{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T20:54:20Z","timestamp":1791060860299,"version":"4.1.0"},"reference-count":26,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100013277","name":"National Clinical Key Specialty Project Foundation","doi-asserted-by":"publisher","award":["20230107"],"award-info":[{"award-number":["20230107"]}],"id":[{"id":"10.13039\/501100013277","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014764","name":"China International Medical Foundation","doi-asserted-by":"publisher","award":["z-2016-23-2101-44"],"award-info":[{"award-number":["z-2016-23-2101-44"]}],"id":[{"id":"10.13039\/501100014764","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004735","name":"Hunan Provincial Natural Science Foundation","doi-asserted-by":"publisher","award":["2024JJ9296"],"award-info":[{"award-number":["2024JJ9296"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","journalofsurgicalresearch.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Surgical Research"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1016\/j.jss.2026.08.034","type":"journal-article","created":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T13:56:47Z","timestamp":1790344607000},"page":"279-290","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Metabolomics Profiles and Prognostic Biomarkers in Sepsis Survivors and Nonsurvivors"],"prefix":"10.1016","volume":"327","author":[{"given":"Jing","family":"Xu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhou","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"He","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaotong","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanjuan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingwen","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jincheng","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhengzhuang","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongling","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanxia","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jss.2026.08.034_bib1","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1007\/s00134-025-07873-6","article-title":"Sepsis subphenotypes, theragnostics and personalized sepsis care","volume":"51","author":"David","year":"2025","journal-title":"Intensive Care Med"},{"key":"10.1016\/j.jss.2026.08.034_bib2","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/S0140-6736(19)32989-7","article-title":"Global, regional, and national sepsis incidence and mortality, 1990-2017: analysis for the Global Burden of Disease Study","volume":"395","author":"Kristina","year":"2020","journal-title":"Lancet"},{"key":"10.1016\/j.jss.2026.08.034_bib3","doi-asserted-by":"crossref","first-page":"3857","DOI":"10.1038\/s41380-024-02603-8","article-title":"Severe mental illness and mortality in sepsis and septic shock: a systematic review and meta-analysis","volume":"29","author":"Ines","year":"2024","journal-title":"Mol Psychiatry"},{"key":"10.1016\/j.jss.2026.08.034_bib4","doi-asserted-by":"crossref","first-page":"3143","DOI":"10.7150\/ijbs.84613","article-title":"VDAC2 malonylation participates in sepsis-induced myocardial dysfunction via mitochondrial-related ferroptosis","volume":"19","author":"Han","year":"2023","journal-title":"Int J Biol Sci"},{"key":"10.1016\/j.jss.2026.08.034_bib5","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1097\/SHK.0b013e318150716b","article-title":"Lactate, procalcitonin, and amino-terminal pro-B-type natriuretic peptide versus cytokine measurements and clinical severity scores for prognostication in septic shock","volume":"29","author":"Jason","year":"2008","journal-title":"Shock"},{"key":"10.1016\/j.jss.2026.08.034_bib6","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1038\/nrm.2016.25","article-title":"Metabolomics: beyond biomarkers and towards mechanisms","volume":"17","author":"Caroline","year":"2016","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10.1016\/j.jss.2026.08.034_bib7","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.semcancer.2025.03.008","article-title":"Diversity of metabolic features and relevance to clinical subtypes of gliomas","volume":"112","author":"Pushan","year":"2025","journal-title":"Semin Cancer Biol"},{"key":"10.1016\/j.jss.2026.08.034_bib8","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1038\/ni.3398","article-title":"Broad defects in the energy metabolism of leukocytes underlie immunoparalysis in sepsis","volume":"17","author":"Shih-Chin","year":"2016","journal-title":"Nat Immunol"},{"key":"10.1016\/j.jss.2026.08.034_bib9","doi-asserted-by":"crossref","first-page":"7641","DOI":"10.1007\/s00216-016-9845-9","article-title":"Application of LC-MS-based metabolomics method in differentiating septic survivors from non-survivors","volume":"408","author":"Liu","year":"2016","journal-title":"Anal Bioanal Chem"},{"key":"10.1016\/j.jss.2026.08.034_bib10","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1007\/s00134-025-07859-4","article-title":"Metabolic septic shock sub-phenotypes, stability over time and association with clinical outcome","volume":"51","author":"David","year":"2025","journal-title":"Intensive Care Med"},{"key":"10.1016\/j.jss.2026.08.034_bib11","article-title":"Metabolomic analysis of serum reveals a unique metabolomic profile in patients with myositis and identified several potential biomarkers in polymyositis versus dermatomyositis patients","volume":"39","author":"Shuoshan","year":"2025","journal-title":"Biomed Chromatogr"},{"key":"10.1016\/j.jss.2026.08.034_bib12","doi-asserted-by":"crossref","first-page":"2003","DOI":"10.1001\/jama.2019.5791","article-title":"Derivation, validation, and potential treatment implications of novel clinical phenotypes for sepsis","volume":"321","author":"Christopher","year":"2019","journal-title":"JAMA"},{"key":"10.1016\/j.jss.2026.08.034_bib13","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1038\/s41574-025-01102-2","article-title":"Steroid hormones as modulators of anti-tumoural immunity","volume":"21","author":"Paul","year":"2025","journal-title":"Nat Rev Endocrinol"},{"key":"10.1016\/j.jss.2026.08.034_bib14","article-title":"Succinylation of SERCA2a at K352 promotes its ubiquitinoylation and degradation by proteasomes in sepsis-induced heart dysfunction","volume":"18","author":"Ni","year":"2025","journal-title":"Circ Heart Fail"},{"key":"10.1016\/j.jss.2026.08.034_bib15","doi-asserted-by":"crossref","first-page":"562","DOI":"10.3390\/cells9030562","article-title":"Carbohydrate and amino acid metabolism as hallmarks for innate immune cell activation and function","volume":"9","author":"Haoxin","year":"2020","journal-title":"Cells"},{"key":"10.1016\/j.jss.2026.08.034_bib16","article-title":"Analysis of signature genes and association with immune cells infiltration in pediatric septic shock","volume":"13","author":"Jiajie","year":"2022","journal-title":"Front Immunol"},{"key":"10.1016\/j.jss.2026.08.034_bib17","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1001\/jamaneurol.2018.0611","article-title":"Use of vitamins and dietary supplements by patients with multiple sclerosis: a review","volume":"75","author":"Emily","year":"2018","journal-title":"JAMA Neurol"},{"key":"10.1016\/j.jss.2026.08.034_bib18","article-title":"Recent advances in riboflavin transporter RFVT and its genetic disease","volume":"233","author":"Congyun","year":"2022","journal-title":"Pharmacol Ther"},{"key":"10.1016\/j.jss.2026.08.034_bib19","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1002\/jimd.12058","article-title":"Disorders of riboflavin metabolism","volume":"42","author":"Shanti","year":"2019","journal-title":"J Inherit Metab Dis"},{"key":"10.1016\/j.jss.2026.08.034_bib20","first-page":"616","article-title":"Systematic review: maternal risk factors, socioeconomic influences, neonatal biomarkers and management of early-onset sepsis in late preterm and term Newborns-A focus on European and Eastern European contexts","volume":"15","author":"Anca","year":"2025","journal-title":"Life (Basel)"},{"key":"10.1016\/j.jss.2026.08.034_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.ab.2023.115332","article-title":"Exploring the potential mechanism of xuebijing injection against sepsis based on metabolomics and network pharmacology","volume":"682","author":"Chen","year":"2023","journal-title":"Anal Biochem"},{"key":"10.1016\/j.jss.2026.08.034_bib22","doi-asserted-by":"crossref","DOI":"10.1016\/j.prostaglandins.2019.106377","article-title":"Eicosanoids derived from cytochrome P450 pathway of arachidonic acid and inflammatory shock","volume":"145","author":"Tunctan","year":"2019","journal-title":"Prostaglandins Other Lipid Mediat"},{"key":"10.1016\/j.jss.2026.08.034_bib23","article-title":"Prostaglandin E2 alleviates inflammatory response and lung injury through EP4\/cAMP\/IKK\/NF-\u03baB pathway","volume":"1871","author":"Yelin","year":"2025","journal-title":"Biochim Biophys Acta Mol Basis Dis"},{"key":"10.1016\/j.jss.2026.08.034_bib24","doi-asserted-by":"crossref","first-page":"9647","DOI":"10.3390\/ijms24119647","article-title":"Pro- and anti-inflammatory prostaglandins and cytokines in humans: a mini review","volume":"24","author":"Wautier","year":"2023","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.jss.2026.08.034_bib25","doi-asserted-by":"crossref","first-page":"2860","DOI":"10.1021\/acs.jproteome.3c00130","article-title":"Integrative profiling of lysine acylome in sepsis-induced liver injury","volume":"22","author":"Na","year":"2023","journal-title":"J Proteome Res"},{"key":"10.1016\/j.jss.2026.08.034_bib26","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1002\/jat.3332","article-title":"4-Nitrophenol exposure alters the AhR signaling pathway and related gene expression in the rat liver","volume":"37","author":"Li","year":"2017","journal-title":"J Appl Toxicol"}],"container-title":["Journal of Surgical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022480426005445?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022480426005445?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T20:16:40Z","timestamp":1791058600000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022480426005445"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,11]]},"references-count":26,"alternative-id":["S0022480426005445"],"URL":"https:\/\/doi.org\/10.1016\/j.jss.2026.08.034","relation":{},"ISSN":["0022-4804"],"issn-type":[{"value":"0022-4804","type":"print"}],"subject":[],"published":{"date-parts":[[2026,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Metabolomics Profiles and Prognostic Biomarkers in Sepsis Survivors and Nonsurvivors","name":"articletitle","label":"Article Title"},{"value":"Journal of Surgical Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jss.2026.08.034","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}