{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T22:31:09Z","timestamp":1786487469728,"version":"build-2736575974"},"reference-count":37,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T00:00:00Z","timestamp":1780358400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2025M772138"],"award-info":[{"award-number":["2025M772138"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82301368"],"award-info":[{"award-number":["82301368"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82370482"],"award-info":[{"award-number":["82370482"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008048","name":"Nanjing University","doi-asserted-by":"publisher","award":["2023-LCYJ-PY-21"],"award-info":[{"award-number":["2023-LCYJ-PY-21"]}],"id":[{"id":"10.13039\/501100008048","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","journalofsurgicalresearch.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Surgical Research"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.jss.2026.05.046","type":"journal-article","created":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T20:09:10Z","timestamp":1782331750000},"page":"404-415","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Serum Metabolomics Analysis Identifies Acetyl-N-formyl-5-methoxykynurenamine as a Promising Dynamic Predictive Biomarker for Postoperative Delirium in Patients With Acute Type A Aortic Dissection"],"prefix":"10.1016","volume":"325","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6539-0797","authenticated-orcid":false,"given":"Wenxue","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Jia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongli","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shengwei","family":"Bai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruisha","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guizhou","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yapeng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongjin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jss.2026.05.046_bib1","doi-asserted-by":"crossref","first-page":"1932","DOI":"10.1053\/j.jvca.2024.05.027","article-title":"Comparison of propofol-based total intravenous anesthesia versus volatile anesthesia with sevoflurane for postoperative delirium in adult coronary artery bypass grafting surgery: a prospective randomized single-blinded study","volume":"38","author":"Varsha","year":"2024","journal-title":"J Cardiothorac Vasc Anesth"},{"key":"10.1016\/j.jss.2026.05.046_bib2","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1016\/j.jalz.2016.03.005","article-title":"The short-term and long-term relationship between delirium and cognitive trajectory in older surgical patients","volume":"12","author":"Inouye","year":"2016","journal-title":"Alzheimers Dement"},{"key":"10.1016\/j.jss.2026.05.046_bib3","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.1001\/jamaneurol.2020.2273","article-title":"Association of delirium with long-term cognitive decline: a meta-analysis","volume":"77","author":"Goldberg","year":"2020","journal-title":"JAMA Neurol"},{"key":"10.1016\/j.jss.2026.05.046_bib4","doi-asserted-by":"crossref","first-page":"1700","DOI":"10.1053\/j.jvca.2023.04.035","article-title":"Association between postoperative delirium and long-term subjective cognitive decline in older patients undergoing cardiac surgery: a secondary analysis of the minimizing intensive care unit neurological dysfunction with Dexmedetomidine-Induced sleep trial","volume":"37","author":"Namirembe","year":"2023","journal-title":"J Cardiothorac Vasc Anesth"},{"key":"10.1016\/j.jss.2026.05.046_bib5","doi-asserted-by":"crossref","first-page":"1703","DOI":"10.1016\/j.jacc.2020.07.061","article-title":"Type A aortic dissection-experience over 5 decades: JACC historical breakthroughs in perspective","volume":"76","author":"Zhu","year":"2020","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jss.2026.05.046_bib6","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1016\/j.jtcvs.2021.04.053","article-title":"2021 the American Association for Thoracic Surgery expert consensus document: surgical treatment of acute type A aortic dissection","volume":"162","author":"Malaisrie","year":"2021","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1016\/j.jss.2026.05.046_bib7","doi-asserted-by":"crossref","first-page":"979","DOI":"10.2147\/NDT.S459892","article-title":"Serum NPTX2 as a potential predictive biomarker for postoperative delirium in patients with acute type A aortic dissection","volume":"20","author":"Liu","year":"2024","journal-title":"Neuropsychiatr Dis Treat"},{"key":"10.1016\/j.jss.2026.05.046_bib8","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1038\/s41572-020-00223-4","article-title":"Delirium","volume":"6","author":"Wilson","year":"2020","journal-title":"Nat Rev Dis Primers"},{"key":"10.1016\/j.jss.2026.05.046_bib9","doi-asserted-by":"crossref","first-page":"1666","DOI":"10.1053\/j.jvca.2025.01.003","article-title":"Cerebral oximetry index-guided blood pressure management during cardiopulmonary bypass reduces postoperative delirium in patients with acute type A aortic dissection","volume":"39","author":"Chen","year":"2025","journal-title":"J Cardiothorac Vasc Anesth"},{"key":"10.1016\/j.jss.2026.05.046_bib10","doi-asserted-by":"crossref","first-page":"3449","DOI":"10.1007\/s11010-021-04159-5","article-title":"Comprehensive plasma metabolomic and lipidomic analyses reveal potential biomarkers for heart failure","volume":"476","author":"Zhou","year":"2021","journal-title":"Mol Cell Biochem"},{"key":"10.1016\/j.jss.2026.05.046_bib11","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1039\/b418288j","article-title":"Measuring the metabolome: current analytical technologies","volume":"130","author":"Dunn","year":"2005","journal-title":"Analyst"},{"key":"10.1016\/j.jss.2026.05.046_bib12","doi-asserted-by":"crossref","DOI":"10.3389\/fnagi.2020.570210","article-title":"Metabolomic and lipidomic profiling of preoperative CSF in elderly hip fracture patients with postoperative delirium","volume":"12","author":"Han","year":"2020","journal-title":"Front Aging Neurosci"},{"key":"10.1016\/j.jss.2026.05.046_bib13","doi-asserted-by":"crossref","first-page":"e1164","DOI":"10.1097\/SLA.0000000000005886","article-title":"Indole-3-Propionic acid, a gut microbiota metabolite, protects against the development of postoperative delirium","volume":"278","author":"Zhou","year":"2023","journal-title":"Ann Surg"},{"key":"10.1016\/j.jss.2026.05.046_bib14","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1002\/epi4.12712","article-title":"Integrating metabolomics and lipidomics revealed a decrease in plasma fatty acids but an increase in triglycerides in children with drug-refractory epilepsy","volume":"8","author":"Guo","year":"2023","journal-title":"Epilepsia Open"},{"key":"10.1016\/j.jss.2026.05.046_bib15","doi-asserted-by":"crossref","first-page":"e243","DOI":"10.1016\/j.bja.2022.01.006","article-title":"Processed electroencephalography-guided general anaesthesia to reduce postoperative delirium: a systematic review and meta-analysis","volume":"130","author":"Sumner","year":"2023","journal-title":"Br J Anaesth"},{"key":"10.1016\/j.jss.2026.05.046_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2021.103490","article-title":"Effects of general versus subarachnoid anaesthesia on circadian melatonin rhythm and postoperative delirium in elderly patients undergoing hip fracture surgery: a prospective cohort clinical trial","volume":"70","author":"Song","year":"2021","journal-title":"EBioMedicine"},{"key":"10.1016\/j.jss.2026.05.046_bib17","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/S0002-9610(01)00761-9","article-title":"Postoperative delirium and melatonin levels in elderly patients","volume":"182","author":"Shigeta","year":"2001","journal-title":"Am J Surg"},{"key":"10.1016\/j.jss.2026.05.046_bib18","doi-asserted-by":"crossref","first-page":"e1286","DOI":"10.1097\/CCM.0000000000004690","article-title":"The effects of melatonin supplementation on sleep quality and assessment of the serum melatonin in ICU patients: a randomized controlled trial","volume":"48","author":"Gandolfi","year":"2020","journal-title":"Crit Care Med"},{"key":"10.1016\/j.jss.2026.05.046_bib19","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.genhosppsych.2023.08.011","article-title":"Efficacy and moderators of prevention and treatment of delirium with melatonin receptor agonists: a systematic review and meta-analysis of randomized controlled trials","volume":"85","author":"Wada","year":"2023","journal-title":"Gen Hosp Psychiatry"},{"key":"10.1016\/j.jss.2026.05.046_bib20","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.jpsychires.2020.12.020","article-title":"Melatonin for delirium prevention in hospitalized patients: a systematic review and meta-analysis","volume":"133","author":"Khaing","year":"2021","journal-title":"J Psychiatr Res"},{"key":"10.1016\/j.jss.2026.05.046_bib21","doi-asserted-by":"crossref","DOI":"10.1111\/jpi.12667","article-title":"Melatonin prevents neuroinflammation and relieves depression by attenuating autophagy impairment through FOXO3a regulation","volume":"69","author":"Ali","year":"2020","journal-title":"J Pineal Res"},{"key":"10.1016\/j.jss.2026.05.046_bib22","doi-asserted-by":"crossref","first-page":"3863","DOI":"10.1007\/s00018-017-2609-7","article-title":"Melatonin as a mitochondria-targeted antioxidant: one of evolution's best ideas","volume":"74","author":"Reiter","year":"2017","journal-title":"Cell Mol Life Sci"},{"key":"10.1016\/j.jss.2026.05.046_bib23","doi-asserted-by":"crossref","DOI":"10.1111\/acel.14074","article-title":"Increased A1 astrocyte activation-driven hippocampal neural network abnormality mediates delirium-like behavior in aged mice undergoing cardiac surgery","volume":"23","author":"Liu","year":"2024","journal-title":"Aging Cell"},{"key":"10.1016\/j.jss.2026.05.046_bib24","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1111\/j.1600-079X.2004.00149.x","article-title":"Oxidation of melatonin and its catabolites, N1-acetyl-N2 -formyl-5-methoxykynuramine and N1-acetyl-5-methoxykynuramine, by activated leukocytes","volume":"37","author":"Silva","year":"2004","journal-title":"J Pineal Res"},{"key":"10.1016\/j.jss.2026.05.046_bib25","doi-asserted-by":"crossref","first-page":"1749","DOI":"10.1213\/ANE.0000000000004455","article-title":"Perioperative oxidative stress: the unseen enemy","volume":"129","author":"Stevens","year":"2019","journal-title":"Anesth Analg"},{"key":"10.1016\/j.jss.2026.05.046_bib26","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1186\/s12974-021-02089-z","article-title":"Sirtuin 3 protects against anesthesia\/surgery-induced cognitive decline in aged mice by suppressing hippocampal neuroinflammation","volume":"18","author":"Liu","year":"2021","journal-title":"J Neuroinflammation"},{"key":"10.1016\/j.jss.2026.05.046_bib27","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.831930","article-title":"Inflammation and oxidative stress in the context of extracorporeal cardiac and pulmonary support","volume":"13","author":"Hatami","year":"2022","journal-title":"Front Immunol"},{"key":"10.1016\/j.jss.2026.05.046_bib28","doi-asserted-by":"crossref","first-page":"2723","DOI":"10.1007\/s00216-018-0950-9","article-title":"Combined untargeted and targeted fingerprinting by comprehensive two-dimensional gas chromatography: revealing fructose-induced changes in mice urinary metabolic signatures","volume":"410","author":"Bressanello","year":"2018","journal-title":"Anal Bioanal Chem"},{"key":"10.1016\/j.jss.2026.05.046_bib29","doi-asserted-by":"crossref","first-page":"2183","DOI":"10.1021\/acs.analchem.2c02507","article-title":"Derivatization of N-Acyl glycines by 3-Nitrophenylhydrazine for targeted metabolomics analysis and their application to the study of diabetes progression in mice","volume":"95","author":"Xiang","year":"2023","journal-title":"Anal Chem"},{"key":"10.1016\/j.jss.2026.05.046_bib30","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1213\/ANE.0000000000006893","article-title":"The association of preoperative diabetes with postoperative delirium in older patients undergoing major orthopedic surgery: a prospective matched cohort study","volume":"138","author":"Shang","year":"2024","journal-title":"Anesth Analg"},{"key":"10.1016\/j.jss.2026.05.046_bib31","doi-asserted-by":"crossref","DOI":"10.1016\/j.cca.2023.117629","article-title":"3-Methylglutarylcarnitine: a biomarker of mitochondrial dysfunction","volume":"551","author":"Jennings","year":"2023","journal-title":"Clin Chim Acta"},{"key":"10.1016\/j.jss.2026.05.046_bib32","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1186\/s12974-024-03285-3","article-title":"Unraveling the role and mechanism of mitochondria in postoperative cognitive dysfunction: a narrative review","volume":"21","author":"Zhang","year":"2024","journal-title":"J Neuroinflammation"},{"key":"10.1016\/j.jss.2026.05.046_bib33","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1053\/j.ajkd.2009.06.019","article-title":"p-Cresol sulfate: further understanding of its cardiovascular disease potential in CKD","volume":"54","author":"Winchester","year":"2009","journal-title":"Am J Kidney Dis"},{"key":"10.1016\/j.jss.2026.05.046_bib34","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1093\/ndt\/gfs133","article-title":"p-Cresol sulfate and indoxyl sulfate induce similar cellular inflammatory gene expressions in cultured proximal renal tubular cells","volume":"28","author":"Sun","year":"2013","journal-title":"Nephrol Dial Transpl"},{"key":"10.1016\/j.jss.2026.05.046_bib35","doi-asserted-by":"crossref","first-page":"367","DOI":"10.3390\/toxins10090367","article-title":"Impacts of indoxyl sulfate and p-Cresol sulfate on chronic kidney disease and mitigating effects of AST-120","volume":"10","author":"Liu","year":"2018","journal-title":"Toxins (Basel)"},{"key":"10.1016\/j.jss.2026.05.046_bib36","doi-asserted-by":"crossref","first-page":"5663","DOI":"10.1002\/fsn3.4226","article-title":"Changes in urinary metabolomic profile show the effectiveness of a nutritional intervention in children 6-12 years old: the ALINFA study","volume":"12","author":"Andueza","year":"2024","journal-title":"Food Sci Nutr"},{"key":"10.1016\/j.jss.2026.05.046_bib37","article-title":"Immunometabolic chaos in septic shock","volume":"117","author":"Shrestha","year":"2024","journal-title":"J Leukoc Biol"}],"container-title":["Journal of Surgical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022480426003380?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022480426003380?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T22:07:52Z","timestamp":1786486072000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022480426003380"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":37,"alternative-id":["S0022480426003380"],"URL":"https:\/\/doi.org\/10.1016\/j.jss.2026.05.046","relation":{},"ISSN":["0022-4804"],"issn-type":[{"value":"0022-4804","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Serum Metabolomics Analysis Identifies Acetyl-N-formyl-5-methoxykynurenamine as a Promising Dynamic Predictive Biomarker for Postoperative Delirium in Patients With Acute Type A Aortic Dissection","name":"articletitle","label":"Article Title"},{"value":"Journal of Surgical Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jss.2026.05.046","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}