{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T22:17:36Z","timestamp":1790979456797,"version":"4.1.0"},"reference-count":43,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","journalofsurgicalresearch.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Surgical Research"],"published-print":{"date-parts":[[2024,5]]},"DOI":"10.1016\/j.jss.2024.02.004","type":"journal-article","created":{"date-parts":[[2024,3,5]],"date-time":"2024-03-05T14:06:16Z","timestamp":1709647576000},"page":"63-70","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"special_numbering":"C","title":["Resveratrol Promotes Diabetic Wound Healing by Inhibiting Notch Pathway"],"prefix":"10.1016","volume":"297","author":[{"given":"Yu","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Biyao","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gang","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-1623-0316","authenticated-orcid":false,"given":"Hai","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jss.2024.02.004_bib1","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1055\/a-1018-9078","article-title":"Definition, classification and Diagnosis of diabetes mellitus","volume":"127","author":"Petersmann","year":"2019","journal-title":"Exp Clin Endocrinol Diabetes"},{"key":"10.1016\/j.jss.2024.02.004_bib2","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/j.diabres.2017.06.001","article-title":"IDF releases report of global survey on access to medicines and supplies for people with diabetes","volume":"129","year":"2017","journal-title":"Diabetes Res Clin Pract"},{"key":"10.1016\/j.jss.2024.02.004_bib3","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.diabres.2018.02.023","article-title":"IDF diabetes atlas: global estimates of diabetes prevalence for 2017 and projections for 2045","volume":"138","author":"Cho","year":"2018","journal-title":"Diabetes Res Clin Pract"},{"key":"10.1016\/j.jss.2024.02.004_bib4","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.diabres.2017.03.024","article-title":"IDF diabetes atlas: global estimates for the prevalence of diabetes for 2015 and 2040","volume":"128","author":"Ogurtsova","year":"2017","journal-title":"Diabetes Res Clin Pract"},{"key":"10.1016\/j.jss.2024.02.004_bib5","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1038\/nrendo.2017.151","article-title":"Global aetiology and epidemiology of type 2 diabetes mellitus and its complications","volume":"14","author":"Zheng","year":"2018","journal-title":"Nat Rev Endocrinol"},{"key":"10.1016\/j.jss.2024.02.004_bib6","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2019.108615","article-title":"Mechanistic insight into diabetic wounds: pathogenesis, molecular targets and treatment strategies to pace wound healing","volume":"112","author":"Patel","year":"2019","journal-title":"Biomed Pharmacother"},{"key":"10.1016\/j.jss.2024.02.004_bib7","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.ijbiomac.2018.10.120","article-title":"Recent advancements in biopolymer and metal nanoparticle-based materials in diabetic wound healing management","volume":"122","author":"Vijayakumar","year":"2019","journal-title":"Int J Biol Macromol"},{"key":"10.1016\/j.jss.2024.02.004_bib8","doi-asserted-by":"crossref","first-page":"5911","DOI":"10.2147\/IJN.S249129","article-title":"Umbilical cord-derived mesenchymal stem cell-derived exosomes combined pluronic F127 hydrogel promote chronic diabetic wound healing and complete skin regeneration","volume":"15","author":"Yang","year":"2020","journal-title":"Int J Nanomedicine"},{"key":"10.1016\/j.jss.2024.02.004_bib9","doi-asserted-by":"crossref","DOI":"10.1002\/wdev.307","article-title":"Dermal fibroblast in cutaneous development and healing","volume":"7","author":"Thulabandu","year":"2018","journal-title":"Wiley Interdiscip Rev Dev Biol"},{"key":"10.1016\/j.jss.2024.02.004_bib10","doi-asserted-by":"crossref","first-page":"1528","DOI":"10.1177\/147323000903700531","article-title":"The wound healing process: an overview of the cellular and molecular mechanisms","volume":"37","author":"Velnar","year":"2009","journal-title":"J Int Med Res"},{"key":"10.1016\/j.jss.2024.02.004_bib11","doi-asserted-by":"crossref","first-page":"4","DOI":"10.3390\/bioengineering6010004","article-title":"Stem cell extracellular vesicles in skin repair","volume":"6","author":"Ferreira","year":"2018","journal-title":"Bioengineering (Basel)"},{"key":"10.1016\/j.jss.2024.02.004_bib12","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1080\/15384101.2021.1894813","article-title":"Exosomes derived from autologous dermal fibroblasts promote diabetic cutaneous wound healing through the Akt\/\u03b2-catenin pathway","volume":"20","author":"Han","year":"2021","journal-title":"Cell Cycle"},{"key":"10.1016\/j.jss.2024.02.004_bib13","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0012228","article-title":"bFGF regulates PI3-kinase-Rac1-JNK pathway and promotes fibroblast migration in wound healing","volume":"5","author":"Kanazawa","year":"2010","journal-title":"PloS one"},{"key":"10.1016\/j.jss.2024.02.004_bib14","doi-asserted-by":"crossref","first-page":"2544","DOI":"10.3390\/biomedicines10102544","article-title":"Effect of MNCQQ cells on migration of human dermal fibroblast in diabetic condition","volume":"10","author":"Jiang","year":"2022","journal-title":"Biomedicines"},{"key":"10.1016\/j.jss.2024.02.004_bib15","doi-asserted-by":"crossref","first-page":"1523","DOI":"10.3390\/ijms20071523","article-title":"Resveratrol and Its Effects on the Vascular System","volume":"20","author":"Breuss","year":"2019","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.jss.2024.02.004_bib16","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1002\/biof.1399","article-title":"Role of resveratrol in regulation of cellular defense systems against oxidative stress","volume":"44","author":"Truong","year":"2018","journal-title":"Biofactors"},{"key":"10.1016\/j.jss.2024.02.004_bib17","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1002\/biof.1400","article-title":"Effect of resveratrol and pterostilbene on aging and longevity","volume":"44","author":"Li","year":"2018","journal-title":"Biofactors"},{"key":"10.1016\/j.jss.2024.02.004_bib18","doi-asserted-by":"crossref","first-page":"8","DOI":"10.3389\/fnut.2016.00008","article-title":"Anticancer molecular mechanisms of resveratrol","volume":"3","author":"Varoni","year":"2016","journal-title":"Front Nutr"},{"key":"10.1016\/j.jss.2024.02.004_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2019.109767","article-title":"A review on the potential of Resveratrol in prevention and therapy of diabetes and diabetic complications","volume":"125","author":"Huang","year":"2020","journal-title":"Biomed Pharmacother"},{"key":"10.1016\/j.jss.2024.02.004_bib20","article-title":"Resveratrol promotes foot ulcer size reduction in type 2 diabetes patients","volume":"2014","author":"Bashmakov","year":"2014","journal-title":"ISRN Endocrinol"},{"key":"10.1016\/j.jss.2024.02.004_bib21","doi-asserted-by":"crossref","first-page":"421","DOI":"10.3389\/fphar.2019.00421","article-title":"Resveratrol promotes diabetic wound healing via SIRT1-FOXO1-c-myc signaling pathway-mediated angiogenesis","volume":"10","author":"Huang","year":"2019","journal-title":"Front Pharmacol"},{"key":"10.1016\/j.jss.2024.02.004_bib22","article-title":"Fibroblasts: Immunomodulatory factors in refractory diabetic wound healing","volume":"13","author":"Liu","year":"2022","journal-title":"Front Immunol"},{"key":"10.1016\/j.jss.2024.02.004_bib23","doi-asserted-by":"crossref","DOI":"10.1136\/bmjdrc-2020-001697","article-title":"Recurrence rates suggest delayed identification of plantar ulceration for patients in diabetic foot remission","volume":"8","author":"Petersen","year":"2020","journal-title":"BMJ Open Diabetes Res Care"},{"key":"10.1016\/j.jss.2024.02.004_bib24","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1007\/s11883-017-0680-z","article-title":"The diabetic foot as a proxy for cardiovascular events and mortality review","volume":"19","author":"Dietrich","year":"2017","journal-title":"Curr Atheroscler Rep"},{"key":"10.1016\/j.jss.2024.02.004_bib25","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1172\/JCI32169","article-title":"Cellular and molecular basis of wound healing in diabetes","volume":"117","author":"Brem","year":"2007","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jss.2024.02.004_bib26","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1159\/000454919","article-title":"Skin wound healing: an Update on the current Knowledge and concepts","volume":"58","author":"Sorg","year":"2017","journal-title":"Eur Surg Res"},{"key":"10.1016\/j.jss.2024.02.004_bib27","first-page":"385","article-title":"Wound healing potential of Spirulina platensis extracts on human dermal fibroblast cells","volume":"14","author":"Syarina","year":"2015","journal-title":"EXCLI J"},{"key":"10.1016\/j.jss.2024.02.004_bib28","doi-asserted-by":"crossref","first-page":"539","DOI":"10.5483\/BMBRep.2020.53.10.120","article-title":"Human collagen alpha-2 type I stimulates collagen synthesis, wound healing, and elastin production in normal human dermal fibroblasts (HDFs)","volume":"53","author":"Hwang","year":"2020","journal-title":"BMB Rep"},{"key":"10.1016\/j.jss.2024.02.004_bib29","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1186\/s12951-021-00894-5","article-title":"Exosomes derived from pioglitazone-pretreated MSCs accelerate diabetic wound healing through enhancing angiogenesis","volume":"19","author":"Hu","year":"2021","journal-title":"J Nanobiotechnology"},{"key":"10.1016\/j.jss.2024.02.004_bib30","first-page":"13","article-title":"Health benefits of resveratrol administration","volume":"66","author":"Galiniak","year":"2019","journal-title":"Acta Biochim Pol"},{"key":"10.1016\/j.jss.2024.02.004_bib31","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1186\/s12906-023-04016-6","article-title":"Structural modification of resveratrol analogue exhibits anticancer activity against lung cancer stem cells via suppression of Akt signaling pathway","volume":"23","author":"Thongsom","year":"2023","journal-title":"BMC Complement Med Ther"},{"key":"10.1016\/j.jss.2024.02.004_bib32","doi-asserted-by":"crossref","first-page":"535","DOI":"10.3390\/ijms20030535","article-title":"The effects of resveratrol in the treatment of metabolic syndrome","volume":"20","author":"Hou","year":"2019","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.jss.2024.02.004_bib33","doi-asserted-by":"crossref","first-page":"7524","DOI":"10.3390\/molecules27217524","article-title":"Progress in the preclinical and clinical study of resveratrol for vascular metabolic disease","volume":"27","author":"Fan","year":"2022","journal-title":"Molecules"},{"key":"10.1016\/j.jss.2024.02.004_bib34","doi-asserted-by":"crossref","first-page":"12614","DOI":"10.3390\/ijms222312614","article-title":"Resveratrol-induced signal transduction in wound healing","volume":"22","author":"Pignet","year":"2021","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.jss.2024.02.004_bib35","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.burns.2020.10.016","article-title":"Resveratrol accelerates wound healing by attenuating oxidative stress-induced impairment of cell proliferation and migration","volume":"47","author":"Zhou","year":"2021","journal-title":"Burns"},{"key":"10.1016\/j.jss.2024.02.004_bib36","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1021\/acs.jproteome.1c00248","article-title":"Resveratrol enhances wound healing in type 1 diabetes mellitus by promoting the expression of extracellular Vesicle-carried MicroRNA-129 derived from mesenchymal stem cells","volume":"21","author":"Hu","year":"2022","journal-title":"J Proteome Res"},{"key":"10.1016\/j.jss.2024.02.004_bib37","doi-asserted-by":"crossref","first-page":"2328","DOI":"10.1080\/13880209.2022.2149821","article-title":"Resveratrol accelerates wound healing by inducing M2 macrophage polarisation in diabetic mice","volume":"60","author":"Ding","year":"2022","journal-title":"Pharm Biol"},{"key":"10.1016\/j.jss.2024.02.004_bib38","doi-asserted-by":"crossref","DOI":"10.1111\/dth.14357","article-title":"Efficacy of resveratrol in the wound healing process by reducing oxidative stress and promoting fibroblast cell proliferation and migration","volume":"33","author":"Kaleci","year":"2020","journal-title":"Dermatol Ther"},{"key":"10.1016\/j.jss.2024.02.004_bib39","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1152\/physrev.00005.2017","article-title":"Notch signaling in development, tissue homeostasis, and disease","volume":"97","author":"Siebel","year":"2017","journal-title":"Physiol Rev"},{"key":"10.1016\/j.jss.2024.02.004_bib40","doi-asserted-by":"crossref","DOI":"10.1016\/j.dsx.2022.102542","article-title":"Notch signaling: a possible therapeutic target and its role in diabetic foot ulcers","volume":"16","author":"Begum","year":"2022","journal-title":"Diabetes Metab Syndr"},{"key":"10.1016\/j.jss.2024.02.004_bib41","doi-asserted-by":"crossref","first-page":"6985","DOI":"10.1073\/pnas.1900351116","article-title":"Triggering of a Dll4-Notch1 loop impairs wound healing in diabetes","volume":"116","author":"Zheng","year":"2019","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jss.2024.02.004_bib42","doi-asserted-by":"crossref","first-page":"4960","DOI":"10.3390\/cimb44100337","article-title":"The Signaling Pathways Induced by Exosomes in Promoting Diabetic Wound Healing: A Mini-Review","volume":"44","author":"Wang","year":"2022","journal-title":"Curr Issues Mol Biol"},{"key":"10.1016\/j.jss.2024.02.004_bib43","doi-asserted-by":"crossref","DOI":"10.1016\/j.diabres.2022.109831","article-title":"AGEs-induced MMP-9 activation mediated by Notch1 signaling is involved in impaired wound healing in diabetic rats","volume":"186","author":"Zhu","year":"2022","journal-title":"Diabetes Res Clin Pract"}],"container-title":["Journal of Surgical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022480424000842?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022480424000842?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T15:04:07Z","timestamp":1758380647000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022480424000842"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5]]},"references-count":43,"alternative-id":["S0022480424000842"],"URL":"https:\/\/doi.org\/10.1016\/j.jss.2024.02.004","relation":{},"ISSN":["0022-4804"],"issn-type":[{"value":"0022-4804","type":"print"}],"subject":[],"published":{"date-parts":[[2024,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Resveratrol Promotes Diabetic Wound Healing by Inhibiting Notch Pathway","name":"articletitle","label":"Article Title"},{"value":"Journal of Surgical Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jss.2024.02.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}