","author":"Trotman","year":"1988","journal-title":"Gut"},{"key":"10.1016\/j.jss.2021.05.043_bib0024","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1038\/nrgastro.2016.107","article-title":"The bowel and beyond: the enteric nervous system in neurological disorders","volume":"13","author":"Rao","year":"2016","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"10.1016\/j.jss.2021.05.043_bib0025","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1136\/jcp.2005.026112","article-title":"Interstitial cells of Cajal, enteric nerves, and glial cells in colonic diverticular disease","volume":"58","author":"Bassotti","year":"2005","journal-title":"J Clin Pathol"}],"container-title":["Journal of Surgical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022480421003577?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022480421003577?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T14:57:31Z","timestamp":1758380251000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022480421003577"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11]]},"references-count":25,"alternative-id":["S0022480421003577"],"URL":"https:\/\/doi.org\/10.1016\/j.jss.2021.05.043","relation":{},"ISSN":["0022-4804"],"issn-type":[{"value":"0022-4804","type":"print"}],"subject":[],"published":{"date-parts":[[2021,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"COLQ and ARHGAP15 are Associated with Diverticular Disease and are Expressed in the Colon","name":"articletitle","label":"Article Title"},{"value":"Journal of Surgical Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jss.2021.05.043","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}