{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T04:39:26Z","timestamp":1785818366236,"version":"3.56.0"},"reference-count":42,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"},{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100003946","name":"European Society for Sexual Medicine","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003946","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jsm.jsexmed.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2016,1,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:sec>\n                  <jats:title>Introduction<\/jats:title>\n                  <jats:p>Novel effective therapeutic strategies are necessary for treating erectile dysfunction secondary to cavernous nerve injury (CNI).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Aim<\/jats:title>\n                  <jats:p>To functionally evaluate the benefits of long-term oral treatment with a phosphodiesterase type 5 inhibitor on the potential capacity of intracavernosal cell therapy to recover erectile function after CNI.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Bilateral crush CNI (BCNI) was produced in anesthetized male rats. After BCNI, rats were treated with the phosphodiesterase type 5 inhibitor tadalafil (TAD; 5 mg\/kg\/d orally; BCNI + TAD), a single intracavernosal injection of bone marrow\u2013derived mesenchymal stem cells (BMSCs; BCNI + BMSC), or dual therapy (BCNI + BMSC + TAD). Ex vivo function of the corpus cavernosum (CC) and in vivo intracavernosal pressure responses to CN electrical stimulation were evaluated 4 weeks after BCNI. Trichrome staining and terminal 2\u2032-deoxyuridine-5\u2032-triphosphate nick-end labeling assay were used for fibrosis and apoptosis determination, respectively, in the CC.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Main Outcome Measures<\/jats:title>\n                  <jats:p>In vivo erectile responses in anesthetized rats, ex vivo evaluation of endothelium-dependent relaxation, neurogenic relaxation and neurogenic contraction in CC strips, and histologic evaluation of fibrosis and apoptosis in cavernosal tissue.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>BCNI resulted in a marked decrease of erectile responses that were partly recovered in the BCNI + TAD and BCNI + BMSC groups. Complete recovery of erectile function was achieved only in the BCNI + BMSC + TAD group. Endothelium-dependent and nitric oxide donor-induced relaxations of the CC were not altered by BCNI or the treatments. BCNI resulted in enhanced neurogenic adrenergic contractions and impaired nitrergic relaxations of the CC. The BCNI + TAD group displayed diminished neurogenic contractions, whereas the BCNI + TAD and BCNI + BMSC groups showed partly recovered nitrergic responses. In the BCNI + BMSC + TAD group, neurogenic contractions were decreased and nitrergic relaxations were normalized. Cavernosal apoptosis and fibrosis were similarly prevented in the BCNI + TAD, BCNI + BMSC, and BCNI + BMSC + TAD groups.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>A dual strategy combining the intracavernosal injection of BMSCs and oral administration of TAD was superior to individual approaches in normalizing neurogenic control of cavernosal tone and preserving erectile function after CNI, suggesting the potential of this dual strategy in the future management of erectile dysfunction after radical prostatectomy.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1016\/j.jsxm.2015.12.001","type":"journal-article","created":{"date-parts":[[2016,1,9]],"date-time":"2016-01-09T03:20:40Z","timestamp":1452309640000},"page":"1-11","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":21,"title":["Dual Strategy with Oral Phosphodiesterase Type 5 Inhibition and Intracavernosal Implantation of Mesenchymal Stem Cells Is Superior to Individual Approaches in the Recovery of Erectile and Cavernosal Functions After Cavernous Nerve Injury in Rats"],"prefix":"10.1093","volume":"13","author":[{"given":"Juan I.","family":"Mart\u00ednez-Salamanca","sequence":"first","affiliation":[{"name":"Servicio de Urolog\u00eda \u00a0 , Madrid, , Spain"},{"name":"Hospital Universitario Puerta de Hierro \u00a0 , Madrid, , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mercedes","family":"Zurita","sequence":"additional","affiliation":[{"name":"Servicio de Neurocirug\u00eda \u00a0 , Madrid, , Spain"},{"name":"Hospital Universitario Puerta de Hierro \u00a0 , Madrid, , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carla","family":"Costa","sequence":"additional","affiliation":[{"name":"Department of Biochemistry \u00a0 \u00a0 , Porto, , Portugal"},{"name":"Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade \u00a0 \u00a0 , Porto, , Portugal"},{"name":"Universidade do Porto \u00a0 \u00a0 , Porto, , Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo","family":"Mart\u00ednez-Salamanca","sequence":"additional","affiliation":[{"name":"Unidad de Investigaci\u00f3n Cardiovascular (IRYCIS\/UFV) \u00a0 , Madrid, , Spain"},{"name":"Hospital Universitario Ram\u00f3n y Cajal \u00a0 , Madrid, , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Argentina","family":"Fern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Unidad de Investigaci\u00f3n Cardiovascular (IRYCIS\/UFV) \u00a0 , Madrid, , Spain"},{"name":"Hospital Universitario Ram\u00f3n y Cajal \u00a0 , Madrid, , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Castela","sequence":"additional","affiliation":[{"name":"Department of Biochemistry \u00a0 \u00a0 , Porto, , Portugal"},{"name":"Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade \u00a0 \u00a0 , Porto, , Portugal"},{"name":"Universidade do Porto \u00a0 \u00a0 , Porto, , Portugal"},{"name":"Institute for Molecular and Cell Biology of the University of Porto (IBMC-UP) , Porto, , Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jes\u00fas","family":"Vaquero","sequence":"additional","affiliation":[{"name":"Servicio de Neurocirug\u00eda \u00a0 , Madrid, , Spain"},{"name":"Hospital Universitario Puerta de Hierro \u00a0 , Madrid, , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joaqu\u00edn","family":"Carballido","sequence":"additional","affiliation":[{"name":"Servicio de Urolog\u00eda \u00a0 , Madrid, , Spain"},{"name":"Hospital Universitario Puerta de Hierro \u00a0 , Madrid, , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier","family":"Angulo","sequence":"additional","affiliation":[{"name":"Unidad de Investigaci\u00f3n Cardiovascular (IRYCIS\/UFV) \u00a0 , Madrid, , Spain"},{"name":"Hospital Universitario Ram\u00f3n y Cajal \u00a0 , Madrid, , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2016,1,1]]},"reference":[{"key":"2024032602341750800_bib1","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/S0022-5347(05)68578-3","article-title":"Potency, continence and complication rates in 1,870 consecutive radical retropubic prostatectomies","volume":"162","author":"Catalona","year":"1999","journal-title":"J Urol"},{"key":"2024032602341750800_bib2","doi-asserted-by":"crossref","first-page":"1929","DOI":"10.1016\/S0022-5347(05)66921-2","article-title":"Factors predicting recovery of erections after radical prostatectomy","volume":"164","author":"Rabbani","year":"2000","journal-title":"J Urol"},{"key":"2024032602341750800_bib3","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1177\/107327480601300302","article-title":"The role of prevalence in the diagnosis of prostate cancer","volume":"13","author":"Delongchamps","year":"2006","journal-title":"Cancer Control"},{"key":"2024032602341750800_bib4","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1016\/S0140-6736(14)62038-9","article-title":"Global surveillance of cancer survival 1995\u20132009: analysis of individual data for 25,676,887 patients from 279 population based registries in 67 countries (CONCORD-2)","volume":"385","author":"Allemani","year":"2015","journal-title":"Lancet"},{"key":"2024032602341750800_bib5","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1111\/j.1743-6109.2007.00519.x","article-title":"FK506 and sildenafil promote erectile function recovery after cavernous nerve injury through antioxidative mechanisms","volume":"4","author":"Lagoda","year":"2007","journal-title":"J Sex Med"},{"key":"2024032602341750800_bib6","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1111\/j.1743-6109.2008.00794.x","article-title":"The functional and structural consequences of cavernous nerve injury are ameliorated by sildenafil citrate","volume":"5","author":"Mulhall","year":"2008","journal-title":"J Sex Med"},{"key":"2024032602341750800_bib7","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/j.urology.2006.05.011","article-title":"Vardenafil prevents fibrosis and loss of corporal smooth muscle that occurs after bilateral cavernosal nerve resection in the rat","volume":"68","author":"Ferrini","year":"2006","journal-title":"Urology"},{"key":"2024032602341750800_bib8","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1111\/j.1464-410X.2007.07223.x","article-title":"Chronic daily tadalafil prevents the corporal fibrosis and veno-occlusive dysfunction that occurs after cavernosal nerve resection","volume":"101","author":"Kovanecz","year":"2008","journal-title":"BJU Int"},{"key":"2024032602341750800_bib9","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1002\/j.1939-4640.2003.tb02668.x","article-title":"Cavernous neurotomy causes hypoxia and fibrosis in rat corpus cavernosum","volume":"24","author":"Leungwattanakij","year":"2003","journal-title":"J Androl"},{"key":"2024032602341750800_bib10","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1097\/01.ju.0000048974.47461.50","article-title":"Penile weight and cell subtype specific changes in a post-radical prostatectomy model of erectile dysfunction","volume":"169","author":"User","year":"2003","journal-title":"J Urol"},{"key":"2024032602341750800_bib11","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1111\/j.1743-6109.2005.00158.x","article-title":"Functional sequelae of cavernous nerve injury in the rat. Is there model dependency?","volume":"3","author":"Mullerad","year":"2006","journal-title":"J Sex Med"},{"key":"2024032602341750800_bib12","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.expneurol.2007.05.011","article-title":"Reduced efficacy of nitrergic neurotransmission exacerbates erectile dysfunction alter penile nerve injury despite axonal regeneration","volume":"207","author":"Nangle","year":"2007","journal-title":"Exp Neurol"},{"key":"2024032602341750800_bib13","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1159\/000127335","article-title":"Histopathologically proven prevention of post-prostatectomy cavernosal fibrosis with sildenafil","volume":"80","author":"Iacono","year":"2008","journal-title":"Urol Int"},{"key":"2024032602341750800_bib14","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1038\/ijir.2008.33","article-title":"Randomized, double-blind, placebo-controlled study of postoperative nightly sildenafil citrate for the prevention of erectile dysfunction after bilateral nerve-sparing radical prostatectomy","volume":"20","author":"Padma-Nathan","year":"2008","journal-title":"Int J Impot Res"},{"key":"2024032602341750800_bib15","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1016\/j.eururo.2008.06.083","article-title":"Effect of nightly versus on-demand vardenafil on recovery of erectile function in men following bilateral nerve-sparing radical prostatectomy","volume":"54","author":"Montorsi","year":"2008","journal-title":"Eur Urol"},{"key":"2024032602341750800_bib16","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1016\/j.eururo.2013.09.051","article-title":"Effects of tadalafil treatment on erectile function recovery following bilateral nerve-sparing radical prostatectomy: a randomized placebo-controlled study (REACTT)","volume":"65","author":"Montorsi","year":"2014","journal-title":"Eur Urol"},{"key":"2024032602341750800_bib17","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1111\/j.1464-410X.2003.05057.x","article-title":"The effect of neural embryonic stem cell therapy in a rat model of cavernosal nerve injury","volume":"94","author":"Bochinski","year":"2004","journal-title":"BJU Int"},{"key":"2024032602341750800_bib18","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1038\/sj.ijir.3901434","article-title":"Injection of skeletal muscle-derived cells into the penis improves erectile function","volume":"18","author":"Kim","year":"2006","journal-title":"Int J Impot Res"},{"key":"2024032602341750800_bib19","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1016\/j.eururo.2008.09.059","article-title":"Apoptosis and effects of intracavernous bone marrow cell injection in a rat model of postprostatectomy erectile dysfunction","volume":"56","author":"Fall","year":"2009","journal-title":"Eur Urol"},{"key":"2024032602341750800_bib20","doi-asserted-by":"crossref","first-page":"3331","DOI":"10.1111\/j.1743-6109.2010.01875.x","article-title":"Injections of adipose tissue-derived stem cells and stem cell lysate improve recovery of erectile function in a rat model of cavernous nerve injury","volume":"7","author":"Albersen","year":"2010","journal-title":"J Sex Med"},{"key":"2024032602341750800_bib21","doi-asserted-by":"crossref","first-page":"1560","DOI":"10.1016\/j.juro.2010.05.088","article-title":"Transplantation of nonhematopoietic adult bone marrow stem\/progenitor cells isolated by p75 nerve growth factor receptor into the penis rescues erectile function in a rat model of cavernous nerve injury","volume":"184","author":"Kendirci","year":"2010","journal-title":"J Urol"},{"key":"2024032602341750800_bib22","doi-asserted-by":"crossref","first-page":"1509.e1","DOI":"10.1016\/j.urology.2010.12.076","article-title":"Cavernous nerve repair with allogenic adipose matrix and autologous adipose-derived stem cells","volume":"77","author":"Lin","year":"2011","journal-title":"Urology"},{"key":"2024032602341750800_bib23","doi-asserted-by":"crossref","first-page":"351","DOI":"10.5966\/sctm.2014-0161","article-title":"Comparative study of autologous stromal vascular fraction and adipose-derived stem cells for erectile function recovery in a rat model of cavernous nerve injury","volume":"4","author":"You","year":"2015","journal-title":"Stem Cells Transl Med"},{"key":"2024032602341750800_bib24","doi-asserted-by":"crossref","first-page":"274","DOI":"10.2174\/156720110793360595","article-title":"Phosphodiesterase inhibitor tadalafil acts on endothelial progenitor cells by CXCR4 signalling","volume":"7","author":"Foresta","year":"2010","journal-title":"Curr Drug Deliv"},{"key":"2024032602341750800_bib25","doi-asserted-by":"crossref","first-page":"878397","DOI":"10.1155\/2014\/878397","article-title":"Stimulation of neural stem cell proliferation by inhibition of phosphodiesterase 5","volume":"2014","author":"Santos","year":"2014","journal-title":"Stem Cells Int"},{"key":"2024032602341750800_bib26","doi-asserted-by":"crossref","first-page":"H1278","DOI":"10.1152\/ajpheart.00685.2006","article-title":"Mesenchymal stem cells alone or ex vivo gene modified with endothelial nitric oxide synthase reverse age-associated erectile dysfunction","volume":"292","author":"Bivalacqua","year":"2007","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"2024032602341750800_bib27","doi-asserted-by":"crossref","first-page":"2814","DOI":"10.1111\/j.1743-6109.2012.02913.x","article-title":"Separate or combined treatments with daily sildenafil, molsidomine, or muscle derived stem cells, prevent erectile dysfunction in a rat model of cavernous nerve damage","volume":"9","author":"Kovanecz","year":"2012","journal-title":"J Sex Med"},{"key":"2024032602341750800_bib28","doi-asserted-by":"crossref","first-page":"1108.e7","DOI":"10.1016\/j.urology.2013.01.022","article-title":"Combined therapeutic effect of udenafil and adipose-derived stem cell (ADSC)\/brain-derived neurotrophic factor (BDNF)-membrane system in a rat model of cavernous nerve injury","volume":"81","author":"Jeong","year":"2013","journal-title":"Urology"},{"key":"2024032602341750800_bib29","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.neulet.2005.12.072","article-title":"Cell therapy using bone marrow stromal cells in chronic paraplegic rats: systemic or local administration?","volume":"398","author":"Vaquero","year":"2006","journal-title":"Neurosci Lett"},{"key":"2024032602341750800_bib30","doi-asserted-by":"crossref","first-page":"560","DOI":"10.4111\/kju.2011.52.8.560","article-title":"Spontaneous recovery of cavernous nerve crush injury","volume":"52","author":"Kim","year":"2011","journal-title":"Korean J Urol"},{"key":"2024032602341750800_bib31","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1111\/j.1743-6109.2008.01088.x","article-title":"The novel antioxidant, AC3056 (2,6-di-t-butyl-4-((dimethyl-4-methoxyphenylsilyl)methyloxy)phenol), reverses erectile dysfunction in diabetic rats and improves NO-mediated responses in penile tissue from diabetic men","volume":"6","author":"Angulo","year":"2009","journal-title":"J Sex Med"},{"key":"2024032602341750800_bib32","doi-asserted-by":"crossref","first-page":"2681","DOI":"10.1111\/j.1743-6109.2010.01710.x","article-title":"Nebivolol dilates human penile arteries and reverses erectile dysfunction in diabetic rats through enhancement of nitric oxide signaling","volume":"7","author":"Angulo","year":"2010","journal-title":"J Sex Med"},{"key":"2024032602341750800_bib33","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1111\/bph.12143","article-title":"Ca2+-activated K+ channel (KCa) stimulation improves relaxant capacity of PDE5 inhibitors in human penile arteries and recovers the reduced efficacy of PDE5 inhibition in diabetes","volume":"169","author":"Gonz\u00e1lez-Corrochano","year":"2013","journal-title":"Br J Pharmacol"},{"key":"2024032602341750800_bib34","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1111\/jsm.12801","article-title":"Nitrergic function is lost but endothelial function is preserved in the corpus cavernosum and penile resistance arteries of men after radical prostatectomy","volume":"12","author":"Mart\u00ednez-Salamanca","year":"2015","journal-title":"J Sex Med"},{"key":"2024032602341750800_bib35","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1089\/scd.2011.0303","article-title":"Stem cell therapy for erectile dysfunction: a critical review","volume":"21","author":"Lin","year":"2012","journal-title":"Stem Cells Dev"},{"key":"2024032602341750800_bib36","doi-asserted-by":"crossref","first-page":"1150","DOI":"10.1038\/sj.jcbfm.9600112","article-title":"Activation of the PI3-K\/Akt pathway mediates cGMP enhanced-neurogenesis in the adult progenitor cells derived from the subventricular zone","volume":"25","author":"Wang","year":"2005","journal-title":"J Cereb Blood Flow Metab"},{"key":"2024032602341750800_bib37","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1038\/sj.ijir.3901465","article-title":"Circulating progenitor cells and endothelial function after chronic tadalafil treatment in subjects with erectile dysfunction","volume":"18","author":"Foresta","year":"2006","journal-title":"Int J Impot Res"},{"key":"2024032602341750800_bib38","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/j.brainres.2006.08.028","article-title":"Tadalafil, a long-acting type 5 phosphodiesterase isoenzyme inhibitor, improves neurological functional recovery in a rat model of embolic stroke","volume":"1118","author":"Zhang","year":"2006","journal-title":"Brain Res"},{"key":"2024032602341750800_bib39","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.1161\/ATVBAHA.109.201327","article-title":"A phosphodiesterase-5 inhibitor vardenafil enhances angiogenesis through a protein kinase G-dependent hypoxia-inducible factor-1\/vascular endotelial growth factor pathway","volume":"30","author":"Sahara","year":"2010","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"2024032602341750800_bib40","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1007\/s10456-011-9211-7","article-title":"Cyclic GMP protects endothelial progenitor cells from oxidative stress","volume":"14","author":"Curatola","year":"2011","journal-title":"Angiogenesis"},{"key":"2024032602341750800_bib41","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.urology.2011.09.009","article-title":"Clinical outcomes of intracavernosal injection in postprostatectomy patients: a single-center experience","volume":"79","author":"Domes","year":"2012","journal-title":"Urology"},{"key":"2024032602341750800_bib42","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1096\/fj.07-9574LSF","article-title":"Dose translation from animal to human studies revisited","volume":"22","author":"Reagan-Shaw","year":"2007","journal-title":"FASEB J"}],"container-title":["The Journal of Sexual Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1743609515000107?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1743609515000107?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/jsm\/article-pdf\/13\/1\/1\/48193136\/jsm_13_1_1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jsm\/article-pdf\/13\/1\/1\/48193136\/jsm_13_1_1.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,26]],"date-time":"2024-03-26T02:40:42Z","timestamp":1711420842000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jsm\/article\/13\/1\/1\/6940219"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,1,1]]},"references-count":42,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2016,1,1]]},"published-print":{"date-parts":[[2016,1,1]]}},"URL":"https:\/\/doi.org\/10.1016\/j.jsxm.2015.12.001","relation":{},"ISSN":["1743-6109","1743-6095"],"issn-type":[{"value":"1743-6109","type":"electronic"},{"value":"1743-6095","type":"print"}],"subject":[],"published-other":{"date-parts":[[2016,1]]},"published":{"date-parts":[[2016,1,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Dual Strategy With Oral Phosphodiesterase Type 5 Inhibition and Intracavernosal Implantation of Mesenchymal Stem Cells Is Superior to Individual Approaches in the Recovery of Erectile and Cavernosal Functions After Cavernous Nerve Injury in Rats","name":"articletitle","label":"Article Title"},{"value":"The Journal of Sexual Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jsxm.2015.12.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2016 International Society for Sexual Medicine. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}