{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T01:16:42Z","timestamp":1789089402106,"version":"build-2803163510"},"reference-count":31,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["RO1 DK104698"],"award-info":[{"award-number":["RO1 DK104698"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["T32 DK007120"],"award-info":[{"award-number":["T32 DK007120"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["T32 DK077653"],"award-info":[{"award-number":["T32 DK077653"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","journalofsurgicalresearch.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Surgical Research"],"published-print":{"date-parts":[[2022,5]]},"DOI":"10.1016\/j.jss.2021.11.015","type":"journal-article","created":{"date-parts":[[2022,1,13]],"date-time":"2022-01-13T01:26:35Z","timestamp":1642037195000},"page":"100-109","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"special_numbering":"C","title":["Distal Small Bowel Resection Yields Enhanced Intestinal and Colonic Adaptation"],"prefix":"10.1016","volume":"273","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8161-8686","authenticated-orcid":false,"given":"Maria E.","family":"Tecos","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9031-2133","authenticated-orcid":false,"given":"Allie E.","family":"Steinberger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brad W.","family":"Warner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jss.2021.11.015_bib1","first-page":"441","article-title":"Intestinal adaptation following massive small bowel resection in the mouse","volume":"183","author":"Helmrath","year":"1996","journal-title":"J Am Coll Surg"},{"key":"10.1016\/j.jss.2021.11.015_bib2","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1097\/MPG.0b013e318268a9a4","article-title":"Time-and segment-related changes of postresected intestine: a 4-dimensional model of intestinal adaptation","volume":"56","author":"Buccigrossi","year":"2013","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"10.1016\/j.jss.2021.11.015_bib3","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1007\/s00383-006-1855-9","article-title":"Intestinal epithelial cell proliferation is dependent on the site of massive small bowel resection","volume":"23","author":"Haxhija","year":"2007","journal-title":"Pediatr Surg Int"},{"key":"10.1016\/j.jss.2021.11.015_bib4","doi-asserted-by":"crossref","first-page":"703","DOI":"10.36290\/vnl.2017.139","article-title":"Intestinal adaptation following gut resection","volume":"63","author":"K\u0159\u00ed\u017eov\u00e1","year":"2017","journal-title":"Vnitrni lekarstvi"},{"key":"10.1016\/j.jss.2021.11.015_bib5","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1016\/j.jpedsurg.2014.02.056","article-title":"Citrulline levels following proximal versus distal small bowel resection","volume":"49","author":"Gutierrez","year":"2014","journal-title":"J Pediatr Surg"},{"key":"10.1016\/j.jss.2021.11.015_bib6","doi-asserted-by":"crossref","first-page":"14S","DOI":"10.1177\/0148607113520005","article-title":"Pathophysiology of short bowel syndrome: considerations of resected and residual anatomy","volume":"38","author":"Tappenden","year":"2014","journal-title":"J Parenter Enteral Nutr"},{"key":"10.1016\/j.jss.2021.11.015_bib7","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/S0022-3468(96)90750-2","article-title":"Partial intestinal obstruction induces substantial mucosal proliferation in the pig","volume":"31","author":"Collins","year":"1996","journal-title":"J Pediatr Surg"},{"key":"10.1016\/j.jss.2021.11.015_bib8","doi-asserted-by":"crossref","first-page":"G1013","DOI":"10.1152\/ajpgi.00218.2007","article-title":"Expansion of intestinal stem cells associated with long-term adaptation following ileocecal resection in mice","volume":"293","author":"Dekaney","year":"2007","journal-title":"Am J Physiol Gastrointestinal Liver Physiol"},{"key":"10.1016\/j.jss.2021.11.015_bib9","first-page":"e52106","article-title":"Murine ileocolic bowel resection with primary anastomosis","author":"Perry","year":"2014","journal-title":"J Vis Exp"},{"key":"10.1016\/j.jss.2021.11.015_bib10","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1016\/j.immuni.2018.07.016","article-title":"A map of Toll-like receptor expression in the intestinal epithelium reveals distinct spatial, cell type-specific, and temporal patterns","volume":"49","author":"Price","year":"2018","journal-title":"Immunity"},{"key":"10.1016\/j.jss.2021.11.015_bib11","doi-asserted-by":"crossref","first-page":"e12225","DOI":"10.14814\/phy2.12225","article-title":"Pattern recognition receptors in the gut: analysis of their expression along the intestinal tract and the crypt\/villus axis","volume":"3","author":"Gourbeyre","year":"2015","journal-title":"Physiol Rep"},{"key":"10.1016\/j.jss.2021.11.015_bib12","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1016\/j.jpedsurg.2017.03.026","article-title":"Toll-like receptor 4 is critical for the development of resection-associated hepatic steatosis","volume":"52","author":"Barron","year":"2017","journal-title":"J Pediatr Surg"},{"key":"10.1016\/j.jss.2021.11.015_bib13","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.jss.2020.08.049","article-title":"Small bowel resection increases paracellular gut barrier permeability via alterations of tight junction Complexes mediated by intestinal TLR4","volume":"258","author":"Courtney","year":"2021","journal-title":"J Surg Res"},{"key":"10.1016\/j.jss.2021.11.015_bib14","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/j.jcmgh.2019.06.001","article-title":"Single-cell analysis reveals regional reprogramming during adaptation to massive small bowel resection in mice","volume":"8","author":"Seiler","year":"2019","journal-title":"Cell Mol Gastroenterol Hepatol"},{"key":"10.1016\/j.jss.2021.11.015_bib15","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1007\/s11605-013-2338-7","article-title":"High-fat diet enhances villus growth during the adaptation response to massive proximal small bowel resection","volume":"18","author":"Choi","year":"2014","journal-title":"J Gastrointest Surg"},{"key":"10.1016\/j.jss.2021.11.015_bib16","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/j.jcmgh.2020.04.006","article-title":"A Central role for lipocalin-2 in the adaptation to short-bowel syndrome through Down-Regulation of IL22 in mice","volume":"10","author":"Zhang","year":"2020","journal-title":"Cell Mol Gastroenterol Hepatol"},{"key":"10.1016\/j.jss.2021.11.015_bib17","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1002\/jpen.1754","article-title":"Key determinants for achieving enteral autonomy and reduced parenteral nutrition exposure in pediatric intestinal failure","volume":"44","author":"Enman","year":"2020","journal-title":"J Parenter Enteral Nutr"},{"key":"10.1016\/j.jss.2021.11.015_bib18","doi-asserted-by":"crossref","first-page":"e79","DOI":"10.1097\/MPG.0000000000002384","article-title":"Outcomes of children with chronic intestinal failure: Experience over 2 decades at a tertiary paediatric hospital","volume":"69","author":"Jo","year":"2019","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"10.1016\/j.jss.2021.11.015_bib19","doi-asserted-by":"crossref","first-page":"G123","DOI":"10.1152\/ajpgi.1992.262.1.G123","article-title":"Sucrase-isomaltase gene expression along crypt-villus axis of human small intestine is regulated at level of mRNA abundance","volume":"262","author":"Traber","year":"1992","journal-title":"Am J Physiol Gastrointestinal Liver Physiol"},{"key":"10.1016\/j.jss.2021.11.015_bib20","first-page":"1","article-title":"Enhancement of colonic absorptive function after the massive resection of the small intestine based on the creation of an Artificial colonic valve","volume":"10","author":"Deng","year":"2020","journal-title":"Sci Rep"},{"key":"10.1016\/j.jss.2021.11.015_bib21","first-page":"99","article-title":"An organoid-based organ-repurposing approach to treat short bowel syndrome","volume":"592","author":"Sugimoto","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.jss.2021.11.015_bib22","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1016\/j.jpedsurg.2020.02.038","article-title":"Adaptation of extracellular matrix to massive small bowel resection in mice","volume":"55","author":"Seiler","year":"2020","journal-title":"J Pediatr Surg"},{"key":"10.1016\/j.jss.2021.11.015_bib23","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1007\/s00441-015-2111-1","article-title":"Tissue underlying the intestinal epithelium elicits proliferation of intestinal stem cells following cytotoxic damage","volume":"361","author":"Seiler","year":"2015","journal-title":"Cell Tissue Res"},{"key":"10.1016\/j.jss.2021.11.015_bib24","doi-asserted-by":"crossref","first-page":"1158","DOI":"10.1007\/s10620-018-5420-x","article-title":"Villus growth, increased intestinal epithelial sodium selectivity, and hyperaldosteronism are mechanisms of adaptation in a murine model of short bowel syndrome","volume":"64","author":"Berlin","year":"2019","journal-title":"Dig Dis Sci"},{"key":"10.1016\/j.jss.2021.11.015_bib25","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1053\/j.sempedsurg.2018.07.002","article-title":"An anatomic approach to understanding mechanisms of intestinal adaptation","volume":"27","author":"Courtney","year":"2018","journal-title":"InSeminars Pediatr Surg"},{"key":"10.1016\/j.jss.2021.11.015_bib26","doi-asserted-by":"crossref","first-page":"G907","DOI":"10.1152\/ajpgi.00284.2020","article-title":"Liver injury after small bowel resection is prevented in obesity-resistant 129S1\/SvImJ mice","volume":"320","author":"Onufer","year":"2021","journal-title":"Am J Physiol Gastrointestinal Liver Physiol"},{"key":"10.1016\/j.jss.2021.11.015_bib27","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1016\/j.jpedsurg.2020.02.037","article-title":"Effects of high-fat diet on liver injury after small bowel resection","volume":"55","author":"Onufer","year":"2020","journal-title":"J Pediatr Surg"},{"key":"10.1016\/j.jss.2021.11.015_bib28","doi-asserted-by":"crossref","first-page":"G727","DOI":"10.1152\/ajpgi.00117.2019","article-title":"Nod2 deficiency functionally impairs adaptation to short bowel syndrome via alterations of the epithelial barrier function","volume":"317","author":"Berlin","year":"2019","journal-title":"Am J Physiol Gastrointestinal Liver Physiol"},{"key":"10.1016\/j.jss.2021.11.015_bib29","doi-asserted-by":"crossref","first-page":"3521","DOI":"10.1007\/s10620-020-06140-6","article-title":"Teduglutide promotes epithelial tight junction pore function in murine short bowel syndrome to alleviate intestinal insufficiency","volume":"65","author":"Reiner","year":"2020","journal-title":"Dig Dis Sci"},{"key":"10.1016\/j.jss.2021.11.015_bib30","doi-asserted-by":"crossref","first-page":"1485","DOI":"10.1016\/j.surg.2016.07.018","article-title":"Liver steatosis induced by small bowel resection is prevented by oral vancomycin","volume":"160","author":"Barron","year":"2016","journal-title":"Surgery"},{"key":"10.1016\/j.jss.2021.11.015_bib31","doi-asserted-by":"crossref","first-page":"4416","DOI":"10.1007\/s00464-016-4760-x","article-title":"Effect of bowel resection on TLR signaling during intestinal\u00a0adaptation in a rat model","volume":"30","author":"Sukhotnik","year":"2016","journal-title":"Surg Endosc"}],"container-title":["Journal of Surgical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S002248042100723X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S002248042100723X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T14:56:44Z","timestamp":1758380204000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S002248042100723X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5]]},"references-count":31,"alternative-id":["S002248042100723X"],"URL":"https:\/\/doi.org\/10.1016\/j.jss.2021.11.015","relation":{},"ISSN":["0022-4804"],"issn-type":[{"value":"0022-4804","type":"print"}],"subject":[],"published":{"date-parts":[[2022,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Distal Small Bowel Resection Yields Enhanced Intestinal and Colonic Adaptation","name":"articletitle","label":"Article Title"},{"value":"Journal of Surgical Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jss.2021.11.015","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}