{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T19:30:43Z","timestamp":1793820643272,"version":"4.6.1"},"reference-count":36,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","journalofsurgicalresearch.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Surgical Research"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.jss.2026.07.048","type":"journal-article","created":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T04:28:56Z","timestamp":1787200136000},"page":"925-933","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Aggregate Index of Systemic Inflammation and C-Reactive Protein\/Albumin Ratio in Sepsis"],"prefix":"10.1016","volume":"326","author":[{"given":"Shugen","family":"Wu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-4010-7333","authenticated-orcid":false,"given":"Junhua","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jss.2026.07.048_bib1","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1001\/jama.2017.17687","article-title":"Enhancing recovery from sepsis: a review","volume":"319","author":"Prescott","year":"2018","journal-title":"JAMA"},{"key":"10.1016\/j.jss.2026.07.048_bib2","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1016\/j.mcna.2020.02.011","article-title":"Sepsis and septic shock - basics of diagnosis, pathophysiology and clinical decision making","volume":"104","author":"Font","year":"2020","journal-title":"Med Clin North Am"},{"key":"10.1016\/j.jss.2026.07.048_bib3","first-page":"67","article-title":"Sepsis definition: what's new in the treatment guidelines","volume":"61","author":"Srzic","year":"2022","journal-title":"Acta Clin Croat"},{"key":"10.1016\/j.jss.2026.07.048_bib4","doi-asserted-by":"crossref","first-page":"32","DOI":"10.7748\/en.2019.e1926","article-title":"Sepsis: an overview of the signs, symptoms, diagnosis, treatment and pathophysiology","volume":"27","author":"Hunt","year":"2019","journal-title":"Emerg Nurse"},{"key":"10.1016\/j.jss.2026.07.048_bib5","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1186\/s13054-020-02993-5","article-title":"Biomarkers of sepsis: time for a reappraisal","volume":"24","author":"Pierrakos","year":"2020","journal-title":"Crit Care"},{"key":"10.1016\/j.jss.2026.07.048_bib6","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1177\/0885066618795400","article-title":"Sequential organ failure assessment component score prediction of In-hospital mortality from sepsis","volume":"35","author":"Gupta","year":"2020","journal-title":"J Intensive Care Med"},{"key":"10.1016\/j.jss.2026.07.048_bib7","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1097\/SHK.0000000000002335","article-title":"Development and validation of a nomogram for predicting 28-Day in-Hospital mortality in sepsis patients based on an optimized acute physiology and chronic health evaluation Ii score","volume":"61","author":"Yuan","year":"2024","journal-title":"Shock"},{"key":"10.1016\/j.jss.2026.07.048_bib8","doi-asserted-by":"crossref","DOI":"10.1016\/j.cca.2025.120558","article-title":"Diagnostic utility of combined coagulation and inflammatory biomarkers in sepsis stratification: a retrospective study","volume":"578","author":"Ding","year":"2026","journal-title":"Clin Chim Acta"},{"key":"10.1016\/j.jss.2026.07.048_bib9","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1007\/s00011-019-01269-1","article-title":"Regulation of C-reactive protein conformation in inflammation","volume":"68","author":"Yao","year":"2019","journal-title":"Inflamm Res"},{"key":"10.1016\/j.jss.2026.07.048_bib10","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.ejim.2023.07.003","article-title":"Albumin administration in internal medicine: a journey between effectiveness and futility","volume":"117","author":"Pompili","year":"2023","journal-title":"Eur J Intern Med"},{"key":"10.1016\/j.jss.2026.07.048_bib11","doi-asserted-by":"crossref","DOI":"10.1080\/13685538.2023.2261540","article-title":"The prognostic value of C-reactive protein to albumin ratio in patients with sepsis: a systematic review and meta-analysis","volume":"26","author":"Liu","year":"2023","journal-title":"Aging Male"},{"key":"10.1016\/j.jss.2026.07.048_bib12","doi-asserted-by":"crossref","DOI":"10.1155\/2021\/6621101","article-title":"C-Reactive protein-to-albumin ratio predicts sepsis and prognosis in patients with severe burn injury","volume":"2021","author":"Yu","year":"2021","journal-title":"Mediators Inflamm"},{"key":"10.1016\/j.jss.2026.07.048_bib13","doi-asserted-by":"crossref","first-page":"2386","DOI":"10.3390\/biomedicines13102386","article-title":"Immune dysregulation in sepsis. A narrative review for the Clinicians","volume":"13","author":"Valsamaki","year":"2025","journal-title":"Biomedicines"},{"key":"10.1016\/j.jss.2026.07.048_bib14","doi-asserted-by":"crossref","first-page":"5031","DOI":"10.2147\/JIR.S512574","article-title":"The aggregate index of systemic inflammation (AISI) is a novel IgA nephropathy prognosis predictor","volume":"18","author":"Liu","year":"2025","journal-title":"J Inflamm Res"},{"key":"10.1016\/j.jss.2026.07.048_bib15","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1186\/s12902-023-01509-w","article-title":"Association of systemic immune-inflammation index (SII) and aggregate index of systemic inflammation (AISI) with thyroid nodules in patients with type 2 diabetes mellitus: a retrospective study","volume":"23","author":"Cao","year":"2023","journal-title":"BMC Endocr Disord"},{"key":"10.1016\/j.jss.2026.07.048_bib16","doi-asserted-by":"crossref","first-page":"7057","DOI":"10.2147\/JIR.S481515","article-title":"Association between the aggregate index of systemic inflammation and clinical outcomes in patients with acute myocardial infarction: a retrospective study","volume":"17","author":"Jiang","year":"2024","journal-title":"J Inflamm Res"},{"key":"10.1016\/j.jss.2026.07.048_bib17","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1001\/jama.2016.0287","article-title":"The third international consensus definitions for sepsis and septic shock (Sepsis-3)","volume":"315","author":"Singer","year":"2016","journal-title":"JAMA"},{"key":"10.1016\/j.jss.2026.07.048_bib18","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1186\/s12879-025-12502-0","article-title":"Coagulation risk in sepsis patients with elevated lactate-to-albumin ratio: a retrospective cohort study","volume":"26","author":"Wang","year":"2026","journal-title":"BMC Infect Dis"},{"key":"10.1016\/j.jss.2026.07.048_bib19","article-title":"Lysophosphatidic acid: a promising biomarker for diagnosing sepsis and predicting in-hospital mortality","volume":"16","author":"Li","year":"2025","journal-title":"Front Immunol"},{"key":"10.1016\/j.jss.2026.07.048_bib20","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1186\/s13049-019-0609-3","article-title":"Prognostic accuracy of the serum lactate level, the SOFA score and the qSOFA score for mortality among adults with sepsis","volume":"27","author":"Liu","year":"2019","journal-title":"Scand J Trauma Resusc Emerg Med"},{"key":"10.1016\/j.jss.2026.07.048_bib21","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1111\/ijlh.14390","article-title":"Role of preoperative inflammatory blood cell indexes as a postoperative risk predictor among patients undergoing On-Pump cardiac surgery","volume":"47","author":"Rodel","year":"2025","journal-title":"Int J Lab Hematol"},{"key":"10.1016\/j.jss.2026.07.048_bib22","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1111\/ans.14557","article-title":"Inflammatory cell indexes as preoperative predictors of hospital stay in open elective thoracic surgery","volume":"88","author":"Paliogiannis","year":"2018","journal-title":"ANZ J Surg"},{"key":"10.1016\/j.jss.2026.07.048_bib23","doi-asserted-by":"crossref","first-page":"4584","DOI":"10.3390\/jcm12144584","article-title":"Aggregate index of systemic inflammation (AISI), disease severity, and mortality in COVID-19: a systematic review and meta-analysis","volume":"12","author":"Zinellu","year":"2023","journal-title":"J Clin Med"},{"key":"10.1016\/j.jss.2026.07.048_bib24","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.3892\/etm.2021.10595","article-title":"Molecular mechanisms in septic shock","volume":"22","author":"Gorecki","year":"2021","journal-title":"Exp Ther Med"},{"key":"10.1016\/j.jss.2026.07.048_bib25","article-title":"The aggregate index of systemic inflammation is positively correlated with the risk of all-cause mortality in sepsis-associated acute kidney injury","volume":"15","author":"Liu","year":"2025","journal-title":"Sci Rep"},{"key":"10.1016\/j.jss.2026.07.048_bib26","doi-asserted-by":"crossref","first-page":"10181","DOI":"10.2147\/JIR.S531272","article-title":"The clinical value of systemic immune inflammatory index in predicting the prognosis of patients with bloodstream infection","volume":"18","author":"Ou","year":"2025","journal-title":"J Inflamm Res"},{"key":"10.1016\/j.jss.2026.07.048_bib27","doi-asserted-by":"crossref","first-page":"943","DOI":"10.3389\/fimmu.2019.00943","article-title":"Evolution of C-Reactive protein","volume":"10","author":"Pathak","year":"2019","journal-title":"Front Immunol"},{"key":"10.1016\/j.jss.2026.07.048_bib28","doi-asserted-by":"crossref","DOI":"10.1097\/MD.0000000000040983","article-title":"Human albumin for adults with sepsis: an updated systematic review and meta-analysis of randomized controlled trials","volume":"103","author":"Bai","year":"2024","journal-title":"Medicine (Baltimore)"},{"key":"10.1016\/j.jss.2026.07.048_bib29","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/j.jfma.2019.05.012","article-title":"The cancer control status and APACHE II score are prognostic factors for critically ill patients with cancer and sepsis","volume":"119","author":"Kuo","year":"2020","journal-title":"J Formos Med Assoc"},{"key":"10.1016\/j.jss.2026.07.048_bib30","article-title":"The aggregate index of systemic inflammation as a predictor of mortality in stroke patients","volume":"16","author":"Gocmen","year":"2024","journal-title":"Cureus"},{"key":"10.1016\/j.jss.2026.07.048_bib31","doi-asserted-by":"crossref","DOI":"10.3389\/fcvm.2023.1163900","article-title":"The aggregate index of systemic inflammation (AISI): a novel predictor for hypertension","volume":"10","author":"Xiu","year":"2023","journal-title":"Front Cardiovasc Med"},{"key":"10.1016\/j.jss.2026.07.048_bib32","doi-asserted-by":"crossref","first-page":"4134","DOI":"10.3390\/jcm10184134","article-title":"The aggregate index of systemic inflammation (AISI): a novel prognostic biomarker in idiopathic pulmonary fibrosis","volume":"10","author":"Zinellu","year":"2021","journal-title":"J Clin Med"},{"key":"10.1016\/j.jss.2026.07.048_bib33","article-title":"Association between serum creatinine to albumin ratio and short- and long-term all-cause mortality in patients with acute pancreatitis admitted to the intensive care unit: a retrospective analysis based on the MIMIC-IV database","volume":"15","author":"Wang","year":"2024","journal-title":"Front Immunol"},{"key":"10.1016\/j.jss.2026.07.048_bib34","doi-asserted-by":"crossref","DOI":"10.1155\/2024\/2715606","article-title":"Review of the predictive value of biomarkers in sepsis mortality","volume":"2024","author":"Zhang","year":"2024","journal-title":"Emerg Med Int"},{"key":"10.1016\/j.jss.2026.07.048_bib35","article-title":"Combination model of neutrophil to high-density lipoprotein ratio and system inflammation response index is more valuable for predicting peripheral arterial disease in type 2 diabetic patients: a cross-sectional study","volume":"14","author":"Song","year":"2023","journal-title":"Front Endocrinol (Lausanne)"},{"key":"10.1016\/j.jss.2026.07.048_bib36","doi-asserted-by":"crossref","first-page":"3207","DOI":"10.2147\/JIR.S321074","article-title":"Predictive value of C-Reactive protein-to-albumin ratio for neonatal sepsis","volume":"14","author":"Li","year":"2021","journal-title":"J Inflamm Res"}],"container-title":["Journal of Surgical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022480426005019?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022480426005019?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T19:14:33Z","timestamp":1793819673000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022480426005019"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":36,"alternative-id":["S0022480426005019"],"URL":"https:\/\/doi.org\/10.1016\/j.jss.2026.07.048","relation":{},"ISSN":["0022-4804"],"issn-type":[{"value":"0022-4804","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Aggregate Index of Systemic Inflammation and C-Reactive Protein\/Albumin Ratio in Sepsis","name":"articletitle","label":"Article Title"},{"value":"Journal of Surgical Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jss.2026.07.048","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}