{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T19:04:47Z","timestamp":1786993487135,"version":"build-2736575974"},"reference-count":41,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2013,10,1]],"date-time":"2013-10-01T00:00:00Z","timestamp":1380585600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Stroke and Cerebrovascular Diseases"],"published-print":{"date-parts":[[2013,10]]},"DOI":"10.1016\/j.jstrokecerebrovasdis.2012.03.005","type":"journal-article","created":{"date-parts":[[2012,4,17]],"date-time":"2012-04-17T10:49:35Z","timestamp":1334659775000},"page":"1018-1027","source":"Crossref","is-referenced-by-count":31,"title":["Balance of Symptomatic Pulmonary Embolism and Symptomatic Intracerebral Hemorrhage with Low-dose Anticoagulation in Recent Ischemic Stroke: A Systematic Review and Meta-analysis of Randomized Controlled Trials"],"prefix":"10.1016","volume":"22","author":[{"given":"Chamila M.","family":"Geeganage","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikola","family":"Sprigg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew W.","family":"Bath","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip M.W.","family":"Bath","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jstrokecerebrovasdis.2012.03.005_bib1","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1111\/j.1538-7836.2005.01443.x","article-title":"Prevention of venous thromboembolism after acute ischemic stroke","volume":"3","author":"Kamphuisen","year":"2005","journal-title":"J Thromb Haemost"},{"key":"10.1016\/j.jstrokecerebrovasdis.2012.03.005_bib2","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1159\/000047570","article-title":"Measures to improve recovery in the acute phase of stroke","volume":"9","author":"Langhorne","year":"1999","journal-title":"Cerebrovasc Dis"},{"key":"10.1016\/j.jstrokecerebrovasdis.2012.03.005_bib3","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1136\/bmj.324.7329.71","article-title":"Collaborative meta-analysis of randomised trials of antiplatelet therapy for prevention of death, myocardial infarction, and stroke in high risk patients","volume":"324","year":"2002","journal-title":"BMJ"},{"key":"10.1016\/j.jstrokecerebrovasdis.2012.03.005_bib4","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.jstrokecerebrovasdis.2005.06.001","article-title":"Compression stockings and the prevention of symptomatic venous thromboembolism: Data from the Tinzaparin in Acute Ischemic Stroke Trial","volume":"4","author":"Sprigg","year":"2005","journal-title":"J Stroke Cerebrovasc Dis"},{"key":"10.1016\/j.jstrokecerebrovasdis.2012.03.005_bib5","first-page":"CD001484","article-title":"Elastic compression stockings for prevention of deep vein thrombosis","volume":"3","author":"Amaragiri","year":"2000","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.jstrokecerebrovasdis.2012.03.005_bib6","doi-asserted-by":"crossref","first-page":"1958","DOI":"10.1016\/S0140-6736(09)60941-7","article-title":"Effectiveness of thigh-length graduated compression stockings to reduce the risk of deep vein thrombosis after stroke (CLOTS trial 1): A multicentre, randomised controlled trial","volume":"373","author":"Dennis","year":"2009","journal-title":"Lancet"},{"key":"10.1016\/j.jstrokecerebrovasdis.2012.03.005_bib7","doi-asserted-by":"crossref","first-page":"1923","DOI":"10.1016\/S0140-6736(09)60990-9","article-title":"Thigh-length compression stockings and DVT after stroke","volume":"373","author":"Bath","year":"2009","journal-title":"Lancet"},{"key":"10.1016\/j.jstrokecerebrovasdis.2012.03.005_bib8","first-page":"CD001922","article-title":"Physical methods for preventing deep vein thrombosis in stroke","volume":"4","author":"Mazzone","year":"2004","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.jstrokecerebrovasdis.2012.03.005_bib9","doi-asserted-by":"crossref","first-page":"610","DOI":"10.7326\/0003-4819-153-9-201011020-00285","article-title":"Should patients with stroke wear compression stockings to prevent venous thromboembolism?","volume":"153","author":"Kearon","year":"2010","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.jstrokecerebrovasdis.2012.03.005_bib10","doi-asserted-by":"crossref","first-page":"1770","DOI":"10.1161\/01.STR.31.7.1770","article-title":"Low-molecular-weight heparins and heparinoids in acute ischemic stroke: A meta-analysis of randomized controlled trials","volume":"31","author":"Bath","year":"2000","journal-title":"Stroke"},{"key":"10.1016\/j.jstrokecerebrovasdis.2012.03.005_bib11","first-page":"CD000024","article-title":"Anticoagulants for acute ischaemic stroke","volume":"4","author":"Gubitz","year":"2004","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.jstrokecerebrovasdis.2012.03.005_bib12","doi-asserted-by":"crossref","first-page":"1569","DOI":"10.1016\/S0140-6736(97)04011-7","article-title":"The International Stroke Trial (IST); A randomised trial of aspirin, subcutaneous heparin, both, or neither among 19435 patients with acute ischaemic stroke","volume":"349","year":"1997","journal-title":"Lancet"},{"key":"10.1016\/j.jstrokecerebrovasdis.2012.03.005_bib13","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1001\/jama.279.16.1265","article-title":"The Publications Committee for the Trial of ORG 10172 in Acute Stroke Treatment (TOAST) Investigators. Low molecular weight heparinoid, ORG 10172 (danaparoid), and outcome after acute ischemic stroke","volume":"279","year":"1998","journal-title":"JAMA"},{"key":"10.1016\/j.jstrokecerebrovasdis.2012.03.005_bib14","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1016\/S0140-6736(01)05837-8","article-title":"Tinzaparin in Acute Ischaemic Stroke (TAIST): A randomised aspirin-controlled trial","volume":"358","author":"Bath","year":"2001","journal-title":"Lancet"},{"key":"10.1016\/j.jstrokecerebrovasdis.2012.03.005_bib15","first-page":"CD000024","article-title":"Anticoagulants for acute ischaemic stroke","volume":"4","author":"Sandercock","year":"2008","journal-title":"Cochrane Database Syst Rev"},{"issue":"Suppl 4","key":"10.1016\/j.jstrokecerebrovasdis.2012.03.005_bib16","first-page":"19","article-title":"Fraxiparine in ischaemic stroke study (FISS bis)","volume":"8","author":"Hommel","year":"1998","journal-title":"Cerebrovasc Dis"},{"key":"10.1016\/j.jstrokecerebrovasdis.2012.03.005_bib17","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.1161\/STROKEAHA.107.181486","volume":"38","author":"Adams","year":"2007","journal-title":"Stroke"},{"key":"10.1016\/j.jstrokecerebrovasdis.2012.03.005_bib18","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1159\/000131083","article-title":"Guidelines for management of ischaemic stroke and transient ischaemic attack 2008","volume":"25","year":"2008","journal-title":"Cerebrovasc Dis"},{"key":"10.1016\/j.jstrokecerebrovasdis.2012.03.005_bib20","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1517\/13543784.7.8.1323","article-title":"Low molecular weight heparin in acute stroke","volume":"7","author":"Bath","year":"1998","journal-title":"Expert Opin Investig Drugs"},{"key":"10.1016\/j.jstrokecerebrovasdis.2012.03.005_bib21","first-page":"CD000248","article-title":"Anticoagulants for\u00a0preventing recurrence following presumed non-cardioembolic ischaemic stroke or transient ischaemic attack","volume":"2","author":"Sandercock","year":"2009","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.jstrokecerebrovasdis.2012.03.005_bib22","first-page":"CD000119","article-title":"Low-molecular-weight heparins or heparinoids versus standard unfractionated heparin for acute ischaemic stroke","volume":"3","author":"Sandercock","year":"2008","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.jstrokecerebrovasdis.2012.03.005_bib23","first-page":"CD000029","article-title":"Antiplatelet therapy for acute ischaemic stroke","volume":"3","author":"Sandercock","year":"2008","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.jstrokecerebrovasdis.2012.03.005_bib24","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1378\/chest.07-1826","article-title":"Differences between low-molecular-weight and unfractionated heparin for venous thromboembolism prevention following ischemic stroke: A metaanalysis","volume":"133","author":"Shorr","year":"2008","journal-title":"Chest"},{"key":"10.1016\/j.jstrokecerebrovasdis.2012.03.005_bib25","series-title":"Royal Pharmaceutical Society of Great Britain. British National Formulary","year":"2010"},{"key":"10.1016\/j.jstrokecerebrovasdis.2012.03.005_bib26","series-title":"Cochrane Handbook for Systematic Reviews of Interventions","author":"Higgins","year":"2008"},{"key":"10.1016\/j.jstrokecerebrovasdis.2012.03.005_bib27","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1136\/bmj.315.7109.629","article-title":"Bias in meta-analysis detected by a simple, graphical test","volume":"315","author":"Egger","year":"1997","journal-title":"BMJ"},{"key":"10.1016\/j.jstrokecerebrovasdis.2012.03.005_bib28","series-title":"Systematic Reviews in Health Care; Meta-analysis in Context","author":"Egger","year":"2001"},{"key":"10.1016\/j.jstrokecerebrovasdis.2012.03.005_bib29","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1016\/S0140-6736(07)60633-3","article-title":"The efficacy and safety of enoxaparin versus unfractionated heparin for the prevention of venous thromboembolism after acute ischaemic stroke (PREVAIL Study): An open-label randomised comparison","volume":"369","author":"Sherman","year":"2007","journal-title":"Lancet"},{"key":"10.1016\/j.jstrokecerebrovasdis.2012.03.005_bib30","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1161\/01.STR.0000195182.67656.ee","article-title":"Prophylaxis of thrombotic and embolic events in acute ischemic stroke with the low-molecular-weight heparin certoparin: Results of the PROTECT trial","volume":"37","author":"Diener","year":"2006","journal-title":"Stroke"},{"key":"10.1016\/j.jstrokecerebrovasdis.2012.03.005_bib31","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1056\/NEJMoa0804656","article-title":"Thrombolysis with alteplase 3 to 4.5 hours after acute ischemic stroke","volume":"359","author":"Hacke","year":"2008","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jstrokecerebrovasdis.2012.03.005_bib32","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1111\/j.0954-6820.1987.tb10956.x","article-title":"Autopsy-verified causes of death after stroke","volume":"222","author":"Viitanen","year":"1987","journal-title":"Acta Med Scand"},{"key":"10.1016\/j.jstrokecerebrovasdis.2012.03.005_bib33","doi-asserted-by":"crossref","first-page":"1588","DOI":"10.1056\/NEJM199512143332402","article-title":"Low-molecular-weight heparin for the treatment of acute ischemic stroke","volume":"333","author":"Kay","year":"1995","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jstrokecerebrovasdis.2012.03.005_bib34","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1034\/j.1600-0404.2002.01215.x","article-title":"Enoxaparin vs heparin for prevention of deep-vein thrombosis in acute ischaemic stroke: A randomized, double-blind study","volume":"106","author":"Hillbom","year":"2002","journal-title":"Acta Neurol Scand"},{"key":"10.1016\/j.jstrokecerebrovasdis.2012.03.005_bib35","first-page":"245","article-title":"Prophylaxis of deep venous thrombosis with a low-molecular-weight heparin (Kabi 2165\/Fragmin) in stroke patients","volume":"19","author":"Prins","year":"1989","journal-title":"Haemostasis"},{"issue":"Suppl","key":"10.1016\/j.jstrokecerebrovasdis.2012.03.005_bib36","first-page":"25","article-title":"A double-blind and randomized placebo-controlled trial of low molecular weight heparin once daily to prevent deep-vein thrombosis in acute ischemic stroke","volume":"16","author":"Sandset","year":"1990","journal-title":"Semin Thromb Hemost"},{"key":"10.1016\/j.jstrokecerebrovasdis.2012.03.005_bib37","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1161\/01.STR.32.1.22","article-title":"Treatment of acute ischemic stroke with the low-molecular-weight heparin certoparin: Results of the TOPAS trial. Therapy of Patients With Acute Stroke (TOPAS) Investigators","volume":"32","author":"Diener","year":"2001","journal-title":"Stroke"},{"key":"10.1016\/j.jstrokecerebrovasdis.2012.03.005_bib38","first-page":"121","article-title":"Mesoglycan in acute focal cerebral ischaemia [in Italian]","volume":"59","author":"Cazzato","year":"1989","journal-title":"Rev Neurol"},{"key":"10.1016\/j.jstrokecerebrovasdis.2012.03.005_bib39","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1093\/ageing\/23.6.512","article-title":"A multicentre, double-blind, randomized study to compare the safety and efficacy of once-daily Org 10172 and twice-daily low dose heparin in preventing deep-vein thrombosis in patients with acute ischemic stroke","volume":"23","author":"Dumas","year":"1994","journal-title":"Age Ageing"},{"key":"10.1016\/j.jstrokecerebrovasdis.2012.03.005_bib40","author":"Hageluken","year":"1992"},{"key":"10.1016\/j.jstrokecerebrovasdis.2012.03.005_bib41","series-title":"An open, randomised, pilot multi-centre study of Org 10172 versus heparin administered for the purpose of deep vein thrombosis prophylaxis in patients with a non-haemorrhagic stroke of recent onset. Internal report SDGRR No. 2310","author":"Stiekema","year":"1988"},{"key":"10.1016\/j.jstrokecerebrovasdis.2012.03.005_bib42","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1016\/S0140-6736(87)90173-5","article-title":"Double-blind randomised trial of Org 10172 low-molecular-weight heparinoid in prevention of deep-vein thrombosis in thrombotic stroke","volume":"1","author":"Turpie","year":"1987","journal-title":"Lancet"}],"container-title":["Journal of Stroke and Cerebrovascular Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1052305712000614?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1052305712000614?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,11,23]],"date-time":"2018-11-23T21:50:49Z","timestamp":1543009849000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1052305712000614"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,10]]},"references-count":41,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2013,10]]}},"alternative-id":["S1052305712000614"],"URL":"https:\/\/doi.org\/10.1016\/j.jstrokecerebrovasdis.2012.03.005","relation":{},"ISSN":["1052-3057"],"issn-type":[{"value":"1052-3057","type":"print"}],"subject":[],"published":{"date-parts":[[2013,10]]}}}