{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T01:13:42Z","timestamp":1778634822551,"version":"3.51.4"},"reference-count":19,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,4,15]],"date-time":"2025-04-15T00:00:00Z","timestamp":1744675200000},"content-version":"am","delay-in-days":318,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"NIA","doi-asserted-by":"publisher","award":["K23AG071945-02"],"award-info":[{"award-number":["K23AG071945-02"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","journalofsurgicalresearch.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Surgical Research"],"published-print":{"date-parts":[[2024,6]]},"DOI":"10.1016\/j.jss.2024.03.018","type":"journal-article","created":{"date-parts":[[2024,4,15]],"date-time":"2024-04-15T13:06:55Z","timestamp":1713186415000},"page":"222-229","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["A Mediation Analysis Examining High Risk, Anticholinergic Medication Use, Delirium, and Dementia After Major Surgery"],"prefix":"10.1016","volume":"298","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0295-3457","authenticated-orcid":false,"given":"Sanjay","family":"Mohanty","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heidi","family":"Lindroth","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lava","family":"Timsina","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emma","family":"Holler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Jenkins","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Damaris","family":"Ortiz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer","family":"Hur","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Gillio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ben","family":"Zarzaur","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Malaz","family":"Boustani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jss.2024.03.018_bib1","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2018-026391","article-title":"Association between cumulative anticholinergic burden and falls and fractures in patients with overactive bladder: US-based retrospective cohort study","volume":"9","author":"Szabo","year":"2019","journal-title":"BMJ Open"},{"key":"10.1016\/j.jss.2024.03.018_bib2","first-page":"225","article-title":"The cognitive impact of anticholinergics: a clinical review","volume":"4","author":"Campbell","year":"2009","journal-title":"Clin Interv Aging"},{"key":"10.1016\/j.jss.2024.03.018_bib3","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.1001\/jamainternmed.2019.0677","article-title":"Anticholinergic drug exposure and the risk of dementia: a nested case-control study","volume":"179","author":"Coupland","year":"2019","journal-title":"JAMA Intern Med"},{"key":"10.1016\/j.jss.2024.03.018_bib4","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1001\/jamainternmed.2014.7663","article-title":"Cumulative use of strong anticholinergics and incident dementia: a prospective cohort study","volume":"175","author":"Gray","year":"2015","journal-title":"JAMA Intern Med"},{"key":"10.1016\/j.jss.2024.03.018_bib5","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1111\/jgs.15767","article-title":"American Geriatrics Society 2019 Updated AGS Beers Criteria\u00ae for potentially inappropriate medication use in older adults","volume":"67","year":"2019","journal-title":"J Am Geriatr Soc"},{"key":"10.1016\/j.jss.2024.03.018_bib6","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.jamda.2020.04.019","article-title":"Anticholinergic drug burden and delirium: a systematic review","volume":"22","author":"Egberts","year":"2021","journal-title":"J Am Med Dir Assoc"},{"key":"10.1016\/j.jss.2024.03.018_bib7","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1111\/jgs.15751","article-title":"Deprescribing in the pharmacologic management of delirium: a randomized trial in the Intensive care unit","volume":"67","author":"Campbell","year":"2019","journal-title":"J Am Geriatr Soc"},{"key":"10.1016\/j.jss.2024.03.018_bib8","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1001\/jamainternmed.2014.949","article-title":"Reduction of inappropriate benzodiazepine prescriptions among older adults through direct patient education: the EMPOWER cluster randomized trial","volume":"174","author":"Tannenbaum","year":"2014","journal-title":"JAMA Intern Med"},{"key":"10.1016\/j.jss.2024.03.018_bib9","doi-asserted-by":"crossref","first-page":"1889","DOI":"10.1001\/jama.2018.16131","article-title":"Effect of a pharmacist-led educational intervention on inappropriate medication prescriptions in older adults: the D-PRESCRIBE randomized clinical trial","volume":"320","author":"Martin","year":"2018","journal-title":"JAMA"},{"key":"10.1016\/j.jss.2024.03.018_bib10","doi-asserted-by":"crossref","first-page":"1150","DOI":"10.1007\/s11606-020-06379-9","article-title":"Characteristics of younger and older adults with hospital-acquired delirium: a claims data study spanning 14 years","volume":"36","author":"Rohatgi","year":"2021","journal-title":"J Gen Intern Med"},{"key":"10.1016\/j.jss.2024.03.018_bib11","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/j.jss.2021.08.043","article-title":"Major surgery and long term cognitive outcomes: the effect of postoperative delirium on dementia in the year following discharge","volume":"270","author":"Mohanty","year":"2022","journal-title":"J Surg Res"},{"key":"10.1016\/j.jss.2024.03.018_bib12","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1097\/00000658-199810000-00006","article-title":"The department of veterans affairs\u2019 NSQIP: the first national, validated, outcome-based, risk-adjusted, and peer-controlled program for the measurement and enhancement of the quality of surgical care. National VA Surgical Quality Improvement Program","volume":"228","author":"Khuri","year":"1998","journal-title":"Ann Surg"},{"key":"10.1016\/j.jss.2024.03.018_bib13","doi-asserted-by":"crossref","first-page":"311","DOI":"10.2217\/1745509X.4.3.311","article-title":"Impact of anticholinergics on the aging brain: a review and practical application","volume":"4","author":"Boustani","year":"2008","journal-title":"Aging Health"},{"key":"10.1016\/j.jss.2024.03.018_bib14","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1002\/pds.4226","article-title":"Evaluation of algorithms to identify delirium in administrative claims and drug utilization database","volume":"26","author":"Kim","year":"2017","journal-title":"Pharmacoepidemiol Drug Saf"},{"key":"10.1016\/j.jss.2024.03.018_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/j.artmed.2019.101771","article-title":"Predicting dementia with routine care EMR data","volume":"102","author":"Ben Miled","year":"2020","journal-title":"Artif Intell Med"},{"key":"10.1016\/j.jss.2024.03.018_bib16","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1093\/ageing\/afu096","article-title":"Effect of medications with anti-cholinergic properties on cognitive function, delirium, physical function and mortality: a systematic review","volume":"43","author":"Fox","year":"2014","journal-title":"Age Ageing"},{"key":"10.1016\/j.jss.2024.03.018_bib17","doi-asserted-by":"crossref","DOI":"10.3389\/fmed.2022.871229","article-title":"Anticholinergic drug exposure increases the risk of delirium in older patients undergoing elective surgery","volume":"9","author":"Herrmann","year":"2022","journal-title":"Front Med"},{"key":"10.1016\/j.jss.2024.03.018_bib18","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0151084","article-title":"Serum anticholinergic activity and cognitive and functional adverse outcomes in older people: a systematic review and meta-analysis of the literature","volume":"11","author":"Salahudeen","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.jss.2024.03.018_bib19","doi-asserted-by":"crossref","first-page":"299","DOI":"10.3389\/fphar.2019.00299","article-title":"Histamine and delirium: current Opinion","volume":"10","author":"Chazot","year":"2019","journal-title":"Front Pharmacol"}],"container-title":["Journal of Surgical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022480424001288?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022480424001288?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T00:34:01Z","timestamp":1778632441000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022480424001288"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6]]},"references-count":19,"alternative-id":["S0022480424001288"],"URL":"https:\/\/doi.org\/10.1016\/j.jss.2024.03.018","relation":{},"ISSN":["0022-4804"],"issn-type":[{"value":"0022-4804","type":"print"}],"subject":[],"published":{"date-parts":[[2024,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A Mediation Analysis Examining High Risk, Anticholinergic Medication Use, Delirium, and Dementia After Major Surgery","name":"articletitle","label":"Article Title"},{"value":"Journal of Surgical Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jss.2024.03.018","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}