{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T09:03:48Z","timestamp":1777626228575,"version":"3.51.4"},"reference-count":36,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,3,29]],"date-time":"2026-03-29T00:00:00Z","timestamp":1774742400000},"content-version":"am","delay-in-days":332,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01GM129641"],"award-info":[{"award-number":["R01GM129641"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000738","name":"U.S. Department of Veterans Affairs","doi-asserted-by":"publisher","award":["I01BX0051631"],"award-info":[{"award-number":["I01BX0051631"]}],"id":[{"id":"10.13039\/100000738","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","journalofsurgicalresearch.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Surgical Research"],"published-print":{"date-parts":[[2025,5]]},"DOI":"10.1016\/j.jss.2025.02.042","type":"journal-article","created":{"date-parts":[[2025,3,30]],"date-time":"2025-03-30T23:39:03Z","timestamp":1743377943000},"page":"25-36","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Aging Impairs the Capacity of Cardiac Functional Recovery Following Endotoxemia: Modulation of Myocardial Klotho Level for Remedy"],"prefix":"10.1016","volume":"309","author":[{"given":"Xueting","family":"Li","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yufeng","family":"Zhai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qingzhou","family":"Yao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erlinda","family":"The","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lihua","family":"Ao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David A.","family":"Fullerton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kai-Jiang","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xianzhong","family":"Meng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jss.2025.02.042_bib1","doi-asserted-by":"crossref","first-page":"1889","DOI":"10.1097\/CCM.0000000000003342","article-title":"Epidemiology and costs of sepsis in the United States\u2014an analysis based on timing of diagnosis and severity level","volume":"46","author":"Paoli","year":"2018","journal-title":"Crit Care Med"},{"key":"10.1016\/j.jss.2025.02.042_bib2","first-page":"20","article-title":"Sepsis and immunosenescence in the elderly patient: a review","volume":"4","author":"Martin","year":"2017","journal-title":"Front Med (Lausanne)"},{"key":"10.1016\/j.jss.2025.02.042_bib3","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1038\/s41569-020-00492-2","article-title":"Pathophysiology of sepsis-induced cardiomyopathy","volume":"18","author":"Hollenberg","year":"2021","journal-title":"Nat Rev Cardiol"},{"key":"10.1016\/j.jss.2025.02.042_bib4","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/S0749-0704(05)70110-X","article-title":"Myocardial dysfunction in septic shock","volume":"16","author":"Kumar","year":"2000","journal-title":"Crit Care Clin"},{"key":"10.1016\/j.jss.2025.02.042_bib5","doi-asserted-by":"crossref","DOI":"10.1155\/2018\/5048031","article-title":"Anti-inflammatory and antioxidant properties of black mulberry (Morusnigra L.) in a model of LPS-induced sepsis","volume":"2018","author":"de P\u00e1dua L\u00facio","year":"2018","journal-title":"Oxid Med Cell Longev"},{"key":"10.1016\/j.jss.2025.02.042_bib6","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1186\/s13054-014-0527-8","article-title":"Enhanced monocyte chemoattractant protein-1 production in aging mice exaggerates cardiac depression during endotoxemia","volume":"18","author":"Slimani","year":"2014","journal-title":"Crit Care"},{"key":"10.1016\/j.jss.2025.02.042_bib7","doi-asserted-by":"crossref","first-page":"15663","DOI":"10.18632\/oncotarget.14933","article-title":"Klotho suppresses the inflammatory responses and ameliorates cardiac dysfunction in aging endotoxemic mice","volume":"8","author":"Hui","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.jss.2025.02.042_bib8","doi-asserted-by":"crossref","first-page":"e919","DOI":"10.1097\/CCM.0000000000003926","article-title":"Old mice demonstrate organ dysfunction as well as prolonged inflammation, immunosuppression, and weight loss in a modified surgical sepsis model","volume":"47","author":"Stortz","year":"2019","journal-title":"Crit Care Med"},{"key":"10.1016\/j.jss.2025.02.042_bib9","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1038\/36285","article-title":"Mutation of the mouse klotho gene leads to a syndrome resembling ageing","volume":"390","author":"Kuro-o","year":"1997","journal-title":"Nature"},{"key":"10.1016\/j.jss.2025.02.042_bib10","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.bone.2017.03.043","article-title":"Tissue expression and source of circulating alphaKlotho","volume":"100","author":"Olauson","year":"2017","journal-title":"Bone"},{"key":"10.1016\/j.jss.2025.02.042_bib11","doi-asserted-by":"crossref","first-page":"E1308","DOI":"10.1210\/jc.2015-1800","article-title":"Alpha-Klotho expression in human tissues","volume":"100","author":"Lim","year":"2015","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.jss.2025.02.042_bib12","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1007\/s00109-017-1527-3","article-title":"Klotho suppresses high phosphate-induced osteogenic responses in human aortic valve interstitial cells through inhibition of Sox9","volume":"95","author":"Li","year":"2017","journal-title":"J Mol Med (Berl)"},{"key":"10.1016\/j.jss.2025.02.042_bib13","doi-asserted-by":"crossref","first-page":"1907","DOI":"10.2337\/db10-1262","article-title":"Klotho depletion contributes to increased inflammation in kidney of the db\/db mouse model of diabetes via RelA (serine)536 phosphorylation","volume":"60","author":"Zhao","year":"2011","journal-title":"Diabetes"},{"key":"10.1016\/j.jss.2025.02.042_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2022.113515","article-title":"Klotho relieves inflammation and exerts a cardioprotective effect during renal ischemia\/reperfusion-induced cardiorenal syndrome","volume":"153","author":"Junho","year":"2022","journal-title":"Biomed Pharmacother"},{"key":"10.1016\/j.jss.2025.02.042_bib15","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1097\/SHK.0b013e3182845445","article-title":"Sepsis-induced hypercytokinemia and lymphocyte apoptosis in aging-accelerated Klotho knockout mice","volume":"39","author":"Inoue","year":"2013","journal-title":"Shock"},{"key":"10.1016\/j.jss.2025.02.042_bib16","doi-asserted-by":"crossref","first-page":"e1196","DOI":"10.1097\/CCM.0000000000003427","article-title":"Renal klotho is reduced in septic patients and pretreatment with recombinant klotho attenuates organ injury in lipopolysaccharide-challenged mice","volume":"46","author":"Jou-Valencia","year":"2018","journal-title":"Crit Care Med"},{"key":"10.1016\/j.jss.2025.02.042_bib17","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1038\/ni.1944","article-title":"IL-37 is a fundamental inhibitor of innate immunity","volume":"11","author":"Nold","year":"2010","journal-title":"Nat Immu-nol"},{"key":"10.1016\/j.jss.2025.02.042_bib18","article-title":"Elevated serum IL-37 concentrations in patients with sepsis","volume":"98","author":"Wang","year":"2019","journal-title":"Medicine"},{"key":"10.1016\/j.jss.2025.02.042_bib19","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.cyto.2017.02.008","article-title":"Interleukin-37 suppresses the inflammatory response to protect cardiac function in old endotoxemic mice","volume":"95","author":"Li","year":"2017","journal-title":"Cytokine"},{"key":"10.1016\/j.jss.2025.02.042_bib20","doi-asserted-by":"crossref","first-page":"R477","DOI":"10.1152\/ajpregu.00034.2002","article-title":"ICAM-1 and VCAM-1 mediate endotoxemic myocardial dysfunction independent of neutrophil accumulation","volume":"283","author":"Raeburn","year":"2002","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"10.1016\/j.jss.2025.02.042_bib21","doi-asserted-by":"crossref","first-page":"1631","DOI":"10.1073\/pnas.1619667114","article-title":"Interleukin-37 suppresses the osteogenic responses of human aortic valve interstitial cells in\u00a0vitro and alleviates valve lesions in mice","volume":"114","author":"Zeng","year":"2017","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jss.2025.02.042_bib22","doi-asserted-by":"crossref","first-page":"1422","DOI":"10.1038\/nprot.2008.138","article-title":"Measurement of cardiac function using pressure\u2013volume conductance catheter technique in mice and rats","volume":"3","author":"Pacher","year":"2008","journal-title":"Nat Protoc"},{"key":"10.1016\/j.jss.2025.02.042_bib23","doi-asserted-by":"crossref","DOI":"10.1093\/ageing\/afac328","article-title":"Inflammaging as a target for healthy ageing","volume":"52","author":"Dugan","year":"2023","journal-title":"Age Ageing"},{"key":"10.1016\/j.jss.2025.02.042_bib24","doi-asserted-by":"crossref","first-page":"1070","DOI":"10.1111\/j.1532-5415.2012.03989.x","article-title":"Population burden of long-term survivorship after severe sepsis in older Americans","volume":"60","author":"Iwashyna","year":"2012","journal-title":"J Am Geriatr Soc"},{"key":"10.1016\/j.jss.2025.02.042_bib25","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.molmed.2019.01.006","article-title":"Is resolution the end of inflammation?","volume":"25","author":"Feehan","year":"2019","journal-title":"Trends Mol Med"},{"key":"10.1016\/j.jss.2025.02.042_bib26","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1111\/j.1749-6632.2000.tb06651.x","article-title":"Inflammaging: an evolutionary perspective on immunosenescence","volume":"908","author":"Franceschi","year":"2000","journal-title":"Ann N Y Acad Sci"},{"key":"10.1016\/j.jss.2025.02.042_bib27","first-page":"392","article-title":"Cardiac dysfunction in severe sepsis and septic shock","volume":"15","author":"Zanotti-Cavazzoni","year":"2009","journal-title":"Curr Opin Crit Care"},{"key":"10.1016\/j.jss.2025.02.042_bib28","doi-asserted-by":"crossref","first-page":"1435","DOI":"10.1016\/S0002-9440(10)63230-0","article-title":"Disturbed homeostasis of lung intercellular adhesion molecule-1 and vascular cell adhesion molecule-1 during sepsis","volume":"164","author":"Laudes","year":"2004","journal-title":"Am J Pathol"},{"key":"10.1016\/j.jss.2025.02.042_bib29","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1161\/01.RES.0000157171.04054.30","article-title":"Association between a functional variant of the KLOTHO gene and high-density lipoprotein cholesterol, blood pressure, stroke, and longevity","volume":"96","author":"Arking","year":"2005","journal-title":"Circ Res"},{"key":"10.1016\/j.jss.2025.02.042_bib30","doi-asserted-by":"crossref","first-page":"F1329","DOI":"10.1152\/ajprenal.00487.2016","article-title":"Downregulation of kidney protective factors by inflammation: role of transcription factors and epigenetic mechanisms","volume":"311","author":"Ruiz-Andres","year":"2016","journal-title":"Am J Physiol Ren Physiol"},{"key":"10.1016\/j.jss.2025.02.042_bib31","doi-asserted-by":"crossref","first-page":"1384","DOI":"10.1053\/j.gastro.2009.12.002","article-title":"Tumor necrosis factor and interferon-\u03b3 down-regulate Klotho in mice with colitis","volume":"138","author":"Thurston","year":"2010","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jss.2025.02.042_bib32","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1038\/s41392-022-00957-5","article-title":"Klotho in Osx+-mesenchymal progenitors exerts pro-osteogenic and anti-inflammatory effects during mandibular alveolar bone formation and repair","volume":"7","author":"Fan","year":"2022","journal-title":"Signal Transduct Target Ther"},{"key":"10.1016\/j.jss.2025.02.042_bib33","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.mce.2017.05.003","article-title":"Klotho protects human monocytes from LPS-induced immune impairment associated with immunosenescent-like phenotype","volume":"470","author":"Mytych","year":"2018","journal-title":"Mol Cell Endocrinol"},{"key":"10.1016\/j.jss.2025.02.042_bib34","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1007\/s12020-009-9181-3","article-title":"Klotho suppresses TNF-\u03b1-induced expression of adhesion molecules in the endothelium and attenuates NF-\u03baB activation","volume":"35","author":"Maekawa","year":"2009","journal-title":"Endocrine"},{"key":"10.1016\/j.jss.2025.02.042_bib35","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.1681\/ASN.2010101073","article-title":"The inflammatory cytokines TWEAK and TNF\u03b1 reduce renal klotho expression through NF-\u03baB","volume":"22","author":"Moreno","year":"2011","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.jss.2025.02.042_bib36","doi-asserted-by":"crossref","first-page":"1596","DOI":"10.1111\/j.1532-5415.2011.03558.x","article-title":"Plasma klotho and cardiovascular disease in adults","volume":"59","author":"Semba","year":"2011","journal-title":"J Am Geriatr Soc"}],"container-title":["Journal of Surgical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022480425001052?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022480425001052?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T00:25:37Z","timestamp":1777422337000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022480425001052"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5]]},"references-count":36,"alternative-id":["S0022480425001052"],"URL":"https:\/\/doi.org\/10.1016\/j.jss.2025.02.042","relation":{},"ISSN":["0022-4804"],"issn-type":[{"value":"0022-4804","type":"print"}],"subject":[],"published":{"date-parts":[[2025,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Aging Impairs the Capacity of Cardiac Functional Recovery Following Endotoxemia: Modulation of Myocardial Klotho Level for Remedy","name":"articletitle","label":"Article Title"},{"value":"Journal of Surgical Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jss.2025.02.042","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}