{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T10:34:03Z","timestamp":1778668443306,"version":"3.51.4"},"reference-count":29,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100016268","name":"US Department of the Air Force","doi-asserted-by":"publisher","award":["FA8650-17-2-6G23"],"award-info":[{"award-number":["FA8650-17-2-6G23"]}],"id":[{"id":"10.13039\/100016268","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006831","name":"U.S. Air Force","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006831","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","journalofsurgicalresearch.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Surgical Research"],"published-print":{"date-parts":[[2021,11]]},"DOI":"10.1016\/j.jss.2021.05.046","type":"journal-article","created":{"date-parts":[[2021,7,3]],"date-time":"2021-07-03T17:59:59Z","timestamp":1625335199000},"page":"424-431","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Antimicrobial Coating Prevents Ventilator-Associated Pneumonia in a 72 hour Large Animal Model"],"prefix":"10.1016","volume":"267","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8549-7615","authenticated-orcid":false,"given":"Aaron","family":"Seitz","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer E.","family":"Baker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nick C.","family":"Levinsky","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mackenzie C.","family":"Morris","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael J.","family":"Edwards","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erich","family":"Gulbins","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1141-0139","authenticated-orcid":false,"given":"Thomas C.","family":"Blakeman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dario","family":"Rodriquez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0912-3360","authenticated-orcid":false,"given":"Richard D.","family":"Branson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Goodman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jss.2021.05.046_bib0001","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1016\/S1473-3099(13)70081-1","article-title":"Attributable mortality of ventilator-associated pneumonia: a meta-analysis of individual patient data from randomised prevention studies","volume":"13","author":"Melsen","year":"2013","journal-title":"Lancet Infect Dis"},{"key":"10.1016\/j.jss.2021.05.046_bib0002","doi-asserted-by":"crossref","DOI":"10.1183\/13993003.00582-2017","volume":"50","author":"Torres","year":"2017","journal-title":"Eur Respir J"},{"key":"10.1016\/j.jss.2021.05.046_bib0003","doi-asserted-by":"crossref","first-page":"e61","DOI":"10.1093\/cid\/ciw353","article-title":"Management of adults with hospital-acquired and ventilator-associated pneumonia: 2016 clinical practice guidelines by the infectious diseases society of america and the american thoracic society","volume":"63","author":"Kalil","year":"2016","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.jss.2021.05.046_bib0004","doi-asserted-by":"crossref","first-page":"2115","DOI":"10.1378\/chest.122.6.2115","article-title":"Epidemiology and outcomes of ventilator-associated pneumonia in a large US database","volume":"122","author":"Rello","year":"2002","journal-title":"Chest"},{"key":"10.1016\/j.jss.2021.05.046_bib0005","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1007\/BF00255791","article-title":"Early onset pneumonia: a multicenter study in intensive care units","volume":"13","author":"Langer","year":"1987","journal-title":"Intensive Care Med"},{"key":"10.1016\/j.jss.2021.05.046_bib0006","doi-asserted-by":"crossref","first-page":"2014","DOI":"10.1128\/jcm.27.9.2014-2018.1989","article-title":"Tracheal tube biofilm as a source of bacterial colonization of the lung","volume":"27","author":"Inglis","year":"1989","journal-title":"J Clin Microbiol"},{"key":"10.1016\/j.jss.2021.05.046_bib0007","doi-asserted-by":"crossref","first-page":"2218","DOI":"10.1097\/CCM.0b013e3182227d52","article-title":"Reducing ventilator-associated pneumonia in intensive care: impact of implementing a care bundle","volume":"39","author":"Morris","year":"2011","journal-title":"Crit Care Med"},{"key":"10.1016\/j.jss.2021.05.046_bib0008","first-page":"219","article-title":"Implementing a ventilator bundle in a community hospital","volume":"33","author":"Youngquist","year":"2007","journal-title":"Jt Comm J Qual Patient Saf"},{"key":"10.1016\/j.jss.2021.05.046_bib0009","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1016\/j.athoracsur.2018.03.058","article-title":"Is the venner-PneuX endotracheal tube system a cost-effective option for post cardiac surgery care?","volume":"106","author":"Andronis","year":"2018","journal-title":"Ann Thorac Surg"},{"key":"10.1016\/j.jss.2021.05.046_bib0010","doi-asserted-by":"crossref","first-page":"1708","DOI":"10.1007\/s00134-017-4778-0","article-title":"Beware the siren's song of novel endotracheal tube designs","volume":"43","author":"Klompas","year":"2017","journal-title":"Intensive Care Med"},{"key":"10.1016\/j.jss.2021.05.046_bib0011","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1097\/QCO.0000000000000358","article-title":"Prevention of ventilator-associated pneumonia","volume":"30","author":"Li Bassi","year":"2017","journal-title":"Curr Opin Infect Dis"},{"key":"10.1016\/j.jss.2021.05.046_bib0012","doi-asserted-by":"crossref","first-page":"2427","DOI":"10.1001\/jama.2016.16226","article-title":"Trend in ventilator-associated pneumonia rates between 2005 and 2013","volume":"316","author":"Metersky","year":"2016","journal-title":"JAMA"},{"key":"10.1016\/j.jss.2021.05.046_bib0013","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1007\/s00134-008-1099-3","article-title":"Antimicrobial-coated endotracheal tubes: an experimental study","volume":"34","author":"Berra","year":"2008","journal-title":"Intensive Care Med"},{"key":"10.1016\/j.jss.2021.05.046_bib0014","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1378\/chest.121.3.863","article-title":"Silver-coated endotracheal tubes associated with reduced bacterial burden in the lungs of mechanically ventilated dogs","volume":"121","author":"Olson","year":"2002","journal-title":"Chest"},{"key":"10.1016\/j.jss.2021.05.046_bib0015","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1007\/s00134-008-1100-1","article-title":"Internally coated endotracheal tubes with silver sulfadiazine in polyurethane to prevent bacterial colonization: a clinical trial","volume":"34","author":"Berra","year":"2008","journal-title":"Intensive Care Med"},{"key":"10.1016\/j.jss.2021.05.046_bib0016","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1001\/jama.300.7.805","article-title":"Silver-coated endotracheal tubes and incidence of ventilator-associated pneumonia: The NASCENT randomized trial","volume":"300","author":"Kollef","year":"2008","journal-title":"JAMA: the journal of the American Medical Association"},{"key":"10.1016\/j.jss.2021.05.046_bib0017","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.biochi.2017.03.014","article-title":"Sphingosine's role in epithelial host defense: a natural antimicrobial and novel therapeutic","volume":"141","author":"Martin","year":"2017","journal-title":"Biochimie"},{"key":"10.1016\/j.jss.2021.05.046_bib0018","doi-asserted-by":"crossref","first-page":"2094","DOI":"10.1159\/000445567","article-title":"Lack of sphingosine causes susceptibility to pulmonary staphylococcus aureus infections in cystic fibrosis","volume":"38","author":"Tavakoli Tabazavareh","year":"2016","journal-title":"Cell Physiol Biochem"},{"key":"10.1016\/j.jss.2021.05.046_bib0019","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.15252\/emmm.201404075","article-title":"Sphingoid long chain bases prevent lung infection by pseudomonas aeruginosa","volume":"6","author":"Pewzner-Jung","year":"2014","journal-title":"EMBO Mol Med"},{"key":"10.1016\/j.jss.2021.05.046_bib0020","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1189\/jlb.3HI0416-197R","article-title":"Frontline science: sphingosine rescues burn-injured mice from pulmonary pseudomonas aeruginosa infection","volume":"100","author":"Rice","year":"2016","journal-title":"J Leukoc Biol"},{"key":"10.1016\/j.jss.2021.05.046_bib0021","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1111\/1523-1747.ep12497842","article-title":"Antimicrobial activity of sphingosines","volume":"98","author":"Bibel","year":"1992","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.jss.2021.05.046_bib0022","unstructured":"National center for biotechnology information. PubChem database. doxycycline, CID=54671203, Available at: https:\/\/Pubchem.ncbi.nlm.nih.gov\/compound\/doxycycline (accessed on nov. 6, 2019)."},{"key":"10.1016\/j.jss.2021.05.046_bib0023","unstructured":"National center for biotechnology information. PubChem database. levofloxacin, CID=149096, Available at: https:\/\/Pubchem.ncbi.nlm.nih.gov\/compound\/levofloxacin (accessed on nov. 6, 2019)."},{"key":"10.1016\/j.jss.2021.05.046_bib0024","unstructured":"National center for biotechnology information. PubChem database. acetylcysteine, CID=12035, Available at: https:\/\/Pubchem.ncbi.nlm.nih.gov\/compound\/acetylcysteine (accessed on nov. 6, 2019)."},{"key":"10.1016\/j.jss.2021.05.046_bib0025","unstructured":"National center for biotechnology information. PubChem database. octadecylamine, CID=15793, Available at: https:\/\/Pubchem.ncbi.nlm.nih.gov\/compound\/octadecylamine (accessed on nov. 6, 2019)."},{"key":"10.1016\/j.jss.2021.05.046_bib0026","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1378\/chest.07-0185","article-title":"Experimental severe pseudomonas aeruginosa pneumonia and antibiotic therapy in piglets receiving mechanical ventilation","volume":"132","author":"Luna","year":"2007","journal-title":"Chest"},{"key":"10.1016\/j.jss.2021.05.046_bib0027","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1097\/CCM.0000000000000487","article-title":"Gravity predominates over ventilatory pattern in the prevention of ventilator-associated pneumonia","volume":"42","author":"Li Bassi","year":"2014","journal-title":"Crit Care Med"},{"key":"10.1016\/j.jss.2021.05.046_bib0028","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1097\/ALN.0000000000000222","article-title":"A novel porcine model of ventilator-associated pneumonia caused by oropharyngeal challenge with pseudomonas aeruginosa","volume":"120","author":"Li Bassi","year":"2014","journal-title":"Anesthesiology"},{"key":"10.1016\/j.jss.2021.05.046_bib0029","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1007\/s00134-012-2495-2","article-title":"Effects of tracheal orientation on development of ventilator-associated pneumonia: An experimental study","volume":"38","author":"Zanella","year":"2012","journal-title":"Intensive Care Med"}],"container-title":["Journal of Surgical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022480421003607?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022480421003607?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T14:57:53Z","timestamp":1758380273000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022480421003607"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11]]},"references-count":29,"alternative-id":["S0022480421003607"],"URL":"https:\/\/doi.org\/10.1016\/j.jss.2021.05.046","relation":{},"ISSN":["0022-4804"],"issn-type":[{"value":"0022-4804","type":"print"}],"subject":[],"published":{"date-parts":[[2021,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Antimicrobial Coating Prevents Ventilator-Associated Pneumonia in a 72 hour Large Animal Model","name":"articletitle","label":"Article Title"},{"value":"Journal of Surgical Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jss.2021.05.046","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}