{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T22:11:44Z","timestamp":1785449504116,"version":"3.56.0"},"reference-count":38,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100003399","name":"Science and Technology Commission of Shanghai Municipality","doi-asserted-by":"publisher","award":["22S31904200\/19411968900\/19YF1432000"],"award-info":[{"award-number":["22S31904200\/19411968900\/19YF1432000"]}],"id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","journalofsurgicalresearch.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Surgical Research"],"published-print":{"date-parts":[[2023,10]]},"DOI":"10.1016\/j.jss.2023.03.012","type":"journal-article","created":{"date-parts":[[2023,5,31]],"date-time":"2023-05-31T16:30:53Z","timestamp":1685550653000},"page":"116-125","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Histopathology of Ganglion Cells in the Proximal Resected Bowel Correlates With the Clinical Outcome in Hirschsprung Disease: A Pilot Study"],"prefix":"10.1016","volume":"290","author":[{"given":"Minzhong","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenbin","family":"Guan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yin","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yeming","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weihua","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jss.2023.03.012_bib1","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1007\/s00383-017-4066-7","article-title":"Guidelines for the management of postoperative obstructive symptoms in children with Hirschsprung disease","volume":"33","author":"Langer","year":"2017","journal-title":"Pediatr Surg Int"},{"key":"10.1016\/j.jss.2023.03.012_bib2","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1007\/s00383-017-4065-8","article-title":"Guidelines for the diagnosis and management of Hirschsprung-associated enterocolitis","volume":"33","author":"Gosain","year":"2017","journal-title":"Pediatr Surg Int"},{"key":"10.1016\/j.jss.2023.03.012_bib3","doi-asserted-by":"crossref","first-page":"2017","DOI":"10.1016\/j.jpedsurg.2019.03.010","article-title":"Guidelines for synoptic reporting of surgery and pathology in Hirschsprung disease","volume":"54","author":"Veras","year":"2019","journal-title":"J Pediatr Surg"},{"key":"10.1016\/j.jss.2023.03.012_bib4","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1186\/s13023-020-01362-3","article-title":"ERNICA guidelines for the management of rectosigmoid Hirschsprung's disease","volume":"15","author":"Kyrklund","year":"2020","journal-title":"Orphanet J Rare Dis"},{"key":"10.1016\/j.jss.2023.03.012_bib5","doi-asserted-by":"crossref","first-page":"2318","DOI":"10.1016\/j.jpedsurg.2019.04.017","article-title":"The extent of the transition zone in Hirschsprung disease","volume":"54","author":"Coyle","year":"2019","journal-title":"J Pediatr Surg"},{"key":"10.1016\/j.jss.2023.03.012_bib6","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.jpedsurg.2019.09.056","article-title":"Variability of the transition zone length in Hirschsprung disease","volume":"55","author":"Thakkar","year":"2020","journal-title":"J Pediatr Surg"},{"key":"10.1016\/j.jss.2023.03.012_bib7","doi-asserted-by":"crossref","first-page":"1467","DOI":"10.5858\/2010-0279-CR.1","article-title":"Total colonic aganglionosis: case report, practical diagnostic approach and pitfalls","volume":"134","author":"Rabah","year":"2010","journal-title":"Arch Pathol Lab Med"},{"key":"10.1016\/j.jss.2023.03.012_bib8","doi-asserted-by":"crossref","first-page":"1972","DOI":"10.1053\/gast.2002.37059","article-title":"Full-thickness biopsy of the jejunum reveals inflammation and enteric neuropathy in irritable bowel syndrome","volume":"123","author":"Tornblom","year":"2002","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jss.2023.03.012_bib9","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1055\/s-2008-1072395","article-title":"Proximal segment histology of resected bowel in Hirschsprung's disease predicts postoperative bowel function","volume":"10","author":"Schulten","year":"2000","journal-title":"Eur J Pediatr Surg"},{"key":"10.1016\/j.jss.2023.03.012_bib10","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1016\/j.jpedsurg.2007.01.052","article-title":"Advantages of intraoperative semiquantitative evaluation of myenteric nervous plexuses in patients with Hirschsprung disease","volume":"42","author":"Boman","year":"2007","journal-title":"J Pediatr Surg"},{"key":"10.1016\/j.jss.2023.03.012_bib11","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1007\/s00383-020-04689-x","article-title":"Resection margin histology may predict intermediate-term outcomes in children with rectosigmoid Hirschsprung disease","volume":"36","author":"Brooks","year":"2020","journal-title":"Pediatr Surg Int"},{"key":"10.1016\/j.jss.2023.03.012_bib12","doi-asserted-by":"crossref","first-page":"1829","DOI":"10.1016\/j.jpedsurg.2020.01.007","article-title":"Histopathological perspective of the pulled-through colon in Hirschsprung disease: impact on clinical outcome","volume":"55","author":"Saad","year":"2020","journal-title":"J Pediatr Surg"},{"key":"10.1016\/j.jss.2023.03.012_bib13","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1097\/SLA.0000000000001695","article-title":"Bowel function and quality of life after transanal endorectal pull-through for Hirschsprung disease: controlled outcomes up to adulthood","volume":"265","author":"Neuvonen","year":"2017","journal-title":"Ann Surg"},{"key":"10.1016\/j.jss.2023.03.012_bib14","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1016\/j.jpedsurg.2017.07.009","article-title":"Critical evaluation of the Hirschsprung-associated enterocolitis (HAEC) score: a multicenter study of 116 children with Hirschsprung disease","volume":"53","author":"Frykman","year":"2018","journal-title":"J Pediatr Surg"},{"key":"10.1016\/j.jss.2023.03.012_bib15","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1007\/s00053-003-5084-6","article-title":"Development of a new scoring system for the evaluation of incontinence and constipation in children","volume":"25","author":"Fichtner-Feigl","year":"2003","journal-title":"Coloproctology"},{"key":"10.1016\/j.jss.2023.03.012_bib16","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.jcm.2016.02.012","article-title":"A Guideline of selecting and reporting intraclass correlation coefficients for reliability research","volume":"15","author":"Koo","year":"2016","journal-title":"J Chiropr Med"},{"key":"10.1016\/j.jss.2023.03.012_bib17","first-page":"192","article-title":"Does functional outcome improve with time postsurgery for Hirschsprung disease?","volume":"26","author":"Aworanti","year":"2016","journal-title":"Eur J Pediatr Surg"},{"key":"10.1016\/j.jss.2023.03.012_bib18","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1007\/s00383-012-3094-6","article-title":"Does the radiographic transition zone correlate with the level of aganglionosis on the specimen in Hirschsprung\u2019s disease?","volume":"28","author":"Muller","year":"2012","journal-title":"Pediatr Surg Int"},{"key":"10.1016\/j.jss.2023.03.012_bib19","first-page":"207","article-title":"Contrast enema for Hirschsprung disease investigation: diagnostic accuracy and validity for subsequent diagnostic and surgical planning","volume":"26","author":"Frongia","year":"2016","journal-title":"Eur J Pediatr Surg"},{"key":"10.1016\/j.jss.2023.03.012_bib20","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1186\/s13104-020-04945-2","article-title":"Accuracy of transition zone in contrast enema to predict intraoperative aganglionosis level in patients with Hirschsprung disease","volume":"13","author":"Haikal","year":"2020","journal-title":"BMC Res Notes"},{"key":"10.1016\/j.jss.2023.03.012_bib21","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1016\/jpsu.2003.50165","article-title":"Correlation between radiographic transition zone and level of aganglionosis in Hirschsprung's disease: implications for surgical approach","volume":"38","author":"Proctor","year":"2003","journal-title":"J Pediatr Surg"},{"key":"10.1016\/j.jss.2023.03.012_bib22","doi-asserted-by":"crossref","first-page":"1637","DOI":"10.1097\/PAS.0000000000000711","article-title":"Histology of the transition zone in Hirschsprung disease","volume":"40","author":"Kapur","year":"2016","journal-title":"Am J Surg Pathol"},{"key":"10.1016\/j.jss.2023.03.012_bib23","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1016\/j.humpath.2009.12.012","article-title":"Counting myenteric ganglion cells in histologic sections: an empirical approach","volume":"41","author":"Swaminathan","year":"2010","journal-title":"Hum Pathol"},{"key":"10.1016\/j.jss.2023.03.012_bib24","doi-asserted-by":"crossref","first-page":"1675","DOI":"10.1097\/00000478-200012000-00013","article-title":"The reliability of frozen-section diagnosis in the pathologic evaluation of Hirschsprung's disease","volume":"24","author":"Maia","year":"2000","journal-title":"Am J Surg Pathol"},{"key":"10.1016\/j.jss.2023.03.012_bib25","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1016\/j.jpedsurg.2004.05.009","article-title":"Reliability of intraoperative frozen sections in the management of Hirschsprung's disease","volume":"39","author":"Shayan","year":"2004","journal-title":"J Pediatr Surg"},{"key":"10.1016\/j.jss.2023.03.012_bib26","doi-asserted-by":"crossref","first-page":"1619","DOI":"10.5858\/2005-129-1619-FSDIPS","article-title":"Frozen section diagnosis in pediatric surgical pathology: a decade's experience in a children's hospital","volume":"129","author":"Coffin","year":"2005","journal-title":"Arch Pathol Lab Med"},{"key":"10.1016\/j.jss.2023.03.012_bib27","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1053\/j.sempedsurg.2012.07.002","article-title":"Laparoscopic and transanal pull-through for Hirschsprung disease","volume":"21","author":"Langer","year":"2012","journal-title":"Semin Pediatr Surg"},{"key":"10.1016\/j.jss.2023.03.012_bib28","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1007\/s00401-009-0527-y","article-title":"Gastrointestinal neuromuscular pathology: guidelines for histological techniques and reporting on behalf of the Gastro 2009 International Working Group","volume":"118","author":"Knowles","year":"2009","journal-title":"Acta Neuropathol"},{"key":"10.1016\/j.jss.2023.03.012_bib29","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/S0022-3468(81)80001-2","article-title":"The validity of rectal biopsy in relation to morphology and distribution of ganglion cells","volume":"16","author":"Venugopal","year":"1981","journal-title":"J Pediatr Surg"},{"key":"10.1016\/j.jss.2023.03.012_bib30","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1016\/j.jpedsurg.2010.11.014","article-title":"Redo pull-through in Hirschprung's disease for obstructive symptoms due to residual aganglionosis and transition zone bowel","volume":"46","author":"Lawal","year":"2011","journal-title":"J Pediatr Surg"},{"key":"10.1016\/j.jss.2023.03.012_bib31","doi-asserted-by":"crossref","first-page":"30","DOI":"10.2350\/11-02-0977-OA.1","article-title":"Reoperation for Hirschsprung disease: pathology of the resected problematic distal pull-through","volume":"15","author":"Coe","year":"2012","journal-title":"Pediatr Dev Pathol"},{"key":"10.1016\/j.jss.2023.03.012_bib32","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1007\/s003830050669","article-title":"Hirschsprung's disease and intestinal neuronal dysplasia \u2013 a frequent association with implications for the postoperative course","volume":"15","author":"Schmittenbecher","year":"1999","journal-title":"Pediatr Surg Int"},{"key":"10.1016\/j.jss.2023.03.012_bib33","doi-asserted-by":"crossref","first-page":"466","DOI":"10.2350\/15-07-1675-OA.1","article-title":"Intestinal neuronal dysplasia-like submucosal ganglion cell hyperplasia at the proximal margins of Hirschsprung disease resections","volume":"18","author":"Swaminathan","year":"2015","journal-title":"Pediatr Dev Pathol"},{"key":"10.1016\/j.jss.2023.03.012_bib34","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1055\/s-2004-821120","article-title":"Updated results on intestinal neuronal dysplasia (IND B)","volume":"14","author":"Meier-Ruge","year":"2004","journal-title":"Eur J Pediatr Surg"},{"key":"10.1016\/j.jss.2023.03.012_bib35","doi-asserted-by":"crossref","first-page":"12474","DOI":"10.1038\/ncomms12474","article-title":"Predicting non-small cell lung cancer prognosis by fully automated microscopic pathology image features","volume":"7","author":"Yu","year":"2016","journal-title":"Nat Commun"},{"key":"10.1016\/j.jss.2023.03.012_bib36","first-page":"191","article-title":"Increasing trend of calretinin-positive mucosal innervation from aganglionic zone toward transition zone in Hirschsprung's disease","volume":"32","author":"Najjar","year":"2021","journal-title":"Eur J Pediatr Surg"},{"key":"10.1016\/j.jss.2023.03.012_bib37","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1177\/1093526619890735","article-title":"Postoperative pullthrough obstruction in Hirschsprung disease: etiologies and diagnosis","volume":"23","author":"Kapur","year":"2020","journal-title":"Pediatr Dev Pathol"},{"key":"10.1016\/j.jss.2023.03.012_bib38","doi-asserted-by":"crossref","first-page":"1555","DOI":"10.1007\/s00383-021-04974-3","article-title":"Long-term outcomes in children with Hirschsprung's disease and transition zone bowel pull-through: impact of surgical techniques and role for conservative approach","volume":"37","author":"Shankar","year":"2021","journal-title":"Pediatr Surg Int"}],"container-title":["Journal of Surgical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022480423001129?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022480423001129?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T15:03:03Z","timestamp":1758380583000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022480423001129"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10]]},"references-count":38,"alternative-id":["S0022480423001129"],"URL":"https:\/\/doi.org\/10.1016\/j.jss.2023.03.012","relation":{},"ISSN":["0022-4804"],"issn-type":[{"value":"0022-4804","type":"print"}],"subject":[],"published":{"date-parts":[[2023,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Histopathology of Ganglion Cells in the Proximal Resected Bowel Correlates With the Clinical Outcome in Hirschsprung Disease: A Pilot Study","name":"articletitle","label":"Article Title"},{"value":"Journal of Surgical Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jss.2023.03.012","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}