{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T17:37:59Z","timestamp":1791999479921,"version":"4.4.0"},"reference-count":14,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2016,4,1]],"date-time":"2016-04-01T00:00:00Z","timestamp":1459468800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"},{"start":{"date-parts":[[2016,4,1]],"date-time":"2016-04-01T00:00:00Z","timestamp":1459468800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["jsm.jsexmed.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2016,4,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:sec>\n                  <jats:title>Introduction<\/jats:title>\n                  <jats:p>Intralesional injection of collagenase clostridium histolyticum (CCH) for Peyronie\u2019s disease (PD) can result in serious adverse events such as hematoma formation and corporal rupture.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Aim<\/jats:title>\n                  <jats:p>To investigate the prevalence of complications from CCH and management trends among CCH prescribers.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>A survey was sent to all 693 members of the Sexual Medicine Society of North America (SMSNA) with valid email addresses. Responders were asked to participate if they were prescribers of CCH. Data regarding prescriber experience with CCH, procedural preferences, and rates and management strategies of complications were collected.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Main Outcome Measure<\/jats:title>\n                  <jats:p>One hundred SMSNA members completed the survey, with 36%, 23%, and 41% of responders having performed \u226410, 10 to 20, and &amp;gt;20 CCH injections, respectively.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Of the responders, 94% reported hematomas in &amp;lt;25% of patients, with 63% preferring to observe and 37% treated with a combination of observation, application of a compressive dressing, and\/or drainage of the hematoma. Corporal ruptures were encountered by 34% of physicians at a median of 5 days (0.5 to 30 days) from the last CCH injection. Rupture was located over the treated plaque in 84% of cases, and surgical intervention was the preferred management option by 67% of members. A distal circumcising degloving incision was used in 76% of cases, and 62% of responders reported the quality of tissue to be worse than would be expected with a non-CCH penile fracture. There were no significant differences in erectile function, ability to have intercourse, change in penile curvature, and patient satisfaction among patients who underwent surveillance vs surgery. One observed patient developed a penile abscess.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>A wide variation exists among SMSNA members\u2019 strategies to prevent and manage complications of CCH. One in 3 prescribers reported encountering a corporal rupture during CCH therapy, and it is currently undetermined if there is a benefit of surgery vs conservative management.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1016\/j.jsxm.2016.02.105","type":"journal-article","created":{"date-parts":[[2016,3,25]],"date-time":"2016-03-25T09:15:29Z","timestamp":1458897329000},"page":"684-689","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":38,"title":["Results of SMSNA Survey Regarding Complications Following Intralesional Injection Therapy with Collagenase Clostridium Histolyticum for Peyronie\u2019s Disease"],"prefix":"10.1093","volume":"13","author":[{"given":"Faysal A.","family":"Yafi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Anaissie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Zurawin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suresh C.","family":"Sikka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wayne J.G.","family":"Hellstrom","sequence":"additional","affiliation":[{"name":"Department of Urology \u00a0 , New Orleans, LA , USA"},{"name":"Tulane University School of Medicine \u00a0 , New Orleans, LA , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2016,4,1]]},"reference":[{"key":"2024032602342417100_bib1","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1016\/j.ucl.2007.08.017","article-title":"Peyronie's Disease","volume":"34","author":"Taylor","year":"2007","journal-title":"Urol Clin North Am"},{"key":"2024032602342417100_bib2","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1111\/andr.12058","article-title":"Therapeutic advances in the treatment of Peyronie's disease","volume":"3","author":"Yafi","year":"2015","journal-title":"Andrology"},{"key":"2024032602342417100_bib3","doi-asserted-by":"crossref","first-page":"2221","DOI":"10.1111\/j.1743-6109.2008.00941.x","article-title":"Surgical correction of Peyronie's disease via tunica albuginea plication or partial plaque excision with pericardial graft: long-term follow up","volume":"5","author":"Taylor","year":"2008","journal-title":"J Sex Med"},{"key":"2024032602342417100_bib4","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1111\/j.1743-6109.2010.02102.x","article-title":"Five-year follow-up of Peyronie's graft surgery: outcomes and patient satisfaction","volume":"8","author":"Chung","year":"2011","journal-title":"J Sex Med"},{"key":"2024032602342417100_bib5","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1038\/aja.2012.92","article-title":"Surgery for Peyronie's disease","volume":"15","author":"Levine","year":"2013","journal-title":"Asian J Androl"},{"key":"2024032602342417100_bib6","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.juro.2013.01.087","article-title":"Clinical efficacy, safety and tolerability of collagenase Clostridium histolyticum for the treatment of peyronie disease in 2 large double-blind, randomized, placebo controlled phase 3 studies","volume":"190","author":"Gelbard","year":"2013","journal-title":"J Urol"},{"key":"2024032602342417100_bib7"},{"key":"2024032602342417100_bib8","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1111\/j.1743-6109.2011.02519.x","article-title":"Combination of penile traction, intralesional verapamil, and oral therapies for Peyronie's disease","volume":"9","author":"Abern","year":"2012","journal-title":"J Sex Med"},{"key":"2024032602342417100_bib9","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1016\/j.juro.2015.03.092","article-title":"The effect of duration of penile traction therapy in patients undergoing intralesional injection therapy for Peyronie's disease","volume":"194","author":"Yafi","year":"2015","journal-title":"J Urol"},{"key":"2024032602342417100_bib10","first-page":"491","article-title":"Penile fracture: long-term results of surgical and conservative management","volume":"71","author":"Gamal","year":"2011","journal-title":"J Trauma"},{"key":"2024032602342417100_bib11","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/S0022-5347(01)66578-9","article-title":"Penile fractures: evaluation, therapeutic approaches and long-term results","volume":"155","author":"Asgari","year":"1996","journal-title":"J Urol"},{"key":"2024032602342417100_bib12","first-page":"121","article-title":"Fracture of the penis: management and long-term results of surgical treatment. 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