{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T06:56:15Z","timestamp":1792133775879,"version":"4.4.0"},"reference-count":25,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,9,2]],"date-time":"2025-09-02T00:00:00Z","timestamp":1756771200000},"content-version":"am","delay-in-days":336,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100000008","name":"Health Canada","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000008","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000005","name":"U.S. Department of Defense","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000005","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart Lung and Blood Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000182","name":"Medical Research and Materiel Command","doi-asserted-by":"publisher","award":["W81XWH-13-2-0090"],"award-info":[{"award-number":["W81XWH-13-2-0090"]}],"id":[{"id":"10.13039\/100000182","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","journalofsurgicalresearch.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Surgical Research"],"published-print":{"date-parts":[[2024,10]]},"DOI":"10.1016\/j.jss.2024.08.003","type":"journal-article","created":{"date-parts":[[2024,9,2]],"date-time":"2024-09-02T09:31:25Z","timestamp":1725269485000},"page":"798-804","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Intravenous Versus Intraosseous Use of Tranexamic Acid in Patients With Traumatic Brain Injury"],"prefix":"10.1016","volume":"302","author":[{"given":"Zachary C.","family":"Newman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victoria O.","family":"Ogbeifun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire E.","family":"Barbosa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W. Ian","family":"McKinley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew J.","family":"Benjamin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myrna Y.","family":"Munar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierce E.","family":"Pramuka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katie D.","family":"McGovern","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel K.","family":"Nordgren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin A.","family":"Schreiber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan E.","family":"Rowell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jss.2024.08.003_bib1","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/S0140-6736(10)60835-5","article-title":"Effects of tranexamic acid on death, vascular occlusive events, and blood transfusion in trauma patients with significant haemorrhage (CRASH-2): a randomised, placebo-controlled trial","volume":"376","author":"Shakur","year":"2010","journal-title":"Lancet"},{"key":"10.1016\/j.jss.2024.08.003_bib2","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1001\/jama.2020.8958","article-title":"Effect of out-of-hospital tranexamic acid vs placebo on 6-month functional neurologic outcomes in patients with moderate or severe traumatic brain injury","volume":"324","author":"Rowell","year":"2020","journal-title":"JAMA"},{"key":"10.1016\/j.jss.2024.08.003_bib3","doi-asserted-by":"crossref","first-page":"36","DOI":"10.55460\/ZWV3-5CBW","article-title":"The use of tranexamic acid in tactical combat casualty care: TCCC proposed change 20-02","volume":"20","author":"Drew","year":"2020","journal-title":"J Spec Oper Med"},{"key":"10.1016\/j.jss.2024.08.003_bib4","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1093\/milmed\/165.7.552","article-title":"A review of intraosseous vascular access: current status and military application","volume":"165","author":"Dubick","year":"2000","journal-title":"Mil Med"},{"key":"10.1016\/j.jss.2024.08.003_bib5","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1007\/s00068-020-01327-y","article-title":"Intraosseous access in the resuscitation of trauma patients: a literature review","volume":"47","author":"Tyler","year":"2021","journal-title":"Eur J Trauma Emerg Surg"},{"key":"10.1016\/j.jss.2024.08.003_bib6","series-title":"Phoenix WinNonlin","year":"2020"},{"key":"10.1016\/j.jss.2024.08.003_bib7","first-page":"136","article-title":"KDIGO 2012 clinical practice guideline for the evaluation and management of chronic kidney disease","volume":"3","year":"2013","journal-title":"Kidney Int Supplements"},{"key":"10.1016\/j.jss.2024.08.003_bib8","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1177\/0013164409344534","article-title":"Weighting by inverse variance or by sample size in random-effects meta-analysis","volume":"70","author":"Mar\u00edn-Mart\u00ednez","year":"2010","journal-title":"Educ Psychol Meas"},{"key":"10.1016\/j.jss.2024.08.003_bib9","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1136\/ebmental-2019-300117","article-title":"How to perform a meta-analysis with R: a practical tutorial","volume":"22","author":"Balduzzi","year":"2019","journal-title":"Evid Based Ment Health"},{"key":"10.1016\/j.jss.2024.08.003_bib10","series-title":"R: a Language and environment for Statistical Computing_","year":"2023"},{"key":"10.1016\/j.jss.2024.08.003_bib11","series-title":"SAS System","year":"2023"},{"key":"10.1016\/j.jss.2024.08.003_bib12","doi-asserted-by":"crossref","first-page":"S135","DOI":"10.1016\/j.wem.2017.02.001","article-title":"Prolonged field care: beyond the \"golden hour\"","volume":"28","author":"Keenan","year":"2017","journal-title":"Wilderness Environ Med"},{"key":"10.1016\/j.jss.2024.08.003_bib13","author":"Remley"},{"key":"10.1016\/j.jss.2024.08.003_bib14","author":"Schauer"},{"key":"10.1016\/j.jss.2024.08.003_bib15","doi-asserted-by":"crossref","first-page":"e1240","DOI":"10.1093\/milmed\/usab401","article-title":"The battalion aid station-the forgotten frontier of the Army Health system during the global war on terrorism","volume":"188","author":"Fisher","year":"2023","journal-title":"Mil Med"},{"key":"10.1016\/j.jss.2024.08.003_bib16","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1097\/TA.0000000000003767","article-title":"The effects of timing of prehospital tranexamic acid on outcomes after traumatic brain injury: subanalysis of a randomized controlled trial","volume":"94","author":"Brito","year":"2023","journal-title":"J Trauma Acute Care Surg"},{"key":"10.1016\/j.jss.2024.08.003_bib17","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1016\/S0140-6736(11)60278-X","article-title":"The importance of early treatment with tranexamic acid in bleeding trauma patients: an exploratory analysis of the CRASH-2 randomised controlled trial","volume":"377","author":"Roberts","year":"2011","journal-title":"Lancet"},{"key":"10.1016\/j.jss.2024.08.003_bib18","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1097\/TA.0000000000001795","article-title":"The intraosseous have it: a prospective observational study of vascular access success rates in patients in extremis using video review","volume":"84","author":"Chreiman","year":"2018","journal-title":"J Trauma Acute Care Surg"},{"key":"10.1016\/j.jss.2024.08.003_bib19","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1097\/TA.0000000000003958","article-title":"Moving the needle on time to resuscitation: an EAST prospective multicenter study of vascular access in hypotensive injured patients using trauma video review","volume":"95","author":"Dumas","year":"2023","journal-title":"J Trauma Acute Care Surg"},{"key":"10.1016\/j.jss.2024.08.003_bib20","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1177\/1460408611430175","article-title":"Intraosseous vascular access: a review","volume":"14","author":"Paxton","year":"2012","journal-title":"Trauma"},{"key":"10.1016\/j.jss.2024.08.003_bib21","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.ajem.2007.03.024","article-title":"Does intraosseous equal intravenous? A pharmacokinetic study","volume":"26","author":"Von Hoff","year":"2008","journal-title":"Am J Emerg Med"},{"key":"10.1016\/j.jss.2024.08.003_bib22","doi-asserted-by":"crossref","first-page":"80","DOI":"10.55460\/COGQ-2CY1","article-title":"Pharmacokinetics of tranexamic acid via intravenous, intraosseous, and Intramuscular routes in a porcine (Sus scrofa) hemorrhagic shock model","volume":"19","author":"DeSoucy","year":"2019","journal-title":"J Spec Oper Med"},{"key":"10.1016\/j.jss.2024.08.003_bib23","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1097\/TA.0000000000001741","article-title":"No intravenous access, no problem: intraosseous administration of tranexamic acid is as effective as intravenous in a porcine hemorrhage model","volume":"84","author":"Lallemand","year":"2018","journal-title":"J Trauma Acute Care Surg"},{"key":"10.1016\/j.jss.2024.08.003_bib24","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.ajem.2016.10.054","article-title":"Comparison of tranexamic acid plasma concentrations when administered via intraosseous and intravenous routes","volume":"35","author":"Boysen","year":"2017","journal-title":"Am J Emerg Med"},{"key":"10.1016\/j.jss.2024.08.003_bib25","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1016\/j.jemermed.2019.08.027","article-title":"An analysis of adherence to tactical combat casualty care guidelines for the administration of tranexamic acid","volume":"57","author":"Fisher","year":"2019","journal-title":"J Emerg Med"}],"container-title":["Journal of Surgical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022480424005080?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022480424005080?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T22:47:42Z","timestamp":1762210062000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022480424005080"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10]]},"references-count":25,"alternative-id":["S0022480424005080"],"URL":"https:\/\/doi.org\/10.1016\/j.jss.2024.08.003","relation":{},"ISSN":["0022-4804"],"issn-type":[{"value":"0022-4804","type":"print"}],"subject":[],"published":{"date-parts":[[2024,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Intravenous Versus Intraosseous Use of Tranexamic Acid in Patients With Traumatic Brain Injury","name":"articletitle","label":"Article Title"},{"value":"Journal of Surgical Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jss.2024.08.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}