{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T23:05:11Z","timestamp":1790895911828,"version":"4.1.0"},"reference-count":112,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,1,5]],"date-time":"2024-01-05T00:00:00Z","timestamp":1704412800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","strokejournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Stroke and Cerebrovascular Diseases"],"published-print":{"date-parts":[[2024,3]]},"DOI":"10.1016\/j.jstrokecerebrovasdis.2024.107557","type":"journal-article","created":{"date-parts":[[2024,1,9]],"date-time":"2024-01-09T17:11:50Z","timestamp":1704820310000},"page":"107557","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":51,"title":["The glymphatic system and cerebral small vessel disease"],"prefix":"10.1016","volume":"33","author":[{"given":"Phillip S.","family":"Ang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douglas M.","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saara-Anne","family":"Azizi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salvador A.","family":"Norton de Matos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4137-2444","authenticated-orcid":false,"given":"James R.","family":"Brorson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jstrokecerebrovasdis.2024.107557_bib0001","doi-asserted-by":"crossref","first-page":"2583","DOI":"10.1007\/s11064-015-1581-6","article-title":"The glymphatic system: a beginner's guide","volume":"40","author":"Jessen","year":"2015","journal-title":"Neurochem Res"},{"key":"10.1016\/j.jstrokecerebrovasdis.2024.107557_bib0002","doi-asserted-by":"crossref","first-page":"147ra111","DOI":"10.1126\/scitranslmed.3003748","article-title":"A paravascular pathway facilitates CSF flow through the brain parenchyma and the clearance of interstitial solutes, including amyloid \u03b2","volume":"4","author":"Iliff","year":"2012","journal-title":"Sci Transl Med"},{"key":"10.1016\/j.jstrokecerebrovasdis.2024.107557_bib0003","doi-asserted-by":"crossref","first-page":"2955","DOI":"10.1016\/j.celrep.2019.02.050","article-title":"PDGF-B is required for development of the glymphatic system","volume":"26","author":"Munk","year":"2019","journal-title":"Cell Rep"},{"key":"10.1016\/j.jstrokecerebrovasdis.2024.107557_bib0004","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1038\/s41586-021-04369-3","article-title":"A human brain vascular atlas reveals diverse cell mediators of Alzheimer's disease risk","volume":"603","author":"Yang","year":"2022","journal-title":"Nature"},{"key":"10.1016\/j.jstrokecerebrovasdis.2024.107557_bib0005","doi-asserted-by":"crossref","DOI":"10.1098\/rsif.2019.0572","article-title":"Fluid dynamics of cerebrospinal fluid flow in perivascular spaces","volume":"16","author":"Thomas","year":"2019","journal-title":"J R Soc Interface"},{"key":"10.1016\/j.jstrokecerebrovasdis.2024.107557_bib0007","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1038\/aps.2011.27","article-title":"Aquaporin-4: orthogonal array assembly, CNS functions, and role in neuromyelitis optica","volume":"32","author":"Verkman","year":"2011","journal-title":"Acta Pharmacol Sin"},{"key":"10.1016\/j.jstrokecerebrovasdis.2024.107557_bib0006","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1038\/s41583-021-00525-w","article-title":"Emerging roles for CNS fibroblasts in health, injury and disease","volume":"23","author":"Dorrier","year":"2022","journal-title":"Nat Rev Neurosci"},{"key":"10.1016\/j.jstrokecerebrovasdis.2024.107557_bib0008","doi-asserted-by":"crossref","first-page":"1146","DOI":"10.1212\/WNL.0000000000007654","article-title":"CNS small vessel disease: a clinical review","volume":"92","author":"Cannistraro","year":"2019","journal-title":"Neurology"},{"key":"10.1016\/j.jstrokecerebrovasdis.2024.107557_bib0009","doi-asserted-by":"crossref","first-page":"2257","DOI":"10.1042\/CS20160381","article-title":"Perivascular spaces, glymphatic dysfunction, and small vessel disease","volume":"131","author":"Mestre","year":"2017","journal-title":"Clin Sci"},{"key":"10.1016\/j.jstrokecerebrovasdis.2024.107557_bib0010","doi-asserted-by":"crossref","DOI":"10.3389\/fnagi.2022.834496","article-title":"Association of cerebral small vessel disease with gait and balance disorders","volume":"14","author":"Su","year":"2022","journal-title":"Front Aging Neurosci"},{"key":"10.1016\/j.jstrokecerebrovasdis.2024.107557_bib0011","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1038\/s41582-020-0312-z","article-title":"Perivascular spaces in the brain: anatomy, physiology and pathology","volume":"16","author":"Wardlaw","year":"2020","journal-title":"Nat Rev Neurol"},{"key":"10.1016\/j.jstrokecerebrovasdis.2024.107557_bib0012","doi-asserted-by":"crossref","first-page":"eaam9507","DOI":"10.1126\/scitranslmed.aam9507","article-title":"Reversal of endothelial dysfunction reduces white matter vulnerability in cerebral small vessel disease in rats","volume":"10","author":"Rajani","year":"2018","journal-title":"Sci Transl Med"},{"key":"10.1016\/j.jstrokecerebrovasdis.2024.107557_bib0013","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1016\/j.neuroscience.2004.07.003","article-title":"Molecular mechanisms of cerebrospinal fluid production","volume":"129","author":"Brown","year":"2004","journal-title":"Neuroscience"},{"key":"10.1016\/j.jstrokecerebrovasdis.2024.107557_bib0014","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/0022-510X(94)90140-6","article-title":"Soluble amyloid \u03b2-protein in the cerebrospinal fluid from patients with Alzheimer's disease, vascular dementia and controls","volume":"127","author":"Pirttil\u00e4","year":"1994","journal-title":"J Neurol Sci"},{"key":"10.1016\/j.jstrokecerebrovasdis.2024.107557_bib0015","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/0924-977X(94)90233-X","article-title":"Normal tau protein and hyperphosphorylated tau protein in cerebrospinal fluid: a biochemical marker for Alzheimer's disease?","volume":"4","author":"Blennow","year":"1994","journal-title":"Eur Neuropsychopharmacol"},{"key":"10.1016\/j.jstrokecerebrovasdis.2024.107557_bib0016","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1186\/s12987-022-00323-1","article-title":"Cerebrospinal fluid production by the choroid plexus: a century of barrier research revisited","volume":"19","author":"MacAulay","year":"2022","journal-title":"Fluids Barriers CNS"},{"key":"10.1016\/j.jstrokecerebrovasdis.2024.107557_bib0017","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1097\/00000658-191908000-00001","article-title":"Experimental hydrocephalus","volume":"70","author":"Dandy","year":"1919","journal-title":"Ann Surg"},{"key":"10.1016\/j.jstrokecerebrovasdis.2024.107557_bib0018","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1172\/JCI67677","article-title":"Brain-wide pathway for waste clearance captured by contrast-enhanced MRI","volume":"123","author":"Iliff","year":"2013","journal-title":"J Clin Investig"},{"key":"10.1016\/j.jstrokecerebrovasdis.2024.107557_bib0019","doi-asserted-by":"crossref","first-page":"2691","DOI":"10.1093\/brain\/awx191","article-title":"Glymphatic MRI in idiopathic normal pressure hydrocephalus","volume":"140","author":"Ringstad","year":"2017","journal-title":"Brain"},{"key":"10.1016\/j.jstrokecerebrovasdis.2024.107557_bib0020","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1073\/pnas.0609551104","article-title":"Penetrating arterioles are a bottleneck in the perfusion of neocortex","volume":"104","author":"Nishimura","year":"2007","journal-title":"Proc Natl Acad Sci"},{"key":"10.1016\/j.jstrokecerebrovasdis.2024.107557_bib0021","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1136\/jnnp.13.3.203","article-title":"The penetration of particulate matter from the cerebrospinal fluid into the spinal ganglia, peripheral nerves, and perivascular spaces of the central nervous system","volume":"13","author":"Brierley","year":"1950","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"10.1016\/j.jstrokecerebrovasdis.2024.107557_bib0022","doi-asserted-by":"crossref","first-page":"18190","DOI":"10.1523\/JNEUROSCI.1592-13.2013","article-title":"Cerebral arterial pulsation drives paravascular CSF-interstitial fluid exchange in the murine brain","volume":"33","author":"Iliff","year":"2013","journal-title":"J Neurosci"},{"key":"10.1016\/j.jstrokecerebrovasdis.2024.107557_bib0023","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/srep02582","article-title":"Paravascular microcirculation facilitates rapid lipid transport and astrocyte signaling in the brain","volume":"3","author":"Thrane","year":"2013","journal-title":"Sci Rep"},{"key":"10.1016\/j.jstrokecerebrovasdis.2024.107557_bib0024","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1002\/ana.24271","article-title":"Impairment of paravascular clearance pathways in the aging brain","volume":"76","author":"Kress","year":"2014","journal-title":"Ann Neurol"},{"key":"10.1016\/j.jstrokecerebrovasdis.2024.107557_bib0025","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1002\/nbm.3306","article-title":"Assessment of blood flow velocity and pulsatility in cerebral perforating arteries with 7-T quantitative flow MRI","volume":"29","author":"Bouvy","year":"2016","journal-title":"NMR Biomed"},{"key":"10.1016\/j.jstrokecerebrovasdis.2024.107557_bib0026","first-page":"624","article-title":"Lifelong cyclic mechanical strain promotes large elastic artery stiffening: increased pulse pressure and old age-related organ failure","volume":"32","author":"Thorin-Trescases","year":"2016","journal-title":"Can J Cardiol"},{"key":"10.1016\/j.jstrokecerebrovasdis.2024.107557_bib0027","doi-asserted-by":"crossref","first-page":"415","DOI":"10.3389\/fnins.2020.00415","article-title":"Most small cerebral cortical veins demonstrate significant flow pulsatility: a human phase contrast MRI study at 7T","volume":"14","author":"Driver","year":"2020","journal-title":"Front Neurosci"},{"key":"10.1016\/j.jstrokecerebrovasdis.2024.107557_bib0028","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41467-018-07318-3","article-title":"Flow of cerebrospinal fluid is driven by arterial pulsations and is reduced in hypertension","volume":"9","author":"Mestre","year":"2018","journal-title":"Nat Commun"},{"key":"10.1016\/j.jstrokecerebrovasdis.2024.107557_bib0029","doi-asserted-by":"crossref","first-page":"e34028","DOI":"10.7554\/eLife.34028","article-title":"Non-invasive imaging of CSF-mediated brain clearance pathways via assessment of perivascular fluid movement with diffusion tensor MRI","volume":"7","author":"Harrison","year":"2018","journal-title":"eLife"},{"key":"10.1016\/j.jstrokecerebrovasdis.2024.107557_bib0030","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.nbd.2016.05.015","article-title":"Suppression of glymphatic fluid transport in a mouse model of Alzheimer's disease","volume":"93","author":"Peng","year":"2016","journal-title":"Neurobiol Dis"},{"key":"10.1016\/j.jstrokecerebrovasdis.2024.107557_bib0031","doi-asserted-by":"crossref","first-page":"2112","DOI":"10.1177\/0271678X16661202","article-title":"Glymphatic clearance controls state-dependent changes in brain lactate concentration","volume":"37","author":"Lundgaard","year":"2017","journal-title":"J Cereb Blood Flow Metab"},{"key":"10.1016\/j.jstrokecerebrovasdis.2024.107557_bib0032","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1002\/glia.20990","article-title":"The perivascular astroglial sheath provides a complete covering of the brain microvessels: an electron microscopic 3D reconstruction","volume":"58","author":"Mathiisen","year":"2010","journal-title":"Glia"},{"key":"10.1016\/j.jstrokecerebrovasdis.2024.107557_bib0033","doi-asserted-by":"crossref","first-page":"e40070","DOI":"10.7554\/eLife.40070","article-title":"Aquaporin-4-dependent glymphatic solute transport in the rodent brain","volume":"7","author":"Mestre","year":"2018","journal-title":"eLife"},{"key":"10.1016\/j.jstrokecerebrovasdis.2024.107557_bib0034","doi-asserted-by":"crossref","first-page":"17815","DOI":"10.1073\/pnas.1110655108","article-title":"Glial-conditional deletion of aquaporin-4 (Aqp4) reduces blood-brain water uptake and confers barrier function on perivascular astrocyte endfeet","volume":"108","author":"Haj-Yasein","year":"2011","journal-title":"Proc Natl Acad Sci"},{"key":"10.1016\/j.jstrokecerebrovasdis.2024.107557_bib0035","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.mri.2022.06.013","article-title":"Visualization of the perivenous glymphatic efflux in human brain after laser interstitial thermal therapy","volume":"92","author":"Bilgili","year":"2022","journal-title":"Magn Reson Imaging"},{"key":"10.1016\/j.jstrokecerebrovasdis.2024.107557_bib0036","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1111\/j.1750-3639.1992.tb00703.x","article-title":"Drainage of brain extracellular fluid into blood and deep cervical lymph and its immunological significance","volume":"2","author":"Cserr","year":"1992","journal-title":"Brain Pathol"},{"key":"10.1016\/j.jstrokecerebrovasdis.2024.107557_bib0037","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1084\/jem.20142290","article-title":"A dural lymphatic vascular system that drains brain interstitial fluid and macromolecules","volume":"212","author":"Aspelund","year":"2015","journal-title":"J Exp Med"},{"key":"10.1016\/j.jstrokecerebrovasdis.2024.107557_bib0038","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1038\/nature14432","article-title":"Structural and functional features of central nervous system lymphatic vessels","volume":"523","author":"Louveau","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.jstrokecerebrovasdis.2024.107557_bib0039","series-title":"Istoria dei Vasi Linfatici. Ed. Seconda da esso Illustrata ed Insieme Accresciuta","author":"Mascagni","year":"1820"},{"key":"10.1016\/j.jstrokecerebrovasdis.2024.107557_bib0040","first-page":"287","article-title":"Probable modification of the lymphatic fissures of the walls of the venous sinuses of the dura mater","volume":"64","author":"Lecco","year":"1953","journal-title":"Arch Ital Otol Rinol Laringol"},{"key":"10.1016\/j.jstrokecerebrovasdis.2024.107557_bib0041","doi-asserted-by":"crossref","first-page":"e29738","DOI":"10.7554\/eLife.29738","article-title":"Human and nonhuman primate meninges harbor lymphatic vessels that can be visualized noninvasively by MRI","volume":"6","author":"Absinta","year":"2017","journal-title":"eLife"},{"key":"10.1016\/j.jstrokecerebrovasdis.2024.107557_bib0042","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1038\/s41586-018-0368-8","article-title":"Functional aspects of meningeal lymphatics in ageing and Alzheimer's disease","volume":"560","author":"Da Mesquita","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.jstrokecerebrovasdis.2024.107557_bib0043","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13024-019-0312-x","article-title":"Dural lymphatics regulate clearance of extracellular tau from the CNS","volume":"14","author":"Patel","year":"2019","journal-title":"Mol Neurodegener"},{"key":"10.1016\/j.jstrokecerebrovasdis.2024.107557_bib0044","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1016\/j.cell.2020.12.040","article-title":"Functional characterization of the dural sinuses as a neuroimmune interface","volume":"184","author":"Rustenhoven","year":"2021","journal-title":"Cell"},{"key":"10.1016\/j.jstrokecerebrovasdis.2024.107557_bib0045","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41467-019-14195-x","article-title":"Cerebrospinal fluid tracer efflux to parasagittal dura in humans","volume":"11","author":"Ringstad","year":"2020","journal-title":"Nat Commun"},{"key":"10.1016\/j.jstrokecerebrovasdis.2024.107557_bib0046","doi-asserted-by":"crossref","first-page":"3210","DOI":"10.1172\/JCI90603","article-title":"Understanding the functions and relationships of the glymphatic system and meningeal lymphatics","volume":"127","author":"Louveau","year":"2017","journal-title":"J Clin Investig"},{"key":"10.1016\/j.jstrokecerebrovasdis.2024.107557_bib0047","doi-asserted-by":"crossref","first-page":"3645","DOI":"10.1084\/jem.20170391","article-title":"Development and plasticity of meningeal lymphatic vessels","volume":"214","author":"Antila","year":"2017","journal-title":"J Exp Med"},{"key":"10.1016\/j.jstrokecerebrovasdis.2024.107557_bib0048","doi-asserted-by":"crossref","first-page":"F329","DOI":"10.1152\/ajprenal.1981.240.4.F329","article-title":"Drainage of cerebral interstitial fluid into deep cervical lymph of the rabbit","volume":"240","author":"Bradbury","year":"1981","journal-title":"Am J Physiol Ren Physiol"},{"key":"10.1016\/j.jstrokecerebrovasdis.2024.107557_bib0049","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-018-25666-4","article-title":"Magnetic resonance imaging provides evidence of glymphatic drainage from human brain to cervical lymph nodes","volume":"8","author":"Eide","year":"2018","journal-title":"Sci Rep"},{"key":"10.1016\/j.jstrokecerebrovasdis.2024.107557_bib0050","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1084\/jem.20220035","article-title":"Conserved meningeal lymphatic drainage circuits in mice and humans","volume":"219","author":"Jacob","year":"2022","journal-title":"J Exp Med"},{"key":"10.1016\/j.jstrokecerebrovasdis.2024.107557_bib0051","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41467-020-18115-2","article-title":"Circadian control of brain glymphatic and lymphatic fluid flow","volume":"11","author":"Hablitz","year":"2020","journal-title":"Nat Commun"},{"key":"10.1016\/j.jstrokecerebrovasdis.2024.107557_bib0052","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1038\/sj.jcbfm.9600315","article-title":"Efflux of drugs and solutes from brain: the interactive roles of diffusional transcapillary transport, bulk flow and capillary transporters","volume":"27","author":"Groothuis","year":"2007","journal-title":"J Cereb Blood Flow Metab"},{"key":"10.1016\/j.jstrokecerebrovasdis.2024.107557_bib0053","doi-asserted-by":"crossref","first-page":"eaav5447","DOI":"10.1126\/sciadv.aav5447","article-title":"Increased glymphatic influx is correlated with high EEG delta power and low heart rate in mice under anesthesia","volume":"5","author":"Hablitz","year":"2019","journal-title":"Sci Adv"},{"key":"10.1016\/j.jstrokecerebrovasdis.2024.107557_bib0054","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1007\/s00401-018-1916-x","article-title":"Rapid lymphatic efflux limits cerebrospinal fluid flow to the brain","volume":"137","author":"Ma","year":"2019","journal-title":"Acta Neuropathol"},{"key":"10.1016\/j.jstrokecerebrovasdis.2024.107557_bib0055","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbamem.2021.183573","article-title":"The effects of trifluoperazine on brain edema, aquaporin-4 expression and metabolic markers during the acute phase of stroke using photothrombotic mouse model","volume":"1863","author":"Sylvain","year":"2021","journal-title":"Biochim Biophys Acta Biomembr"},{"key":"10.1016\/j.jstrokecerebrovasdis.2024.107557_bib0056","doi-asserted-by":"crossref","first-page":"eaax7171","DOI":"10.1126\/science.aax7171","article-title":"Cerebrospinal fluid influx drives acute ischemic tissue swelling","volume":"367","author":"Mestre","year":"2020","journal-title":"Science"},{"key":"10.1016\/j.jstrokecerebrovasdis.2024.107557_bib0057","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1177\/0271678X18822921","article-title":"Impaired meningeal lymphatic vessel development worsens stroke outcome","volume":"40","author":"Yanev","year":"2020","journal-title":"J Cereb Blood Flow Metab"},{"key":"10.1016\/j.jstrokecerebrovasdis.2024.107557_bib0058","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1016\/j.devcel.2019.03.022","article-title":"Cerebrovascular injuries induce lymphatic invasion into brain parenchyma to guide vascular regeneration in zebrafish","volume":"49","author":"Chen","year":"2019","journal-title":"Dev Cell"},{"key":"10.1016\/j.jstrokecerebrovasdis.2024.107557_bib0059","doi-asserted-by":"crossref","first-page":"1210","DOI":"10.1161\/HYPERTENSIONAHA.119.12830","article-title":"Cerebral small vessel disease and stage 1 hypertension defined by the 2017 American College of Cardiology\/American Heart Association Guidelines","volume":"73","author":"Nam","year":"2019","journal-title":"Hypertension"},{"key":"10.1016\/j.jstrokecerebrovasdis.2024.107557_bib0060","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1016\/S1474-4422(12)70241-7","article-title":"Effects of systolic blood pressure on white-matter integrity in young adults in the Framingham Heart Study: a cross-sectional study","volume":"11","author":"Maillard","year":"2012","journal-title":"Lancet Neurol"},{"key":"10.1016\/j.jstrokecerebrovasdis.2024.107557_bib0061","doi-asserted-by":"crossref","first-page":"6365","DOI":"10.1523\/JNEUROSCI.1974-18.2019","article-title":"Impaired glymphatic transport in spontaneously hypertensive rats","volume":"39","author":"Mortensen","year":"2019","journal-title":"J Neurosci"},{"key":"10.1016\/j.jstrokecerebrovasdis.2024.107557_bib0062","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1161\/01.RES.71.1.145","article-title":"Arterial mechanics in spontaneously hypertensive rats. Mechanical properties, hydraulic conductivity, and two-phase (solid\/fluid) finite element models","volume":"71","author":"Gaballa","year":"1992","journal-title":"Circ Res"},{"key":"10.1016\/j.jstrokecerebrovasdis.2024.107557_bib0063","doi-asserted-by":"crossref","first-page":"48","DOI":"10.3174\/ajnr.A7334","article-title":"An investigation of water diffusivity changes along the perivascular space in elderly subjects with hypertension","volume":"43","author":"Kikuta","year":"2022","journal-title":"Am J Neuroradiol"},{"key":"10.1016\/j.jstrokecerebrovasdis.2024.107557_bib0064","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.1161\/STROKEAHA.117.020536","article-title":"Causal impact of type 2 diabetes mellitus on cerebral small vessel disease: a Mendelian randomization analysis","volume":"49","author":"Liu","year":"2018","journal-title":"Stroke"},{"key":"10.1016\/j.jstrokecerebrovasdis.2024.107557_bib0065","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1007\/s00395-011-0201-0","article-title":"Coronary arterioles in type 2 diabetic (db\/db) mice undergo a distinct pattern of remodeling associated with decreased vessel stiffness","volume":"106","author":"Katz","year":"2011","journal-title":"Basic Res Cardiol"},{"key":"10.1016\/j.jstrokecerebrovasdis.2024.107557_bib0066","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.1161\/HYPERTENSIONAHA.122.19256","article-title":"Hypertension, arterial stiffness, and diabetes: a prospective cohort study","volume":"79","author":"Tian","year":"2022","journal-title":"Hypertension"},{"key":"10.1016\/j.jstrokecerebrovasdis.2024.107557_bib0067","doi-asserted-by":"crossref","first-page":"1326","DOI":"10.1177\/0271678X16654702","article-title":"Impairment of the glymphatic system after diabetes","volume":"37","author":"Jiang","year":"2017","journal-title":"J Cereb Blood Flow Metab"},{"key":"10.1016\/j.jstrokecerebrovasdis.2024.107557_bib0068","doi-asserted-by":"crossref","first-page":"300","DOI":"10.3389\/fnhum.2020.00300","article-title":"Evaluation of glymphatic system using diffusion MR technique in T2DM cases","volume":"14","author":"Yang","year":"2020","journal-title":"Front Hum Neurosci"},{"key":"10.1016\/j.jstrokecerebrovasdis.2024.107557_bib0069","doi-asserted-by":"crossref","first-page":"1482","DOI":"10.1111\/ene.12775","article-title":"Cerebral small vessel disease is related to disturbed 24-h activity rhythms: a population-based study","volume":"22","author":"Zuurbier","year":"2015","journal-title":"Eur J Neurol"},{"key":"10.1016\/j.jstrokecerebrovasdis.2024.107557_bib0070","article-title":"Effect of obstructive sleep apnea on cerebrovascular compliance and cerebral small vessel disease","volume":"16","author":"Lee","year":"2021","journal-title":"PLoS One"},{"key":"10.1016\/j.jstrokecerebrovasdis.2024.107557_bib0071","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1212\/WNL.0000000000013077","article-title":"Physiology and clinical relevance of enlarged perivascular spaces in the aging brain","volume":"98","author":"Bown","year":"2022","journal-title":"Neurology"},{"key":"10.1016\/j.jstrokecerebrovasdis.2024.107557_bib0072","doi-asserted-by":"crossref","DOI":"10.3389\/fnagi.2021.751369","article-title":"Sleep quality mediates the association between cerebral small vessel disease burden and frailty: a community-based study","volume":"13","author":"Zhao","year":"2021","journal-title":"Front Aging Neurosci"},{"key":"10.1016\/j.jstrokecerebrovasdis.2024.107557_bib0073","doi-asserted-by":"crossref","first-page":"765","DOI":"10.2147\/NSS.S357586","article-title":"Association of excessive daytime sleepiness with cerebral small vessel disease in community-dwelling older adults","volume":"14","author":"Zhao","year":"2022","journal-title":"Nat Sci Sleep"},{"key":"10.1016\/j.jstrokecerebrovasdis.2024.107557_bib0074","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1126\/science.1241224","article-title":"Sleep drives metabolite clearance from the adult brain","volume":"342","author":"Xie","year":"2013","journal-title":"Science"},{"key":"10.1016\/j.jstrokecerebrovasdis.2024.107557_bib0075","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1126\/science.aax5440","article-title":"Coupled electrophysiological, hemodynamic, and cerebrospinal fluid oscillations in human sleep","volume":"366","author":"Fultz","year":"2019","journal-title":"Science"},{"key":"10.1016\/j.jstrokecerebrovasdis.2024.107557_bib0076","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13024-016-0138-8","article-title":"Glymphatic distribution of CSF-derived apoE into brain is isoform specific and suppressed during sleep deprivation","volume":"11","author":"Achariyar","year":"2016","journal-title":"Mol Neurodegener"},{"key":"10.1016\/j.jstrokecerebrovasdis.2024.107557_bib0077","doi-asserted-by":"crossref","first-page":"4483","DOI":"10.1073\/pnas.1721694115","article-title":"\u03b2-Amyloid accumulation in the human brain after one night of sleep deprivation","volume":"115","author":"Shokri-Kojori","year":"2018","journal-title":"Proc Natl Acad Sci"},{"key":"10.1016\/j.jstrokecerebrovasdis.2024.107557_bib0078","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1038\/jcbfm.2014.256","article-title":"Aging impairs myogenic adaptation to pulsatile pressure in mouse cerebral arteries","volume":"35","author":"Springo","year":"2015","journal-title":"J Cereb Blood Flow Metab"},{"key":"10.1016\/j.jstrokecerebrovasdis.2024.107557_bib0079","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1161\/HYPERTENSIONAHA.108.126342","article-title":"Arterial pulse wave velocity and cognition with advancing age","volume":"53","author":"Elias","year":"2009","journal-title":"Hypertension"},{"key":"10.1016\/j.jstrokecerebrovasdis.2024.107557_bib0080","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41467-022-31257-9","article-title":"Periarteriolar spaces modulate cerebrospinal fluid transport into brain and demonstrate altered morphology in aging and Alzheimer's disease","volume":"13","author":"Mestre","year":"2022","journal-title":"Nat Commun"},{"key":"10.1016\/j.jstrokecerebrovasdis.2024.107557_bib0081","doi-asserted-by":"crossref","first-page":"2264","DOI":"10.1177\/0271678X21996175","article-title":"Glymphatic pathways in the gyrencephalic brain","volume":"41","author":"B\u00e8chet","year":"2021","journal-title":"J Cereb Blood Flow Metab"},{"key":"10.1016\/j.jstrokecerebrovasdis.2024.107557_bib0082","doi-asserted-by":"crossref","DOI":"10.3389\/fnagi.2021.625931","article-title":"Differential patterns of gyral and sulcal morphological changes during normal aging process","volume":"13","author":"Lin","year":"2021","journal-title":"Front Aging Neurosci"},{"key":"10.1016\/j.jstrokecerebrovasdis.2024.107557_bib0083","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1038\/s41586-022-05397-3","article-title":"Parenchymal border macrophages regulate the flow dynamics of the cerebrospinal fluid","volume":"611","author":"Drieu","year":"2022","journal-title":"Nature"},{"key":"10.1016\/j.jstrokecerebrovasdis.2024.107557_bib0084","doi-asserted-by":"crossref","first-page":"eabe4601","DOI":"10.1126\/sciadv.abe4601","article-title":"Aging-associated deficit in CCR7 is linked to worsened glymphatic function, cognition, neuroinflammation, and \u03b2-amyloid pathology","volume":"7","author":"Da Mesquita","year":"2021","journal-title":"Sci Adv"},{"key":"10.1016\/j.jstrokecerebrovasdis.2024.107557_bib0085","doi-asserted-by":"crossref","DOI":"10.15252\/embj.2018101064","article-title":"Systemic inflammation impairs microglial A\u03b2 clearance through NLRP 3 inflammasome","volume":"38","author":"Tejera","year":"2019","journal-title":"EMBO J"},{"key":"10.1016\/j.jstrokecerebrovasdis.2024.107557_bib0086","series-title":"Lipids, Beta-Secretase 1, and Alzheimer's Disease","first-page":"289","author":"Villamil-Ortiz","year":"2021"},{"key":"10.1016\/j.jstrokecerebrovasdis.2024.107557_bib0087","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1007\/s00401-011-0851-x","article-title":"Heterogeneity in age-related white matter changes","volume":"122","author":"Schmidt","year":"2011","journal-title":"Acta Neuropathol"},{"key":"10.1016\/j.jstrokecerebrovasdis.2024.107557_bib0088","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1093\/brain\/awab003","article-title":"Microglial activation and blood\u2013brain barrier permeability in cerebral small vessel disease","volume":"144","author":"Walsh","year":"2021","journal-title":"Brain"},{"key":"10.1016\/j.jstrokecerebrovasdis.2024.107557_bib0089","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1126\/science.abb8739","article-title":"Glymphatic failure as a final common pathway to dementia","volume":"370","author":"Nedergaard","year":"2020","journal-title":"Science"},{"key":"10.1016\/j.jstrokecerebrovasdis.2024.107557_bib0090","doi-asserted-by":"crossref","first-page":"4524","DOI":"10.1038\/s41467-020-18113-4","article-title":"Meningeal lymphatic dysfunction exacerbates traumatic brain injury pathogenesis","volume":"11","author":"Bolte","year":"2020","journal-title":"Nat Commun"},{"key":"10.1016\/j.jstrokecerebrovasdis.2024.107557_bib0091","doi-asserted-by":"crossref","first-page":"104","DOI":"10.5607\/en.2019.28.1.104","article-title":"Persistent malfunction of glymphatic and meningeal lymphatic drainage in a mouse model of subarachnoid hemorrhage","volume":"28","author":"Pu","year":"2019","journal-title":"Exp Neurobiol"},{"key":"10.1016\/j.jstrokecerebrovasdis.2024.107557_bib0092","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-020-63022-7","article-title":"Repetitive mild traumatic brain injury alters glymphatic clearance rates in limbic structures of adolescent female rats","volume":"10","author":"Christensen","year":"2020","journal-title":"Sci Rep"},{"key":"10.1016\/j.jstrokecerebrovasdis.2024.107557_bib0093","doi-asserted-by":"crossref","DOI":"10.1016\/j.expneurol.2019.113003","article-title":"Astrogliosis inhibition attenuates hydrocephalus by increasing cerebrospinal fluid reabsorption through the glymphatic system after germinal matrix hemorrhage","volume":"320","author":"Ding","year":"2019","journal-title":"Exp Neurol"},{"key":"10.1016\/j.jstrokecerebrovasdis.2024.107557_bib0094","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/S1474-4422(11)70307-6","article-title":"Cerebral microinfarcts: the invisible lesions","volume":"11","author":"Smith","year":"2012","journal-title":"Lancet Neurol"},{"key":"10.1016\/j.jstrokecerebrovasdis.2024.107557_bib0095","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1016\/S1474-4422(17)30196-5","article-title":"Detection, risk factors, and functional consequences of cerebral microinfarcts","volume":"16","author":"van Veluw","year":"2017","journal-title":"Lancet Neurol"},{"key":"10.1016\/j.jstrokecerebrovasdis.2024.107557_bib0096","doi-asserted-by":"crossref","first-page":"2870","DOI":"10.1523\/JNEUROSCI.2112-16.2017","article-title":"Focal solute trapping and global glymphatic pathway impairment in a murine model of multiple microinfarcts","volume":"37","author":"Wang","year":"2017","journal-title":"J Neurosci"},{"key":"10.1016\/j.jstrokecerebrovasdis.2024.107557_bib0097","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13041-020-00659-5","article-title":"Overexpression of Slit2 decreases neuronal excitotoxicity, accelerates glymphatic clearance, and improves cognition in a multiple microinfarcts model","volume":"13","author":"He","year":"2020","journal-title":"Mol Brain"},{"key":"10.1016\/j.jstrokecerebrovasdis.2024.107557_bib0098","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1038\/nrg3272","article-title":"The Notch signalling system: recent insights into the complexity of a conserved pathway","volume":"13","author":"Guruharsha","year":"2012","journal-title":"Nat Rev Genet"},{"key":"10.1016\/j.jstrokecerebrovasdis.2024.107557_bib0099","doi-asserted-by":"crossref","first-page":"1","DOI":"10.14806\/ej.24.0.921","article-title":"NOTCH3 and CADASIL syndrome: a genetic and structural overview","volume":"24","author":"Papakonstantinou","year":"2019","journal-title":"EMBnet J"},{"key":"10.1016\/j.jstrokecerebrovasdis.2024.107557_bib0100","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1186\/s12916-017-0778-8","article-title":"Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) as a model of small vessel disease: update on clinical, diagnostic, and management aspects","volume":"15","author":"Di Donato","year":"2017","journal-title":"BMC Med"},{"key":"10.1016\/j.jstrokecerebrovasdis.2024.107557_bib0101","doi-asserted-by":"crossref","first-page":"2533","DOI":"10.1093\/brain\/awh282","article-title":"Long-term prognosis and causes of death in CADASIL: a retrospective study in 411 patients","volume":"127","author":"Opherk","year":"2004","journal-title":"Brain"},{"key":"10.1016\/j.jstrokecerebrovasdis.2024.107557_bib0102","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1159\/000356982","article-title":"Dilated perivascular spaces in small-vessel disease: a study in CADASIL","volume":"37","author":"Yao","year":"2014","journal-title":"Cerebrovasc Dis"},{"key":"10.1016\/j.jstrokecerebrovasdis.2024.107557_bib0103","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1002\/ana.24512","article-title":"Pericytes are involved in the pathogenesis of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy","volume":"78","author":"Ghosh","year":"2015","journal-title":"Ann Neurol"},{"key":"10.1016\/j.jstrokecerebrovasdis.2024.107557_bib0104","doi-asserted-by":"crossref","DOI":"10.3389\/fnagi.2020.559603","article-title":"Dysfunction of the glymphatic system might be related to iron deposition in the normal aging brain","volume":"12","author":"Zhou","year":"2020","journal-title":"Front Aging Neurosci"},{"key":"10.1016\/j.jstrokecerebrovasdis.2024.107557_bib0105","doi-asserted-by":"crossref","first-page":"1750","DOI":"10.1161\/STROKEAHA.119.028812","article-title":"Deep gray matter iron deposition and its relationship to clinical features in cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy patients: a 7.0-T magnetic resonance imaging study","volume":"51","author":"Sun","year":"2020","journal-title":"Stroke"},{"key":"10.1016\/j.jstrokecerebrovasdis.2024.107557_bib0106","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1038\/s41582-019-0281-2","article-title":"Cerebral amyloid angiopathy and Alzheimer disease \u2014 one peptide, two pathways","volume":"16","author":"Greenberg","year":"2020","journal-title":"Nat Rev Neurol"},{"key":"10.1016\/j.jstrokecerebrovasdis.2024.107557_bib0107","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1046\/j.1365-2990.2003.00424.x","article-title":"Capillary and arterial cerebral amyloid angiopathy in Alzheimer's disease: defining the perivascular route for the elimination of amyloid \u03b2 from the human brain","volume":"29","author":"Preston","year":"2003","journal-title":"Neuropathol Appl Neurobiol"},{"key":"10.1016\/j.jstrokecerebrovasdis.2024.107557_bib0108","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1161\/STROKEAHA.117.016990","article-title":"Diagnosis of cerebral amyloid angiopathy: evolution of the Boston criteria","volume":"49","author":"Greenberg","year":"2018","journal-title":"Stroke"},{"key":"10.1016\/j.jstrokecerebrovasdis.2024.107557_bib0109","doi-asserted-by":"crossref","first-page":"2356","DOI":"10.1161\/STROKEAHA.120.032139","article-title":"Centrum semiovale perivascular space and amyloid deposition in spontaneous intracerebral hemorrhage","volume":"52","author":"Tsai","year":"2021","journal-title":"Stroke"},{"key":"10.1016\/j.jstrokecerebrovasdis.2024.107557_bib0110","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1177\/0271678X15620434","article-title":"Cerebral amyloid angiopathy severity is linked to dilation of juxtacortical perivascular spaces","volume":"36","author":"Van Veluw","year":"2016","journal-title":"J Cereb Blood Flow Metab"},{"key":"10.1016\/j.jstrokecerebrovasdis.2024.107557_bib0111","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1038\/s43587-022-00181-4","article-title":"Cerebral amyloid angiopathy is associated with glymphatic transport reduction and time-delayed solute drainage along the neck arteries","volume":"2","author":"Chen","year":"2022","journal-title":"Nat Aging"},{"key":"10.1016\/j.jstrokecerebrovasdis.2024.107557_bib0112","doi-asserted-by":"crossref","first-page":"2895","DOI":"10.1111\/ene.15450","article-title":"Glymphatic dysfunction correlates with severity of small vessel disease and cognitive impairment in cerebral amyloid angiopathy","volume":"29","author":"Xu","year":"2022","journal-title":"Eur J Neurol"}],"container-title":["Journal of Stroke and Cerebrovascular Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S105230572400003X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S105230572400003X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T06:59:09Z","timestamp":1760943549000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S105230572400003X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3]]},"references-count":112,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2024,3]]}},"alternative-id":["S105230572400003X"],"URL":"https:\/\/doi.org\/10.1016\/j.jstrokecerebrovasdis.2024.107557","relation":{},"ISSN":["1052-3057"],"issn-type":[{"value":"1052-3057","type":"print"}],"subject":[],"published":{"date-parts":[[2024,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The glymphatic system and cerebral small vessel disease","name":"articletitle","label":"Article Title"},{"value":"Journal of Stroke and Cerebrovascular Diseases","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jstrokecerebrovasdis.2024.107557","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"107557"}}