{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T20:30:15Z","timestamp":1792096215386,"version":"4.4.0"},"reference-count":264,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,7,23]],"date-time":"2025-07-23T00:00:00Z","timestamp":1753228800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100008732","name":"Uehara Memorial Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008732","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008965","name":"Takahashi Industrial and Economic Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008965","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["21H02983"],"award-info":[{"award-number":["21H02983"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["20K20472"],"award-info":[{"award-number":["20K20472"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["20K08299"],"award-info":[{"award-number":["20K08299"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","journalofsurgicalresearch.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Surgical Research"],"published-print":{"date-parts":[[2025,10]]},"DOI":"10.1016\/j.jss.2025.07.039","type":"journal-article","created":{"date-parts":[[2025,8,14]],"date-time":"2025-08-14T10:04:09Z","timestamp":1755165849000},"page":"377-392","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Surgical Stress and Liver Response: Injury, Regeneration, and Protection"],"prefix":"10.1016","volume":"314","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4458-5082","authenticated-orcid":false,"given":"Michitaka","family":"Ozaki","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanae","family":"Haga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jss.2025.07.039_bib1","doi-asserted-by":"crossref","first-page":"S58","DOI":"10.1016\/j.jhep.2014.07.012","article-title":"Natural history of hepatitis C","volume":"61","author":"Westbrook","year":"2014","journal-title":"J Hepatol"},{"key":"10.1016\/j.jss.2025.07.039_bib2","doi-asserted-by":"crossref","first-page":"s185","DOI":"10.1002\/hep.1840360724","article-title":"Treatment of patients with hepatitis C and cirrhosis","volume":"36","author":"Wright","year":"2002","journal-title":"Hepatology"},{"key":"10.1016\/j.jss.2025.07.039_bib3","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1055\/s-2006-939752","article-title":"Hepatitis B virus-related cirrhosis: natural history and treatment","volume":"26","author":"Chu","year":"2006","journal-title":"Semin Liver Dis"},{"key":"10.1016\/j.jss.2025.07.039_bib4","doi-asserted-by":"crossref","first-page":"97","DOI":"10.3109\/10408363.2011.596521","article-title":"Non-alcoholic fatty liver disease","volume":"48","author":"Smith","year":"2011","journal-title":"Crit Rev Clin Lab Sci"},{"key":"10.1016\/j.jss.2025.07.039_bib5","doi-asserted-by":"crossref","first-page":"2758","DOI":"10.1056\/NEJMra0805786","article-title":"Alcoholic hepatitis","volume":"360","author":"Lucey","year":"2009","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jss.2025.07.039_bib6","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.semcdb.2019.10.007","article-title":"Cellular and molecular mechanisms of liver regeneration: proliferation, growth, death and protection of hepatocytes","volume":"100","author":"Ozaki","year":"2020","journal-title":"Semin Cell Dev Biol"},{"key":"10.1016\/j.jss.2025.07.039_bib7","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1210\/en.2005-0570","article-title":"Saturated fatty acids promote endoplasmic reticulum stress and liver injury in rats with hepatic steatosis","volume":"147","author":"Wang","year":"2006","journal-title":"Endocrinology"},{"key":"10.1016\/j.jss.2025.07.039_bib8","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1053\/j.gastro.2003.10.065","article-title":"Diabetes increases the risk of chronic liver disease and hepatocellular carcinoma","volume":"126","author":"El-Serag","year":"2004","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jss.2025.07.039_bib9","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/j.semcancer.2013.07.003","article-title":"Obesity, insulin resistance, NASH and hepatocellular carcinoma","volume":"23","author":"Yu","year":"2013","journal-title":"Semin Cancer Biol"},{"key":"10.1016\/j.jss.2025.07.039_bib10","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1172\/JCI200422422","article-title":"Molecular mediators of hepatic steatosis and liver injury","volume":"114","author":"Browning","year":"2004","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jss.2025.07.039_bib11","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1007\/s11901-014-0224-8","article-title":"Mechanisms of liver injury in non-alcoholic steatohepatitis","volume":"13","author":"Duwaerts","year":"2014","journal-title":"Curr Hepatol Rep"},{"key":"10.1016\/j.jss.2025.07.039_bib12","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/S0168-8278(00)00089-1","article-title":"Hepatocyte apoptosis is a pathologic feature of human alcoholic hepatitis","volume":"34","author":"Natori","year":"2001","journal-title":"J Hepatol"},{"key":"10.1016\/j.jss.2025.07.039_bib13","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1016\/S1072-7515(98)00301-9","article-title":"Postoperative liver failure after major hepatic resection for hepatocellular carcinoma in the modern era with special reference to remnant liver volume","volume":"188","author":"Shirabe","year":"1999","journal-title":"J Am Coll Surg"},{"key":"10.1016\/j.jss.2025.07.039_bib14","doi-asserted-by":"crossref","first-page":"483","DOI":"10.2174\/1566524033479528","article-title":"Mechanisms of liver injury: an overview","volume":"3","author":"Higuchi","year":"2005","journal-title":"Curr Mol Med"},{"key":"10.1016\/j.jss.2025.07.039_bib15","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1055\/s-2003-42641","article-title":"Acute liver failure in the United States","volume":"23","author":"Lee","year":"2003","journal-title":"Semin Liver Dis"},{"key":"10.1016\/j.jss.2025.07.039_bib16","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/S0140-6736(10)60274-7","article-title":"Acute liver failure","volume":"376","author":"Bernal","year":"2010","journal-title":"Lancet"},{"key":"10.1016\/j.jss.2025.07.039_bib17","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1002\/lt.500050102","article-title":"Etiology and outcome for 295 patients with acute liver failure in the United States","volume":"5","author":"Schiodt","year":"1999","journal-title":"Liver Transpl Surg"},{"key":"10.1016\/j.jss.2025.07.039_bib18","doi-asserted-by":"crossref","first-page":"1364","DOI":"10.1002\/hep.20948","article-title":"Acetaminophen-induced acute liver failure: results of a United States multicenter, prospective study","volume":"42","author":"Larson","year":"2005","journal-title":"Hepatology"},{"key":"10.1016\/j.jss.2025.07.039_bib19","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1053\/jhep.2003.50366","article-title":"Viral and clinical factors associated with the fulminant course of hepatitis A infection","volume":"38","author":"Rezende","year":"2003","journal-title":"Hepatology"},{"key":"10.1016\/j.jss.2025.07.039_bib20","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1002\/hep.20293","article-title":"Acetaminophen and the U.S. acute liver failure study group: lowering the risks of hepatic failure","volume":"40","author":"Lee","year":"2004","journal-title":"Hepatology"},{"key":"10.1016\/j.jss.2025.07.039_bib21","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1097\/00000658-198707000-00005","article-title":"Human liver regeneration after major hepatic resection","volume":"206","author":"Nagasue","year":"1987","journal-title":"Ann Surg"},{"key":"10.1016\/j.jss.2025.07.039_bib22","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1111\/j.1478-3231.2008.01777.x","article-title":"Liver failure after partial hepatic resection: definition, pathophysiology, risk factors and treatment","volume":"28","author":"Van den Broek","year":"2008","journal-title":"Liver Int"},{"key":"10.1016\/j.jss.2025.07.039_bib23","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.hpb.2020.05.008","article-title":"A novel model for predicting posthepatectomy liver failure based on liver function and degree of liver resection in patients with hepatocellular carcinoma","volume":"23","author":"Honmyo","year":"2021","journal-title":"HPB"},{"key":"10.1016\/j.jss.2025.07.039_bib24","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1097\/01.sla.0000201483.95911.08","article-title":"Predictive indices of morbidity and mortality after liver resection","volume":"243","author":"Schroeder","year":"2006","journal-title":"Ann Surg"},{"key":"10.1016\/j.jss.2025.07.039_bib25","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1016\/j.surg.2010.10.001","article-title":"Posthepatectomy liver failure: a definition and grading by the international study group of liver surgery (ISGLS)","volume":"149","author":"Rahbari","year":"2011","journal-title":"Surgery"},{"key":"10.1016\/j.jss.2025.07.039_bib26","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1007\/s00534-008-0017-y","article-title":"Liver failure after major hepatic resection","volume":"16","author":"Garcea","year":"2009","journal-title":"J Hepatobiliary Pancreat Surg"},{"key":"10.1016\/j.jss.2025.07.039_bib27","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1007\/978-1-4615-2604-9_20","article-title":"Causes of death in patients undergoing liver surgery","volume":"69","author":"Detroz","year":"1994","journal-title":"Cancer Treat Res"},{"key":"10.1016\/j.jss.2025.07.039_bib28","doi-asserted-by":"crossref","first-page":"12024","DOI":"10.1073\/pnas.1305538110","article-title":"Two independent pathways of regulated necrosis mediate ischemia-reperfusion injury","volume":"110","author":"Linkermann","year":"2013","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jss.2025.07.039_bib29","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1053\/j.gastro.2014.07.018","article-title":"Cell death and cell death responses in liver disease: mechanisms and clinical relevance","volume":"147","author":"Luedde","year":"2014","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jss.2025.07.039_bib30","doi-asserted-by":"crossref","first-page":"S48","DOI":"10.1038\/sj.cdd.4401119","article-title":"Apoptosis in hepatitis C virus infection","volume":"10","author":"Bantel","year":"2003","journal-title":"Cell Death Differ"},{"key":"10.1016\/j.jss.2025.07.039_bib31","doi-asserted-by":"crossref","first-page":"1498","DOI":"10.1002\/hep.21846","article-title":"Increased hepatotoxicity of tumor necrosis factor-related apoptosis-inducing ligand in diseased human liver","volume":"46","author":"Volkmann","year":"2007","journal-title":"Hepatology"},{"key":"10.1016\/j.jss.2025.07.039_bib32","doi-asserted-by":"crossref","first-page":"1641","DOI":"10.1053\/j.gastro.2008.03.002","article-title":"Cellular and molecular mechanisms of liver injury","volume":"134","author":"Malhi","year":"2008","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jss.2025.07.039_bib33","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1172\/JCI200317970","article-title":"Stat3 protects against fas-induced liver injury by redox-dependent and -independent mechanisms","volume":"112","author":"Haga","year":"2003","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jss.2025.07.039_bib34","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1136\/gut.2004.053850","article-title":"Apoptosis: a mechanism of acute and chronic liver injury","volume":"54","author":"Guicciardi","year":"2005","journal-title":"Gut"},{"key":"10.1016\/j.jss.2025.07.039_bib35","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1097\/00000658-199903000-00010","article-title":"Continuous versus intermittent portal triad clamping for liver resection: a controlled study","volume":"229","author":"Belghiti","year":"1999","journal-title":"Ann Surg"},{"key":"10.1016\/j.jss.2025.07.039_bib36","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1007\/s00268-003-6978-8","article-title":"Selective hepatic vascular exclusion versus pringle maneuver in major liver resections: prospective study","volume":"27","author":"Smyrniotis","year":"2003","journal-title":"World J Surg"},{"key":"10.1016\/j.jss.2025.07.039_bib37","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/S0002-9610(01)00864-9","article-title":"Total versus selective hepatic vascular exclusion in major liver resections","volume":"183","author":"Smyrniotis","year":"2002","journal-title":"Am J Surg"},{"key":"10.1016\/j.jss.2025.07.039_bib38","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1097\/00000658-198902000-00012","article-title":"Vascular occlusions for liver resections. Operative management and tolerance to hepatic ischemia: 142 cases","volume":"209","author":"Delva","year":"1989","journal-title":"Ann Surg"},{"key":"10.1016\/j.jss.2025.07.039_bib39","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/S0002-9610(00)00573-0","article-title":"Hepatic ischemia-reperfusion injury","volume":"181","author":"Serracino-Inglott","year":"2001","journal-title":"Am J Surg"},{"key":"10.1016\/j.jss.2025.07.039_bib40","doi-asserted-by":"crossref","first-page":"2563","DOI":"10.1089\/ars.2009.2681","article-title":"Hepatic ischemia induced immediate oxidative stress after reperfusion and determined the severity of the reperfusion-induced damage","volume":"11","author":"Haga","year":"2009","journal-title":"Antioxid Redox Signal"},{"key":"10.1016\/j.jss.2025.07.039_bib41","doi-asserted-by":"crossref","first-page":"366","DOI":"10.3109\/08941939.2014.932473","article-title":"Liver ischemia\/reperfusion injury: an overview","volume":"27","author":"Saidi","year":"2014","journal-title":"J Invest Surg"},{"key":"10.1016\/j.jss.2025.07.039_bib42","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1016\/j.jhep.2004.08.019","article-title":"Stat3 confers resistance against hypoxia\/reoxygenation-induced oxidative injury in hepatocytes through upregulation of Mn-SOD","volume":"41","author":"Terui","year":"2004","journal-title":"J Hepatol"},{"key":"10.1016\/j.jss.2025.07.039_bib43","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1096\/fasebj.14.2.418","article-title":"Inhibition of the Rac1 GTPase protects against nonlethal ischemia\/reperfusion-induced necrosis and apoptosis in vivo","volume":"14","author":"Ozaki","year":"2000","journal-title":"FASEB J"},{"key":"10.1016\/j.jss.2025.07.039_bib44","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1016\/j.jhep.2007.11.018","article-title":"Preventing hypoxia\/reoxygenation damage to hepatocytes by p66shc ablation: up-regulation of anti-oxidant and anti-apoptotic proteins","volume":"48","author":"Haga","year":"2008","journal-title":"J Hepatol"},{"key":"10.1016\/j.jss.2025.07.039_bib45","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.jss.2021.09.008","article-title":"Poly(ADP-Ribose) polymerase (PARP) is critically involved in liver ischemia\/reperfusion-injury","volume":"270","author":"Haga","year":"2022","journal-title":"J Surg Res"},{"key":"10.1016\/j.jss.2025.07.039_bib46","doi-asserted-by":"crossref","first-page":"503","DOI":"10.3727\/096504017X15005102445191","article-title":"Detection of necroptosis in ligand-mediated and hypoxia-induced injury of hepatocytes using a novel optic probe-detecting receptor-interacting protein (RIP)1\/RIP3 binding","volume":"26","author":"Haga","year":"2018","journal-title":"Oncol Res"},{"key":"10.1016\/j.jss.2025.07.039_bib47","doi-asserted-by":"crossref","first-page":"6611","DOI":"10.1007\/s11033-014-3544-4","article-title":"Ischemic injury of the liver in a porcine model of cardiac death assessed by in vivo microdialysis","volume":"41","author":"Yi","year":"2014","journal-title":"Mol Biol Rep"},{"key":"10.1016\/j.jss.2025.07.039_bib48","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1159\/000008724","article-title":"Evaluation of ischemic injury during liver procurement from non-heart-beating donors","volume":"31","author":"Garc\u00eda-Valdecasas","year":"1999","journal-title":"Eur Surg Res"},{"key":"10.1016\/j.jss.2025.07.039_bib49","doi-asserted-by":"crossref","first-page":"35377","DOI":"10.1074\/jbc.M005287200","article-title":"Rac1 regulates stress-induced, redox-dependent heat shock factor activation","volume":"275","author":"Ozaki","year":"2000","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jss.2025.07.039_bib50","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1038\/sj.cdd.4401172","article-title":"Inhibition of hypoxia\/reoxygenenation-induced oxidative stress in HGF-stimulated antiapoptotic signaling: role of PI3-K and Akt kinase upon Rac1","volume":"10","author":"Ozaki","year":"2003","journal-title":"Cell Death Differ"},{"key":"10.1016\/j.jss.2025.07.039_bib51","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1042\/BJ20081386","article-title":"How mitochondria produce reactive oxygen species","volume":"417","author":"Murphy","year":"2009","journal-title":"Biochem J"},{"key":"10.1016\/j.jss.2025.07.039_bib52","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1007\/s10541-005-0102-7","article-title":"Mitochondrial metabolism of reactive oxygen species","volume":"70","author":"Andreyev","year":"2005","journal-title":"Biochemistry (Mosc)"},{"key":"10.1016\/j.jss.2025.07.039_bib53","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1016\/j.redox.2015.09.005","article-title":"Reactive oxygen species and mitochondria: a nexus of cellular homeostasis","volume":"6","author":"Dan Dunn","year":"2015","journal-title":"Redox Biol"},{"key":"10.1016\/j.jss.2025.07.039_bib54","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1177\/1074248413508003","article-title":"Reduction of early reperfusion injury with the mitochondria-targeting peptide bendavia","volume":"19","author":"Brown","year":"2014","journal-title":"J Cardiovasc Pharmacol Ther"},{"key":"10.1016\/j.jss.2025.07.039_bib55","article-title":"The role of mitochondria in liver ischemia-reperfusion injury: from aspects of mitochondrial oxidative stress, mitochondrial fission, mitochondrial membrane permeable transport pore formation, mitophagy, and mitochondria-related protective measures","volume":"2021","author":"Zhang","year":"2021","journal-title":"Oxid Med Cell Longev"},{"key":"10.1016\/j.jss.2025.07.039_bib56","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1007\/s00534-010-0328-7","article-title":"Allopurinol and xanthine oxidase inhibition in liver ischemia reperfusion","volume":"18","author":"Peglow","year":"2011","journal-title":"J Hepatobiliary Pancreat Sci"},{"key":"10.1016\/j.jss.2025.07.039_bib57","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/0016-5085(86)90078-8","article-title":"Xanthine oxidase inhibitors attenuate ischemia-induced vascular permeability changes in the cat intestine","volume":"90","author":"Granger","year":"1986","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jss.2025.07.039_bib58","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1056\/NEJM198501173120305","article-title":"Oxygen-derived free radicals in postischemic tissue injury","volume":"312","author":"Epstein","year":"1985","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jss.2025.07.039_bib59","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1016\/j.redox.2015.08.020","article-title":"Reperfusion injury and reactive oxygen species: the evolution of a concept","volume":"6","author":"Granger","year":"2015","journal-title":"Redox Biol"},{"key":"10.1016\/j.jss.2025.07.039_bib60","doi-asserted-by":"crossref","first-page":"225","DOI":"10.3892\/mmr.2021.11864","article-title":"Ferroptosis in hepatic ischemia-reperfusion injury: regulatory mechanisms and new methods for therapy (Review)","volume":"23","author":"Luo","year":"2021","journal-title":"Mol Med Rep"},{"key":"10.1016\/j.jss.2025.07.039_bib61","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1002\/lt.25488","article-title":"Necroptotic cell death in liver transplantation and underlying diseases: mechanisms and clinical perspective","volume":"25","author":"Shi","year":"2019","journal-title":"Liver Transpl"},{"key":"10.1016\/j.jss.2025.07.039_bib62","doi-asserted-by":"crossref","first-page":"19","DOI":"10.4137\/JCD.S39824","article-title":"Mechanism of hepatocyte apoptosis","volume":"9","author":"Cao","year":"2016","journal-title":"J Cell Death"},{"key":"10.1016\/j.jss.2025.07.039_bib63","doi-asserted-by":"crossref","first-page":"2357","DOI":"10.3390\/ijms23042357","article-title":"Role of mitochondrial pathways in cell apoptosis during He-patic ischemia\/reperfusion injury","volume":"23","author":"Zhang","year":"2022","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.jss.2025.07.039_bib64","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1007\/s00795-018-0205-z","article-title":"Protective role of heme oxygenase-1 in fatty liver ischemia\u2013reperfusion injury","volume":"52","author":"Li","year":"2019","journal-title":"Med Mol Morphol"},{"key":"10.1016\/j.jss.2025.07.039_bib65","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1590\/s0102-865020180080000008","article-title":"Liver ischemia and reperfusion injury. Pathophysiology and new horizons in preconditioning and therapy","volume":"33","author":"Nakazato","year":"2018","journal-title":"Acta Cir Bras"},{"key":"10.1016\/j.jss.2025.07.039_bib66","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2021.119321","article-title":"Long effects of non-drug treatment on liver cells apoptosis during hepatic ischemia-reperfusion injury","volume":"275","author":"Wang","year":"2021","journal-title":"Life Sci"},{"key":"10.1016\/j.jss.2025.07.039_bib67","doi-asserted-by":"crossref","DOI":"10.4110\/in.2018.18.e24","article-title":"Dual effect of hepatic macrophages on liver ischemia and reperfusion injury during liver transplantation","volume":"18","author":"Lu","year":"2018","journal-title":"Immune Netw"},{"key":"10.1016\/j.jss.2025.07.039_bib68","doi-asserted-by":"crossref","DOI":"10.1016\/j.trre.2021.100674","article-title":"Interleukin-27 in liver xenotransplantation: a rational target to mitigate ischemia reperfusion injury and increase xenograft survival","volume":"36","author":"Matheson","year":"2022","journal-title":"Transplant Rev"},{"key":"10.1016\/j.jss.2025.07.039_bib69","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1016\/j.jhep.2013.03.033","article-title":"Decoding cell death signals in liver inflammation","volume":"59","author":"Brenner","year":"2013","journal-title":"J Hepatol"},{"key":"10.1016\/j.jss.2025.07.039_bib70","doi-asserted-by":"crossref","first-page":"1737","DOI":"10.7150\/ijms.28382","article-title":"Pathophysiologic implications of cytokines secretion during liver transplantation surgery","volume":"15","author":"Hwang","year":"2018","journal-title":"Int J Med Sci"},{"key":"10.1016\/j.jss.2025.07.039_bib71","doi-asserted-by":"crossref","first-page":"d1899","DOI":"10.2741\/A887","article-title":"Chemokines in liver inflammation and fibrosis","volume":"7","author":"Marra","year":"2002","journal-title":"Front Biosci"},{"key":"10.1016\/j.jss.2025.07.039_bib72","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.cytogfr.2012.04.006","article-title":"The sterile immune response during hepatic ischemia\/reperfusion","volume":"23","author":"van Golen","year":"2012","journal-title":"Cytokine Growth Factor Rev"},{"issue":"Suppl 1","key":"10.1016\/j.jss.2025.07.039_bib73","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1111\/j.1440-1746.2010.06592.x","article-title":"Reactive oxygen and mechanisms of inflammatory liver injury: present concepts","volume":"26","author":"Jaeschke","year":"2011","journal-title":"J Gastroenterol Hepatol"},{"key":"10.1016\/j.jss.2025.07.039_bib74","doi-asserted-by":"crossref","first-page":"1158","DOI":"10.1053\/j.gastro.2012.09.008","article-title":"Sterile inflammation in the liver","volume":"143","author":"Kubes","year":"2012","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jss.2025.07.039_bib75","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1586\/17474124.2015.1060855","article-title":"Sterile inflammation in acute liver injury: myth or mystery?","volume":"9","author":"Woolbright","year":"2015","journal-title":"Expert Rev Gastroenterol Hepatol"},{"key":"10.1016\/j.jss.2025.07.039_bib76","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1111\/j.1478-3231.2006.01330.x","article-title":"Ischemic preconditioning improves liver regeneration by sustaining energy metabolism after partial hepatectomy under ischemia in rats","volume":"26","author":"Kerem","year":"2006","journal-title":"Liver Int"},{"key":"10.1016\/j.jss.2025.07.039_bib77","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1002\/hep.1840200528","article-title":"Liver injury following normothermic ischemia in steatotic rat liver","volume":"20","author":"Hui","year":"1994","journal-title":"Hepatology"},{"key":"10.1016\/j.jss.2025.07.039_bib78","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.ejphar.2005.10.044","article-title":"Resveratrol protects against cold ischemia-warm reoxygenation-induced damages to mitochondria and cells in rat liver","volume":"528","author":"Plin","year":"2005","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.jss.2025.07.039_bib79","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/j.arcmed.2005.09.016","article-title":"Cold preservation of pig liver grafts with warm ischemia and pentoxifylline-UW solution","volume":"37","author":"Qing","year":"2006","journal-title":"Arch Med Res"},{"key":"10.1016\/j.jss.2025.07.039_bib80","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1016\/0022-4804(86)90170-8","article-title":"Quantitative analysis of the effect of ATP-MgCl2 and adenosine-MgCl2 on the extent of necrosis in rat liver after ischemia","volume":"41","author":"Frederiks","year":"1986","journal-title":"J Surg Res"},{"key":"10.1016\/j.jss.2025.07.039_bib81","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1080\/08941930390205764","article-title":"Liver ischemia: apoptosis as a central mechanism of injury","volume":"16","author":"R\u00fcdiger","year":"2003","journal-title":"J Invest Surg"},{"key":"10.1016\/j.jss.2025.07.039_bib82","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/B978-0-12-394309-5.00006-7","article-title":"Cell biology of ischemia\/reperfusion injury","volume":"298","author":"Kalogeris","year":"2012","journal-title":"Int Rev Cell Mol Biol"},{"key":"10.1016\/j.jss.2025.07.039_bib83","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1002\/j.2040-4603.2017.tb00741.x","article-title":"Ischemia\/reperfusion","volume":"7","author":"Kalogeris","year":"2017","journal-title":"Compr Physiol"},{"key":"10.1016\/j.jss.2025.07.039_bib84","doi-asserted-by":"crossref","first-page":"329","DOI":"10.3389\/fimmu.2019.00329","article-title":"Complement therapeutics in the multi-organ donor: do or don\u2019t?","volume":"10","author":"Zanden","year":"2019","journal-title":"Front Immunol"},{"key":"10.1016\/j.jss.2025.07.039_bib85","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2020.173484","article-title":"AMP-activated protein kinase: an attractive therapeutic target for ischemia-reperfusion injury","volume":"888","author":"Ding","year":"2020","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.jss.2025.07.039_bib86","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1016\/j.biopha.2018.01.113","article-title":"A comprehensive review on regulatory effects of crocin on ischemia\/reperfusion injury in multiple organs","volume":"99","author":"Akbari","year":"2018","journal-title":"Biomed Pharmacother"},{"key":"10.1016\/j.jss.2025.07.039_bib87","doi-asserted-by":"crossref","DOI":"10.1155\/2016\/2183026","article-title":"ROS-mediated NLRP3 inflammasome activation in brain, heart, kidney, and testis ischemia\/reperfusion injury","volume":"2016","author":"Minutoli","year":"2016","journal-title":"Oxid Med Cell Longev"},{"key":"10.1016\/j.jss.2025.07.039_bib88","doi-asserted-by":"crossref","first-page":"3279","DOI":"10.1016\/j.transproceed.2008.10.004","article-title":"Ischemia\/reperfusion injury in kidney transplantation: mechanisms and prevention","volume":"40","author":"Kosieradzki","year":"2008","journal-title":"Transplant Proc"},{"key":"10.1016\/j.jss.2025.07.039_bib89","doi-asserted-by":"crossref","first-page":"875","DOI":"10.2310\/JIM.0b013e3181e5d719","article-title":"Effects of dantrolene on ischemia-reperfusion injury in animal models: a review of outcomes in heart, brain, liver, and kidney","volume":"58","author":"Boys","year":"2010","journal-title":"J Invest Med"},{"key":"10.1016\/j.jss.2025.07.039_bib90","doi-asserted-by":"crossref","first-page":"445","DOI":"10.7555\/JBR.29.20140142","article-title":"The evolving concept of physiological ischemia training vs. Ischemia preconditioning","volume":"29","author":"Ni","year":"2015","journal-title":"J Biomed Res"},{"key":"10.1016\/j.jss.2025.07.039_bib91","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1016\/j.jss.2007.12.747","article-title":"Remote ischemic preconditioning: a novel protective method from ischemia reperfusion injury-A review","volume":"150","author":"Tapuria","year":"2008","journal-title":"J Surg Res"},{"key":"10.1016\/j.jss.2025.07.039_bib92","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1007\/s00595-010-4444-4","article-title":"Ischemia\/reperfusion injury in liver resection: a review of preconditioning methods","volume":"41","author":"Theodoraki","year":"2011","journal-title":"Surg Today"},{"key":"10.1016\/j.jss.2025.07.039_bib93","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2020.173380","article-title":"Remote ischemic preconditioning-induced neuroprotection in cerebral ischemia-reperfusion injury: preclinical evidence and mechanisms","volume":"883","author":"Sharma","year":"2020","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.jss.2025.07.039_bib94","doi-asserted-by":"crossref","first-page":"1441","DOI":"10.1152\/japplphysiol.00642.2007","article-title":"Preconditioning and postconditioning: innate cardioprotection from ischemia-reperfusion injury","volume":"103","author":"Vinten-Johansen","year":"2007","journal-title":"J Appl Physiol"},{"key":"10.1016\/j.jss.2025.07.039_bib95","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1097\/HCO.0000000000000447","article-title":"Protecting the heart from ischemia\/reperfusion injury: an update on remote ischemic preconditioning and postconditioning","volume":"32","author":"Donato","year":"2017","journal-title":"Curr Opin Cardiol"},{"key":"10.1016\/j.jss.2025.07.039_bib96","doi-asserted-by":"crossref","first-page":"220","DOI":"10.2174\/1573403X113099990033","article-title":"Exercise and cardiac preconditioning against ischemia reperfusion injury","volume":"9","author":"Quindry","year":"2013","journal-title":"Curr Cardiol Rev"},{"key":"10.1016\/j.jss.2025.07.039_bib97","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1097\/MOT.0b013e3282f6a164","article-title":"Ischemic preconditioning in hepatic ischemia and reperfusion","volume":"13","author":"Suzuki","year":"2008","journal-title":"Curr Opin Organ Transplant"},{"key":"10.1016\/j.jss.2025.07.039_bib98","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1097\/00007890-200204270-00004","article-title":"Ischemic preconditioning: a defense mechanism against the reactive oxygen species generated after hepatic ischemia reperfusion","volume":"73","author":"Peralta","year":"2002","journal-title":"Transplantation"},{"key":"10.1016\/j.jss.2025.07.039_bib99","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/S0022-2143(96)90026-8","article-title":"Ischemic preconditioning of the liver in rats: implications of heat shock protein induction to increase tolerance of ischemia-reperfusion injury","volume":"128","author":"Kume","year":"1996","journal-title":"J Lab Clin Med"},{"key":"10.1016\/j.jss.2025.07.039_bib100","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1097\/00007890-199807270-00002","article-title":"Protective effect of ischemic preconditioning on liver preservation- reperfusion injury in rats","volume":"66","author":"Yin","year":"1998","journal-title":"Transplantation"},{"key":"10.1016\/j.jss.2025.07.039_bib101","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1053\/jhep.2002.34616","article-title":"Preconditioning protects liver and lung damage in rat liver transplantation: role of xanthine\/xanthine oxidase","volume":"36","author":"Fern\u00e1ndez","year":"2002","journal-title":"Hepatology"},{"key":"10.1016\/j.jss.2025.07.039_bib102","doi-asserted-by":"crossref","first-page":"1636","DOI":"10.1046\/j.1365-2168.1998.00917.x","article-title":"Amelioration of liver injury by ischaemic preconditioning","volume":"85","author":"Yoshizumi","year":"1998","journal-title":"Br J Surg"},{"key":"10.1016\/j.jss.2025.07.039_bib103","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1053\/jhep.2001.20529","article-title":"Preconditioning protects against systemic disorders associated with hepatic ischemia-reperfusion through blockade of tumor necrosis factor-induced P-selectin up-regulation in the rat","volume":"33","author":"Peralta","year":"2001","journal-title":"Hepatology"},{"key":"10.1016\/j.jss.2025.07.039_bib104","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1159\/000292647","article-title":"Ischemic preconditioning attenuates morphological and biochemical changes in hepatic ischemia\/reperfusion in rats","volume":"77","author":"Jin","year":"2010","journal-title":"Pathobiology"},{"key":"10.1016\/j.jss.2025.07.039_bib105","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1053\/jhep.2002.33134","article-title":"Hepatic ischemic preconditioning in mice is associated with activation of NF-\u03baB, p38 kinase, and cell cycle entry","volume":"36","author":"Teoh","year":"2002","journal-title":"Hepatology"},{"key":"10.1016\/j.jss.2025.07.039_bib106","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1159\/000072064","article-title":"Protection of the liver by ischemic preconditioning: a review of mechanisms and clinical applications","volume":"20","author":"Koti","year":"2003","journal-title":"Dig Surg"},{"key":"10.1016\/j.jss.2025.07.039_bib107","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.1016\/S0003-4975(97)00104-5","article-title":"Effect of spinal cord preconditioning on paraplegia during cross- clamping of the thoracic aorta","volume":"63","author":"Matsuyama","year":"1997","journal-title":"Ann Thorac Surg"},{"key":"10.1016\/j.jss.2025.07.039_bib108","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1006\/jmcc.1996.0265","article-title":"Oxygen radicals released during ischemic preconditioning contribute to cardioprotection in the rabbit myocardium","volume":"29","author":"Baines","year":"1997","journal-title":"J Mol Cell Cardiol"},{"key":"10.1016\/j.jss.2025.07.039_bib109","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1007\/s10741-007-9025-2","article-title":"Signaling pathways in ischemic preconditioning","volume":"12","author":"Downey","year":"2007","journal-title":"Heart Fail Rev"},{"key":"10.1016\/j.jss.2025.07.039_bib110","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1006\/jsre.1995.1045","article-title":"Duration of liver ischemia and hepatic regeneration after hepatectomy in rats","volume":"58","author":"Maruyama","year":"1995","journal-title":"J Surg Res"},{"key":"10.1016\/j.jss.2025.07.039_bib111","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0199177","article-title":"Upregulation of krebs cycle and anaerobic glycolysis activity early after onset of liver ischemia","volume":"13","author":"Chan","year":"2018","journal-title":"PLoS One"},{"key":"10.1016\/j.jss.2025.07.039_bib112","first-page":"68","article-title":"Use of magnesium-ATP following liver ischemia","volume":"7","author":"Chaudry","year":"1988","journal-title":"Magnesium"},{"key":"10.1016\/j.jss.2025.07.039_bib113","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1046\/j.1440-1746.2003.03056.x","article-title":"Hepatic ischemia reperfusion injury: pathogenic mechanisms and basis for hepatoprotection","volume":"18","author":"Teoh","year":"2003","journal-title":"J Gastroenterol Hepatol"},{"key":"10.1016\/j.jss.2025.07.039_bib114","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s595-002-8105-8","article-title":"Ischemia-reperfusion injury of the liver with special reference to calcium-dependent mechanisms","volume":"32","author":"Sakon","year":"2002","journal-title":"Surg Today"},{"key":"10.1016\/j.jss.2025.07.039_bib115","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1007\/s00204-014-1437-x","article-title":"Molecular responses to ischemia and reperfusion in the liver","volume":"89","author":"Quesnelle","year":"2015","journal-title":"Arch Toxicol"},{"key":"10.1016\/j.jss.2025.07.039_bib116","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1161\/01.STR.29.3.705","article-title":"Calcium in ischemic cell death","volume":"29","author":"Kristi\u00e1n","year":"1998","journal-title":"Stroke"},{"key":"10.1016\/j.jss.2025.07.039_bib117","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1023\/A:1005419617371","article-title":"Mitochondrial dysfunction in the pathogenesis of necrotic and apoptotic cell death","volume":"31","author":"Lemasters","year":"1999","journal-title":"J Bioenerg Biomembr"},{"key":"10.1016\/j.jss.2025.07.039_bib118","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1007\/BF02110643","article-title":"The permeability transition pore as a mitochondrial Calcium release channel: a critical appraisal","volume":"28","author":"Bernardi","year":"1996","journal-title":"J Bioenerg Biomembr"},{"key":"10.1016\/j.jss.2025.07.039_bib119","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1152\/physrev.1999.79.3.917","article-title":"Cardiac ionic currents and acute ischemia: from channels to arrhythmias","volume":"79","author":"Carmeliet","year":"1999","journal-title":"Physiol Rev"},{"key":"10.1016\/j.jss.2025.07.039_bib120","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1111\/j.1469-7793.2000.00023.x","article-title":"Pathophysiological and protective roles of mitochondrial ion channels","volume":"529","author":"O\u2019Rourke","year":"2000","journal-title":"J Physiol"},{"key":"10.1016\/j.jss.2025.07.039_bib121","doi-asserted-by":"crossref","first-page":"95","DOI":"10.3389\/fphys.2013.00095","article-title":"The mitochondrial permeability transition pore: a mystery solved?","volume":"4","author":"Bernardi","year":"2013","journal-title":"Front Physiol"},{"key":"10.1016\/j.jss.2025.07.039_bib122","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1007\/s00109-007-0277-z","article-title":"Hypoxia and gastrointestinal disease","volume":"85","author":"Taylor","year":"2007","journal-title":"J Mol Med"},{"key":"10.1016\/j.jss.2025.07.039_bib123","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1016\/S0891-5849(01)00657-8","article-title":"Transduction pathways involved in hypoxia-inducible factor-1 phosphorylation and activation","volume":"31","author":"Minet","year":"2001","journal-title":"Free Radic Biol Med"},{"key":"10.1016\/j.jss.2025.07.039_bib124","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.tplants.2016.08.002","article-title":"ROS are good","volume":"22","author":"Mittler","year":"2017","journal-title":"Trends Plant Sci"},{"key":"10.1016\/j.jss.2025.07.039_bib125","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1038\/nrm2256","article-title":"ROS as signalling molecules: mechanisms that generate specificity in ROS homeostasis","volume":"8","author":"D\u2019Autr\u00e9aux","year":"2007","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10.1016\/j.jss.2025.07.039_bib126","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1089\/ars.2007.1957","article-title":"Redox regulation of cell survival","volume":"10","author":"Trachootham","year":"2008","journal-title":"Antioxid Redox Signal"},{"key":"10.1016\/j.jss.2025.07.039_bib127","first-page":"H341","article-title":"Influence of neutrophil depletion on myocardial function and flow after reversible ischemia","volume":"256","author":"O\u2019Neill","year":"1989","journal-title":"Am J Physiol"},{"key":"10.1016\/j.jss.2025.07.039_bib128","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1016\/j.redox.2014.05.006","article-title":"Mitochondrial reactive oxygen species: a double edged sword in ischemia\/reperfusion vs preconditioning","volume":"2","author":"Kalogeris","year":"2014","journal-title":"Redox Biol"},{"key":"10.1016\/j.jss.2025.07.039_bib129","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1172\/JCI118449","article-title":"Evidence for an essential role of reactive oxygen species in the genesis of late preconditioning against myocardial stunning in conscious pigs","volume":"97","author":"Sun","year":"1996","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jss.2025.07.039_bib130","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1016\/S0022-2828(87)80350-4","article-title":"Xanthine oxidase is not a source of free radicals in the ischemic rabbit heart","volume":"19","author":"Downey","year":"1987","journal-title":"J Mol Cell Cardiol"},{"key":"10.1016\/j.jss.2025.07.039_bib131","first-page":"111","article-title":"The role of xanthine oxidase in ischemia\/reperfusion damage of rat liver","volume":"10","author":"Frederiks","year":"1995","journal-title":"Histol Histopathol"},{"key":"10.1016\/j.jss.2025.07.039_bib132","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1161\/01.CIR.71.5.1069","article-title":"Failure of the xanthine oxidase inhibitor allopurinol to limit infarct size after ischemia and reperfusion in dogs","volume":"71","author":"Reimer","year":"1985","journal-title":"Circulation"},{"key":"10.1016\/j.jss.2025.07.039_bib133","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1007\/BF02576235","article-title":"Normothermic liver ischemia in rats: xanthine oxidase is not the main source of oxygen free radicals","volume":"193","author":"Karwinski","year":"1993","journal-title":"Res Exp Med"},{"key":"10.1016\/j.jss.2025.07.039_bib134","doi-asserted-by":"crossref","first-page":"R491","DOI":"10.1152\/ajpregu.00432.2003","article-title":"Mitochondrial dysfunction in a long-term rodent model of sepsis and organ failure","volume":"286","author":"Brealey","year":"2004","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"10.1016\/j.jss.2025.07.039_bib135","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1023\/A:1007649815992","article-title":"Hepatotoxicity due to mitochondrial dysfunction","volume":"15","author":"Pessayre","year":"1999","journal-title":"Cell Biol Toxicol"},{"key":"10.1016\/j.jss.2025.07.039_bib136","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1007\/s00018-008-8552-x","article-title":"Rac1 GTPase: a \u201crac\u201d of all trades","volume":"66","author":"Bosco","year":"2008","journal-title":"Cell Mol Life Sci"},{"key":"10.1016\/j.jss.2025.07.039_bib137","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1039\/c0ib00052c","article-title":"Determinants of leader cells in collective cell migration","volume":"2","author":"Khalil","year":"2010","journal-title":"Integr Biol"},{"key":"10.1016\/j.jss.2025.07.039_bib138","doi-asserted-by":"crossref","first-page":"1441","DOI":"10.1042\/bst0311441","article-title":"Reactive oxygen species in oncogenic transformation","volume":"31","author":"Behrend","year":"2003","journal-title":"Biochem Soc Trans"},{"key":"10.1016\/j.jss.2025.07.039_bib139","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.coph.2009.11.004","article-title":"Novel aspects of the roles of Rac1 GTPase in the cardiovascular system","volume":"10","author":"Sawada","year":"2010","journal-title":"Curr Opin Pharmacol"},{"key":"10.1016\/j.jss.2025.07.039_bib140","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1161\/01.RES.0000204727.46710.5e","article-title":"Regulation of NADPH oxidases: the role of rac proteins","volume":"98","author":"Hordijk","year":"2006","journal-title":"Circ Res"},{"key":"10.1016\/j.jss.2025.07.039_bib141","first-page":"199","article-title":"Phagocyte NADPH oxidase: a multicomponent enzyme essential for host defenses","volume":"53","author":"El","year":"2005","journal-title":"Arch Immunol Ther Exp"},{"key":"10.1016\/j.jss.2025.07.039_bib142","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/j.cardiores.2006.05.003","article-title":"Reactive oxygen species in vascular endothelial cell motility. Roles of NAD(P)H oxidase and Rac1","volume":"71","author":"Moldovan","year":"2006","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.jss.2025.07.039_bib143","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1016\/S0968-0004(03)00194-4","article-title":"NADPH oxidases: not just for leukocytes anymore!","volume":"28","author":"Bokoch","year":"2003","journal-title":"Trends Biochem Sci"},{"key":"10.1016\/j.jss.2025.07.039_bib144","doi-asserted-by":"crossref","first-page":"1649","DOI":"10.1126\/science.275.5306.1649","article-title":"Mitogenic signaling mediated by oxidants in ras-transformed fibroblasts","volume":"275","author":"Irani","year":"1997","journal-title":"Science"},{"key":"10.1016\/j.jss.2025.07.039_bib145","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1161\/01.RES.87.3.179","article-title":"Oxidant signaling in vascular cell growth, death, and survival: a review of the roles of reactive oxygen species in smooth muscle and endothelial cell mitogenic and apoptotic signaling","volume":"87","author":"Irani","year":"2000","journal-title":"Circ Res"},{"key":"10.1016\/j.jss.2025.07.039_bib146","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1007\/s001099900029","article-title":"Therapeutic approaches for ischemia\/reperfusion injury in the liver","volume":"77","author":"Fan","year":"1999","journal-title":"J Mol Med"},{"key":"10.1016\/j.jss.2025.07.039_bib147","doi-asserted-by":"crossref","first-page":"1332","DOI":"10.1016\/j.transproceed.2006.11.021","article-title":"Role of reactive oxygen species in mediating hepatic ischemia-reperfusion injury and its therapeutic applications in liver transplantation","volume":"39","author":"Zhang","year":"2007","journal-title":"Transplant Proc"},{"key":"10.1016\/j.jss.2025.07.039_bib148","doi-asserted-by":"crossref","first-page":"G15","DOI":"10.1152\/ajpgi.00342.2002","article-title":"Molecular mechanisms of hepatic ischemia-reperfusion injury and preconditioning","volume":"284","author":"Jaeschke","year":"2003","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1016\/j.jss.2025.07.039_bib149","article-title":"N-acetylcysteine attenuates ischemia-reperfusion-induced apoptosis and autophagy in mouse liver via regulation of the ROS\/JNK\/Bcl-2 pathway","volume":"9","author":"Wang","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.jss.2025.07.039_bib150","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1034\/j.1600-065X.2003.00048.x","article-title":"Caspase-activation pathways in apoptosis and immunity","volume":"193","author":"Creagh","year":"2003","journal-title":"Immunol Rev"},{"key":"10.1016\/j.jss.2025.07.039_bib151","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1385\/MN:24:1-3:131","article-title":"Caspase-dependent apoptotic pathways in CNS injury","volume":"24","author":"Yakovlev","year":"2001","journal-title":"Mol Neurobiol"},{"key":"10.1016\/j.jss.2025.07.039_bib152","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1111\/j.1745-7270.2005.00108.x","article-title":"Caspase family proteases and apoptosis","volume":"37","author":"Fan","year":"2005","journal-title":"Acta Biochim Biophys Sin"},{"key":"10.1016\/j.jss.2025.07.039_bib153","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1016\/j.cellbi.2005.04.001","article-title":"Pathways to caspase activation","volume":"29","author":"Wang","year":"2005","journal-title":"Cell Biol Int"},{"key":"10.1016\/j.jss.2025.07.039_bib154","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1038\/ni.1703","article-title":"The inflammasome: a caspase-1-activation platform that regulates immune responses and disease pathogenesis","volume":"10","author":"Franchi","year":"2009","journal-title":"Nat Immunol"},{"key":"10.1016\/j.jss.2025.07.039_bib155","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1038\/sj.cdd.4400598","article-title":"Caspase structure, proteolytic substrates, and function during apoptotic cell death","volume":"6","author":"Nicholson","year":"1999","journal-title":"Cell Death Differ"},{"key":"10.1016\/j.jss.2025.07.039_bib156","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1038\/sj.cdd.4402038","article-title":"Inflammatory caspases and inflammasomes: master switches of inflammation","volume":"14","author":"Martinon","year":"2007","journal-title":"Cell Death Differ"},{"key":"10.1016\/j.jss.2025.07.039_bib157","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.2174\/156802609789869646","article-title":"Neuron protection as a therapeutic target in acute ischemic stroke","volume":"9","author":"Tuttolomondo","year":"2009","journal-title":"Curr Top Med Chem"},{"key":"10.1016\/j.jss.2025.07.039_bib158","doi-asserted-by":"crossref","first-page":"1502","DOI":"10.1111\/j.1582-4934.2008.00292.x","article-title":"Caspases as therapeutic targets","volume":"12","author":"Howley","year":"2008","journal-title":"J Cell Mol Med"},{"key":"10.1016\/j.jss.2025.07.039_bib159","doi-asserted-by":"crossref","first-page":"269","DOI":"10.2174\/1568008054863754","article-title":"Caspases as drug targets in ischemic organ injury","volume":"5","author":"Faubel","year":"2005","journal-title":"Curr Drug Targets Immune Endocr Metabol Disord"},{"key":"10.1016\/j.jss.2025.07.039_bib160","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1186\/s12943-019-1029-8","article-title":"The role of necroptosis in cancer biology and therapy","volume":"18","author":"Gong","year":"2019","journal-title":"Mol Cancer"},{"key":"10.1016\/j.jss.2025.07.039_bib161","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1146\/annurev-biochem-060815-014830","article-title":"Necroptosis and inflammation","volume":"85","author":"Newton","year":"2016","journal-title":"Annu Rev Biochem"},{"key":"10.1016\/j.jss.2025.07.039_bib162","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1056\/NEJMra1310050","article-title":"Necroptosis","volume":"370","author":"Linkermann","year":"2014","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jss.2025.07.039_bib163","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1007\/978-3-030-27378-1_53","article-title":"Parthanatos as a cell death pathway underlying retinal disease","volume":"1185","author":"Greenwald","year":"2019","journal-title":"Adv Exp Med Biol"},{"key":"10.1016\/j.jss.2025.07.039_bib164","doi-asserted-by":"crossref","first-page":"2000","DOI":"10.1111\/bph.12416","article-title":"Parthanatos: mitochondrial-linked mechanisms and therapeutic opportunities","volume":"171","author":"Fatokun","year":"2014","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.jss.2025.07.039_bib165","doi-asserted-by":"crossref","first-page":"971","DOI":"10.3389\/fonc.2019.00971","article-title":"Induction of pyroptosis and its implications in cancer management","volume":"9","author":"Wang","year":"2019","journal-title":"Front Oncol"},{"key":"10.1016\/j.jss.2025.07.039_bib166","doi-asserted-by":"crossref","first-page":"2195","DOI":"10.1007\/s00018-016-2194-1","article-title":"Mechanisms of ferroptosis","volume":"73","author":"Cao","year":"2016","journal-title":"Cell Mol Life Sci"},{"key":"10.1016\/j.jss.2025.07.039_bib167","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.semcdb.2014.07.013","article-title":"Necroptosis in health and diseases","volume":"35","author":"Zhou","year":"2014","journal-title":"Semin Cell Dev Biol"},{"key":"10.1016\/j.jss.2025.07.039_bib168","doi-asserted-by":"crossref","first-page":"G354","DOI":"10.1152\/ajpgi.2000.278.3.G354","article-title":"Fas and Fas ligand in gut and liver","volume":"278","author":"Pinkoski","year":"2000","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1016\/j.jss.2025.07.039_bib169","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1007\/978-3-642-79850-4_6","article-title":"Apoptosis mediated by the Fas system","volume":"16","author":"Nagata","year":"1996","journal-title":"Prog Mol Subcell Biol"},{"key":"10.1016\/j.jss.2025.07.039_bib170","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1046\/j.1365-2893.1999.00175.x","article-title":"Involvement of Fas system-mediated apoptosis in pathogenesis of viral hepatitis","volume":"6","author":"Hayashi","year":"1999","journal-title":"J Viral Hepat"},{"key":"10.1016\/j.jss.2025.07.039_bib171","doi-asserted-by":"crossref","DOI":"10.1155\/2019\/3950818","article-title":"Associations of oxidative stress and postoperative outcome in liver surgery with an outlook to future potential therapeutic options","volume":"2019","author":"Senoner","year":"2019","journal-title":"Oxid Med Cell Longev"},{"key":"10.1016\/j.jss.2025.07.039_bib172","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1007\/s005340050065","article-title":"Apoptosis and the liver: relevance for the hepato-biliary-pancreatic surgeon","volume":"5","author":"Miyoshi","year":"1998","journal-title":"J Hepatobiliary Pancreat Surg"},{"key":"10.1016\/j.jss.2025.07.039_bib173","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1007\/s00430-015-0410-5","article-title":"Manipulation of apoptosis and necroptosis signaling by herpesviruses","volume":"204","author":"Guo","year":"2015","journal-title":"Med Microbiol Immunol"},{"key":"10.1016\/j.jss.2025.07.039_bib174","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1515\/hsz-2014-0164","article-title":"Inflammatory outcomes of apoptosis, necrosis and necroptosis","volume":"395","author":"Davidovich","year":"2014","journal-title":"Biol Chem"},{"key":"10.1016\/j.jss.2025.07.039_bib175","first-page":"1","article-title":"Programmed necrosis: from molecules to health and disease","volume":"289","author":"Galluzzi","year":"2011","journal-title":"Int Rev Cell Mol Biol"},{"key":"10.1016\/j.jss.2025.07.039_bib176","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12929-021-00722-w","article-title":"Targeting necroptosis as therapeutic potential in chronic myocardial infarction","volume":"28","author":"Piamsiri","year":"2021","journal-title":"J Biomed Sci"},{"key":"10.1016\/j.jss.2025.07.039_bib177","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1007\/s10495-015-1192-3","article-title":"Necroptosis: a potential, promising target and switch in acute pancreatitis","volume":"21","author":"Wang","year":"2015","journal-title":"Apoptosis"},{"key":"10.1016\/j.jss.2025.07.039_bib178","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.molcel.2010.06.017","article-title":"The PARP side of the nucleus: molecular actions, physiological outcomes, and clinical targets","volume":"39","author":"Krishnakumar","year":"2010","journal-title":"Mol Cell"},{"key":"10.1016\/j.jss.2025.07.039_bib179","doi-asserted-by":"crossref","first-page":"1534","DOI":"10.1007\/s00018-002-8527-2","article-title":"The functional role of poly(ADP-Ribose)Polymerase 1 as novel coactivator of NF-\u039aB in inflammatory disorders","volume":"59","author":"Hassa","year":"2002","journal-title":"Cell Mol Life Sci"},{"key":"10.1016\/j.jss.2025.07.039_bib180","doi-asserted-by":"crossref","first-page":"3046","DOI":"10.2741\/2909","article-title":"The diverse biological roles of mammalian PARPS, a small but powerful family of poly-ADP-ribose polymerases","volume":"13","author":"Hassa","year":"2008","journal-title":"Front Biosci"},{"key":"10.1016\/j.jss.2025.07.039_bib181","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1016\/j.gde.2010.06.001","article-title":"The roles of PARP1 in gene control and cell differentiation","volume":"20","author":"Ji","year":"2010","journal-title":"Curr Opin Genet Dev"},{"key":"10.1016\/j.jss.2025.07.039_bib182","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1128\/MMBR.00040-05","article-title":"Nuclear ADP-ribosylation reactions in mammalian cells: where are we today and where are we going?","volume":"70","author":"Hassa","year":"2006","journal-title":"Microbiol Mol Biol Rev"},{"key":"10.1016\/j.jss.2025.07.039_bib183","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1038\/nrm3376","article-title":"New insights into the molecular and cellular functions of poly(ADP-ribose) and PARPs","volume":"13","author":"Gibson","year":"2012","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10.1016\/j.jss.2025.07.039_bib184","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1083\/jcb.201402114","article-title":"Poly(ADP-Ribose): an organizer of cellular architecture","volume":"205","author":"Leung","year":"2014","journal-title":"J Cell Biol"},{"key":"10.1016\/j.jss.2025.07.039_bib185","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.tibs.2009.12.003","article-title":"Toward a unified nomenclature for mammalian ADP-ribosyltransferases","volume":"35","author":"Hottiger","year":"2010","journal-title":"Trends Biochem Sci"},{"key":"10.1016\/j.jss.2025.07.039_bib186","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1007\/s00018-004-4506-0","article-title":"Pathophysiologic role of oxidative stress-induced poly(ADP-ribose) polymerase-1 activation: focus on cell death and transcriptional regulation","volume":"62","author":"Erd\u00e9lyi","year":"2005","journal-title":"Cell Mol Life Sci"},{"key":"10.1016\/j.jss.2025.07.039_bib187","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1038\/nrm2970","article-title":"Molecular mechanisms of necroptosis: an ordered cellular explosion","volume":"11","author":"Vandenabeele","year":"2010","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10.1016\/j.jss.2025.07.039_bib188","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1007\/s00018-013-1381-6","article-title":"TNF-induced necroptosis and PARP-1-mediated necrosis represent distinct routes to programmed necrotic cell death","volume":"71","author":"Sosna","year":"2014","journal-title":"Cell Mol Life Sci"},{"key":"10.1016\/j.jss.2025.07.039_bib189","doi-asserted-by":"crossref","first-page":"1282","DOI":"10.1086\/302389","article-title":"Poly(ADP-Ribose) polymerase in the cellular response to DNA damage, apoptosis, and disease","volume":"64","author":"Oliver","year":"1999","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.jss.2025.07.039_bib190","doi-asserted-by":"crossref","first-page":"943","DOI":"10.3390\/cancers5030943","article-title":"PARP-1: friend or foe of DNA damage and repair in tumorigenesis?","volume":"5","author":"Swindall","year":"2013","journal-title":"Cancers"},{"key":"10.1016\/j.jss.2025.07.039_bib191","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.jss.2007.06.015","article-title":"Factors in the pathophysiology of the liver ischemia-reperfusion injury","volume":"147","author":"Montalvo-Jave","year":"2008","journal-title":"J Surg Res"},{"key":"10.1016\/j.jss.2025.07.039_bib192","doi-asserted-by":"crossref","first-page":"6867","DOI":"10.1038\/sj.onc.1203219","article-title":"How NF-\u03baB is activated: the role of the I\u03baB kinase (IKK) complex","volume":"18","author":"Karin","year":"1999","journal-title":"Oncogene"},{"key":"10.1016\/j.jss.2025.07.039_bib193","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1007\/978-981-13-9367-9_10","article-title":"NF-\u039aB, I\u03baB, and IKK: integral components of immune system signaling","volume":"1172","author":"Mulero","year":"2019","journal-title":"Adv Exp Med Biol"},{"key":"10.1016\/j.jss.2025.07.039_bib194","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1038\/344678a0","article-title":"Activation in vitro of NF-\u03baB\" by phosphorylation of its inhibitor I\u03baB\"","volume":"344","author":"Ghosh","year":"1990","journal-title":"Nature"},{"key":"10.1016\/j.jss.2025.07.039_bib195","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/0092-8674(87)90362-X","article-title":"The role of the \u03ba enhancer and its binding factor NF-\u039aB in the developmental regulation of \u03ba gene transcription","volume":"48","author":"Atchison","year":"1987","journal-title":"Cell"},{"key":"10.1016\/j.jss.2025.07.039_bib196","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1111\/j.1432-1033.1993.tb17824.x","article-title":"The contraction of hepatic stellate (ito) cells stimulated with vasoactive substances: possible involvement of endothelin 1 and nitric oxide in the regulation of the sinusoidal tonus","volume":"213","author":"Kawada","year":"1993","journal-title":"Eur J Biochem"},{"key":"10.1016\/j.jss.2025.07.039_bib197","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1038\/nrm1489","article-title":"Liver regeneration: from myth to mechanism","volume":"5","author":"Taub","year":"2004","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10.1016\/j.jss.2025.07.039_bib198","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1358\/dot.2005.41.7.893622","article-title":"The role of STAT3 in liver regeneration","volume":"41","author":"Terui","year":"2005","journal-title":"Drugs Today"},{"key":"10.1016\/j.jss.2025.07.039_bib199","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1002\/hep.22583","article-title":"The survival pathways phosphatidylinositol-3 kinase (PI3-K)\/Phosphoinositide-Dependent protein kinase 1 (PDK1)\/Akt modulate liver regeneration through hepatocyte size rather than proliferation","volume":"49","author":"Haga","year":"2009","journal-title":"Hepatology"},{"key":"10.1016\/j.jss.2025.07.039_bib200","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1111\/j.1600-6143.2004.00444.x","article-title":"Improved hepatic regeneration with reduced injury by redox factor-1 in a rat small-sized liver transplant model","volume":"4","author":"Guo","year":"2004","journal-title":"Am J Transplant"},{"key":"10.1016\/j.jss.2025.07.039_bib201","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1016\/j.jhep.2005.03.027","article-title":"Compensatory recovery of liver mass by Akt-mediated hepatocellular hypertrophy in liver-specific STAT3-deficient mice","volume":"43","author":"Haga","year":"2005","journal-title":"J Hepatol"},{"key":"10.1016\/j.jss.2025.07.039_bib202","doi-asserted-by":"crossref","first-page":"532","DOI":"10.3389\/fendo.2019.00532","article-title":"The role of thyroid hormones in hepatocyte proliferation and liver cancer","volume":"10","author":"Gionfra","year":"2019","journal-title":"Front Endocrinol"},{"key":"10.1016\/j.jss.2025.07.039_bib203","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.mayocpiqo.2020.02.001","article-title":"Hormonal contribution to liver regeneration","volume":"4","author":"Abu Rmilah","year":"2020","journal-title":"Mayo Clin Proc Innov Qual Outcomes"},{"key":"10.1016\/j.jss.2025.07.039_bib204","doi-asserted-by":"crossref","first-page":"1470","DOI":"10.1016\/0016-5085(79)90418-9","article-title":"Hormonal control of rat liver regeneration","volume":"76","author":"Leffert","year":"1979","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jss.2025.07.039_bib205","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1002\/9781119436812.ch45","article-title":"Liver regeneration","volume":"CH45","author":"Michalopoulos","year":"2020","journal-title":"Liver"},{"key":"10.1016\/j.jss.2025.07.039_bib206","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1007\/s00268-006-0772-3","article-title":"Platelets promote liver regeneration in early period after hepatectomy in mice","volume":"31","author":"Murata","year":"2007","journal-title":"World J Surg"},{"key":"10.1016\/j.jss.2025.07.039_bib207","doi-asserted-by":"crossref","DOI":"10.1155\/2017\/4256352","article-title":"Liver regeneration: analysis of the main relevant signaling molecules","volume":"2017","author":"Tao","year":"2017","journal-title":"Mediators Inflamm"},{"key":"10.1016\/j.jss.2025.07.039_bib208","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/B978-0-12-391498-9.00003-6","article-title":"Control of growth during regeneration","volume":"108","author":"Sun","year":"2014","journal-title":"Curr Top Dev Biol"},{"key":"10.1016\/j.jss.2025.07.039_bib209","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/j.jss.2008.02.059","article-title":"Autonomic regulation of liver regeneration after partial hepatectomy in mice","volume":"152","author":"Ikeda","year":"2009","journal-title":"J Surg Res"},{"key":"10.1016\/j.jss.2025.07.039_bib210","doi-asserted-by":"crossref","first-page":"8414","DOI":"10.3390\/ijms21218414","article-title":"Liver regeneration after hepatectomy and partial liver transplantation","volume":"21","author":"Yagi","year":"2020","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.jss.2025.07.039_bib211","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1111\/j.1872-034X.2007.00278.x","article-title":"Identification of de Novo STAT3 target gene in liver regeneration","volume":"38","author":"Zhang","year":"2008","journal-title":"Hepatol Res"},{"key":"10.1016\/j.jss.2025.07.039_bib212","doi-asserted-by":"crossref","first-page":"28411","DOI":"10.1074\/jbc.M202807200","article-title":"STAT3 contributes to the mitogenic response of hepatocytes during liver regeneration","volume":"277","author":"Li","year":"2002","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jss.2025.07.039_bib213","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1006\/jsre.2001.6086","article-title":"Activation of interleukin-6\/STAT3 and liver regeneration following transplantation","volume":"96","author":"Debonera","year":"2001","journal-title":"J Surg Res"},{"key":"10.1016\/j.jss.2025.07.039_bib214","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1007\/s00534-010-0304-2","article-title":"Molecular mechanisms of liver regeneration and protection for treatment of liver dysfunction and diseases","volume":"18","author":"Fujiyoshi","year":"2011","journal-title":"J Hepatobiliary Pancreat Sci"},{"key":"10.1016\/j.jss.2025.07.039_bib215","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1016\/S1072-7515(03)00374-0","article-title":"Liver regeneration","volume":"197","author":"Koniaris","year":"2003","journal-title":"J Am Coll Surg"},{"key":"10.1016\/j.jss.2025.07.039_bib216","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1126\/science.276.5309.60","article-title":"Liver regeneration","volume":"276","author":"Michalopoulos","year":"1979","journal-title":"Science"},{"key":"10.1016\/j.jss.2025.07.039_bib217","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.1126\/science.274.5291.1379","article-title":"Liver failure and defective hepatocyte regeneration in interleukin-6-deficient mice","volume":"274","author":"Cressman","year":"1979","journal-title":"Science"},{"key":"10.1016\/j.jss.2025.07.039_bib218","doi-asserted-by":"crossref","first-page":"3354","DOI":"10.1182\/blood-2009-08-240317","article-title":"STAT3 controls the neutrophil migratory response to CXCR2 ligands by direct activation of G-CSF\u2013induced CXCR2 expression and via modulation of CXCR2 signal transduction","volume":"115","author":"Nguyen-Jackson","year":"2010","journal-title":"Blood"},{"key":"10.1016\/j.jss.2025.07.039_bib219","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.cmet.2006.04.014","article-title":"Critical role of STAT3 in leptin\u2019s metabolic actions","volume":"4","author":"Buettner","year":"2006","journal-title":"Cell Metab"},{"key":"10.1016\/j.jss.2025.07.039_bib220","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1126\/science.1066355","article-title":"Transcription: signal transduction and the control of gene expression","volume":"295","author":"Brivanlou","year":"1979","journal-title":"Science"},{"key":"10.1016\/j.jss.2025.07.039_bib221","doi-asserted-by":"crossref","first-page":"1630","DOI":"10.1126\/science.277.5332.1630","article-title":"STATs and gene regulation","volume":"277","author":"Darnell","year":"1979","journal-title":"Science"},{"key":"10.1016\/j.jss.2025.07.039_bib222","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1111\/j.1365-2443.2011.01575.x","article-title":"Phospho-Ser727 of STAT3 regulates STAT3 activity by enhancing dephosphorylation of phospho-tyr705 largely through TC45","volume":"17","author":"Wakahara","year":"2012","journal-title":"Genes Cells"},{"key":"10.1016\/j.jss.2025.07.039_bib223","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1038\/nm980","article-title":"Role of STAT-3 in regulation of hepatic gluconeogenic genes and carbohydrate metabolism in vivo","volume":"10","author":"Inoue","year":"2004","journal-title":"Nat Med"},{"key":"10.1016\/j.jss.2025.07.039_bib224","doi-asserted-by":"crossref","first-page":"2276","DOI":"10.1091\/mbc.01-12-0584","article-title":"Akt maintains cell size and survival by increasing MTOR-dependent nutrient uptake","volume":"13","author":"Edinger","year":"2002","journal-title":"Mol Biol Cell"},{"key":"10.1016\/j.jss.2025.07.039_bib225","doi-asserted-by":"crossref","first-page":"12333","DOI":"10.1073\/pnas.172376399","article-title":"Akt induces enhanced myocardial contractility and cell size in vivo in transgenic mice","volume":"99","author":"Condorelli","year":"2002","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jss.2025.07.039_bib226","doi-asserted-by":"crossref","first-page":"E964","DOI":"10.1152\/ajpendo.00239.2003","article-title":"Akt promotes increased mammalian cell size by stimulating protein synthesis and inhibiting protein degradation","volume":"285","author":"Faridi","year":"2003","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"10.1016\/j.jss.2025.07.039_bib227","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1161\/01.CIR.0000118462.22970.BE","article-title":"Unique, highly proliferative growth phenotype expressed by embryonic and neointimal smooth muscle cells is driven by constitutive Akt, mTOR, and p70S6K signaling and is actively repressed by PTEN","volume":"109","author":"Mourani","year":"2004","journal-title":"Circulation"},{"key":"10.1016\/j.jss.2025.07.039_bib228","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1196\/annals.1302.021","article-title":"Regulation of cell size and contractile function by AKT in cardiomyocytes","volume":"1015","author":"Latronico","year":"2004","journal-title":"Ann N Y Acad Sci"},{"key":"10.1016\/j.jss.2025.07.039_bib229","doi-asserted-by":"crossref","first-page":"17892","DOI":"10.1074\/jbc.M112351200","article-title":"Pro-inflammatory cytokines tumor necrosis factor \u03b1 and interleukin-6 and survival factor epidermal growth factor positively regulate the murine GSTA4 enzyme in hepatocytes","volume":"277","author":"Desmots","year":"2002","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jss.2025.07.039_bib230","first-page":"173","article-title":"TNF-\u03b1-Induced sphingosine 1-phosphate inhibits apoptosis through a phosphatidylinositol 3-kinase\/Akt pathway in human hepatocytes","volume":"167","author":"Moriwaki Brenner","year":"2001","journal-title":"Am Assoc Immnol"},{"key":"10.1016\/j.jss.2025.07.039_bib231","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1016\/j.bbrc.2003.04.002","article-title":"Hepatocyte growth factor exerts a proliferative effect on oval cells through the PI3K\/AKT signaling pathway","volume":"309","author":"Okano","year":"2003","journal-title":"Biochem Biophysical Res Commun"},{"key":"10.1016\/j.jss.2025.07.039_bib232","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1016\/S1072-7515(03)00374-0","article-title":"Liver regeneration","volume":"197","author":"Koniaris","year":"2003","journal-title":"J Am Coll Surg"},{"key":"10.1016\/j.jss.2025.07.039_bib233","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1182\/blood-2004-10-4041","article-title":"P85\u03b1 subunit of class IA PI-3 kinase is crucial for macrophage growth and migration","volume":"106","author":"Munugalavadla","year":"2005","journal-title":"Blood"},{"key":"10.1016\/j.jss.2025.07.039_bib234","doi-asserted-by":"crossref","first-page":"6541","DOI":"10.1002\/j.1460-2075.1996.tb01045.x","article-title":"Mechanism of activation of protein kinase B by insulin and IGF-1","volume":"15","author":"Alessi","year":"1996","journal-title":"EMBO J"},{"key":"10.1016\/j.jss.2025.07.039_bib235","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1126\/science.275.5300.665","article-title":"Direct regulation of the Akt proto-oncogene product by phosphatidylinositol-3,4-bisphosphate","volume":"275","author":"Franke","year":"1979","journal-title":"Science"},{"key":"10.1016\/j.jss.2025.07.039_bib236","doi-asserted-by":"crossref","first-page":"1472","DOI":"10.1101\/gad.995802","article-title":"Mammalian cell size is controlled by MTOR and its downstream targets S6K1 and 4EBP1\/EIF4E","volume":"16","author":"Fingar","year":"2002","journal-title":"Genes Dev"},{"key":"10.1016\/j.jss.2025.07.039_bib237","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1016\/j.tibs.2006.04.003","article-title":"Ribosomal protein S6 phosphorylation: from protein synthesis to cell size","volume":"31","author":"Ruvinsky","year":"2006","journal-title":"Trends Biochem Sci"},{"key":"10.1016\/j.jss.2025.07.039_bib238","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1007\/BF00268898","article-title":"Purification and immunoelectron microscopic localization of cellular glutathione peroxidase in rat hepatocytes: quantitative analysis by postembedding method","volume":"102","author":"Asayama","year":"1994","journal-title":"Histochemistry"},{"key":"10.1016\/j.jss.2025.07.039_bib239","doi-asserted-by":"crossref","first-page":"4973","DOI":"10.1182\/blood.V90.12.4973","article-title":"Direct evidence for catalase as the predominant H2O2 -removing enzyme in human erythrocytes","volume":"90","author":"Mueller","year":"1997","journal-title":"Blood"},{"key":"10.1016\/j.jss.2025.07.039_bib240","doi-asserted-by":"crossref","first-page":"207","DOI":"10.7150\/thno.3806","article-title":"In vivo monitoring of liver damage using caspase-3 probe","volume":"2","author":"Ozaki","year":"2012","journal-title":"Theranostics"},{"key":"10.1016\/j.jss.2025.07.039_bib241","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1038\/nrm1496","article-title":"Molecular mechanisms of caspase regulation during apoptosis","volume":"5","author":"Riedl","year":"2004","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10.1016\/j.jss.2025.07.039_bib242","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1002\/hep.510310123","article-title":"Increased toxin-induced liver injury and fibrosis in interleukin-6\u2013deficient mice","volume":"31","author":"Kovalovich","year":"2000","journal-title":"Hepatology"},{"key":"10.1016\/j.jss.2025.07.039_bib243","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1084\/jem.193.4.545","article-title":"Activated Akt protects the lung from oxidant-induced injury and delays death of mice","volume":"193","author":"Lu","year":"2001","journal-title":"J Exp Med"},{"key":"10.1016\/j.jss.2025.07.039_bib244","doi-asserted-by":"crossref","first-page":"21085","DOI":"10.1074\/jbc.M400063200","article-title":"Phosphorylation of Bax ser184 by Akt regulates its activity and apoptosis in neutrophils","volume":"279","author":"Gardai","year":"2004","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jss.2025.07.039_bib245","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1038\/ncb1117","article-title":"Akt interacts directly with Smad3 to regulate the sensitivity to TGF-\u03b2-induced apoptosis","volume":"6","author":"Conery","year":"2004","journal-title":"Nat Cell Biol"},{"key":"10.1016\/j.jss.2025.07.039_bib246","doi-asserted-by":"crossref","first-page":"588","DOI":"10.2183\/pjab.86.588","article-title":"The discovery of hepatocyte growth factor (HGF) and its significance for cell biology, life sciences and clinical medicine","volume":"86","author":"Nakamura","year":"2010","journal-title":"Proc Jpn Acad Ser B Phys Biol Sci"},{"key":"10.1016\/j.jss.2025.07.039_bib247","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1080\/08941939.2016.1206999","article-title":"Akt: a therapeutic target in hepatic ischemia\u2013reperfusion injury","volume":"30","author":"Covington","year":"2017","journal-title":"J Invest Surg"},{"key":"10.1016\/j.jss.2025.07.039_bib248","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1007\/s12192-019-00977-1","article-title":"Antioxidant effects of ginkgolides and bilobalide against cerebral ischemia injury by activating the Akt\/Nrf2 pathway in vitro and in vivo","volume":"24","author":"Liu","year":"2019","journal-title":"Cell Stress Chaperones"},{"key":"10.1016\/j.jss.2025.07.039_bib249","doi-asserted-by":"crossref","first-page":"1671","DOI":"10.1167\/iovs.07-1099","article-title":"Essential roles of the PI3 kinase\/Akt pathway in regulating Nrf2-dependent antioxidant functions in the RPE","volume":"49","author":"Wang","year":"2008","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.jss.2025.07.039_bib250","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.taap.2015.10.001","article-title":"Totarol prevents neuronal injury in vitro and ameliorates brain ischemic stroke: potential roles of Akt activation and HO-1 induction","volume":"289","author":"Gao","year":"2015","journal-title":"Toxicol Appl Pharmacol"},{"key":"10.1016\/j.jss.2025.07.039_bib251","doi-asserted-by":"crossref","first-page":"7324","DOI":"10.1523\/JNEUROSCI.2111-04.2004","article-title":"Regulation of Cu\/Zn-superoxide dismutase expression via the Phosphatidylinositol 3 kinase\/Akt pathway and Nuclear Factor-\u03baB","volume":"24","author":"Rojo","year":"2004","journal-title":"J Neurosci"},{"key":"10.1016\/j.jss.2025.07.039_bib252","first-page":"1717","article-title":"Vitexin ameliorates glycochenodeoxycholate-induced hepatocyte injury through SIRT6 and JAK2\/STAT3 pathways","volume":"24","author":"Zhang","year":"2021","journal-title":"Iran J Basic Med Sci"},{"key":"10.1016\/j.jss.2025.07.039_bib253","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2020.122905","article-title":"Chlorpyrifos induces the apoptosis and necroptosis of L8824 cells through the ROS\/PTEN\/PI3K\/AKT Axis","volume":"398","author":"Wang","year":"2020","journal-title":"J Hazard Mater"},{"key":"10.1016\/j.jss.2025.07.039_bib254","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12964-021-00806-y","article-title":"Inhibition of AKT induces p53\/SIRT6\/PARP1-dependent parthanatos to suppress tumor growth","volume":"20","author":"Zhang","year":"2022","journal-title":"Cell Commun Signal"},{"key":"10.1016\/j.jss.2025.07.039_bib255","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1002\/jlb.65.3.337","article-title":"Signal transduction by reactive oxygen species in non-phagocytic cells","volume":"65","author":"Finkel","year":"1999","journal-title":"J Leukoc Biol"},{"key":"10.1016\/j.jss.2025.07.039_bib256","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1097\/SLA.0000000000004720","article-title":"Preoperative single-dose methylprednisolone prevents surgical site infections after major liver resection: a randomized controlled trial","volume":"275","author":"Bressan","year":"2022","journal-title":"Ann Surg"},{"key":"10.1016\/j.jss.2025.07.039_bib257","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1210\/jc.2011-1598","article-title":"High-dose insulin therapy reduces postoperative liver dysfunction and complications in liver resection patients through reduced apoptosis and altered inflammation","volume":"97","author":"Fisette","year":"2012","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.jss.2025.07.039_bib258","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1111\/hpb.12384","article-title":"Does inchinkoto, a herbal medicine, have hepatoprotective effects in major hepatectomy? A prospective randomized study","volume":"17","author":"Mizutani","year":"2015","journal-title":"HPB"},{"key":"10.1016\/j.jss.2025.07.039_bib259","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1001\/jama.1989.03420050061039","article-title":"Extended preservation of human liver grafts with UW solution","volume":"261","author":"Todo","year":"1989","journal-title":"J Am Med Assoc"},{"key":"10.1016\/j.jss.2025.07.039_bib260","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1007\/s00534-009-0058-x","article-title":"Mechanism of liver regeneration after liver resection and portal vein embolization (ligation) is different?","volume":"16","author":"Tashiro","year":"2009","journal-title":"J Hepatobiliary Pancreat Surg"},{"key":"10.1016\/j.jss.2025.07.039_bib261","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2022.916286","article-title":"Mechanism of liver regeneration during ALPPS","volume":"10","author":"Xiao","year":"2022","journal-title":"Front Cell Dev Biol"},{"key":"10.1016\/j.jss.2025.07.039_bib262","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1007\/s00268-006-0526-2","article-title":"Mechanisms of hepatic regeneration following portal vein embolization and partial hepatectomy: a review","volume":"31","author":"Yokoyama","year":"2007","journal-title":"World J Surg"},{"key":"10.1016\/j.jss.2025.07.039_bib263","doi-asserted-by":"crossref","first-page":"1615","DOI":"10.1002\/hep.22164","article-title":"Selective portal vein embolization and ligation trigger different regenerative responses in the rat liver","volume":"47","author":"Furrer","year":"2008","journal-title":"Hepatology"},{"key":"10.1016\/j.jss.2025.07.039_bib264","doi-asserted-by":"crossref","first-page":"1448","DOI":"10.1001\/archsurg.1978.01370240070012","article-title":"Tolerance of the human liver to prolonged normothermic ischemia: a biological study of 20 patients submitted to extensive hepatectomy","volume":"113","author":"Huguet","year":"1978","journal-title":"Arch Surg"}],"container-title":["Journal of Surgical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022480425004834?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022480425004834?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T13:31:12Z","timestamp":1777123872000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022480425004834"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10]]},"references-count":264,"alternative-id":["S0022480425004834"],"URL":"https:\/\/doi.org\/10.1016\/j.jss.2025.07.039","relation":{},"ISSN":["0022-4804"],"issn-type":[{"value":"0022-4804","type":"print"}],"subject":[],"published":{"date-parts":[[2025,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Surgical Stress and Liver Response: Injury, Regeneration, and Protection","name":"articletitle","label":"Article Title"},{"value":"Journal of Surgical Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jss.2025.07.039","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}