{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T19:23:24Z","timestamp":1787167404234,"version":"build-2736575974"},"reference-count":24,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2016,4,1]],"date-time":"2016-04-01T00:00:00Z","timestamp":1459468800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"},{"start":{"date-parts":[[2016,4,1]],"date-time":"2016-04-01T00:00:00Z","timestamp":1459468800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100004312","name":"Eli Lilly and Company","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004312","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jsm.jsexmed.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2016,4,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction and Aim<\/jats:title>\n                    <jats:p>The multicenter, randomized, double-blind, double-dummy, placebo-controlled REACTT trial suggested that treatment with tadalafil once daily (OaD) started early after bilateral nerve-sparing radical prostatectomy (nsRP) for prostate cancer may contribute to erectile function (EF)-recovery, which was predefined as achieving an International Index of Erectile Function (IIEF)-EF score \u226522. Here, we report descriptive post-hoc analyses, using the more strict definition for EF-recovery of returning back to the pre-surgery IIEF-EF-level (\u201cback-to-baseline analysis\u201d).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>REACTT included 422 men &amp;lt;68 years with adenocarcinoma of the prostate and preoperative IIEF-EF \u226522 who underwent nsRP at 50 centers from 9 European countries and Canada. Patients were randomized post-nsRP 1:1:1 to 9-month double-blind treatment (DBT) with tadalafil 5 mg OaD (n = 139), tadalafil 20 mg on-demand (pro-re-nata, PRN; n = 142), or placebo (n = 141), followed by 6-week drug-free washout (DFW) and 3-month open-label tadalafil OaD treatment (OLT).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Main Outcome Measures<\/jats:title>\n                    <jats:p>Proportion of patients returning to their preoperative IIEF-EF category (22\u201325 or \u226526) at the end of DBT, DFW, and OLT.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Overall, 92.4% of patients had pre-surgery (baseline) IIEF-EF scores \u226526 (tadalafil OaD 94.2%, PRN 91.6%, placebo 91.5%), 7.4% had IIEF-EF 22\u201325. At the end of DBT, 22.3% of patients on tadalafil OaD had achieved \u201cback-to-baseline\u201d IIEF-EF, compared with 11.3% on tadalafil PRN and 7.8% on placebo. Of all 58 patients \u201cback-to-baseline\u201d at the end of DBT, only 1 PRN-group patient had started from a baseline IIEF-EF &amp;lt;26. The treatment-group difference at the end of DBT was not maintained after DFW. After 3 months of OLT with tadalafil OaD, the proportion of patients with \u201cback-to-baseline\u201d IIEF-EF had almost doubled in all 3 groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Changing the definition for EF-recovery from IIEF-EF \u226522 to the more strict definition of \u201creturning back-to-baseline IIEF-EF\u201d had no major impact. Tadalafil OaD started early after nsRP improved drug-assisted EF, but had no effect on unassisted EF following treatment cessation after 9 months.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1016\/j.jsxm.2016.01.022","type":"journal-article","created":{"date-parts":[[2016,3,25]],"date-time":"2016-03-25T05:15:29Z","timestamp":1458882929000},"page":"679-683","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":21,"title":["Effects of Tadalafil Once-Daily or On-Demand vs Placebo on Return to Baseline Erectile Function After Bilateral Nerve-Sparing Radical Prostatectomy \u2013 Results from a Randomized Controlled Trial (REACTT)"],"prefix":"10.1093","volume":"13","author":[{"given":"John P.","family":"Mulhall","sequence":"first","affiliation":[{"name":"Department of Urology \u00a0 , New York, NY , USA"},{"name":"Memorial Sloan-Kettering Cancer Center \u00a0 , New York, NY , 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A.","family":"Probst","sequence":"additional","affiliation":[{"name":"Department of Urology \u00a0 , Homburg, Saar , Germany"},{"name":"Saarland University Medical Center \u00a0 , Homburg, Saar , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carsten","family":"Henneges","sequence":"additional","affiliation":[{"name":"Global Statistical Sciences \u00a0 \u00a0 , Bad Homburg, , Germany"},{"name":"EU Statistics \u00a0 \u00a0 , Bad Homburg, , Germany"},{"name":"Lilly Deutschland GmbH \u00a0 \u00a0 , Bad Homburg, , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianluca","family":"d'Anzeo","sequence":"additional","affiliation":[{"name":"Medical Department \u00a0 , Florence, , Italy"},{"name":"Eli Lilly S.p.A. \u00a0 , Florence, , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Rossi","sequence":"additional","affiliation":[{"name":"Medical Department \u00a0 , Florence, , Italy"},{"name":"Eli Lilly 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