{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T16:25:07Z","timestamp":1782577507695,"version":"3.54.5"},"reference-count":30,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["5T32DK007639-30"],"award-info":[{"award-number":["5T32DK007639-30"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","journalofsurgicalresearch.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Surgical Research"],"published-print":{"date-parts":[[2024,12]]},"DOI":"10.1016\/j.jss.2024.09.038","type":"journal-article","created":{"date-parts":[[2024,11,23]],"date-time":"2024-11-23T00:55:46Z","timestamp":1732323346000},"page":"305-314","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Novel Compound HJC0416 Attenuates Hepatic Fibrosis via HSP90\/NF-\u03baB\u2013Associated Mechanism"],"prefix":"10.1016","volume":"304","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8958-4521","authenticated-orcid":false,"given":"Jana","family":"DeJesus","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaofu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanping","family":"Gu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui-Min","family":"Mao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ravi","family":"Radhakrishnan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jss.2024.09.038_bib1","doi-asserted-by":"crossref","first-page":"5910","DOI":"10.3748\/wjg.v28.i41.5910","article-title":"Epidemiology of liver cirrhosis and associated complications: current knowledge and future directions","volume":"28","author":"Liu","year":"2022","journal-title":"World J Gastroenterol"},{"key":"10.1016\/j.jss.2024.09.038_bib2","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1038\/s41392-020-00312-6","article-title":"Targeting NF-\u03baB pathway for the therapy of diseases: mechanism and clinical study","volume":"5","author":"Yu","year":"2020","journal-title":"Signal Transduct Target Ther"},{"key":"10.1016\/j.jss.2024.09.038_bib3","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1002\/hep.510300327","article-title":"Persistent activation of nuclear factor-kappaB in cultured rat hepatic stellate cells involves the induction of potentially novel Rel-like factors and prolonged changes in the expression of IkappaB family proteins","volume":"30","author":"Elsharkawy","year":"1999","journal-title":"Hepatology"},{"key":"10.1016\/j.jss.2024.09.038_bib4","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1016\/j.jhep.2007.12.019","article-title":"NF-kappaB is a critical regulator of the survival of rodent and human hepatic myofibroblasts","volume":"48","author":"Watson","year":"2008","journal-title":"J Hepatol"},{"key":"10.1016\/j.jss.2024.09.038_bib5","doi-asserted-by":"crossref","first-page":"1174","DOI":"10.1136\/gut.2005.082701","article-title":"Overexpression of Bcl-2 by activated human hepatic stellate cells: resistance to apoptosis as a mechanism of progressive hepatic fibrogenesis in humans","volume":"55","author":"Novo","year":"2006","journal-title":"Gut"},{"key":"10.1016\/j.jss.2024.09.038_bib6","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.ccr.2009.01.009","article-title":"Inflammation and cancer: IL-6 and STAT3 complete the link","volume":"15","author":"Bromberg","year":"2009","journal-title":"Cancer Cell"},{"key":"10.1016\/j.jss.2024.09.038_bib7","doi-asserted-by":"crossref","DOI":"10.1016\/j.aohep.2020.06.010","article-title":"STAT3: a key regulator in liver fibrosis","volume":"21","author":"Zhao","year":"2021","journal-title":"Ann Hepatol"},{"key":"10.1016\/j.jss.2024.09.038_bib8","doi-asserted-by":"crossref","first-page":"2299","DOI":"10.3390\/ijms19082299","article-title":"Contribution of STAT3 to inflammatory and fibrotic diseases and prospects for its targeting for treatment","volume":"19","author":"Kasembeli","year":"2018","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.jss.2024.09.038_bib9","doi-asserted-by":"crossref","first-page":"100652","DOI":"10.1039\/C6RA17459K","article-title":"STAT3 inhibition suppresses hepatic stellate cell fibrogenesis: HJC0123, a potential therapeutic agent for liver fibrosis","volume":"6","author":"Nunez Lopez","year":"2016","journal-title":"RSC Adv"},{"key":"10.1016\/j.jss.2024.09.038_bib10","doi-asserted-by":"crossref","first-page":"1535","DOI":"10.1517\/13543784.2012.713939","article-title":"The role of heat shock protein 90 in modulating ischemia\u2013reperfusion injury in the kidney","volume":"21","author":"O\u2019Neill","year":"2012","journal-title":"Expert Opin Investig Drugs"},{"key":"10.1016\/j.jss.2024.09.038_bib11","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1016\/j.ejmech.2013.01.023","article-title":"Fragment-based drug design and identification of HJC0123, a novel orally bioavailable STAT3 inhibitor for cancer therapy","volume":"62","author":"Chen","year":"2013","journal-title":"Eur J Med Chem"},{"key":"10.1016\/j.jss.2024.09.038_bib12","doi-asserted-by":"crossref","first-page":"6857","DOI":"10.2147\/CMAR.S188364","article-title":"HJC0152, a novel STAT3 inhibitor with promising anti-tumor effect in gastric cancer","volume":"10","author":"Jiang","year":"2018","journal-title":"Cancer Manag Res"},{"key":"10.1016\/j.jss.2024.09.038_bib13","doi-asserted-by":"crossref","DOI":"10.1111\/cpr.12777","article-title":"HJC0152 suppresses human non-small-cell lung cancer by inhibiting STAT3 and modulating metabolism","volume":"53","author":"Lu","year":"2020","journal-title":"Cell Prolif"},{"key":"10.1016\/j.jss.2024.09.038_bib14","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1016\/j.jss.2020.12.045","article-title":"HJC0416 attenuates fibrogenesis in activated hepatic stellate cells via STAT3 and NF-\u03baB pathways","volume":"261","author":"Sommerhalder","year":"2021","journal-title":"J Surg Res"},{"key":"10.1016\/j.jss.2024.09.038_bib15","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/j.jss.2015.07.042","article-title":"Enhanced effects of novel oridonin analog CYD0682 for hepatic fibrosis","volume":"199","author":"Bohanon","year":"2015","journal-title":"J Surg Res"},{"key":"10.1016\/j.jss.2024.09.038_bib16","doi-asserted-by":"crossref","first-page":"L964","DOI":"10.1152\/ajplung.00054.2016","article-title":"Hsp90 inhibition suppresses NF-\u03baB transcriptional activation via Sirt-2 in human lung microvascular endothelial cells","volume":"310","author":"Thangjam","year":"2016","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"10.1016\/j.jss.2024.09.038_bib17","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1002\/iub.607","article-title":"STAT3 interacts directly with Hsp90","volume":"64","author":"Prinsloo","year":"2012","journal-title":"IUBMB Life"},{"key":"10.1016\/j.jss.2024.09.038_bib18","doi-asserted-by":"crossref","DOI":"10.3390\/ijms231810669","article-title":"Fragment-based drug discovery against mycobacteria: the success and challenges","volume":"23","author":"Togre","year":"2022","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.jss.2024.09.038_bib19","doi-asserted-by":"crossref","first-page":"4309","DOI":"10.3390\/molecules24234309","article-title":"Concepts and core principles of fragment-based drug design","volume":"24","author":"Kirsch","year":"2019","journal-title":"Molecules"},{"key":"10.1016\/j.jss.2024.09.038_bib20","doi-asserted-by":"crossref","first-page":"180","DOI":"10.3389\/fmolb.2020.00180","article-title":"Application of fragment-based drug discovery to versatile targets","volume":"7","author":"Li","year":"2020","journal-title":"Front Mol Biosci"},{"key":"10.1016\/j.jss.2024.09.038_bib21","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.smim.2014.05.004","article-title":"Regulation of NF-\u03baB by TNF family cytokines","volume":"26","author":"Hayden","year":"2014","journal-title":"Semin Immunol"},{"key":"10.1016\/j.jss.2024.09.038_bib22","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a000034","article-title":"The NF-kappaB family of transcription factors and its regulation","volume":"1","author":"Oeckinghaus","year":"2009","journal-title":"Cold Spring Harb Perspect Biol"},{"key":"10.1016\/j.jss.2024.09.038_bib23","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1053\/j.gastro.2004.10.003","article-title":"Inhibition of inhibitor of kappaB kinases stimulates hepatic stellate cell apoptosis and accelerated recovery from rat liver fibrosis","volume":"128","author":"Oakley","year":"2005","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jss.2024.09.038_bib24","doi-asserted-by":"crossref","first-page":"2334","DOI":"10.1053\/j.gastro.2009.02.081","article-title":"Angiotensin II activates I kappaB kinase phosphorylation of RelA at Ser 536 to promote myofibroblast survival and liver fibrosis","volume":"136","author":"Oakley","year":"2009","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jss.2024.09.038_bib25","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1002\/hep.23922","article-title":"Micro-RNA profiling reveals a role for miR-29 in human and murine liver fibrosis","volume":"53","author":"Roderburg","year":"2011","journal-title":"Hepatology"},{"key":"10.1016\/j.jss.2024.09.038_bib26","doi-asserted-by":"crossref","first-page":"5378","DOI":"10.1038\/sj.onc.1207705","article-title":"Requirement of Hsp90 activity for IkappaB kinase (IKK) biosynthesis and for constitutive and inducible IKK and NF-kappaB activation","volume":"23","author":"Broemer","year":"2004","journal-title":"Oncogene"},{"key":"10.1016\/j.jss.2024.09.038_bib27","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.1038\/s41467-017-01236-6","article-title":"Activation of STAT3 integrates common profibrotic pathways to promote fibroblast activation and tissue fibrosis","volume":"8","author":"Chakraborty","year":"2017","journal-title":"Nat Commun"},{"key":"10.1016\/j.jss.2024.09.038_bib28","series-title":"Novel Oridonin Analog CYD0682 Inhibits Hepatic Stellate Cell Activation by Reducing STAT3 Activation and HSP90-Dependent Target Protein Expression","author":"DeJesus","year":"2023"},{"key":"10.1016\/j.jss.2024.09.038_bib29","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1136\/gut.2004.042127","article-title":"Human hepatic stellate cell lines, LX-1 and LX-2: new tools for analysis of hepatic fibrosis","volume":"54","author":"Xu","year":"2005","journal-title":"Gut"},{"key":"10.1016\/j.jss.2024.09.038_bib30","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0075692","article-title":"Genetic characteristics of the human hepatic stellate cell line LX-2","volume":"8","author":"Weiskirchen","year":"2013","journal-title":"PLoS One"}],"container-title":["Journal of Surgical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022480424005857?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022480424005857?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,12,12]],"date-time":"2024-12-12T10:25:48Z","timestamp":1733999148000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022480424005857"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12]]},"references-count":30,"alternative-id":["S0022480424005857"],"URL":"https:\/\/doi.org\/10.1016\/j.jss.2024.09.038","relation":{},"ISSN":["0022-4804"],"issn-type":[{"value":"0022-4804","type":"print"}],"subject":[],"published":{"date-parts":[[2024,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Novel Compound HJC0416 Attenuates Hepatic Fibrosis via HSP90\/NF-\u03baB\u2013Associated Mechanism","name":"articletitle","label":"Article Title"},{"value":"Journal of Surgical Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jss.2024.09.038","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}