{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T08:45:35Z","timestamp":1782722735253,"version":"3.54.5"},"reference-count":34,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","journalofsurgicalresearch.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Surgical Research"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1016\/j.jss.2026.04.030","type":"journal-article","created":{"date-parts":[[2026,5,23]],"date-time":"2026-05-23T00:34:56Z","timestamp":1779496496000},"page":"79-89","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Endothelium Protective Effect of 5% Human Albumin-Based Fluid Therapy in Perforation Peritonitis Patients Undergoing Emergency Laparotomy: A Randomized Controlled Trial"],"prefix":"10.1016","volume":"324","author":[{"given":"Harshita","family":"Mehrotra","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8671-6875","authenticated-orcid":false,"given":"Sulagna","family":"Bhattacharjee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sudip Kumar","family":"Datta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vishnu","family":"Narayanan M R","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rahul Kumar","family":"Anand","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sunil","family":"Chumber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Souvik","family":"Maitra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jss.2026.04.030_bib1","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1007\/s00424-007-0212-8","article-title":"The endothelial glycocalyx: composition, functions, and visualization","volume":"454","author":"Reitsma","year":"2007","journal-title":"Pflugers Arch"},{"key":"10.1016\/j.jss.2026.04.030_bib2","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1186\/s13054-018-2292-6","article-title":"The glycocalyx: a novel diagnostic and therapeutic target in sepsis","volume":"23","author":"Uchimido","year":"2019","journal-title":"Crit Care"},{"key":"10.1016\/j.jss.2026.04.030_bib3","doi-asserted-by":"crossref","first-page":"S65","DOI":"10.1097\/TA.0000000000003298","article-title":"Role of albumin on endothelial basement membrane and hemostasis in a rat model of hemorrhagic shock","volume":"91","author":"Torres","year":"2021","journal-title":"J Trauma Acute Care Surg"},{"key":"10.1016\/j.jss.2026.04.030_bib4","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1186\/s13613-020-00697-1","article-title":"Role of albumin in the preservation of endothelial glycocalyx integrity and the microcirculation: a review","volume":"10","author":"Aldecoa","year":"2020","journal-title":"Ann Intensive Care"},{"key":"10.1016\/j.jss.2026.04.030_bib5","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1186\/s13054-021-03545-1","article-title":"Endothelial damage in septic shock patients as evidenced by circulating syndecan-1, sphingosine-1-phosphate and soluble VE-cadherin: a substudy of ALBIOS","volume":"25","author":"Piotti","year":"2021","journal-title":"Crit Care"},{"key":"10.1016\/j.jss.2026.04.030_bib6","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1186\/s12871-019-0896-2","article-title":"Endothelial glycocalyx in acute care surgery - what anaesthesiologists need to know for clinical practice","volume":"19","author":"Astapenko","year":"2019","journal-title":"BMC Anesthesiol"},{"key":"10.1016\/j.jss.2026.04.030_bib7","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.jss.2009.04.034","article-title":"Sepsis and major abdominal surgery lead to flaking of the endothelial glycocalix","volume":"165","author":"Steppan","year":"2011","journal-title":"J Surg Res"},{"key":"10.1016\/j.jss.2026.04.030_bib8","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2025.139548","article-title":"Sepsis-associated endothelial glycocalyx damage: a review of animal models, clinical evidence, and molecular mechanisms","volume":"295","author":"Zhan","year":"2025","journal-title":"Int J Biol Macromol"},{"key":"10.1016\/j.jss.2026.04.030_bib9","doi-asserted-by":"crossref","first-page":"1412","DOI":"10.1056\/NEJMoa1305727","article-title":"Albumin replacement in patients with severe sepsis or septic shock","volume":"370","author":"Caironi","year":"2014","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jss.2026.04.030_bib10","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1186\/s40560-021-00543-x","article-title":"A longitudinal change of syndecan-1 predicts risk of acute respiratory distress syndrome and cumulative fluid balance in patients with septic shock: a preliminary study","volume":"9","author":"Kajita","year":"2021","journal-title":"J Intensive Care"},{"key":"10.1016\/j.jss.2026.04.030_bib11","doi-asserted-by":"crossref","first-page":"8864","DOI":"10.1038\/s41598-021-88303-7","article-title":"Serum syndecan-1 reflects organ dysfunction in critically ill patients","volume":"11","author":"Suzuki","year":"2021","journal-title":"Sci Rep"},{"key":"10.1016\/j.jss.2026.04.030_bib12","first-page":"257","article-title":"Albumin as a drug: its biological effects beyond volume expansion","volume":"22","author":"Bihari","year":"2020","journal-title":"Crit Care Resusc"},{"key":"10.1016\/j.jss.2026.04.030_bib13","doi-asserted-by":"crossref","first-page":"L328","DOI":"10.1152\/ajplung.00390.2006","article-title":"Fluorescence correlation spectroscopy can probe albumin dynamics inside lung endothelial glycocalyx","volume":"293","author":"Stevens","year":"2007","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"10.1016\/j.jss.2026.04.030_bib14","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1002\/2211-5463.13362","article-title":"Nitric oxide inhibits endothelial cell apoptosis by inhibiting cysteine-dependent SOD1 monomerization","volume":"12","author":"Peng","year":"2022","journal-title":"FEBS Open Bio"},{"key":"10.1016\/j.jss.2026.04.030_bib15","article-title":"Effects of albumin infusion on serum levels of albumin, proinflammatory cytokines (TNF-\u03b1, IL-1, and IL-6), CRP, and MMP-8; tissue expression of EGRF, ERK1, ERK2, TGF-\u03b2, collagen, and MMP-8; and wound healing in sprague dawley rats","volume":"2020","author":"Utariani","year":"2020","journal-title":"Int J Inflam"},{"key":"10.1016\/j.jss.2026.04.030_bib16","doi-asserted-by":"crossref","first-page":"1414","DOI":"10.1097\/CCM.0b013e318211ff6e","article-title":"Human serum albumin improves endothelial dysfunction and survival during experimental endotoxemia: concentration-dependent properties","volume":"39","author":"Kremer","year":"2011","journal-title":"Crit Care Med"},{"key":"10.1016\/j.jss.2026.04.030_bib17","doi-asserted-by":"crossref","DOI":"10.1186\/cc13993","article-title":"Relationship between acid-base status and inflammation in the critically ill","volume":"18","author":"Zampieri","year":"2014","journal-title":"Crit Care"},{"key":"10.1016\/j.jss.2026.04.030_bib18","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1016\/j.bbamcr.2011.01.034","article-title":"The pro- and anti-inflammatory properties of the cytokine interleukin-6","volume":"1813","author":"Scheller","year":"2011","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.jss.2026.04.030_bib19","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a016295","article-title":"IL-6 in inflammation, immunity, and disease","volume":"6","author":"Tanaka","year":"2014","journal-title":"Cold Spring Harb Perspect Biol"},{"key":"10.1016\/j.jss.2026.04.030_bib20","doi-asserted-by":"crossref","DOI":"10.3389\/fmolb.2023.1146685","article-title":"Heparan sulfates and heparan sulfate binding proteins in sepsis","volume":"10","author":"Liao","year":"2023","journal-title":"Front Mol Biosci"},{"key":"10.1016\/j.jss.2026.04.030_bib21","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1055\/s-0041-1725064","article-title":"Endothelial heparan sulfate proteoglycans in sepsis: the role of the glycocalyx","volume":"47","author":"Oshima","year":"2021","journal-title":"Semin Thromb Hemost"},{"key":"10.1016\/j.jss.2026.04.030_bib22","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.01181-21","article-title":"Endothelial heparan sulfate mediates hepatic neutrophil trafficking and injury during Staphylococcus aureus sepsis","volume":"12","author":"Golden","year":"2021","journal-title":"mBio"},{"key":"10.1016\/j.jss.2026.04.030_bib23","doi-asserted-by":"crossref","first-page":"174","DOI":"10.5152\/balkanmedj.2011.016","article-title":"Several cytokines and protein C levels with the apache II scoring System for evaluation of patients with sepsis","volume":"29","author":"Kartal","year":"2012","journal-title":"Balkan Med J"},{"key":"10.1016\/j.jss.2026.04.030_bib24","doi-asserted-by":"crossref","first-page":"383","DOI":"10.4103\/ija.IJA_1457_20","article-title":"Effect of positive cumulative fluid balance on postoperative complications after living donor liver transplantation: a retrospective analysis","volume":"65","author":"Kohli","year":"2021","journal-title":"Indian J Anaesth"},{"key":"10.1016\/j.jss.2026.04.030_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.surg.2025.109525","article-title":"Association between cumulative fluid balance to estimated colloid oncotic pressure ratio and postoperative outcome in surgical patients requiring intensive management","volume":"185","author":"Arushi","year":"2025","journal-title":"Surgery"},{"key":"10.1016\/j.jss.2026.04.030_bib26","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1186\/s13054-019-2534-2","article-title":"Intravenous fluid resuscitation is associated with septic endothelial glycocalyx degradation","volume":"23","author":"Hippensteel","year":"2019","journal-title":"Crit Care"},{"key":"10.1016\/j.jss.2026.04.030_bib27","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s40560-020-00515-7","article-title":"The effects of a limited infusion rate of fluid in the early resuscitation of sepsis on glycocalyx shedding measured by plasma syndecan-1: a randomized controlled trial","volume":"9","author":"Saoraya","year":"2021","journal-title":"J Intensive Care"},{"key":"10.1016\/j.jss.2026.04.030_bib28","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1097\/ALN.0000000000001051","article-title":"Effect of exogenous albumin on the incidence of postoperative acute kidney injury in patients undergoing off-pump coronary artery bypass surgery with a preoperative albumin level of less than 4.0 g\/dl","volume":"124","author":"Lee","year":"2016","journal-title":"Anesthesiology"},{"key":"10.1016\/j.jss.2026.04.030_bib29","doi-asserted-by":"crossref","first-page":"2920","DOI":"10.1053\/j.jvca.2019.03.049","article-title":"20% human albumin solution fluid bolus administration therapy in patients after cardiac surgery (the HAS FLAIR Study)","volume":"33","author":"Wigmore","year":"2019","journal-title":"J Cardiothorac Vasc Anesth"},{"key":"10.1016\/j.jss.2026.04.030_bib30","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1007\/s00134-012-2531-2","article-title":"Adverse cardiac events during catecholamine vasopressor therapy: a prospective observational study","volume":"38","author":"Schmittinger","year":"2012","journal-title":"Intensive Care Med"},{"key":"10.1016\/j.jss.2026.04.030_bib31","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1097\/CCM.0000000000006119","article-title":"Antibiotics, sedatives, and catecholamines further compromise sepsis-induced immune suppression in peripheral blood mononuclear cells","volume":"52","author":"Miller","year":"2024","journal-title":"Crit Care Med"},{"key":"10.1016\/j.jss.2026.04.030_bib32","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1001\/jama.2022.10461","article-title":"Effect of 4% albumin solution vs ringer acetate on major adverse events in patients undergoing cardiac surgery with cardiopulmonary bypass: a randomized clinical trial","volume":"328","author":"Pesonen","year":"2022","journal-title":"JAMA"},{"key":"10.1016\/j.jss.2026.04.030_bib33","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1042\/CS20040303","article-title":"Volume expansion and plasma protein clearance during intravenous infusion of 5% albumin and autologous plasma","volume":"108","author":"Hedin","year":"2005","journal-title":"Clin Sci (Lond)"},{"key":"10.1016\/j.jss.2026.04.030_bib34","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.jss.2025.04.038","article-title":"Surgical mortality and morbidity predictors in patients with perforated peptic ulcer: a cohort Study","volume":"312","author":"Pouroushaninia","year":"2025","journal-title":"J Surg Res"}],"container-title":["Journal of Surgical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022480426002684?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022480426002684?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T08:07:20Z","timestamp":1782720440000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022480426002684"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":34,"alternative-id":["S0022480426002684"],"URL":"https:\/\/doi.org\/10.1016\/j.jss.2026.04.030","relation":{},"ISSN":["0022-4804"],"issn-type":[{"value":"0022-4804","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Endothelium Protective Effect of 5% Human Albumin-Based Fluid Therapy in Perforation Peritonitis Patients Undergoing Emergency Laparotomy: A Randomized Controlled Trial","name":"articletitle","label":"Article Title"},{"value":"Journal of Surgical Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jss.2026.04.030","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}