{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T17:00:08Z","timestamp":1783443608788,"version":"3.54.6"},"reference-count":29,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,2,21]],"date-time":"2024-02-21T00:00:00Z","timestamp":1708473600000},"content-version":"am","delay-in-days":265,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["RO1 HL106582"],"award-info":[{"award-number":["RO1 HL106582"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","journalofsurgicalresearch.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Surgical Research"],"published-print":{"date-parts":[[2023,6]]},"DOI":"10.1016\/j.jss.2022.12.028","type":"journal-article","created":{"date-parts":[[2023,2,21]],"date-time":"2023-02-21T07:54:44Z","timestamp":1676966084000},"page":"118-126","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Complement Cross Talks With H-K-ATPase to Upregulate Runx2 in Human Aortic Valve Interstitial Cells"],"prefix":"10.1016","volume":"286","author":[{"given":"Xin-sheng","family":"Deng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianzhong","family":"Meng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Fullerton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Stone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Iguidbashian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Jaggers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jss.2022.12.028_bib1","doi-asserted-by":"crossref","first-page":"1670","DOI":"10.1161\/CIRCULATIONAHA.119.043391","article-title":"Global, regional, and national burden of calcific aortic valve and degenerative mitral valve diseases, 1990-2017","volume":"141","author":"Yadgir","year":"2020","journal-title":"Circulation"},{"key":"10.1016\/j.jss.2022.12.028_bib2","doi-asserted-by":"crossref","first-page":"913","DOI":"10.3390\/ijms22020913","article-title":"Matrix in calcific aortic valve disease: architecture, dynamic and perspectives","volume":"22","author":"Di Vito","year":"2021","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.jss.2022.12.028_bib3","doi-asserted-by":"crossref","first-page":"2387","DOI":"10.1161\/ATVBAHA.114.302523","article-title":"Calcific aortic valve disease: a consensus summary from the alliance of investigators on calcific aortic valve disease","volume":"34","author":"Yutzey","year":"2014","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.jss.2022.12.028_bib4","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.atherosclerosis.2007.03.040","article-title":"Complement system is activated in stenotic aortic valves","volume":"196","author":"Helske","year":"2008","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.jss.2022.12.028_bib5","doi-asserted-by":"crossref","first-page":"1973","DOI":"10.4049\/jimmunol.1801244","article-title":"Increased complement factor B and bb levels are associated with mortality in patients with severe aortic stenosis","volume":"203","author":"Shahini","year":"2019","journal-title":"J Immunol"},{"key":"10.1016\/j.jss.2022.12.028_bib6","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/j.semnephrol.2013.08.001","article-title":"Overview of complement activation and regulation","volume":"33","author":"Noris","year":"2013","journal-title":"Semin Nephrol"},{"key":"10.1016\/j.jss.2022.12.028_bib7","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/j.amjmed.2011.01.007","article-title":"Proton pump inhibitors and risk of fractures: a meta-analysis of 11 international studies","volume":"124","author":"Yu","year":"2011","journal-title":"Am J Med"},{"key":"10.1016\/j.jss.2022.12.028_bib8","doi-asserted-by":"crossref","first-page":"1571","DOI":"10.3390\/ijerph16091571","article-title":"Proton pump inhibitors and fracture risk: a Review of current evidence and mechanisms involved","volume":"16","author":"Thong","year":"2019","journal-title":"Int J Environ Res Public Health"},{"key":"10.1016\/j.jss.2022.12.028_bib9","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1002\/jcb.23337","article-title":"Decreased bone mineral density and reduced bone quality in H(+)\/K(+) ATPase beta-subunit deficient mice","volume":"113","author":"Fossmark","year":"2012","journal-title":"J Cell Biochem"},{"key":"10.1016\/j.jss.2022.12.028_bib10","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/j.ydbio.2015.08.014","article-title":"(+)\/K (+) ATPase activity is required for biomineralization in sea urchin embryos","volume":"406","author":"Schatzberg","year":"2015","journal-title":"Dev Biol"},{"key":"10.1016\/j.jss.2022.12.028_bib11","doi-asserted-by":"crossref","first-page":"301","DOI":"10.18388\/abp.2009_2462","article-title":"Lansoprazole is an uncompetitive inhibitor of tissue-nonspecific alkaline phosphatase","volume":"56","author":"Delomen\u00e8de","year":"2009","journal-title":"Acta Biochim Pol"},{"key":"10.1016\/j.jss.2022.12.028_bib12","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1161\/CIRCULATIONAHA.106.666008","article-title":"Negative inotropy of the gastric proton pump inhibitor pantoprazole in myocardium from humans and rabbits: evaluation of mechanisms","volume":"116","author":"Schillinger","year":"2007","journal-title":"Circulation"},{"key":"10.1016\/j.jss.2022.12.028_bib13","doi-asserted-by":"crossref","first-page":"627701","DOI":"10.3389\/fonc.2020.627701","article-title":"\u201cComplimenting the complement\u201d: mechanistic insights and opportunities for therapeutics in hepatocellular carcinoma","volume":"10","author":"Malik","year":"2021","journal-title":"Front Oncol"},{"key":"10.1016\/j.jss.2022.12.028_bib15","doi-asserted-by":"crossref","first-page":"1962","DOI":"10.1016\/j.athoracsur.2020.12.058","article-title":"Complement up-regulates Runx-2 to induce pro-fibrogenic change in aortic valve interstitial cells","volume":"112","author":"Deng","year":"2021","journal-title":"Ann Thorac Surg"},{"key":"10.1016\/j.jss.2022.12.028_bib16","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1016\/j.athoracsur.2016.03.033","article-title":"Rapamycin decreases the osteogenic response in aortic valve interstitial cells through the Stat3 pathway","volume":"102","author":"Deng","year":"2016","journal-title":"Ann Thorac Surg"},{"key":"10.1016\/j.jss.2022.12.028_bib17","doi-asserted-by":"crossref","first-page":"C697","DOI":"10.1152\/ajpcell.00292.2016","article-title":"Neurotrophin 3 upregulates proliferation and collagen production in human aortic valve interstitial cells: a potential role in aortic valve sclerosis","volume":"312","author":"Yao","year":"2017","journal-title":"Am J Physiol Cell Physiol"},{"key":"10.1016\/j.jss.2022.12.028_bib18","doi-asserted-by":"crossref","first-page":"1344","DOI":"10.1161\/CIRCRESAHA.121.318011","article-title":"Inflammatory and biomechanical drivers of endothelial-interstitial interactions in calcific aortic valve disease","volume":"128","author":"Driscoll","year":"2021","journal-title":"Circ Res"},{"key":"10.1016\/j.jss.2022.12.028_bib19","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1038\/s41582-020-0400-0","article-title":"Complement in neurological disorders and emerging complement-targeted therapeutics","volume":"16","author":"Dalakas","year":"2020","journal-title":"Nat Rev Neurol"},{"key":"10.1016\/j.jss.2022.12.028_bib20","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.molimm.2014.06.036","article-title":"A vital role for complement in heart disease","volume":"61","author":"Lappeg\u00e5rd","year":"2014","journal-title":"Mol Immunol"},{"key":"10.1016\/j.jss.2022.12.028_bib21","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.tmrv.2019.08.004","article-title":"Complement and coagulation: cross talk through time","volume":"33","author":"Dzik","year":"2019","journal-title":"Transfus Med Rev"},{"key":"10.1016\/j.jss.2022.12.028_bib22","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1016\/j.atherosclerosis.2015.05.038","article-title":"The complement system and toll-like receptors as integrated players in the pathophysiology of atherosclerosis","volume":"241","author":"Hovland","year":"2015","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.jss.2022.12.028_bib23","doi-asserted-by":"crossref","first-page":"1298","DOI":"10.1016\/j.cell.2012.03.047","article-title":"Complement C1q activates canonical Wnt signaling and promotes aging-related phenotypes","volume":"149","author":"Naito","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.jss.2022.12.028_bib24","doi-asserted-by":"crossref","first-page":"1507","DOI":"10.1159\/000366355","article-title":"The putative role of the non-gastric H\u207a\/K\u207a-ATPase ATP12A (ATP1AL1) as anti-apoptotic ion transporter: effect of the H\u207a\/K\u207a ATPase inhibitor SCH28080 on butyrate-stimulated myelomonocytic HL-60 cells","volume":"34","author":"Jakab","year":"2014","journal-title":"Cell Physiol Biochem"},{"key":"10.1016\/j.jss.2022.12.028_bib25","doi-asserted-by":"crossref","first-page":"16","DOI":"10.3389\/fphar.2017.00016","article-title":"Therapeutic efficacy of esomeprazole in cotton smoke-induced lung injury model","volume":"8","author":"Nelson","year":"2017","journal-title":"Front Pharmacol"},{"key":"10.1016\/j.jss.2022.12.028_bib26","doi-asserted-by":"crossref","first-page":"e123616","DOI":"10.1172\/jci.insight.123616","article-title":"Increased expression of ATP12A proton pump in cystic fibrosis airways","volume":"3","author":"Scudieri","year":"2018","journal-title":"JCI Insight"},{"key":"10.1016\/j.jss.2022.12.028_bib27","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1002\/jbmr.561","article-title":"Interactions between extracellular signal-regulated kinase 1\/2 and p38 MAP kinase pathways in the control of RUNX2 phosphorylation and transcriptional activity","volume":"27","author":"Ge","year":"2012","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.jss.2022.12.028_bib28","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.jare.2020.07.005","article-title":"Hydrogen sulfide inhibits aortic valve calcification in heart via regulating RUNX2 by NF-\u03baB, a link between inflammation and mineralization","volume":"27","author":"Sikura","year":"2020","journal-title":"J Adv Res"},{"key":"10.1016\/j.jss.2022.12.028_bib29","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.7150\/thno.49771","article-title":"ERK1\/2 inhibition reduces vascular calcification by activating miR-126-3p-DKK1\/LRP6 pathway","volume":"11","author":"Zeng","year":"2021","journal-title":"Theranostics"},{"key":"10.1016\/j.jss.2022.12.028_bib30","doi-asserted-by":"crossref","first-page":"791646","DOI":"10.3389\/fcvm.2021.791646","article-title":"The complex interplay of inflammation, metabolism, epigenetics, and sex in calcific disease of the aortic valve","volume":"8","author":"Ferrari","year":"2022","journal-title":"Front Cardiovasc Med"}],"container-title":["Journal of Surgical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022480422008502?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022480422008502?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T15:01:56Z","timestamp":1758380516000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022480422008502"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6]]},"references-count":29,"alternative-id":["S0022480422008502"],"URL":"https:\/\/doi.org\/10.1016\/j.jss.2022.12.028","relation":{},"ISSN":["0022-4804"],"issn-type":[{"value":"0022-4804","type":"print"}],"subject":[],"published":{"date-parts":[[2023,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Complement Cross Talks With H-K-ATPase to Upregulate Runx2 in Human Aortic Valve Interstitial Cells","name":"articletitle","label":"Article Title"},{"value":"Journal of Surgical Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jss.2022.12.028","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}