{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T03:15:10Z","timestamp":1787627710177,"version":"build-2736575974"},"reference-count":35,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2016,2,1]],"date-time":"2016-02-01T00:00:00Z","timestamp":1454284800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"},{"start":{"date-parts":[[2016,2,1]],"date-time":"2016-02-01T00:00:00Z","timestamp":1454284800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["jsm.jsexmed.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2016,2,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:sec>\n                  <jats:title>Introduction<\/jats:title>\n                  <jats:p>Impaired penile color Doppler ultrasound predicts major adverse cardiovascular (CV) events (MACE), particularly in men at low-risk. However, penile color Doppler ultrasound is not recommended in routine clinical checkups.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Aim<\/jats:title>\n                  <jats:p>To evaluate whether the difference between vascular and chronological age (\u0394age), as derived from the SCORE algorithm, is a predictor of MACE in subjects consulting for erectile dysfunction (ED) independently from other CV risk factors, including penile color Doppler ultrasound parameters.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>A consecutive series of 1687 male patients attending the Outpatient Clinic for ED for the first time was retrospectively studied. Among them, the SCORE was applicable in 49.9% (n = 841) men, of whom 87.9% (n = 739) were free from previous MACE and were analyzed.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Main Outcome Measures<\/jats:title>\n                  <jats:p>Vascular age was derived from the SCORE algorithm and the \u0394age was considered. Information on MACE was obtained through the City of Florence Registry Office.<\/jats:p>\n                  <jats:p>MACE were identified using the International Classification of Diseases, and fatal and nonfatal MACE were coded as 410\u2013414 (ischemic heart disease), 420\u2013429 (other heart diseases), or 798\u2013799 (sudden death from cardiac diseases), 430\u2013434 or 436\u2013438 (cerebrovascular disease), and 440 (peripheral arterial disease).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>\u0394age was associated with incident MACE. When dividing the population according to the median age (56 years), family history of CV diseases, and the presence of metabolic syndrome, the association between \u0394age and MACE was maintained only in low-risk subjects, even after adjusting for confounders [HR = 1.09(1.03\u20131.16), 1.05(1.01\u20131.10) and 1.08(1.01\u20131.16) for younger men, without CV family history or metabolic syndrome, respectively, all P &amp;lt; .05], including penile color Doppler ultrasound parameters.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>In subjects consulting for ED, \u0394age is associated with incident MACE, in particular in low-risk men. The prediction of MACE by \u0394age is independent from other risk factors including penile color Doppler ultrasound parameters, so it can be used as a costless and safe surrogate marker of penile vascular damage.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1016\/j.jsxm.2015.11.014","type":"journal-article","created":{"date-parts":[[2016,2,18]],"date-time":"2016-02-18T15:50:31Z","timestamp":1455810631000},"page":"200-208","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"title":["Vascular and Chronological Age in Men with Erectile Dysfunction: A Longitudinal Study"],"prefix":"10.1093","volume":"13","author":[{"given":"Giulia","family":"Rastrelli","sequence":"first","affiliation":[{"name":"Sexual Medicine and Andrology Unit \u00a0 \u00a0 , 50139 Florence, Viale Pieraccini 6 , Italy"},{"name":"Department of Experimental and Clinical Biomedical Sciences \u00a0 \u00a0 , 50139 Florence, Viale Pieraccini 6 , Italy"},{"name":"University of Florence \u00a0 \u00a0 , 50139 Florence, Viale Pieraccini 6 , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Corona","sequence":"additional","affiliation":[{"name":"Sexual Medicine and Andrology Unit \u00a0 \u00a0 , 50139 Florence, Viale Pieraccini 6 , Italy"},{"name":"Department of Experimental and Clinical Biomedical Sciences \u00a0 \u00a0 , 50139 Florence, Viale Pieraccini 6 , Italy"},{"name":"University of Florence \u00a0 \u00a0 , 50139 Florence, Viale Pieraccini 6 , Italy"},{"name":"Endocrinology Section \u00a0 , 40133 Bologna, Largo Nigrisoli 2 , Italy"},{"name":"Maggiore Hospital \u00a0 , 40133 Bologna, Largo Nigrisoli 2 , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edoardo","family":"Mannucci","sequence":"additional","affiliation":[{"name":"Diabetes Section Geriatric Unit \u00a0 \u00a0 , 50139 Florence, Via delle Oblate 1 , Italy"},{"name":"Department of Critical Care \u00a0 \u00a0 , 50139 Florence, Via delle Oblate 1 , Italy"},{"name":"University of Florence \u00a0 \u00a0 , 50139 Florence, Via delle Oblate 1 , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario","family":"Maggi","sequence":"additional","affiliation":[{"name":"Sexual Medicine and Andrology Unit \u00a0 \u00a0 , 50139 Florence, Viale Pieraccini 6 , Italy"},{"name":"Department of Experimental and Clinical Biomedical Sciences \u00a0 \u00a0 , 50139 Florence, Viale Pieraccini 6 , Italy"},{"name":"University of Florence \u00a0 \u00a0 , 50139 Florence, Viale Pieraccini 6 , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2016,2,1]]},"reference":[{"key":"2024032602344077900_bib1","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/S0022-5347(17)34871-1","article-title":"Impotence and its medical and psychosocial correlates: results of the Massachusetts Male Aging Study","volume":"151","author":"Feldman","year":"1994","journal-title":"J Urol"},{"key":"2024032602344077900_bib2","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/S0090-4295(00)00614-2","article-title":"Modifiable risk factors and erectile dysfunction: can lifestyle changes modify risk?","volume":"56","author":"Derby","year":"2000","journal-title":"Urology"},{"key":"2024032602344077900_bib3","doi-asserted-by":"crossref","first-page":"2341","DOI":"10.1097\/01.ju.0000125198.32936.38","article-title":"The prevalence of hypertension, hyperlipidemia, diabetes mellitus and depression in men with erectile dysfunction","volume":"171","author":"Seftel","year":"2004","journal-title":"J Urol"},{"key":"2024032602344077900_bib4","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1111\/jsm.12832","article-title":"Prevalence of endocrine and metabolic disorders in subjects with erectile dysfunction: a comparative study","volume":"12","author":"Maseroli","year":"2015","journal-title":"J Sex Med"},{"key":"2024032602344077900_bib5","doi-asserted-by":"crossref","first-page":"2065","DOI":"10.1111\/jsm.12601","article-title":"Gruppo di studio SUBITO-DE. 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