{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T07:57:33Z","timestamp":1788508653568,"version":"build-2803163510"},"reference-count":35,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2016,5,1]],"date-time":"2016-05-01T00:00:00Z","timestamp":1462060800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"},{"start":{"date-parts":[[2016,5,1]],"date-time":"2016-05-01T00:00:00Z","timestamp":1462060800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100019491","name":"National Natural Sciences Foundation of China","doi-asserted-by":"publisher","award":["81300477"],"award-info":[{"award-number":["81300477"]}],"id":[{"id":"10.13039\/501100019491","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jsm.jsexmed.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2016,5,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>For patients with diabetes, erectile dysfunction (ED) is common and greatly affects quality of life. However, these patients often exhibit a poor response to first-line oral phosphodiesterase type 5 inhibitors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To investigate whether taurine, a sulfur-containing amino acid, affects diabetic ED (DED).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Type 1 diabetes mellitus was induced in male rats by using streptozotocin. After 12 weeks, an apomorphine test was conducted to confirm DED. Only rats with DED were administered taurine or vehicle for 4 weeks. Age-matched nondiabetic rats were administered saline intraperitoneally for 4 weeks.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main Outcome Measures<\/jats:title><jats:p>Erectile function was evaluated by electrical stimulation of the cavernous nerve. Histologic and molecular alterations of the corpus cavernosum also were analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Erectile function was significantly reduced in the diabetic rats compared with in the nondiabetic rats, and was improved in the diabetic rats treated with taurine. The corpus cavernosum of the rats with DED exhibited severe fibrosis and decreased smooth muscle content. Deposition of extracellular matrix proteins was increased in the diabetic rats, while expression of endothelial nitric oxide synthase\/cyclic guanosine monophosphate\/nitric oxide pathway\u2013related proteins was reduced. Taurine supplementation ameliorated erectile response as well as histologic and molecular alterations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Taurine supplementation improves erectile function in rats with DED probably by potential antifibrotic activity. This finding provides evidence for a potential new therapy for DED.<\/jats:p><\/jats:sec>","DOI":"10.1016\/j.jsxm.2016.02.164","type":"journal-article","created":{"date-parts":[[2016,3,24]],"date-time":"2016-03-24T07:33:57Z","timestamp":1458804837000},"page":"778-785","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":34,"title":["Taurine Supplementation Improves Erectile Function in Rats with Streptozotocin-induced Type 1 Diabetes via Amelioration of Penile Fibrosis and Endothelial Dysfunction"],"prefix":"10.1093","volume":"13","author":[{"given":"Yajun","family":"Ruan","sequence":"first","affiliation":[{"name":"Department of Urology , , Hubei , China"},{"name":"Tongji Hospital , , Hubei , China"},{"name":"Tongji Medical College , , Hubei , China"},{"name":"Huazhong University of Science and Technology , , Hubei , China"},{"name":"Institute of Urology , , Hubei , China"},{"name":"Tongji Hospital , , Hubei , China"},{"name":"Tongji Medical College , , Hubei , China"},{"name":"Huazhong University of Science and Technology , , Hubei , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingchao","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Urology , , Hubei , China"},{"name":"Tongji Hospital , , Hubei , China"},{"name":"Tongji Medical College , , Hubei , China"},{"name":"Huazhong University of Science and Technology , , Hubei , China"},{"name":"Institute of Urology , , Hubei , China"},{"name":"Tongji Hospital , , Hubei , China"},{"name":"Tongji Medical College , , Hubei , China"},{"name":"Huazhong University of Science and Technology , , Hubei , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Urology , , Hubei , China"},{"name":"Tongji Hospital , , Hubei , China"},{"name":"Tongji Medical College , , Hubei , China"},{"name":"Huazhong University of Science and Technology , , Hubei , China"},{"name":"Institute of Urology , , Hubei , China"},{"name":"Tongji Hospital , , Hubei , China"},{"name":"Tongji Medical College , , Hubei , China"},{"name":"Huazhong University of Science and Technology , , Hubei , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Urology , , Hubei , China"},{"name":"Tongji Hospital , , Hubei , China"},{"name":"Tongji Medical College , , Hubei , China"},{"name":"Huazhong University of Science and Technology , , Hubei , China"},{"name":"Institute of Urology , , Hubei , China"},{"name":"Tongji Hospital , , Hubei , China"},{"name":"Tongji Medical College , , Hubei , China"},{"name":"Huazhong University of Science and Technology , , Hubei , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ke","family":"Rao","sequence":"additional","affiliation":[{"name":"Department of Urology , , Hubei , China"},{"name":"Tongji Hospital , , Hubei , China"},{"name":"Tongji Medical College , , Hubei , China"},{"name":"Huazhong University of Science and Technology , , Hubei , China"},{"name":"Institute of Urology , , Hubei , China"},{"name":"Tongji Hospital , , Hubei , China"},{"name":"Tongji Medical College , , Hubei , China"},{"name":"Huazhong University of Science and Technology , , Hubei , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaogang","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Urology , , Hubei , China"},{"name":"Tongji Hospital , , Hubei , China"},{"name":"Tongji Medical College , , Hubei , China"},{"name":"Huazhong University of Science and Technology , , Hubei , China"},{"name":"Institute of Urology , , Hubei , China"},{"name":"Tongji Hospital , , Hubei , China"},{"name":"Tongji Medical College , , Hubei , China"},{"name":"Huazhong University of Science and Technology , , Hubei , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiming","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Urology , , Hubei , China"},{"name":"Tongji Hospital , , Hubei , China"},{"name":"Tongji Medical College , , Hubei , China"},{"name":"Huazhong University of Science and Technology , , Hubei , China"},{"name":"Institute of Urology , , Hubei , China"},{"name":"Tongji Hospital , , Hubei , China"},{"name":"Tongji Medical College , , Hubei , China"},{"name":"Huazhong University of Science and Technology , , Hubei , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jihong","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Urology , , Hubei , China"},{"name":"Tongji Hospital , , Hubei , China"},{"name":"Tongji Medical College , , Hubei , China"},{"name":"Huazhong University of Science and Technology , , Hubei , China"},{"name":"Institute of Urology , , Hubei , China"},{"name":"Tongji Hospital , , Hubei , China"},{"name":"Tongji Medical College , , Hubei , China"},{"name":"Huazhong University of Science and Technology , , Hubei , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhangqun","family":"Ye","sequence":"additional","affiliation":[{"name":"Department of Urology , , Hubei , China"},{"name":"Tongji Hospital , , Hubei , China"},{"name":"Tongji Medical College , , Hubei , China"},{"name":"Huazhong University of Science and Technology , , Hubei , China"},{"name":"Institute of Urology , , Hubei , China"},{"name":"Tongji Hospital , , Hubei , China"},{"name":"Tongji Medical College , , Hubei , China"},{"name":"Huazhong University of Science and Technology , , Hubei , China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2016,5,1]]},"reference":[{"key":"2023041406271389800_","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/S0140-6736(12)60520-0","article-title":"Erectile dysfunction","volume":"381","author":"Shamloul","year":"2013","journal-title":"Lancet"},{"key":"2023041406271389800_","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1097\/HJH.0b013e328342c659","article-title":"Hypertension and sexual dysfunction: Time to act","volume":"29","author":"Viigimaa","year":"2011","journal-title":"J Hypertens"},{"key":"2023041406271389800_","volume-title":"Erectile dysfunction in hypertension and cardiovascular disease: A guide for clinicians","author":"Viigimaa","year":"2014"},{"key":"2023041406271389800_","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1016\/S0022-5347(05)67900-1","article-title":"Incidence of erectile dysfunction in men 40 to 69 years old: Longitudinal results from the massachusetts male aging study","volume":"163","author":"Johannes","year":"2000","journal-title":"J Urol"},{"key":"2023041406271389800_","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1097\/01.ju.0000164463.19239.19","article-title":"Chapter 1: The management of erectile dysfunction: An AUA update","volume":"174","author":"Montague","year":"2005","journal-title":"J Urol"},{"key":"2023041406271389800_","doi-asserted-by":"crossref","DOI":"10.1016\/j.eururo.2010.02.020","article-title":"Guidelines on male sexual dysfunction: Erectile dysfunction and premature ejaculation","volume-title":"European association of urology","author":"Hatzimouratidis"},{"key":"2023041406271389800_","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1159\/000049850","article-title":"Prognostic factors for response to sildenafil in patients with erectile dysfunction","volume":"40","author":"Martinez-Jabaloyas","year":"2001","journal-title":"Eur Urol"},{"key":"2023041406271389800_","first-page":"1","article-title":"Erectile dysfunction and its management in patients with diabetes mellitus","volume-title":"Rev Endocr Metab Disord","author":"Defeudis","year":"2015"},{"key":"2023041406271389800_","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1152\/physrev.1992.72.1.101","article-title":"Physiological actions of taurine","volume":"72","author":"Huxtable","year":"1992","journal-title":"Physiol Rev"},{"key":"2023041406271389800_","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.atherosclerosis.2009.06.002","article-title":"The potential protective effects of taurine on coronary heart disease","volume":"208","author":"Wojcik","year":"2010","journal-title":"Atherosclerosis"},{"key":"2023041406271389800_","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1007\/978-1-4614-6093-0_32","article-title":"Taurine enhances the sexual response and mating ability in aged male rats","volume-title":"Taurine 8","author":"Yang","year":"2013"},{"key":"2023041406271389800_","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1016\/S0090-4295(99)80073-9","article-title":"Apomorphine versus mating behavior in testing erectile capabilities of diabetic rats","volume":"45","author":"Elabbady","year":"1995","journal-title":"Urology"},{"key":"2023041406271389800_","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1016\/j.juro.2012.12.001","article-title":"Protective effects of hydrogen-rich saline against erectile dysfunction in a streptozotocin induced diabetic rat model","volume":"190","author":"Fan","year":"2013","journal-title":"J Urol"},{"key":"2023041406271389800_","doi-asserted-by":"crossref","first-page":"187","DOI":"10.2220\/biomedres.32.187","article-title":"Protective effect of taurine on diabetic rat endothelial dysfunction","volume":"32","author":"Ikubo","year":"2011","journal-title":"Biomed Res"},{"key":"2023041406271389800_","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1111\/fcp.12041","article-title":"Chronic treatment with taurine ameliorates diabetes-induced dysfunction of nitric oxide-mediated neurogenic and endothelium-dependent corpus cavernosum relaxation in rats","volume":"28","author":"Dalaklioglu","year":"2014","journal-title":"Fundam Clin Pharmacol"},{"key":"2023041406271389800_","doi-asserted-by":"crossref","first-page":"e105851","DOI":"10.1371\/journal.pone.0105851","article-title":"Taurine supplementation reduces blood pressure and prevents endothelial dysfunction and oxidative stress in post-weaning protein-restricted rats","volume":"9","author":"Maia","year":"2014","journal-title":"PLoS One"},{"key":"2023041406271389800_","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1016\/S0022-5347(17)38543-9","article-title":"The characterization of a bio-assay of erectile function in a rat model","volume":"145","author":"Heaton","year":"1991","journal-title":"J Urol"},{"key":"2023041406271389800_","doi-asserted-by":"crossref","first-page":"3041","DOI":"10.1111\/j.1743-6109.2012.02960.x","article-title":"Apocynin improves erectile function in diabetic rats through regulation of nadph oxidase expression","volume":"9","author":"Li","year":"2012","journal-title":"J Sex Med"},{"key":"2023041406271389800_","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1111\/j.1743-6109.2005.00158.x","article-title":"Functional sequelae of cavernous nerve injury in the rat: Is there model dependency","volume":"3","author":"Mullerad","year":"2006","journal-title":"J Sex Med"},{"key":"2023041406271389800_","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1016\/j.juro.2013.03.043","article-title":"Sarna guided inos up-regulation improves erectile function of diabetic rats","volume":"190","author":"Wang","year":"2013","journal-title":"J Urol"},{"key":"2023041406271389800_","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1111\/j.2047-2927.2012.00060.x","article-title":"S-allyl cysteine restores erectile function through inhibition of reactive oxygen species generation in diabetic rats","volume":"1","author":"Yang","year":"2013","journal-title":"Andrology"},{"issue":"Suppl 1","key":"2023041406271389800_","doi-asserted-by":"crossref","first-page":"S6","DOI":"10.1186\/1423-0127-17-S1-S6","article-title":"Taurine in health and diseases: Consistent evidence from experimental and epidemiological studies","volume":"17","author":"Yamori","year":"2010","journal-title":"J Biomed Sci"},{"key":"2023041406271389800_","doi-asserted-by":"crossref","first-page":"2040","DOI":"10.1016\/j.jacc.2007.10.069","article-title":"Erectile dysfunction as a predictor of cardiovascular events and death in diabetic patients with angiographically proven asymptomatic coronary artery disease: A potential protective role for statins and 5-phosphodiesterase inhibitors","volume":"51","author":"Gazzaruso","year":"2008","journal-title":"J Am Coll Cardiol"},{"key":"2023041406271389800_","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.1056\/NEJMra1300575","article-title":"Fibrosis \u2013 a common pathway to organ injury and failure","volume":"372","author":"Rockey","year":"2015","journal-title":"N Engl J Med"},{"key":"2023041406271389800_","doi-asserted-by":"crossref","first-page":"651","DOI":"10.2164\/jandrol.111.014456","article-title":"The tgf-beta1\/smad\/ctgf pathway and corpus cavernosum fibrous-muscular alterations in rats with streptozotocin-induced diabetes","volume":"33","author":"Zhou","year":"2012","journal-title":"J Androl"},{"key":"2023041406271389800_","doi-asserted-by":"crossref","first-page":"832","DOI":"10.2164\/jandrol.111.015172","article-title":"Effects of icariside ii on improving erectile function in rats with streptozotocin-induced diabetes","volume":"33","author":"Zhou","year":"2012","journal-title":"J Androl"},{"key":"2023041406271389800_","doi-asserted-by":"crossref","first-page":"2318","DOI":"10.1111\/j.1743-6109.2008.00977.x","article-title":"Role of increased penile expression of transforming growth factor-beta1 and activation of the smad signaling pathway in erectile dysfunction in streptozotocin-induced diabetic rats","volume":"5","author":"Zhang","year":"2008","journal-title":"J Sex Med"},{"key":"2023041406271389800_","doi-asserted-by":"crossref","first-page":"82","DOI":"10.3389\/fphys.2015.00082","article-title":"Tgf-beta\/smad signaling in renal fibrosis","volume":"6","author":"Meng","year":"2015","journal-title":"Front Physiol"},{"key":"2023041406271389800_","doi-asserted-by":"crossref","first-page":"324","DOI":"10.2164\/jandrol.109.008730","article-title":"Amelioration of penile fibrosis: Myth or reality","volume":"31","author":"El-Sakka","year":"2010","journal-title":"J Androl"},{"key":"2023041406271389800_","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1002\/jcp.22783","article-title":"Pai-1 in tissue fibrosis","volume":"227","author":"Ghosh","year":"2012","journal-title":"J Cell Physiol"},{"key":"2023041406271389800_","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1165\/ajrcmb.18.3.2867","article-title":"Regulation of transforming growth factor-beta1 mrna expression by taurine and niacin in the bleomycin hamster model of lung fibrosis","volume":"18","author":"Gurujeyalakshmi","year":"1998","journal-title":"Am J Respir Cell Mol Biol"},{"key":"2023041406271389800_","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.hepres.2004.04.006","article-title":"Transforming growth factor-beta-induced stimulation of formation of collagen fiber network and anti-fibrotic effect of taurine in an in vitro model of hepatic fibrosis","volume":"30","author":"Kato","year":"2004","journal-title":"Hepatol Res"},{"key":"2023041406271389800_","doi-asserted-by":"crossref","first-page":"1762","DOI":"10.1111\/j.1523-1755.2005.00274.x","article-title":"Reactive oxygen species mediate high glucose-induced plasminogen activator inhibitor-1 up-regulation in mesangial cells and in diabetic kidney","volume":"67","author":"Lee","year":"2005","journal-title":"Kidney Int"},{"key":"2023041406271389800_","doi-asserted-by":"crossref","first-page":"3291","DOI":"10.1111\/j.1743-6109.2011.02505.x","article-title":"Investigative models in erectile dysfunction: A state-of-the-art review of current animal models","volume":"8","author":"Chung","year":"2011","journal-title":"J Sex Med"},{"key":"2023041406271389800_","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1111\/jsm.12447","article-title":"Assessment of androgen replacement therapy for erectile function in rats with type 2 diabetes mellitus by examining nitric oxide-related and inflammatory factors","volume":"11","author":"Kataoka","year":"2014","journal-title":"J Sex Med"}],"container-title":["The Journal of Sexual Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1743609516003180?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1743609516003180?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/jsm\/article-pdf\/13\/5\/778\/49886279\/jsm_13_5_778.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jsm\/article-pdf\/13\/5\/778\/49886279\/jsm_13_5_778.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,17]],"date-time":"2023-08-17T10:10:37Z","timestamp":1692267037000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jsm\/article\/13\/5\/778\/6940202"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,5,1]]},"references-count":35,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2016,5,1]]},"published-print":{"date-parts":[[2016,5,1]]}},"URL":"https:\/\/doi.org\/10.1016\/j.jsxm.2016.02.164","relation":{},"ISSN":["1743-6109","1743-6095"],"issn-type":[{"value":"1743-6109","type":"electronic"},{"value":"1743-6095","type":"print"}],"subject":[],"published-other":{"date-parts":[[2016,5]]},"published":{"date-parts":[[2016,5,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Taurine Supplementation Improves Erectile Function in Rats with Streptozotocin-induced Type 1 Diabetes via Amelioration of Penile Fibrosis and Endothelial Dysfunction","name":"articletitle","label":"Article Title"},{"value":"The Journal of Sexual Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jsxm.2016.02.164","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 International Society for Sexual Medicine. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}