{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T11:04:15Z","timestamp":1773399855010,"version":"3.50.1"},"reference-count":38,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,4,4]],"date-time":"2024-04-04T00:00:00Z","timestamp":1712188800000},"content-version":"am","delay-in-days":247,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["RO1GM129533"],"award-info":[{"award-number":["RO1GM129533"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","journalofsurgicalresearch.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Surgical Research"],"published-print":{"date-parts":[[2023,8]]},"DOI":"10.1016\/j.jss.2023.02.043","type":"journal-article","created":{"date-parts":[[2023,4,5]],"date-time":"2023-04-05T12:17:48Z","timestamp":1680697068000},"page":"208-214","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["Fibrinogen Inhibits Metalloproteinase-9 Activation and Syndecan-1 Cleavage to Protect Lung Function in ApoE Null Mice After Hemorrhagic Shock"],"prefix":"10.1016","volume":"288","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3113-2332","authenticated-orcid":false,"given":"Feng","family":"Wu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brooke","family":"Dorman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmad","family":"Zeineddin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9198-7351","authenticated-orcid":false,"given":"Rosemary Ann","family":"Kozar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jss.2023.02.043_bib5","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1097\/00005373-199109000-00009","article-title":"Obesity and increased mortality in blunt trauma","volume":"31","author":"Choban","year":"1991","journal-title":"J Trauma"},{"key":"10.1016\/j.jss.2023.02.043_bib29","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1001\/archsurg.139.9.983","article-title":"Obesity is an independent risk factor of mortality in severely injured blunt trauma patients","volume":"139","author":"Neville","year":"2004","journal-title":"Arch Surg"},{"key":"10.1016\/j.jss.2023.02.043_bib30","doi-asserted-by":"crossref","first-page":"R77","DOI":"10.1186\/cc11334","article-title":"Obese trauma patients are at increased risk of early hypovolemic shock: a retrospective cohort analysis of 1,084 severely injured patients","volume":"16","author":"Nelson","year":"2012","journal-title":"Crit Care"},{"key":"10.1016\/j.jss.2023.02.043_bib6","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1161\/CIRCULATIONAHA.120.047574","article-title":"Endotheliopathy of obesity","volume":"142","author":"Cooke","year":"2020","journal-title":"Circulation"},{"key":"10.1016\/j.jss.2023.02.043_bib20","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1007\/s00424-007-0212-8","article-title":"The endothelial glycocalyx: composition, functions, and visualization","volume":"454","author":"Reitsma","year":"2007","journal-title":"Pflugers Arch"},{"key":"10.1016\/j.jss.2023.02.043_bib35","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1369\/0022155420937087","article-title":"Heparanase-enhanced shedding of syndecan-1 and its role in driving disease pathogenesis and progression","volume":"68","author":"Rangarajan","year":"2020","journal-title":"J Histochem Cytochem"},{"key":"10.1016\/j.jss.2023.02.043_bib1","doi-asserted-by":"crossref","first-page":"e32672","DOI":"10.1371\/journal.pone.0032672","article-title":"Protease activity increases in plasma, peritoneal fluid, and vital organs after hemorrhagic shock in rats","volume":"7","author":"Altshuler","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.jss.2023.02.043_bib8","doi-asserted-by":"crossref","first-page":"269","DOI":"10.2174\/157015909790031157","article-title":"Mmp-9, a potential target for cerebral ischemic treatment","volume":"7","author":"Dong","year":"2009","journal-title":"Curr Neuropharmacol"},{"key":"10.1016\/j.jss.2023.02.043_bib38","doi-asserted-by":"crossref","first-page":"56","DOI":"10.3389\/fncel.2016.00056","article-title":"Implications of MMP9 for blood brain barrier disruption and hemorrhagic transformation following ischemic stroke","volume":"10","author":"Turner","year":"2016","journal-title":"Front Cell Neurosci"},{"key":"10.1016\/j.jss.2023.02.043_bib42","doi-asserted-by":"crossref","first-page":"5801","DOI":"10.2147\/JIR.S331020","article-title":"Syndecan-1 shedding by matrix metalloproteinase-9 signaling regulates alveolar epithelial tight junction in lipopolysaccharide-induced early acute lung injury","volume":"14","author":"Zhang","year":"2021","journal-title":"J Inflamm Res"},{"key":"10.1016\/j.jss.2023.02.043_bib11","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/j.jamcollsurg.2017.05.012","article-title":"Syndecan-1: a quantitative marker for the endotheliopathy of trauma","volume":"225","author":"Gonzalez Rodriguez","year":"2017","journal-title":"J Am Coll Surg"},{"key":"10.1016\/j.jss.2023.02.043_bib14","doi-asserted-by":"crossref","first-page":"e23530","DOI":"10.1371\/journal.pone.0023530","article-title":"Modulation of syndecan-1 shedding after hemorrhagic shock and resuscitation","volume":"6","author":"Haywood-Watson","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.jss.2023.02.043_bib16","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1097\/SLA.0000000000001751","article-title":"Traumatic\u00a0endotheliopathy: a prospective observational study of 424 severely injured patients","volume":"265","author":"Johansson","year":"2017","journal-title":"Ann Surg"},{"key":"10.1016\/j.jss.2023.02.043_bib24","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1213\/ANE.0b013e318210385c","article-title":"Plasma restoration of endothelial glycocalyx in a rodent model of hemorrhagic shock","volume":"112","author":"Kozar","year":"2011","journal-title":"Anesth Analg"},{"key":"10.1016\/j.jss.2023.02.043_bib17","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1097\/SLA.0b013e318226113d","article-title":"A high admission syndecan-1 level, a marker of endothelial glycocalyx degradation, is associated with inflammation, protein C depletion, fibrinolysis, and increased mortality in trauma patients","volume":"254","author":"Johansson","year":"2011","journal-title":"Ann Surg"},{"key":"10.1016\/j.jss.2023.02.043_bib9","doi-asserted-by":"crossref","first-page":"e000711","DOI":"10.1136\/tsaco-2021-000711","article-title":"The effect of perturbations of the glycocalyx on microvascular perfusion in the obese trauma population: an in\u00a0vitro study","volume":"6","author":"Diebel","year":"2021","journal-title":"Trauma Surg Acute Care Open"},{"key":"10.1016\/j.jss.2023.02.043_bib23","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1038\/oby.2009.176","article-title":"A murine model of obesity with accelerated atherosclerosis","volume":"18","author":"King","year":"2010","journal-title":"Obesity"},{"key":"10.1016\/j.jss.2023.02.043_bib4","first-page":"420","article-title":"Fibrinogen inhibits microRNA-19b, a novel mechanism for repair of haemorrhagic shock-induced endothelial cell dysfunction","volume":"19","author":"Chipman","year":"2021","journal-title":"Blood Transfus"},{"key":"10.1016\/j.jss.2023.02.043_bib40","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1097\/SHK.0000000000001207","article-title":"Fibrinogen protects against barrier dysfunction through maintaining cell surface syndecan-1 in\u00a0vitro","volume":"51","author":"Wu","year":"2019","journal-title":"Shock"},{"key":"10.1016\/j.jss.2023.02.043_bib33","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1097\/SHK.0b013e31829f91fc","article-title":"Fresh frozen plasma lessens pulmonary endothelial inflammation and hyperpermeability after hemorrhagic shock and is associated with loss of syndecan 1","volume":"40","author":"Peng","year":"2013","journal-title":"Shock"},{"issue":"Suppl 3","key":"10.1016\/j.jss.2023.02.043_bib37","doi-asserted-by":"crossref","first-page":"S20","DOI":"10.1016\/j.injury.2014.08.013","article-title":"Female sex protects from organ failure and sepsis after major trauma hemorrhage","volume":"45","author":"Trentzsch","year":"2014","journal-title":"Injury"},{"key":"10.1016\/j.jss.2023.02.043_bib10","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1183\/09031936.00014808","article-title":"Amifostine reduces lung vascular permeability via suppression of inflammatory signalling","volume":"33","author":"Fu","year":"2009","journal-title":"Eur Respir J"},{"key":"10.1016\/j.jss.2023.02.043_bib13","doi-asserted-by":"crossref","first-page":"6373","DOI":"10.4049\/jimmunol.174.10.6373","article-title":"Gastrointestinal ischemia-reperfusion injury is lectin complement pathway dependent without involving C1q1","volume":"174","author":"Hart","year":"2005","journal-title":"J Immunol"},{"key":"10.1016\/j.jss.2023.02.043_bib26","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"10.1016\/j.jss.2023.02.043_bib18","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1097\/SHK.0b013e3182635aca","article-title":"Resuscitation of traumatic hemorrhagic shock patients with hypertonic saline-without dextran-inhibits neutrophil and endothelial cell activation","volume":"38","author":"Junger","year":"2012","journal-title":"Shock"},{"key":"10.1016\/j.jss.2023.02.043_bib32","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1097\/TA.0000000000001056","article-title":"Intraluminal tranexamic acid inhibits intestinal sheddases and mitigates gut and lung injury and inflammation in a rodent model of hemorrhagic shock","volume":"81","author":"Peng","year":"2016","journal-title":"J Trauma Acute Care Surg"},{"key":"10.1016\/j.jss.2023.02.043_bib15","doi-asserted-by":"crossref","first-page":"739699","DOI":"10.3389\/fncel.2021.739699","article-title":"The structure and function of the glycocalyx and its connection with blood-brain barrier","volume":"15","author":"Jin","year":"2021","journal-title":"Front Cell Neurosci"},{"key":"10.1016\/j.jss.2023.02.043_bib34","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1074\/jbc.M109.059394","article-title":"A disintegrin and metalloproteinase 17 (ADAM17) mediates inflammation-induced shedding of syndecan-1 and -4 by lung epithelial cells","volume":"285","author":"Pruessmeyer","year":"2010","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jss.2023.02.043_bib21","doi-asserted-by":"crossref","first-page":"1583","DOI":"10.4049\/jimmunol.166.3.1583","article-title":"TNF-alpha-converting enzyme cleaves the macrophage colony-stimulating factor receptor in macrophages undergoing activation","volume":"166","author":"Rovida","year":"2001","journal-title":"J Immunol"},{"key":"10.1016\/j.jss.2023.02.043_bib39","doi-asserted-by":"crossref","first-page":"2993","DOI":"10.1210\/jc.2009-2623","article-title":"Matrix metalloproteinase-9 is increased in obese subjects and decreases in response to pioglitazone","volume":"95","author":"Unal","year":"2010","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.jss.2023.02.043_bib7","doi-asserted-by":"crossref","first-page":"912726","DOI":"10.1155\/2015\/912726","article-title":"Dexamethasone suppressed LPS-induced matrix metalloproteinase and its effect on endothelial glycocalyx shedding","volume":"2015","author":"Cui","year":"2015","journal-title":"Mediators Inflamm"},{"key":"10.1016\/j.jss.2023.02.043_bib28","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1007\/s11011-014-9550-3","article-title":"Ablation of matrix metalloproteinase-9 gene decreases cerebrovascular permeability and fibrinogen deposition post traumatic brain injury in mice","volume":"30","author":"Muradashvili","year":"2015","journal-title":"Metab Brain Dis"},{"key":"10.1016\/j.jss.2023.02.043_bib22","doi-asserted-by":"crossref","first-page":"e13","DOI":"10.1161\/ATVBAHA.117.308564","article-title":"Fibrinogen and fibrin in hemostasis and thrombosis","volume":"37","author":"Kattula","year":"2017","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.jss.2023.02.043_bib19","doi-asserted-by":"crossref","first-page":"9952","DOI":"10.1074\/jbc.M111.330803","article-title":"Heparan sulfate chains of syndecan-1 regulate ectodomain shedding","volume":"287","author":"Ramani","year":"2012","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jss.2023.02.043_bib27","doi-asserted-by":"crossref","first-page":"4563","DOI":"10.1073\/pnas.1221602110","article-title":"Heparin-binding domain of fibrin(ogen) binds growth factors and promotes tissue repair when incorporated within a synthetic matrix","volume":"110","author":"Martino","year":"2013","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.jss.2023.02.043_bib3","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1183\/09031936.00209911","article-title":"Matrix metalloproteinases and their inhibitors in pulmonary hypertension","volume":"40","author":"Chelladurai","year":"2012","journal-title":"Eur Respir J"},{"key":"10.1016\/j.jss.2023.02.043_bib2","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1016\/j.metabol.2003.12.009","article-title":"Body fat is the main predictor of fibrinogen levels in healthy non-obese men","volume":"53","author":"Bo","year":"2004","journal-title":"Metabolism"},{"key":"10.1016\/j.jss.2023.02.043_bib12","doi-asserted-by":"crossref","first-page":"6366","DOI":"10.4049\/jimmunol.173.10.6366","article-title":"Apolipoprotein E modulates clearance of apoptotic bodies in\u00a0vitro and in\u00a0vivo, resulting in a systemic proinflammatory state in apolipoprotein E-deficient mice","volume":"173","author":"Grainger","year":"2004","journal-title":"J Immunol"}],"container-title":["Journal of Surgical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022480423000951?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022480423000951?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T15:02:39Z","timestamp":1758380559000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022480423000951"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8]]},"references-count":38,"alternative-id":["S0022480423000951"],"URL":"https:\/\/doi.org\/10.1016\/j.jss.2023.02.043","relation":{},"ISSN":["0022-4804"],"issn-type":[{"value":"0022-4804","type":"print"}],"subject":[],"published":{"date-parts":[[2023,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Fibrinogen Inhibits Metalloproteinase-9 Activation and Syndecan-1 Cleavage to Protect Lung Function in ApoE Null Mice After Hemorrhagic Shock","name":"articletitle","label":"Article Title"},{"value":"Journal of Surgical Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jss.2023.02.043","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}